tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Doi R et al. | Biochemical characterization of the effects of FK506 on signal transduction in exocytotic function of rat pancreatic acini. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7679738 |
| Klintmalm GB et al. | Use of Prograf (FK 506) as rescue therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679840 |
| Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
| Gregory CR et al. | Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. | 1993 | Transplant. Proc. | pmid:7679842 |
| Zeevi A et al. | Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. | 1993 | Transplant. Proc. | pmid:7679843 |
| Inoue T et al. | Isolation of mitochondrial cyclophilin from bovine heart. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7679902 |
| D'Ambrosio R et al. | Validation and quality assurance program for monitoring tacrolimus (FK 506) concentrations in plasma and whole blood. | 1993 | Ther Drug Monit | pmid:7504339 |
| Reese JC et al. | The effect of FK506 on canine bile flow. | 1993 | Transplantation | pmid:7504342 |
| Woodle ES et al. | FK506--reversal of humorally mediated cardiac allograft rejection in the presence of preformed anti-class I antibody. | 1993 | Transplantation | pmid:7504346 |
| Jindal RM et al. | Effect of deoxyspergualin on the endocrine function of the rat pancreas. | 1993 | Transplantation | pmid:7504347 |
| Kodama M et al. | FK506 therapy of experimental autoimmune myocarditis after onset of the disease. | 1993 | Am. Heart J. | pmid:7504393 |
| Nishinaka Y et al. | Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart. | 1993 | J. Cardiovasc. Pharmacol. | pmid:7681507 |
| Luan S et al. | Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7681590 |
| Doi R et al. | Structural and functional changes of exocrine pancreas induced by FK506 in rats. | 1993 | Gastroenterology | pmid:7681795 |
| Rotonda J et al. | Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis. | 1993 | J. Biol. Chem. | pmid:7681823 |
| Simek SL et al. | Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. | 1993 | Genomics | pmid:7507077 |
| Wakugami T et al. | Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. | 1993 | Tohoku J. Exp. Med. | pmid:7692621 |
| Quesniaux VF | Immunosuppressants: tools to investigate the physiological role of cytokines. | 1993 | Bioessays | pmid:7507316 |
| Hill CC et al. | Penile prosthesis surgery in the immunosuppressed patient. | 1993 | Transplantation | pmid:7692633 |
| Roberts JP et al. | Reversal of chronic rejection after treatment failure with FK506 and RS61443. | 1993 | Transplantation | pmid:7692634 |
| Storb R et al. | FK-506 and methotrexate prevent graft-versus-host disease in dogs given 9.2 Gy total body irradiation and marrow grafts from unrelated dog leukocyte antigen-nonidentical donors. | 1993 | Transplantation | pmid:7692635 |
| McDiarmid SV et al. | A comparison of renal function in cyclosporine- and FK-506-treated patients after primary orthotopic liver transplantation. | 1993 | Transplantation | pmid:7692636 |
| Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
| Clipstone NA and Crabtree GR | Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509131 |
| Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
| Thomson AW et al. | Incidence of CD4+ IL-2R alpha+ and CD4+ CD45RA+ T-cells in progressive multiple sclerosis and the influence of short-term (3 months) FK 506 therapy. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509133 |
| Kadmon M et al. | Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. | 1993 | Gastroenterology | pmid:7683296 |
| Denesyuk AI et al. | Structural similarity of the binding sites of cyclophilin A-cyclosporin A and FKBP-FK506 systems. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7683466 |
| Waschulewski IH et al. | Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. | 1993 | Br. J. Pharmacol. | pmid:7683567 |
| Ohtake M et al. | Enhanced liver regeneration in rats treated with 15-deoxyspergualin alone and in combination with FK 506. | 1993 | Gastroenterol. Jpn. | pmid:7683616 |
| Ohnishi H et al. | Natural killer cell may impair liver regeneration in fulminant hepatic failure. | 1993 | Gastroenterol. Jpn. | pmid:7683619 |
| Natazuka T et al. | FK506 and cyclosporin a regulate proliferation and proto-oncogene expression in HTLV-1-associated myelopathy/tropical-spastic-paraparesis-derived T cells. | 1993 | Int. J. Cancer | pmid:7683633 |
| Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
| Murphy MP and Morris RE | Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model. | 1993 | Transplant. Proc. | pmid:7685955 |
| Li W and Handschumacher RE | Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin. | 1993 | J. Biol. Chem. | pmid:7686148 |
| Wong PY et al. | Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression. | 1993 | J. Hepatol. | pmid:7686192 |
| Sakr MF et al. | FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion. | 1993 | J. Hepatol. | pmid:7686193 |
| Smith DF et al. | Two FKBP-related proteins are associated with progesterone receptor complexes. | 1993 | J. Biol. Chem. | pmid:7688746 |
| Jacobs JC et al. | Pyoderma gangrenosum in infancy. | 1993 | J. Am. Acad. Dermatol. | pmid:7688775 |
| Garrity GM et al. | Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin. | 1993 | J. Ind. Microbiol. | pmid:7688970 |
| Hoof T et al. | Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin. | 1993 | Eur. J. Pharmacol. | pmid:7689059 |
| Jin YJ and Burakoff SJ | The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7689229 |
| Lieberman R | FK506, artificial intelligence and pharmacoeconomics. | 1993 | J Clin Pharmacol | pmid:7690045 |
| McMichael J et al. | An intelligent and cost-effective computer dosing system for individualizing FK506 therapy in transplantation and autoimmune disorders. | 1993 | J Clin Pharmacol | pmid:7690046 |
| Jain AB et al. | Pharmacokinetics of FK506 in liver transplant recipients after continuous intravenous infusion. | 1993 | J Clin Pharmacol | pmid:7690047 |
| Cheng JW et al. | 15N NMR relaxation studies of the FK506 binding protein: backbone dynamics of the uncomplexed receptor. | 1993 | Biochemistry | pmid:7690248 |
| Ito K and Komatsu Y | [Drug induced hemolytic uremic syndrome]. | 1993 | Nippon Rinsho | pmid:7679450 |
| Langrehr JM et al. | Clinical course, morphology, and treatment of chronically rejecting small bowel allografts. | 1993 | Transplantation | pmid:7679526 |
| Uemoto S et al. | Experience with FK506 in living-related liver transplantation. | 1993 | Transplantation | pmid:7679528 |
| Talento A et al. | A single administration of LFA-1 antibody confers prolonged allograft survival. | 1993 | Transplantation | pmid:7679531 |