Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
López Lago AM et al. | Evolution of hepatorenal syndrome after orthotopic liver transplantation: comparative analysis with patients who developed acute renal failure in the early postoperative period of liver transplantation. | 2007 | Transplant. Proc. | pmid:17889176 |
van Duijnhoven E et al. | The effect of breakfast on the oral bioavailability of tacrolimus in diabetic and nondiabetic patients before transplantation. | 1998 | Transplant. Proc. | pmid:9636515 |
Crespo M et al. | De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715848 |
Riveiro-Barciela M et al. | Hyperkalemic distal renal tubular acidosis caused by immunosuppressant treatment with tacrolimus in a liver transplant patient: case report. | 2011 | Transplant. Proc. | pmid:22172892 |
Pascual J et al. | One-center comparison between primary immunosuppression based on neoral cyclosporine and tacrolimus for renal transplantation. | 2002 | Transplant. Proc. | pmid:11959200 |
Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
Gregory CR et al. | Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. | 1993 | Transplant. Proc. | pmid:7679842 |
Jain AB et al. | Pharmacokinetics of cyclosporine and nephrotoxicity in orthotopic liver transplant patients rescued with FK 506. | 1991 | Transplant. Proc. | pmid:1721274 |
Lee KK et al. | Successful orthotopic small bowel transplantation with short-term FK 506 immunosuppressive therapy. | 1990 | Transplant. Proc. | pmid:1689908 |
McMichael J et al. | Evaluation of a novel "intelligent" dosing system for optimizing FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721275 |
Namii Y et al. | Tetrahydropyranyladriamycin with FK 506 combination therapy for hamster-to-rat-concordant xenotransplantation. | 1996 | Transplant. Proc. | pmid:8623358 |
Valdivia LA et al. | Prolonged survival of hearts obtained from chimeric donors in a mouse to rat xenotransplant model. | 1996 | Transplant. Proc. | pmid:8623371 |
Melo MJ et al. | Impact of conversion from Advagraf to twice-daily generic tacrolimus in kidney transplant recipients: a single-center study. | 2015 | Transplant. Proc. | pmid:26036484 |
Bilbao I et al. | Experience with neoral cyclosporine through the oral route in liver transplantation. | 1998 | Transplant. Proc. | pmid:9636580 |
Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120037 |
Langrehr JM et al. | Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636583 |
Nakao A et al. | Combined effect of donor-specific bone marrow transplantation via portal vein and FK506 on small bowel transplantation in the rat. | 2000 | Transplant. Proc. | pmid:11120044 |
Viganó J et al. | Incidence of graft rejection in small bowel transplanted pigs after immunosuppression withdrawal. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908291 |
Undre NA et al. | Pharmacokinetics of tacrolimus: clinically relevant aspects. | 1999 | Transplant. Proc. | pmid:10576037 |
Yilmaz A et al. | Severe angioedema caused by banana allergy under tacrolimus immunosuppression. | 2005 | Transplant. Proc. | pmid:16387091 |
Lai WJ et al. | Is sirolimus a safe alternative to reduce or eliminate calcineurin inhibitors in chronic allograft nephropathy in kidney transplantation? | 2004 | Transplant. Proc. | pmid:15518744 |
Colak H et al. | Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation. | 2015 | Transplant. Proc. | pmid:25964218 |
Rosborough SL et al. | Identification of FKBP-related proteins with antibodies of predetermined specificity and isolation by FK 506 affinity chromatography. | 1991 | Transplant. Proc. | pmid:1721306 |
Metcalfe S et al. | FK 506 and cyclosporine A: early effects on activation and gene induction in mouse spleen cells. | 1990 | Transplant. Proc. | pmid:1697107 |
Morris RE et al. | A study of the contrasting effects of cyclosporine, FK 506, and rapamycin on the suppression of allograft rejection. | 1990 | Transplant. Proc. | pmid:1697111 |
Zhao DQ et al. | Sirolimus-Based Immunosuppressive Regimens in Renal Transplantation: A Systemic Review. | Transplant. Proc. | pmid:26915834 | |
Li D et al. | Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms. | 2006 | Transplant. Proc. | pmid:17112846 |
Azuma T et al. | Study of graft-infiltrating cells in the rat small bowel allograft using low-dose FK 506. | 1999 | Transplant. Proc. | pmid:10578293 |
Antoniou EA et al. | Effect of donor-specific transfusion in combination with FK 506 in rat cardiac allotransplantation. | 1999 | Transplant. Proc. | pmid:10578296 |
Andres A et al. | Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation. | 2005 | Transplant. Proc. | pmid:15848711 |
Petan JA et al. | Physiochemical properties of generic formulations of tacrolimus in Mexico. | 2008 | Transplant. Proc. | pmid:18589125 |
Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
Abecassis MM et al. | Patient outcomes and economics of once-daily tacrolimus in renal transplant patients: results of a modeling analysis. | 2008 | Transplant. Proc. | pmid:18589126 |
Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
Timmermann W et al. | A randomised trial comparing the efficacy and safety of tacrolimus with microemulsified cyclosporine after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176463 |
Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. | 1992 | Transplant. Proc. | pmid:1376532 |
Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
Hassoun Z et al. | The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176464 |
McDiarmid SV et al. | FK 506 rescue therapy in liver transplantation: outcome and complications. | 1991 | Transplant. Proc. | pmid:1721339 |
Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
Rintala JM et al. | The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. | 2006 | Transplant. Proc. | pmid:17098049 |
Zhou W et al. | Calcineurin inhibitors block B-1 cell differentiation: the relevance to immunosuppressive treatment in ABO-incompatible transplantation. | 2005 | Transplant. Proc. | pmid:15919474 |
Niel OR et al. | Long-term glomerular filtration rate in liver allograft recipients according to the type of calcineurin inhibitors. | 2009 | Transplant. Proc. | pmid:19857743 |
Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
Charco R et al. | Low incidence of hypercholesterolemia among liver transplant patients under tacrolimus monotherapy immunosuppression. | 2002 | Transplant. Proc. | pmid:12176482 |
Cheng CY et al. | Intervention of Online Percent Coefficient of Variation Reporting System Reduces the Variability of Tacrolimus Trough Concentration in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30316366 |
Fries D et al. | Development of renal dysfunction and renal histological lesions in two patients treated with FK 506 for acute rejection following liver transplantation. | 1991 | Transplant. Proc. | pmid:1721370 |
Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
Jain AB et al. | Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1703354 |
Wijnen RM et al. | Toxicity of FK 506 in the cynomolgus monkey: noncorrelation with FK 506 serum levels. | 1991 | Transplant. Proc. | pmid:1721371 |
Venkataramanan R et al. | Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1703355 |
Goh BL et al. | FK506 rescue therapy for acute renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9838574 |
Goh BL and Tan SY | FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838575 |
Melk A et al. | P-glycoprotein expression in patients before and after kidney transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083115 |
Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
Tacrolimus in renal transplantation: a comparison of induction vs noninduction therapy (triple therapy): three-month results. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083131 | |
Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
Veroux P et al. | Tacrolimus-induced neurotoxicity in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12493415 |
Izbicki G et al. | Improved survival after lung transplantation in patients treated with tacrolimus/mycophenolate mofetil as compared with cyclosporine/azathioprine. | 2002 | Transplant. Proc. | pmid:12493439 |
Katoh H et al. | Effectiveness of 15-deoxyspergualin on steroid-resistant acute rejection in living related liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123125 |
Meiser BM et al. | Tacrolimus (FK506) proves superior to OKT3 for treating episodes of persistent rejection following intrathoracic transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123150 |
Takeuchi H et al. | Evidence of different pharmacokinetics between cyclosporine and tacrolimus in renal transplant recipients: why cyclosporine is monitored by C2 level and tacrolimus by trough level. | 2008 | Transplant. Proc. | pmid:18790203 |
Scolari MP et al. | Acute rejection after renal transplantation with tacrolimus-based therapy in conditions of normal clinical practice. | 2002 | Transplant. Proc. | pmid:12176529 |
Shimizu T et al. | Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts. | 2008 | Transplant. Proc. | pmid:18790237 |
Ushigome H et al. | Immunosuppression in cadaveric renal transplant recipients from non-heart-beating donors in a single center. | 2002 | Transplant. Proc. | pmid:12176533 |
Arita S et al. | Effect of FK 506 in experimental pancreas transplantation. | 1995 | Transplant. Proc. | pmid:7536980 |
Viebahn R et al. | Hypoxic and reoxygenation injury in human and rat hepatocytes--influence of FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721401 |
Sato K et al. | Effectiveness of triple drug immunosuppression for pancreaticoduodenal allotransplantation in dogs. | 1992 | Transplant. Proc. | pmid:1379753 |
Masaki Y et al. | Microchimerism and rat small bowel transplantation combined with donor-type bone marrow cells. | 1996 | Transplant. Proc. | pmid:8769154 |
Murphy MP and Morris RE | Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model. | 1993 | Transplant. Proc. | pmid:7685955 |
Kobayashi C et al. | Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506. | 1989 | Transplant. Proc. | pmid:2468254 |
Mohamed MA et al. | The effect of cyclosporin A and tacrolimus on cultured human epithelial cells: the role of TGF-beta. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083523 |
Furtado A et al. | Local immunosuppression in clinical small bowel transplantation (report of two cases). | 2000 | Transplant. Proc. | pmid:10995910 |
Ayar Y et al. | Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. | 2017 | Transplant. Proc. | pmid:28219583 |
Sheng H et al. | Ocular complications of heart transplantation in a Chinese population. | 2008 | Transplant. Proc. | pmid:19100445 |
Chariat MN et al. | Basiliximab in the therapy of acute rejection after organ transplantation. | 2001 | Transplant. Proc. | pmid:11377567 |
Chan MC et al. | Conversion of cyclosporine to tacrolimus for refractory or persistent myocardial rejection. | 2002 | Transplant. Proc. | pmid:12176601 |
Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
Akbas SH et al. | The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients. | 2006 | Transplant. Proc. | pmid:16797284 |
Franke GH et al. | Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation. | 2006 | Transplant. Proc. | pmid:16797285 |
Kobayashi N et al. | Effect of FK 506 on abdominal organ cluster transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1721434 |
Felipe CR et al. | Choosing the right dose of new immunossuppressive drugs for new populations: importance of pharmacokinetic studies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267207 |
Evans NJ et al. | The expression of endothelin and inducible nitric oxide synthase in human renal allografts and their role in chronic renal allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267247 |
Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
Minematsu T et al. | Effect of hematocrit on pharmacokinetics of tacrolimus in adult living donor liver transplant recipients. | 2004 | Transplant. Proc. | pmid:15251372 |
Dikow R et al. | Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine. | 2004 | Transplant. Proc. | pmid:15251373 |
Busuttil RW and Holt CD | Tacrolimus is superior to cyclosporine in liver transplantation. | 1998 | Transplant. Proc. | pmid:9723432 |
Gasser M et al. | Effect of selective immunosuppression with FK 506, anti-IL-2R, and anti-ICAM-1 MAb in rat small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745510 |
Jonas S et al. | Five-year follow-up of tacrolimus as primary immunosuppressant after liver transplantation. | 1998 | Transplant. Proc. | pmid:9723433 |
Dutta S et al. | Liposomal tacrolimus and intestinal drug concentration. | 1998 | Transplant. Proc. | pmid:9745533 |
Toyoki Y et al. | Primary immunosuppression regimen of rapid steroid withdrawal after living related liver transplantation: a single-center experience. | 2004 | Transplant. Proc. | pmid:15561218 |
Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
Burke GW et al. | Ten-year survival after simultaneous pancreas/kidney transplantation with bladder drainage and tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267467 |
Kobashigawa JA | Controversies in heart and lung transplantation immunosuppression: tacrolimus versus cyclosporine. | 1998 | Transplant. Proc. | pmid:9636445 |
Rieber J et al. | Effects of tacrolimus and cyclosporine on the coronary microcirculation after heart transplantation: a prospective study with serial intracoronary flow measurements. | 1998 | Transplant. Proc. | pmid:9636446 |
Wong YT et al. | Audit of diabetes in a renal transplant population. | 2005 | Transplant. Proc. | pmid:16298573 |
Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
Jiang H et al. | Effect of FK 506 on heart allograft survival in highly sensitized recipient rats in comparison with cyclosporine. | 1991 | Transplant. Proc. | pmid:1703702 |