Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Garg V et al. | Proglycosomes: A novel nano-vesicle for ocular delivery of tacrolimus. | 2017 | Colloids Surf B Biointerfaces | pmid:28575739 |
Jogiraju VK et al. | Application of physiologically based pharmacokinetic modeling to predict drug disposition in pregnant populations. | 2017 | Biopharm Drug Dispos | pmid:28474821 |
Suetsugu K et al. | Analysis of the variable factors influencing tacrolimus blood concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:27822915 |
Kharfan-Dabaja MA et al. | Tacrolimus plus sirolimus with or without ATG as GVHD prophylaxis in HLA-mismatched unrelated donor allogeneic stem cell transplantation. | 2017 | Bone Marrow Transplant. | pmid:27819684 |
Trasi NS et al. | Non-Sink Dissolution Behavior and Solubility Limit of Commercial Tacrolimus Amorphous Formulations. | 2017 | J Pharm Sci | pmid:27816263 |
David-Neto E et al. | Longitudinal Pharmacokinetics of Everolimus When Combined With Low-level of Tacrolimus in Elderly Renal Transplant Recipients. | 2017 | Transplantation | pmid:27798513 |
Lim SW et al. | Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. | 2017 | Lab. Invest. | pmid:28759009 |
Alloway RR | Mounting Clinical Evidence With Tacrolimus Generic Products. | 2017 | Transplantation | pmid:28749820 |
Solmaz S et al. | Tacrolimus-Induced Diabetic Ketoacidosis After Allogeneic Bone Marrow Transplant. | 2017 | Exp Clin Transplant | pmid:26643544 |
Rhu J et al. | Clinical Implication of Mycophenolic Acid Trough Concentration Monitoring in Kidney Transplant Patients on a Tacrolimus Triple Maintenance Regimen: A Single-Center Experience. | 2017 | Ann. Transplant. | pmid:29180612 |
Wei L et al. | Therapeutic Effects of FK506 on IgA Nephropathy Rat. | 2017 | Kidney Blood Press. Res. | pmid:29179182 |
An Q et al. | High Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis. | 2017 | Chin. Med. J. | pmid:28685715 |
Wang Y et al. | Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans. | 2017 | Molecules | pmid:28672869 |
Lee D et al. | Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression. | 2017 | Transplantation | pmid:27779572 |
Li X et al. | Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28669722 |
Yuan D et al. | Effect of Vitamin D and Tacrolimus Combination Therapy on IgA Nephropathy. | 2017 | Med. Sci. Monit. | pmid:28659572 |
Devaux S et al. | RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis. | 2017 | Mol. Cell Proteomics | pmid:28659490 |
Qazi Y et al. | Efficacy and Safety of Everolimus Plus Low-Dose Tacrolimus Versus Mycophenolate Mofetil Plus Standard-Dose Tacrolimus in De Novo Renal Transplant Recipients: 12-Month Data. | 2017 | Am. J. Transplant. | pmid:27775865 |
Arns W et al. | Pharmacokinetics and Clinical Outcomes of Generic Tacrolimus (Hexal) Versus Branded Tacrolimus in De Novo Kidney Transplant Patients: A Multicenter, Randomized Trial. | 2017 | Transplantation | pmid:28658202 |
Gao L et al. | Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis. | 2017 | Antimicrob. Agents Chemother. | pmid:28923863 |
Ginocchio L et al. | Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. | 2017 | Adv Skin Wound Care | pmid:28914682 |
Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
Liang Q et al. | The efficacy and safety of tacrolimus monotherapy in adult-onset nephrotic syndrome caused by idiopathic membranous nephropathy. | 2017 | Ren Fail | pmid:28562168 |
Sharma N et al. | Myositis-associated Interstitial Lung Disease: Predictors of Failure of Conventional Treatment and Response to Tacrolimus in a US Cohort. | 2017 | J. Rheumatol. | pmid:28864644 |
Zhang J et al. | MicroRNA expression analysis during FK506-induced osteogenic differentiation in rat bone marrow stromal cells. | 2017 | Mol Med Rep | pmid:28560399 |
Asada A et al. | The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus. | 2017 | Dig Liver Dis | pmid:27717793 |
Park SS et al. | Beneficial Role of Low-Dose Antithymocyte Globulin in Unrelated Stem Cell Transplantation for Adult Patients with Acquired Severe Aplastic Anemia: Reduction of Graft-versus-Host Disease and Improvement of Graft-versus-Host Disease-Free, Failure-Free Survival Rate. | 2017 | Biol. Blood Marrow Transplant. | pmid:28554856 |
Chen YS et al. | Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients. | 2017 | Acta Pharmacol. Sin. | pmid:28552913 |
Kim HS et al. | The Protective Effect of Febuxostat on Chronic Tacrolimus-Induced Nephrotoxicity in Rats. | 2017 | Nephron | pmid:27701176 |
Pinsk V et al. | Complete Reversion of Familial Adenomatous Polyposis Phenotype Associated with Tacrolimus and Mycophenolate Mofetil Treatment Following Kidney Transplantation. | 2017 | Anticancer Res. | pmid:28551651 |
Jin SE et al. | Evaluation of tacrolimus sorption to PVC- and non-PVC-based tubes in administration sets: Pump method vs. drip method. | 2017 | Int J Pharm | pmid:28549974 |
Berntsen HF et al. | The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. | 2017 | Toxicology | pmid:29037868 |
Jin H et al. | Inappropriate amounts of topical tacrolimus applied on Korean patients with eczema. | 2017 | J Dermatolog Treat | pmid:27588441 |
Shen CL et al. | Tacrolimus Blood Level Fluctuation Predisposes to Coexisting BK Virus Nephropathy and Acute Allograft Rejection. | 2017 | Sci Rep | pmid:28512328 |
Eleftheriadis T et al. | In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity. | 2017 | Int Urol Nephrol | pmid:28508247 |
Henderson CN et al. | Continuous Abdominal Irrigation for Treatment of Tertiary Peritonitis in the Immunosuppressed Patient after Solid Organ Transplant: A Novel Approach. | 2017 | Am Surg | pmid:28424115 |
Kofod L et al. | Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. | 2017 | Am. J. Reprod. Immunol. | pmid:28440588 |
Chen B et al. | Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder. | 2017 | Sci Rep | pmid:28400553 |
Banovic F et al. | Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus. | 2017 | Vet. Dermatol. | pmid:28439997 |
Vanhove T et al. | Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients. | 2017 | Clin. Pharmacol. Ther. | pmid:28437851 |
Alvarez-ElÃas AC et al. | A Retrospective Study on Mycophenolic Acid Drug Interactions: Effect of Prednisone, Sirolimus, and Tacrolimus With MPA. | 2017 | Ther Drug Monit | pmid:28437284 |
Alhamad T et al. | Targeting High Calcineurin Inhibitor Levels After Acute Rejection With Less Tremor: A New Strategy. | 2017 | Transplantation | pmid:28422926 |
Labroo P et al. | Effect Of combining FK506 and neurotrophins on neurite branching and elongation. | 2017 | Muscle Nerve | pmid:27503321 |
Bhari N et al. | Tacrolimus induced dermatophyte infection overlying a plaque morphea. | 2017 | Dermatol Ther | pmid:27502443 |
Zhang H et al. | Multitarget Therapy for Maintenance Treatment of Lupus Nephritis. | 2017 | J. Am. Soc. Nephrol. | pmid:28760751 |
Calo S et al. | A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. | 2017 | PLoS Genet. | pmid:28339467 |
Peng T et al. | Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats. | 2017 | Mol Med Rep | pmid:28339051 |
Huang TQ et al. | Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury. | 2017 | Mol Med Rep | pmid:28339015 |
Varela-Veiga A et al. | Long-standing Papules on the Scrotum. | 2017 | Actas Dermosifiliogr | pmid:27328825 |
Saeki H | Management of Atopic Dermatitis in Japan. | 2017 | J Nippon Med Sch | pmid:28331140 |
Ito A et al. | Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3. | 2017 | Biochem. Genet. | pmid:28324194 |
Marini BL et al. | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 2017 | J Oncol Pharm Pract | pmid:26970572 |
Truffinet O et al. | Tacrolimus Exerts Only a Transient Effectiveness in Refractory Pediatric Crohn Disease: A Case Series. | 2017 | J. Pediatr. Gastroenterol. Nutr. | pmid:27429426 |
Riva N et al. | Therapeutic monitoring of pediatric transplant patients with conversion to generic tacrolimus. | 2017 | Farm Hosp | pmid:28236795 |
Madsen MJ et al. | The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients. | 2017 | Drugs R D | pmid:28229376 |
Vanhove T et al. | Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients. | 2017 | Am. J. Transplant. | pmid:28224698 |
Spallanzani V et al. | Red blood cell exchange as an approach for treating a case of severe tacrolimus overexposure. | 2017 | Transfus. Apher. Sci. | pmid:28223040 |
Kasahara M et al. | Living donor liver transplantation during the first 3 months of life. | 2017 | Liver Transpl. | pmid:28220684 |
Chen WY et al. | Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28219593 |
Dai Y et al. | A case report of coup de sabre patient with hair transplantation. | 2017 | J Dermatolog Treat | pmid:28142293 |
Shihab F et al. | Association of Clinical Events With Everolimus Exposure in Kidney Transplant Patients Receiving Low Doses of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:28141897 |
Son SY et al. | Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients. | 2017 | Drug Des Devel Ther | pmid:28138224 |
Regunath H et al. | Early diagnosis of Ehrlichia ewingii infection in a lung transplant recipient by peripheral blood smear. | 2017 | Transpl Infect Dis | pmid:28036138 |
Shoughy SS and Tabbara KF | Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis. | 2017 | Br J Ophthalmol | pmid:28137823 |
Onodera M et al. | ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis. | 2017 | J. Gastroenterol. Hepatol. | pmid:28135009 |
Chu CH et al. | Radiation recall dermatitis induced by topical tacrolimus for post-irradiation morphea. | 2017 | J Eur Acad Dermatol Venereol | pmid:27256845 |
Kirpalani A et al. | Idiosyncratic drug reactions and membranous glomerulopathy. | 2017 | BMJ Case Rep | pmid:28137906 |
Lewis K et al. | Autoimmune enteropathy and hepatitis in pediatric heart transplant recipient. | 2017 | Pediatr Transplant | pmid:28097735 |
Sommer W et al. | Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. | 2017 | Transpl. Int. | pmid:28095640 |
Classen J et al. | Seasonal leukotrichia in a German shepherd dog. A case report. | 2017 | Tierarztl Prax Ausg K Kleintiere Heimtiere | pmid:28094416 |
Kim JM et al. | Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients. | 2017 | Med Princ Pract | pmid:28092916 |
Viklicky O et al. | Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial. | 2017 | PLoS ONE | pmid:28085915 |
Naniwa T et al. | Efficacy of add-on tacrolimus on methotrexate to maintain clinical remission after rediscontinuation of a tumor necrosis factor inhibitor in rheumatoid arthritis patients who relapsed shortly after discontinuation of the same tumor necrosis factor inhibitor due to clinical remission. | 2017 | Mod Rheumatol | pmid:27143107 |
Pimentel AL et al. | Diagnostic accuracy of glycated hemoglobin for post-transplantation diabetes mellitus after kidney transplantation: systematic review and meta-analysis. | 2017 | Nephrol. Dial. Transplant. | pmid:28088775 |
Li R et al. | Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis. | 2017 | Photodermatol Photoimmunol Photomed | pmid:27696531 |
Hayes W et al. | Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28039534 |
Carnevale-Schianca F et al. | Post-Transplant Cyclophosphamide and Tacrolimus-Mycophenolate Mofetil Combination Prevents Graft-versus-Host Disease in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors. | 2017 | Biol. Blood Marrow Transplant. | pmid:28039079 |
Srivastava AK et al. | Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis. | 2017 | Exp. Neurol. | pmid:28038988 |
Yang D et al. | JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature. | 2017 | Transpl Infect Dis | pmid:28036142 |
Xu D et al. | Tacrolimus improves proteinuria remission in adults with cyclosporine A-resistant or -dependent minimal change disease. | 2017 | Nephrology (Carlton) | pmid:28035723 |
Hu Y et al. | FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the CaN‑NFATc1 signaling pathway in retinal microvascular epithelial cells. | 2017 | Mol Med Rep | pmid:28901449 |
Igata S et al. | Acute right heart failure caused by tacrolimus after renal transplantation: Serial observation by speckle tracking and Doppler echocardiography. | 2017 | Echocardiography | pmid:29178293 |
Spiekerkoetter E et al. | Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension. | 2017 | Eur. Respir. J. | pmid:28893866 |
Sathyasaikumar KV et al. | Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. | 2017 | Neuroscience | pmid:29031603 |
Li J et al. | Wuzhi Tablet ( Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study. | 2017 | Drug Metab. Dispos. | pmid:28864749 |
Ordóñez-Robles M et al. | Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28983826 |
Van Laecke S et al. | Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial. | 2017 | Ann. Transplant. | pmid:28848225 |
Cohen L et al. | A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: a case report. | 2017 | J Med Case Rep | pmid:28844207 |
Watanabe M et al. | Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. | 2017 | Ann. Hematol. | pmid:28508935 |
Dang W et al. | Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. | 2017 | Antimicrob. Agents Chemother. | pmid:28807916 |
Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
Andrews LM et al. | Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 2017 | Expert Opin Drug Metab Toxicol | pmid:29084469 |
Noceti O et al. | Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List: Factors of Variability and Response to Tacrolimus Inhibition. | 2017 | Clin. Chem. | pmid:29054923 |
Soiffer RJ et al. | Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation. | 2017 | J. Clin. Oncol. | pmid:29040031 |
Hasegawa J et al. | Preemptive anti-cytomegalovirus therapy in high-risk (donor-positive, recipient-negative cytomegalovirus serostatus) kidney transplant recipients. | 2017 | Int. J. Infect. Dis. | pmid:28986314 |
Olariu R et al. | Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation. | 2017 | J. Surg. Res. | pmid:28985877 |
Vanhove T et al. | Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28603840 |
Whitehouse G et al. | IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584086 |
Al-Kadhimi Z et al. | Low incidence of severe cGvHD and late NRM in a phase II trial of thymoglobulin, tacrolimus and sirolimus for GvHD prevention. | 2017 | Bone Marrow Transplant. | pmid:28581472 |
Dardis G et al. | Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. | 2017 | Dev. Dyn. | pmid:28577298 |