Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Misra DP et al. | Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. | 2014 | BMJ Case Rep | pmid:25398925 |
Weng LC et al. | Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24656004 |
Takahashi K et al. | Safety and efficacy of once-daily modified-release tacrolimus in kidney transplant recipients: interim analysis of multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24655975 |
Kamburova EG et al. | Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. | 2014 | PLoS ONE | pmid:25393622 |
Wu MJ et al. | Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5. | 2014 | Transplant. Proc. | pmid:24655974 |
Filler G and Smith N | The need for tacrolimus assay standardization. | 2014 | Ther Drug Monit | pmid:25390282 |
Jun H et al. | Experiences on conversion to once-daily Advagraf and sirolimus combination in stable kidney recipients. | 2014 | Transplant. Proc. | pmid:24655973 |
Sachewsky N et al. | Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway. | 2014 | Dis Model Mech | pmid:25056698 |
Masutani K et al. | Protocol biopsy findings in living donor kidney transplant patients treated with once-daily or twice-daily tacrolimus formulation. | 2014 | Transplant. Proc. | pmid:24655972 |
Tian SY et al. | Immunosuppressive therapies for the induction treatment of proliferative lupus nephritis: a systematic review and network metaanalysis. | 2014 | J. Rheumatol. | pmid:25225281 |
Leung EK et al. | Clinical evaluation of the QMS® Tacrolimus immunoassay. | 2014 | Clin. Chim. Acta | pmid:24518359 |
Qi R et al. | FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. | 2014 | Ren Fail | pmid:24512120 |
Klawitter J et al. | Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. | 2014 | PLoS ONE | pmid:24497939 |
Filler G | Finding the optimal therapeutic window for tacrolimus. | 2014 | Pediatr Transplant | pmid:25345999 |
Thölking G et al. | The tacrolimus metabolism rate influences renal function after kidney transplantation. | 2014 | PLoS ONE | pmid:25340655 |
DU C et al. | [In vitro effects of tacrolimus on platelet function]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:25339327 |
Lipson EJ et al. | Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. | 2014 | J. Clin. Oncol. | pmid:24493726 |
Yin Z et al. | Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin. | 2014 | Drug Des Devel Ther | pmid:25336924 |
Pulsipher MA et al. | The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. | 2014 | Blood | pmid:24497539 |
Verma M et al. | Impact of single immunosuppressive drug withdrawal on lymphocyte immunoreactivity. | 2014 | J. Surg. Res. | pmid:24485875 |
El-Sheikh AA et al. | Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus. | 2014 | Transl Res | pmid:24486136 |
Carr L et al. | Calcineurin activity assay measurement by liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring mode. | 2014 | Clin. Chem. | pmid:24281780 |
Rehman S et al. | Effect of different tacrolimus levels on early outcomes after kidney transplantation. | 2014 | Ann. Transplant. | pmid:24509826 |
Xie M et al. | Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience. | 2014 | Pediatr Transplant | pmid:24283660 |
Qin XL et al. | In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. | 2014 | Drug Metab. Dispos. | pmid:24195812 |
Peng ZG and Tian J | Higher Serum Trough Levels of Tacrolimus Increase 5-Year Allograft Survival in Antibody Positive Renal Transplant Patients. | 2014 | Clin Transpl | pmid:26281147 |
Filler G et al. | Similar MPA exposure on modified release and regular tacrolimus. | 2014 | Ther Drug Monit | pmid:24365986 |
Vavic N et al. | The influence of comedication on tacrolimus blood concentration in patients subjected to kidney transplantation: a retrospective study. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24356808 |
Chen D et al. | Association of hemoglobin levels, CYP3A5, and NR1I3 gene polymorphisms with tacrolimus pharmacokinetics in liver transplant patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24351870 |
Bruel A et al. | Early protocol biopsies in pediatric renal transplantation: interest for the adaptation of immunosuppression. | 2014 | Pediatr Transplant | pmid:24341571 |
Jain A et al. | Delayed introduction of tacrolimus postliver transplant with intravenous mycophenolate mofetil preserves renal function without incurring rejection. | 2014 | Transplantation | pmid:25285953 |
Cho A et al. | Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. | 2014 | Neuron | pmid:24698271 |
Teraki Y | [Atopic dermatitis in pregnancy]. | 2014 | Arerugi | pmid:24714179 |
Casey MJ et al. | Prolonged immunosuppression preserves nonsensitization status after kidney transplant failure. | 2014 | Transplantation | pmid:24717218 |
Hirai F et al. | Impact of CYP3A5 genetic polymorphisms on the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus. | 2014 | J. Gastroenterol. Hepatol. | pmid:24033383 |
Protic M et al. | The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients. | 2014 | J Crohns Colitis | pmid:24908178 |
Hayashi K et al. | Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Intern. Med. | pmid:25400189 |
Sugiyama K et al. | Immune monitoring with a lymphocyte adenosine triphosphate assay in kidney transplant recipients treated with a calcineurin inhibitor. | 2014 | Exp Clin Transplant | pmid:24907718 |
Lankarani KB et al. | New onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:23902591 |
Shlivko IL et al. | Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus. | 2014 | Skin Res Technol | pmid:23808907 |
Jalil MH et al. | Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients. | 2014 | Br J Clin Pharmacol | pmid:23738951 |
Deng Z et al. | [Early diagnosis and comprehensive treatments of post-transplantation lymphoproliferative disorder after pediatric liver transplantation]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25224233 |
Tanaka H et al. | Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis. | 2014 | Lupus | pmid:24651669 |
Ichinose K et al. | [Rare case of systemic lupus erythematosus with encapsulating peritoneal sclerosis during hemodialysis]. | 2014 | Nihon Jinzo Gakkai Shi | pmid:24730352 |
Jacobo-Cabral CO et al. | Limustin®, a non-innovator tacrolimus formulation, yields reduced drug exposure in pediatric renal transplant recipients. | 2014 | Pediatr Transplant | pmid:25156476 |
Shah NP et al. | Treatment of a Crohn's disease-related cutaneous facial lesion with topical tacrolimus. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25151593 |
Werk AN et al. | Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. | 2014 | Clin. Pharmacol. Ther. | pmid:24126681 |
Carcas-Sansuán AJ et al. | Conversion from Prograf to Advagraf in stable paediatric renal transplant patients and 1-year follow-up. | 2014 | Pediatr. Nephrol. | pmid:23907143 |
Thorat A et al. | Effects of converting tacrolimus formulation from twice-daily to once-daily in liver transplantation recipients. | 2014 | Biomed Res Int | pmid:25121091 |
Griffith RD et al. | Cells to surgery quiz: September 2014. | 2014 | J. Invest. Dermatol. | pmid:25120152 |
Tolar J and McGrath JA | Augmentation of cutaneous wound healing by pharmacologic mobilization of endogenous bone marrow stem cells. | 2014 | J. Invest. Dermatol. | pmid:25120149 |
Pichler R et al. | De novo renal cell carcinoma in a kidney allograft with focus on contrast-enhanced ultrasound. | 2014 | Urol. Int. | pmid:25115614 |
Gionchetti P and Rizzello F | IBD. Sequential rescue therapy in steroid-refractory ulcerative colitis. | 2014 | Nat Rev Gastroenterol Hepatol | pmid:25023033 |
Van der Hauwaert C et al. | Expression profiles of genes involved in xenobiotic metabolism and disposition in human renal tissues and renal cell models. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25036895 |
ZivÄić-Ćosić S et al. | Immune reactivity of renal transplant recipients receiving interleukin-2 receptor antagonists during the early posttransplant period. | 2014 | Int Urol Nephrol | pmid:23515930 |
Hadjipanagi D et al. | Genetic polymorphisms in warfarin and tacrolimus-related genes VKORC1, CYP2C9 and CYP3A5 in the Greek-Cypriot population. | 2014 | BMC Res Notes | pmid:24593903 |
Helenius-Hietala J et al. | Oral mucosal health in liver transplant recipients and controls. | 2014 | Liver Transpl. | pmid:24142471 |
Yan YH et al. | Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. | 2014 | Neurosci. Lett. | pmid:24607931 |
Bogan JS | Endocytic cycling of glucose transporters and insulin resistance due to immunosuppressive agents. | 2014 | J. Clin. Endocrinol. Metab. | pmid:25279573 |
Demmers MW et al. | Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus. | 2014 | Transplantation | pmid:24157471 |
Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
Li Q et al. | Proniosome-derived niosomes for tacrolimus topical ocular delivery: in vitro cornea permeation, ocular irritation, and in vivo anti-allograft rejection. | 2014 | Eur J Pharm Sci | pmid:24905830 |
Shimizu M et al. | Treatment of refractory polyarticular juvenile idiopathic arthritis with tacrolimus. | 2014 | Rheumatology (Oxford) | pmid:25065006 |
Dai YJ et al. | Effect of pharmacological intervention on MIP-1α, MIP-1β and MCP-1 expression in patients with psoriasis vulgaris. | 2014 | Asian Pac J Trop Med | pmid:25063291 |
Oda K and Yamano K | Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:25059890 |
Lapteva M et al. | Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis. | 2014 | Mol. Pharm. | pmid:25057896 |
Di Stasio D et al. | Oral lichen planus: a narrative review. | 2014 | Front Biosci (Elite Ed) | pmid:24896212 |
Levinger E et al. | Topical 0.03% tacrolimus for subepithelial infiltrates secondary to adenoviral keratoconjunctivitis. | 2014 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:24696044 |
Nikitin AV | [Mechanisms of nephrotoxic action of immunodepressants, calcineurine inhibitors]. | 2014 | Antibiot. Khimioter. | pmid:25051716 |
Sun J et al. | [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:24985179 |
GoriaÄnov VA et al. | [Effect of tacrolimus on the results of living related kidney donor transplantation]. | 2014 | Ter. Arkh. | pmid:25095659 |
Shilpa PS et al. | Topical tacrolimus in the management of oral lichen planus: literature review. | 2014 | J Calif Dent Assoc | pmid:25080722 |
Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
Kuramitsu S et al. | [Case report of introducing MMF and steroids as an immunosuppressive therapy after living-donor liver transplantation for a patient with the diabetic nephropathy]. | 2014 | Fukuoka Igaku Zasshi | pmid:25000660 |
Kassir N et al. | Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in paediatric liver transplant recipients. | 2014 | Br J Clin Pharmacol | pmid:24977292 |
Lan X et al. | Efficacy of immunosuppression monotherapy after liver transplantation: a meta-analysis. | 2014 | World J. Gastroenterol. | pmid:25232269 |
Nath PR et al. | Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G. | 2014 | J. Immunol. | pmid:25225668 |
Buechter M et al. | Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. | 2014 | Z Gastroenterol | pmid:24905108 |
Wohlfahrtova M and Viklicky O | Recent trials in immunosuppression and their consequences for current therapy. | 2014 | Curr Opin Organ Transplant | pmid:24905020 |
Hayashi T and Harada N | Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation. | 2014 | FEBS J. | pmid:25158681 |
Savikko J et al. | Different effects of tacrolimus and cyclosporine on PDGF induction and chronic allograft injury: evidence for improved kidney graft outcome. | 2014 | Transpl. Immunol. | pmid:25158212 |
Lebel MJ et al. | Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. | 2014 | Pediatr Transplant | pmid:25156571 |
Reynolds BC et al. | Use of belatacept to maintain adequate early immunosuppression in calcineurin-mediated microangiopathic hemolysis post-renal transplant. | 2014 | Pediatr Transplant | pmid:24815506 |
Kim YE and Eun SC | Effect of FK506 ointment (Protopic) on rat skin allograft model. | 2014 | Transplant. Proc. | pmid:24815165 |
Lee KM and Eun SC | Experimental canine facial transplantation. | 2014 | Transplant. Proc. | pmid:24815162 |
Kurbalija V et al. | Time-series analysis in the medical domain: a study of Tacrolimus administration and influence on kidney graft function. | 2014 | Comput. Biol. Med. | pmid:24813681 |
Reitamo S and Remitz A | An update on current pharmacotherapy options in atopic dermatitis. | 2014 | Expert Opin Pharmacother | pmid:24811606 |
Osmola-Mańkowska A et al. | Topical tacrolimus vs medium-dose ultraviolet A1 phototherapy in the treatment of atopic dermatitis - a preliminary study in relation to parameters of the epidermal barrier function and high-frequency ultrasonography. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25555886 |
Yamanaka M et al. | Development and evaluation of a tacrolimus cream formulation using a binary solvent system. | 2014 | Int J Pharm | pmid:24456671 |
Dipchand AI et al. | Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. | 2014 | Pediatr Transplant | pmid:25118092 |
Upadhyay V et al. | Rapid and sensitive UPLC-MS-MS determination of tacrolimus in Wistar rats and human blood. | 2014 | J Chromatogr Sci | pmid:23264321 |
Hilgers M and Megahed M | [Oral lichen planus. Insight into the pathogenesis and therapeutic options]. | 2014 | Hautarzt | pmid:24722910 |
Shipkova M et al. | Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. | 2014 | Clin. Biochem. | pmid:24721684 |
Lin BW et al. | Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25491293 |
Hošková L et al. | Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system. | 2014 | Hypertens. Res. | pmid:24718302 |
Lee SJ et al. | Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants. | 2014 | Sci Rep | pmid:25491116 |
Miller EC et al. | Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. | 2014 | Eur. J. Neurosci. | pmid:24713000 |
Fernandes MB et al. | Supplementation with omega-3 polyunsaturated fatty acids and experimental tacrolimus-induced nephrotoxicity. | 2014 | Exp Clin Transplant | pmid:25489802 |
Larkins N and Matsell DG | Tacrolimus therapeutic drug monitoring and pediatric renal transplant graft outcomes. | 2014 | Pediatr Transplant | pmid:25284168 |
Kharfan-Dabaja M et al. | Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease in people receiving allogeneic hematopoietic stem cell transplantation. | 2014 | Cochrane Database Syst Rev | pmid:25061777 |