tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stienstra NA et al. | Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. | 2016 | Ther Drug Monit | pmid:27805928 |
| Quist SR et al. | Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis. | 2016 | Acta Derm. Venereol. | pmid:26911315 |
| Prytula A et al. | Tacrolimus Predose Concentration Is Associated With Hypertension in Pediatric Liver Transplant Recipients. | 2016 | J. Pediatr. Gastroenterol. Nutr. | pmid:26910645 |
| Wang X et al. | Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro. | 2016 | Mol Nutr Food Res | pmid:27061233 |
| Tang J et al. | ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts. | 2016 | Cell. Physiol. Biochem. | pmid:27771715 |
| Ghareeb M and Akhlaghi F | Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27771258 |
| Jannot AS et al. | A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26829596 |
| Sayar E et al. | The Ineffectiveness of Tacrolimus in an Infant With a Mutation in the IL-10 Receptor. | 2016 | J. Clin. Gastroenterol. | pmid:26828243 |
| Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
| Gathogo E et al. | Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. | 2016 | Transplantation | pmid:26413990 |
| Sienkiewicz B et al. | The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation. | 2016 | Pharmazie | pmid:29441922 |
| Cortes X et al. | Successful use of infliximab and tacrolimus combination therapy in a patient with ulcerative colitis refractory to infliximab dose intensification plus azathioprine. | 2016 | Int J Clin Pharmacol Ther | pmid:26754306 |
| Vanhove T et al. | Clinical determinants of calcineurin inhibitor disposition: a mechanistic review. | 2016 | Drug Metab. Rev. | pmid:26912097 |
| Bae JM et al. | Repigmentation of poliosis in a patient with segmental vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27317537 |
| Tamhankar MA et al. | Tacrolimus-induced cerebral blindness in a liver transplant patient. | 2016 | Indian J Ophthalmol | pmid:23619482 |
| Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
| Wang J et al. | Evaluation of mycophenolate mofetil or tacrolimus in children with steroid sensitive but frequently relapsing or steroid-dependent nephrotic syndrome. | 2016 | Nephrology (Carlton) | pmid:26697959 |
| Yang Y et al. | STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. | 2016 | Neuroreport | pmid:26694943 |
| Ganetsky A et al. | Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:26691423 |
| Okuda K et al. | Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. | 2016 | PLoS ONE | pmid:27501378 |
| Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Bessa AB et al. | Prospective Randomized Trial Investigating the Influence of Pharmaceutical Care on the Intra-Individual Variability of Tacrolimus Concentrations Early After Kidney Transplant. | 2016 | Ther Drug Monit | pmid:27414973 |
| Mehraj V et al. | The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. | 2016 | EBioMedicine | pmid:27397514 |
| Wu Q et al. | Repair of Neurological Function in Response to FK506 Through CaN/NFATc1 Pathway Following Traumatic Brain Injury in Rats. | 2016 | Neurochem. Res. | pmid:27386875 |
| Pastor-Clerigues A et al. | Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test. | 2016 | Curr. Eye Res. | pmid:26554729 |
| Mittal A et al. | Pilot Study to Evaluate the Efficacy and Safety of Oral Tacrolimus in Adult Patients With Refractory Severe Plaque Psoriasis. | 2016 | J Cutan Med Surg | pmid:26553734 |
| Roblin E et al. | Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. | 2016 | Pediatr Transplant | pmid:26750745 |
| Dunyak BM and Gestwicki JE | Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. | 2016 | J. Med. Chem. | pmid:27409354 |
| Oetting WS et al. | Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. | 2016 | Am. J. Transplant. | pmid:26485092 |
| Sun W et al. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. | 2016 | Pflugers Arch. | pmid:27318696 |
| Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
| Baek CH et al. | Usefulness of Tacrolimus without Basiliximab in Well-Matched Living-Donor Renal Transplant Recipients in Korea. | 2016 | Exp Clin Transplant | pmid:27228054 |
| Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
| Yousef AM et al. | Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients. | 2016 | Iran J Kidney Dis | pmid:27225724 |
| Schmidt KJ et al. | Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues. | 2016 | J Crohns Colitis | pmid:26419459 |
| Sommerer C and Giese T | Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:26418701 |
| Yamamoto T et al. | Letter: which patient profile for tacrolimus in ulcerative colitis? Authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27137731 |
| Laharie D and Poullenot F | Letter: which patient profile for tacrolimus in ulcerative colitis? | 2016 | Aliment. Pharmacol. Ther. | pmid:27137730 |
| Wei Q et al. | Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma. | 2016 | Gut Liver | pmid:27074818 |
| Wowro SJ et al. | Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells. | 2016 | Int. Immunopharmacol. | pmid:26613512 |
| SelimoÄŸlu MA et al. | Evaluation of renal functions in pediatric liver transplantation. | 2016 | Pediatr Transplant | pmid:26607307 |
| Adler M et al. | A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. | 2016 | J. Am. Soc. Nephrol. | pmid:26260164 |
| Ueda Y and Uemoto S | Decreased tacrolimus concentration following a temporal increase during interferon-free therapy with asunaprevir and daclatasvir in patients with recurrent hepatitis C after liver transplantation. | 2016 | Transpl. Int. | pmid:26270021 |
| Jung H and Oh ES | FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression. | 2016 | Pigment Cell Melanoma Res | pmid:27060922 |
| Brito-Costa A et al. | Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation: The Potential Influence of Immunosuppressive Agents. | 2016 | Transplantation | pmid:27136260 |
| Myers AL et al. | Stability of tacrolimus injection diluted in 0.9% sodium chloride injection and stored in Excel bags. | 2016 | Am J Health Syst Pharm | pmid:27919876 |
| Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
| Thervet É | [Applied pharmacogenetic]. | 2016 | Nephrol. Ther. | pmid:26972091 |
| Moiseev IS et al. | Graft-versus-Host Disease Prophylaxis in Unrelated Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil. | 2016 | Biol. Blood Marrow Transplant. | pmid:26970381 |