tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mor E et al. | Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. | 1994 | Transpl. Int. | pmid:11271340 |
| Uemoto S et al. | Long-term use of FK 506 in living related liver transplantation. | 1994 | Transpl. Int. | pmid:11271341 |
| Dmitrewski J et al. | Steroid withdrawal 3 months after liver transplantation--does FK 506 confer any advantage over cyclosporin? | 1994 | Transpl. Int. | pmid:11271342 |
| von Schnakenburg C et al. | Post-transplant epididymitis and orchitis following Listeria monocytogenes septicaemia. | 2000 | Pediatr Transplant | pmid:11272610 |
| Martel J et al. | [Subcutaneous mycosis due to Scopulariopsis brevicaulis in an immunocompromised patient]. | 2001 | Ann Dermatol Venereol | pmid:11275588 |
| Tahara K et al. | Experimental small bowel transplantation using newborn intestine in rats: III. Long-term cryopreservation of rat newborn intestine. | 2001 | J. Pediatr. Surg. | pmid:11283886 |
| Krisp A and Hoffmann R | [Letter concerning the article by E.C.Bornhövd, E.Schuller, T.Bieber, A.Wollenberg: "Immunosuppressive macrolides and their use in dermatology". Der Hautarzt (2000) 51:646-654]. | 2001 | Hautarzt | pmid:11284076 |
| Schwrer H et al. | Pantoprazole and cyclosporine or tacrolimus. | 2001 | Aliment. Pharmacol. Ther. | pmid:11284790 |
| Kasper RC et al. | Anetoderma arising in cutaneous B-cell lymphoproliferative disease. | 2001 | Am J Dermatopathol | pmid:11285407 |
| Trimarchi H et al. | Cyclosporine-associated thrombotic microangiopathy during daclizumab induction: a suggested therapeutic approach. | 2001 | Nephron | pmid:11287781 |
| Fredduzzi S et al. | Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat. | 2001 | Neurosci. Lett. | pmid:11290402 |
| Lunz JG et al. | Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. | 2001 | Am. J. Pathol. | pmid:11290556 |
| Zoeteweij JP et al. | Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. | 2001 | Blood | pmid:11290600 |
| Fortin JF et al. | Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat-driven transcription and a possible implication of SHP-1. | 2001 | Blood | pmid:11290602 |
| van Gelder T et al. | Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid. | 2001 | Ther Drug Monit | pmid:11294511 |
| Macchi-Andanson M et al. | Failure of traditional trough levels to predict tacrolimus concentrations. | 2001 | Ther Drug Monit | pmid:11294512 |
| Lener EV et al. | Successful treatment of erosive lichen planus with topical tacrolimus. | 2001 | Arch Dermatol | pmid:11295919 |
| Ishikawa M et al. | [Blood concentrations and side effects of tacrolimus in a living renal transplantation]. | 2001 | Masui | pmid:11296433 |
| Yada T et al. | Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis. | 2001 | J. Biol. Chem. | pmid:11297516 |
| Griffiths CE | Ascomycin: an advance in the management of atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298524 |
| Harper J et al. | First experience of topical SDZ ASM 981 in children with atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298537 |
| Luger T et al. | SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298538 |
| Li S et al. | Combined host-conditioning with CTLA4-Ig, tacrolimus, anti-lymphocyte serum, and low-dose radiation leads to stable mixed hematopoietic chimerism. | 2001 | Exp. Hematol. | pmid:11301194 |
| Arima H et al. | Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11303042 |
| Shiraishi S et al. | Up-regulation of cell surface sodium channels by cyclosporin A, FK506, and rapamycin in adrenal chromaffin cells. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11303055 |
| Mardini M et al. | Cyclosporine and FK506 differentially regulate the sarcolemmal Na(+)-K(+) pump. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11303073 |
| Trotter JF et al. | Liver transplantation using sirolimus and minimal corticosteroids (3-day taper). | 2001 | Liver Transpl. | pmid:11303295 |
| Jones NF et al. | Comparison of long-term immunosuppression for limb transplantation using cyclosporine, tacrolimus, and mycophenolate mofetil: implications for clinical composite tissue transplantation. | 2001 | Plast. Reconstr. Surg. | pmid:11304605 |
| Topical tacrolimus for treatment of atopic dermatitis. | 2001 | Med Lett Drugs Ther | pmid:11309535 | |
| Sheehy EC et al. | Oral health in children undergoing liver transplantation. | 2000 | Int J Paediatr Dent | pmid:11310095 |
| Monegal A et al. | Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A. | 2001 | Calcif. Tissue Int. | pmid:11310351 |
| Freyschmidt-Paul P et al. | Current and potential agents for the treatment of alopecia areata. | 2001 | Curr. Pharm. Des. | pmid:11311114 |
| Rumora L et al. | MKP-1 as a target for pharmacological manipulations in PC12 cell survival. | 2001 | Neurochem. Int. | pmid:11311446 |
| Yoshimoto T et al. | Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. | 2001 | Brain Res. | pmid:11311876 |
| Takatsuki M et al. | Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance. | 2001 | Transpl. Immunol. | pmid:11316071 |
| Smith KM and Van Etten RA | Activation of c-Abl kinase activity and transformation by a chemical inducer of dimerization. | 2001 | J. Biol. Chem. | pmid:11320088 |
| Pohanka E et al. | [Dosage and monitoring of tacrolimus after kidney transplantation]. | 2000 | Dtsch. Med. Wochenschr. | pmid:11320722 |
| Russell RK et al. | Systemic absorption with complications during topical tacrolimus treatment for orofacial Crohn disease. | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11321395 |
| StrestÃková P et al. | Different mechanisms in inhibition of rat macrophage nitric oxide synthase expression by FK 506 and cyclosporin A. | 2001 | Immunopharmacol Immunotoxicol | pmid:11322650 |
| Gaziev D and Lucarelli G | Novel approaches to the treatment of chronic graft-versus-host disease. | 2001 | Expert Opin Investig Drugs | pmid:11322865 |
| Lang-Lazdunski L et al. | The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. | 2001 | Anesth. Analg. | pmid:11323353 |
| Kennedy DS and Linden GJ | Resolution of gingival overgrowth following change from cyclosporin to tacrolimus therapy in a renal transplant patient. | 2000 | J Ir Dent Assoc | pmid:11323935 |
| Weinberg JM and Silverberg NB | A kinder, gentler therapy? | 2001 | Cutis | pmid:11324387 |
| Kulkarni P | Review: uveitis and immunosuppressive drugs. | 2001 | J Ocul Pharmacol Ther | pmid:11324985 |
| Kawada N et al. | Role of mast cells in antigen-induced airway inflammation and bronchial hyperresponsiveness in rats. | 2001 | Jpn. J. Pharmacol. | pmid:11325017 |
| Sche PP et al. | Corrigendum to: "Display cloning: functional identification of natural product receptors using cDNA-phage display" [Chemistry & Biology 6 (1999) 707-716]. | 2001 | Chem. Biol. | pmid:11325595 |
| Mollee P et al. | Combination therapy with tacrolimus and anti-thymocyte globulin for the treatment of steroid-resistant acute graft-versus-host disease developing during cyclosporine prophylaxis. | 2001 | Br. J. Haematol. | pmid:11328304 |
| Dicarlo JB and McCall CO | Pharmacologic alternatives for severe atopic dermatitis. | 2001 | Int. J. Dermatol. | pmid:11328387 |
| Mittal N et al. | Tacrolimus and diarrhea: pathogenesis of altered metabolism. | 2001 | Pediatr Transplant | pmid:11328543 |
| Frühwirth M et al. | Rotavirus infection as cause of tacrolimus elevation in solid-organ-transplanted children. | 2001 | Pediatr Transplant | pmid:11328545 |
| Jain A et al. | Reasons why some children receiving tacrolimus therapy require steroids more than 5 years post liver transplantation. | 2001 | Pediatr Transplant | pmid:11328546 |
| MacFarlane GD et al. | Therapeutic drug monitoring of tacrolimus in pediatric liver transplant patients. | 2001 | Pediatr Transplant | pmid:11328550 |
| Dobrolet NC et al. | Hematologic abnormalities in children and young adults receiving tacrolimus-based immunosuppression following cardiothoracic transplantation. | 2001 | Pediatr Transplant | pmid:11328551 |
| Frühwirth M et al. | Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: a case report. | 2001 | Pediatr Transplant | pmid:11328552 |
| Ogawa Y et al. | Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids. | 2001 | Cornea | pmid:11333336 |
| pmid:11334064 | ||||
| Mackinnon SE et al. | Clinical outcome following nerve allograft transplantation. | 2001 | Plast. Reconstr. Surg. | pmid:11335811 |
| Parasrampuria DA et al. | A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. | 2001 | Pharm. Res. | pmid:11336351 |
| Lee TH | Skin disease. Eczema. | 2001 | Harv Health Lett | pmid:11340028 |
| Obata K et al. | Role of FK506-binding protein 12 in development of the chick embryonic heart. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11341768 |
| De Bonis M et al. | Tacrolimus as a rescue immunosuppressant after heart transplantation. | 2001 | Eur J Cardiothorac Surg | pmid:11343954 |
| Treede H et al. | Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomized two-center trial comparing two different immunosuppressive protocols. | 2001 | J. Heart Lung Transplant. | pmid:11343977 |
| Yan M et al. | The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes. | 2001 | FASEB J. | pmid:11344081 |
| Sutherland DE et al. | Pancreas transplantation for treatment of diabetes mellitus. | 2001 | World J Surg | pmid:11344403 |
| Skaehill PA | Tacrolimus in dermatologic disorders. | 2001 | Ann Pharmacother | pmid:11346066 |
| Kawamura I et al. | Induction of choleresis by immunosuppressant FK506 through stimulation of insulin-like growth factor-I production in the liver of rats. | 2001 | Eur. J. Pharmacol. | pmid:11348636 |
| Trotter JF et al. | Dyslipidemia during sirolimus therapy in liver transplant recipients occurs with concomitant cyclosporine but not tacrolimus. | 2001 | Liver Transpl. | pmid:11349259 |
| Ahuja M et al. | Polyoma virus infection after renal transplantation. Use of immunostaining as a guide to diagnosis. | 2001 | Transplantation | pmid:11349723 |
| Pérgola PE et al. | Kidney transplantation during the first trimester of pregnancy: immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone. | 2001 | Transplantation | pmid:11349738 |
| Stover JF et al. | Effects of tacrolimus on hemispheric water content and cerebrospinal fluid levels of glutamate, hypoxanthine, interleukin-6, and tumor necrosis factor-alpha following controlled cortical impact injury in rats. | 2001 | J. Neurosurg. | pmid:11354410 |
| Yang DY et al. | Simultaneous monitoring of extracellular glucose, pyruvate, lactate and glutamate in gerbil cortex during focal cerebral ischemia by dual probe microdialysis. | 2001 | J Chromatogr A | pmid:11355832 |
| Arima H et al. | Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats. | 2001 | J Pharm Sci | pmid:11357172 |
| Sakuma S et al. | Effects of FK506 and other immunosuppressive anti-rheumatic agents on T cell activation mediated IL-6 and IgM production in vitro. | 2001 | Int. Immunopharmacol. | pmid:11357886 |
| Ebisu T et al. | Early and delayed neuroprotective effects of FK506 on experimental focal ischemia quantitatively assessed by diffusion-weighted MRI. | 2001 | Magn Reson Imaging | pmid:11358652 |
| Guo X et al. | Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. | 2001 | Eur. J. Neurosci. | pmid:11359520 |
| Lensmeyer GL and Poquette MA | Therapeutic monitoring of tacrolimus concentrations in blood: semi-automated extraction and liquid chromatography-electrospray ionization mass spectrometry. | 2001 | Ther Drug Monit | pmid:11360032 |
| Venkataramanan R et al. | Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients. | 2001 | J Clin Pharmacol | pmid:11361051 |
| Wallemacq PE and Verbeeck RK | Comparative clinical pharmacokinetics of tacrolimus in paediatric and adult patients. | 2001 | Clin Pharmacokinet | pmid:11368293 |
| Otto KG et al. | Cell proliferation through forced engagement of c-Kit and Flt-3. | 2001 | Blood | pmid:11369667 |
| Morales JM et al. | Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation. | 2001 | Nephrol. Dial. Transplant. | pmid:11369839 |
| Goldman D | Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. | 2001 | J. Am. Acad. Dermatol. | pmid:11369912 |
| Poirier SN et al. | FK506 blocks intracellular Ca2+ oscillations in bovine adrenal glomerulosa cells. | 2001 | Biochemistry | pmid:11371212 |
| Hashida T et al. | Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation. | 2001 | Clin. Pharmacol. Ther. | pmid:11371998 |
| Mathis AS et al. | Sex and ethnicity may chiefly influence the interaction of fluconazole with calcineurin inhibitors. | 2001 | Transplantation | pmid:11374405 |
| Jain A et al. | Reasons for long-term use of steroid in primary adult liver transplantation under tacrolimus. | 2001 | Transplantation | pmid:11374410 |
| Neumann UP et al. | Significance of a T-lymphocytotoxic crossmatch in liver and combined liver-kidney transplantation. | 2001 | Transplantation | pmid:11374419 |
| Yamamoto-Yamaguchi Y et al. | Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors. | 2001 | Exp. Hematol. | pmid:11376870 |
| Paul LC | Overview of side effects of immunosuppressive therapy. | 2001 | Transplant. Proc. | pmid:11377462 |
| Ierardi E et al. | Long-term tacrolimus: a promising therapeutic approach for Crohn's disease. | 2001 | Transplant. Proc. | pmid:11377467 |
| Bilbao I et al. | Comparison between tacrolimus and neoral cyclosporine administered by oral route in liver transplantation. | 2001 | Transplant. Proc. | pmid:11377472 |
| Braun F et al. | Pharmacokinetics of tacrolimus primary immunosuppression in kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377473 |
| Gerbase MW et al. | Low doses of mycophenolate mofetil with low doses of tacrolimus prevent acute rejection and long-term function loss after lung transplantation. | 2001 | Transplant. Proc. | pmid:11377481 |
| Gerhardt U et al. | High QT dispersion in tacrolimus-treated kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377482 |
| Hesse CJ et al. | The value of routine monitoring of mycophenolic acid plasma levels after clinical heart transplantation. | 2001 | Transplant. Proc. | pmid:11377487 |
| Klupp J et al. | New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus. | 2001 | Transplant. Proc. | pmid:11377491 |
| McGrath JS and Shehata M | The effect of differing immunosuppressive regimes on the functional and morphologic changes in a rat renal allograft model of chronic rejection. | 2001 | Transplant. Proc. | pmid:11377499 |
| McGrath JS and Shehata M | Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitution. | 2001 | Transplant. Proc. | pmid:11377500 |
| Kelly JS and Sharkey J | Immunosuppressants-ligands as neuroprotectants. | 2001 | Transplant. Proc. | pmid:11377506 |
| Mohacsi P et al. | Immunosuppression in ABO-incompatible transplantation. | 2001 | Transplant. Proc. | pmid:11377508 |
| Jonas S et al. | Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy. | 2001 | Transplant. Proc. | pmid:11377511 |