tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morena M et al. | Low-density lipoprotein composition and oxidation are not influenced by calcineurin inhibitors in renal transplant patients. | 2000 | Transplant. Proc. | pmid:11134805 |
| Fischer S et al. | Initial experience of combined immunosuppressive induction therapy with polyclonal antithymocyte antibody, FK 506 (tacrolimus), and prednisolone in clinical liver transplantation. | 2000 | Transplant. Proc. | pmid:11134815 |
| Sam WJ et al. | Population pharmacokinetics of tacrolimus in Asian paediatric liver transplant patients. | 2000 | Br J Clin Pharmacol | pmid:11136292 |
| Sestak K et al. | Tacrolimus-FK506 induced immunosuppression in gnotobiotic piglets. | 2000 | Vet. Immunol. Immunopathol. | pmid:11137126 |
| Michnick SW | Chemical biology beyond binary codes. | 2000 | Chem. Biol. | pmid:11137822 |
| Lopau K et al. | Tacrolimus in acute renal failure: does L-arginine-infusion prevent changes in renal hemodynamics? | 2000 | Transpl. Int. | pmid:11140242 |
| Abraham KA et al. | Hemolytic-uremic syndrome in association with both cyclosporine and tacrolimus. | 2000 | Transpl. Int. | pmid:11140243 |
| Haas M et al. | Hypothyroidism as a cause of tacrolimus intoxication and acute renal failure: a case report. | 2000 | Wien. Klin. Wochenschr. | pmid:11144010 |
| Barone GW et al. | The tolerability of newer immunosuppressive medications in a patient with acute intermittent porphyria. | 2001 | J Clin Pharmacol | pmid:11144989 |
| Bekersky I et al. | Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis. | 2001 | J. Am. Acad. Dermatol. | pmid:11145792 |
| Hanifin JM et al. | Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part I, efficacy. | 2001 | J. Am. Acad. Dermatol. | pmid:11145793 |
| Soter NA et al. | Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. | 2001 | J. Am. Acad. Dermatol. | pmid:11145794 |
| Paller A et al. | A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients. | 2001 | J. Am. Acad. Dermatol. | pmid:11145795 |
| Kang S et al. | Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. | 2001 | J. Am. Acad. Dermatol. | pmid:11145796 |
| Drake L et al. | The impact of tacrolimus ointment on health-related quality of life of adult and pediatric patients with atopic dermatitis. | 2001 | J. Am. Acad. Dermatol. | pmid:11145797 |
| Vallejo C et al. | Resolution of cyclosporine-induced gingival hyperplasia resistant to azithromycin by switching to tacrolimus. | 2001 | Haematologica | pmid:11146586 |
| Nghiem P | "Topical immunomodulators?": introducing old friends and a new ally, tacrolimus. | 2001 | J. Am. Acad. Dermatol. | pmid:11148486 |
| Butani L and Makker SP | Conversion from tacrolimus to neoral for postrenal transplant diabetes. | 2000 | Pediatr. Nephrol. | pmid:11149106 |
| Gondo H et al. | Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. | 2000 | Bone Marrow Transplant. | pmid:11149744 |
| Remitz A et al. | Tacrolimus ointment reduces staphylococcal colonization of atopic dermatitis lesions. | 2001 | J. Allergy Clin. Immunol. | pmid:11150013 |
| Emre S et al. | Safety and risk of using pediatric donor livers in adult liver transplantation. | 2001 | Liver Transpl. | pmid:11150421 |
| Nagatomo I et al. | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. | 2001 | Brain Res. | pmid:11150489 |
| Hamar P et al. | Interleukin-2-dependent mechanisms are involved in the development of glomerulosclerosis after partial renal ablation in rats. | 2001 Mar-Apr | Exp. Nephrol. | pmid:11150862 |
| Bain JR | Peripheral nerve and neuromuscular allotransplantation: current status. | 2000 | Microsurgery | pmid:11150988 |
| Gruber SA et al. | Local drug delivery to composite tissue allografts. | 2000 | Microsurgery | pmid:11150992 |
| König A et al. | Intravascular ultrasound for assessment of coronary allograft vasculopathy. | 2000 | Z Kardiol | pmid:11151792 |
| Kainz A et al. | Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. | 2000 | Transplantation | pmid:11152103 |
| MacDonald AS | Impact of immunosuppressive therapy on hypertension. | 2000 | Transplantation | pmid:11152235 |
| Cather JC et al. | Cyclosporine and tacrolimus in dermatology. | 2001 | Dermatol Clin | pmid:11155577 |
| Tolou-Ghamari Z et al. | In vitro pentamer formation as a biomarker of tacrolimus-related immunosuppressive activity after liver transplantation. | 2000 | Clin. Chem. Lab. Med. | pmid:11156362 |
| Mathis AS and Friedman GS | Coadministration of digoxin with itraconazole in renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11157404 |
| Prestle J et al. | Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility. | 2001 | Circ. Res. | pmid:11157671 |
| Ligtenberg G et al. | Cardiovascular risk factors in renal transplant patients: cyclosporin A versus tacrolimus. | 2001 | J. Am. Soc. Nephrol. | pmid:11158228 |
| Coupes BM et al. | Plasma transforming growth factor beta(1) and platelet activation: implications for studies in transplant recipients. | 2001 | Nephrol. Dial. Transplant. | pmid:11158413 |
| Hanauer SB and Dassopoulos T | Evolving treatment strategies for inflammatory bowel disease. | 2001 | Annu. Rev. Med. | pmid:11160781 |
| Rose N and Lever A | The rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5' long terminal repeat. | 2001 | J. Gen. Virol. | pmid:11161283 |
| Peeling J et al. | Effect of FK-506 on inflammation and behavioral outcome following intracerebral hemorrhage in rat. | 2001 | Exp. Neurol. | pmid:11161622 |
| Hofbauer LC et al. | Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162519 |
| Wakugawa M et al. | Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels. | 2001 | J. Dermatol. Sci. | pmid:11164708 |
| Baran DA et al. | Tacrolimus monotherapy in adult cardiac transplant recipients: intermediate-term results. | 2001 | J. Heart Lung Transplant. | pmid:11166613 |
| Tanaka K et al. | Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells. | 2001 | Brain Res. | pmid:11166708 |
| Macleod MR et al. | Serum withdrawal causes apoptosis in SHSY 5Y cells. | 2001 | Brain Res. | pmid:11166724 |
| Boulad F et al. | Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts. | 2000 | Br. J. Haematol. | pmid:11167755 |
| Jørgensen PF et al. | Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production. | 2001 | Scand. J. Immunol. | pmid:11169223 |
| Bayguinov O et al. | Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171588 |
| Manzarbeitia C et al. | Tacrolimus conversion improves hyperlipidemic states in stable liver transplant recipients. | 2001 | Liver Transpl. | pmid:11172391 |
| Shibazaki Y et al. | Effect of the immunosuppressant drug FK506 on neonatal cerebral mitochondrial function and energy metabolism after transient intrauterine ischemia in rats. | 2001 | Brain Res. | pmid:11172783 |
| Panhans-Gross A et al. | Human epidermal Langerhans' cells are targets for the immunosuppressive macrolide tacrolimus (FK506). | 2001 | J. Allergy Clin. Immunol. | pmid:11174203 |
| Hauk PJ and Leung DY | Tacrolimus (FK506): new treatment approach in superantigen-associated diseases like atopic dermatitis? | 2001 | J. Allergy Clin. Immunol. | pmid:11174211 |
| Paller AS | Use of nonsteroidal topical immunomodulators for the treatment of atopic dermatitis in the pediatric population. | 2001 | J. Pediatr. | pmid:11174611 |
| Hashimoto M et al. | Feasibility of cryopreserved tracheal xenotransplants with the use of short-course immunosuppression. | 2001 | J. Thorac. Cardiovasc. Surg. | pmid:11174729 |
| Hunt SA | New immunosuppressive agents in clinical use: mycophenolate mofetil and tacrolimus. | 2000 May-Jun | Cardiol Rev | pmid:11174892 |
| Frankel SJ and Kerdel FA | Topical tacrolimus. | 2001 | Skin Therapy Lett. | pmid:11176043 |
| Schwetz BA | From the Food and Drug Administration. | 2001 | JAMA | pmid:11176890 |
| Mancinelli LM et al. | The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. | 2001 | Clin. Pharmacol. Ther. | pmid:11180035 |
| Lester LB et al. | Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation. | 2001 | Endocrinology | pmid:11181538 |
| Duijnhoven EM et al. | Influence of tacrolimus on glucose metabolism before and after renal transplantation: a prospective study. | 2001 | J. Am. Soc. Nephrol. | pmid:11181807 |
| O'hara M et al. | Latent intracellular Epstein-Barr Virus DNA demonstrated in ocular posttransplant lymphoproliferative disorder mimicking granulomatous uveitis with iris nodules in a child. | 2001 | J AAPOS | pmid:11182679 |
| Lee RK and Wurtman RJ | Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:11193162 |
| Okabe H et al. | Pharmacokinetics and bioavailability of tacrolimus in rats with experimental renal dysfunction. | 2000 | J. Pharm. Pharmacol. | pmid:11197074 |
| Tenney F and Sakarcan A | Fatal cytomegalovirus disease in a high-risk renal transplant recipient. | 2001 | Pediatr. Nephrol. | pmid:11198610 |
| Pouteil-Noble C and Guebre F | [Effect of immunosuppressants on lipids]. | 2000 | Nephrologie | pmid:11200615 |
| Odorico JS et al. | Improved solitary pancreas transplant graft survival in the modern immunosuppressive era. | 2000 Nov-Dec | Cell Transplant | pmid:11202579 |
| Pou L et al. | Mycophenolic acid plasma concentrations: influence of comedication. | 2001 | Ther Drug Monit | pmid:11206040 |
| Ierardi E et al. | Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance. | 2001 | Aliment. Pharmacol. Ther. | pmid:11207512 |
| Koshika T et al. | Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208629 |
| Wong PW et al. | ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. | 2001 | J. Neurochem. | pmid:11208908 |
| Bekersky I et al. | Effect of low- and high-fat meals on tacrolimus absorption following 5 mg single oral doses to healthy human subjects. | 2001 | J Clin Pharmacol | pmid:11210398 |
| Leidig-Bruckner G et al. | Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up study. | 2001 | Lancet | pmid:11210996 |
| Kasahara M et al. | Living-related liver transplantation for type II citrullinemia using a graft from heterozygote donor. | 2001 | Transplantation | pmid:11211185 |
| Ohashi H and Ohno R | [Immunodeficiency induced by immunosuppressive agents]. | 2000 | Ryoikibetsu Shokogun Shirizu | pmid:11212769 |
| Wang K et al. | Transplantation of infantile bladder in rats: an alternative procedure for bladder augmentation. | 2001 | Transplantation | pmid:11213059 |
| Mollevà DG et al. | Heart and liver xenotransplantation under low-dose tacrolimus: graft survival after withdrawal of immunosuppression. | 2001 | Transplantation | pmid:11213062 |
| Paolillo JA et al. | Posttransplant diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression. | 2001 | Transplantation | pmid:11213069 |
| Molmenti EP et al. | Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. | 2001 | Transplantation | pmid:11213072 |
| Pauli-Magnus C et al. | Short-term efficacy of tacrolimus ointment in severe uremic pruritus. | 2000 Nov-Dec | Perit Dial Int | pmid:11216583 |
| Mahalati K and Kahan BD | Pharmacological surrogates of allograft outcome. | 2000 | Ann. Transplant. | pmid:11217202 |
| Petering H et al. | [Pyoderma gangrenosum: successful topical therapy with tacrolimus (FK506)]. | 2001 | Hautarzt | pmid:11220239 |
| van Mourik ID and Kelly DA | Immunosuppressive drugs in paediatric liver transplantation. | 2001 | Paediatr Drugs | pmid:11220404 |
| Pyrzynska B et al. | Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes. | 2001 | Neurochem. Int. | pmid:11222921 |
| Passerini P and Ponticelli C | Treatment of focal segmental glomerulosclerosis. | 2001 | Curr. Opin. Nephrol. Hypertens. | pmid:11224693 |
| Feng FY et al. | FK506 rescues peripheral nerve allografts in acute rejection. | 2001 | J. Neurotrauma | pmid:11229713 |
| Cruz MC et al. | Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. | 2001 | EMBO J. | pmid:11230126 |
| Pournaras CC et al. | Staphylococcal colonization in atopic dermatitis treatment with topical tacrolimus (Fk506). | 2001 | J. Invest. Dermatol. | pmid:11231333 |
| Easing eczema. | 2001 | Health News | pmid:11232120 | |
| Günther M et al. | Rapid decline of antibodies after hepatitis A immunization in liver and renal transplant recipients. | 2001 | Transplantation | pmid:11233913 |
| GarcÃa Sánchez MJ et al. | Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy. | 2001 | Clin Pharmacokinet | pmid:11236810 |
| Riggins PS and Clipstone NA | T cell activation signals upregulate CBP-dependent transcriptional activity. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11237736 |
| Hassan-Walker AF et al. | CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: correlation with time from transplant to receipt of tacrolimus. | 2001 | J. Infect. Dis. | pmid:11237798 |
| Armstrong VW and Oellerich M | New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. | 2001 | Clin. Biochem. | pmid:11239509 |
| Reitamo S | Tacrolimus: a new topical immunomodulatory therapy for atopic dermatitis. | 2001 | J. Allergy Clin. Immunol. | pmid:11240943 |
| Wollenberg A et al. | Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. | 2001 | J. Allergy Clin. Immunol. | pmid:11240954 |
| Yamamoto T and Nishioka K | Topical tacrolimus is effective for facial lesions of psoriasis. | 2000 Nov-Dec | Acta Derm. Venereol. | pmid:11243645 |
| Leinwand LA | Calcineurin inhibition and cardiac hypertrophy: a matter of balance. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248009 |
| Fox DS et al. | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. | 2001 | Mol. Microbiol. | pmid:11251806 |
| US FDA advisory committee recommends approval of tacrolimus ointment. | 2000 | Skin Therapy Lett. | pmid:11252243 | |
| StrestÃková P et al. | Inhibitory effect of FK 506 and cyclosporin A on nitric oxide production by LPS-treated cultured rat macrophages. | 2000 | Physiol Res | pmid:11252540 |
| Fellermann K et al. | [Sweet syndrome and erythema nodosum in ulcerative colitis, refractory to steroids: successful treatment with tacrolimus]. | 2001 | Med. Klin. (Munich) | pmid:11253280 |
| Shimoyama M et al. | [Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension]. | 2001 | J Cardiol | pmid:11255695 |
| Wang L et al. | Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats. | 2001 | Ren Fail | pmid:11256520 |