tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gonzalez Molina M et al. | Renal function in patients with cadaveric kidney transplants treated with tacrolimus or cyclosporine. | 2007 | Transplant. Proc. | pmid:17889126 |
| Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
| Christiaans M et al. | Effect of breakfast on the oral bioavailability of tacrolimus and changes in pharmacokinetics at different times posttransplant in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636516 |
| Gavela E et al. | Histological findings of early graft biopsies in old donor renal transplant patients receiving induction therapy. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715842 |
| Wang SS et al. | Clinical experience of tacrolimus with everolimus in heart transplantation. | 2012 | Transplant. Proc. | pmid:22564581 |
| Smoter P et al. | Risk factors of acute renal failure after orthotopic liver transplantation: single-center experience. | 2014 | Transplant. Proc. | pmid:25380918 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Nazmul MN et al. | Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. | 2017 | Transplant. Proc. | pmid:29198681 |
| Tanabe K et al. | ABO-incompatible living donor kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119903 |
| Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
| Friob MC et al. | A combined HPLC-ELISA evaluation of FK 506 in transplant patients. | 1991 | Transplant. Proc. | pmid:1721265 |
| Nakajima H and Oka T | The inhibition of T-cell-receptor-induced Fas ligand upregulation by cyclosporine and FK 506. | 1996 | Transplant. Proc. | pmid:8623224 |
| Zhao Y et al. | Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808586 |
| Berman M et al. | Lipid metabolism and immunosuppressive therapy in heart transplant recipients. | 2003 | Transplant. Proc. | pmid:12644091 |
| Rajnoch J et al. | Regulators of angiogenesis in renal ischemia/reperfusion injury in normotensive and hypertensive rats: effect of tacrolimus. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808641 |
| Lauzurica R et al. | Monotherapy with tacrolimus and corticosteroid withdrawal. | 2002 | Transplant. Proc. | pmid:11959217 |
| Bilbao I et al. | Experience with neoral cyclosporine through the oral route in liver transplantation. | 1998 | Transplant. Proc. | pmid:9636580 |
| Langrehr JM et al. | Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636583 |
| Kay JE et al. | The mechanism of action of FK 506. | 1990 | Transplant. Proc. | pmid:1689914 |
| Boran M et al. | Determining renal resistive and pulsatility indexes long-term after kidney transplantation in kidney transplant recipients on cyclosporine a-, tacrolimus-, or sirolimus-based regimens. | 2014 | Transplant. Proc. | pmid:24935296 |
| Yoshida S et al. | Combination therapy with FK 506 and RS61443 for rejection following allogeneic small bowel transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120262 |
| Troppmann C et al. | Perioperative immunosuppression as a critical determinant of early outcome after discordant xenoislet transplantation: a comparative study. | 1996 | Transplant. Proc. | pmid:8623487 |
| McKenna BA et al. | Tacrolimus (FK 506): a whole blood assay as measured on the Abbott IMx analyzer. | 1996 | Transplant. Proc. | pmid:8623491 |
| Jordan ML et al. | Outcome of tacrolimus conversion therapy for renal allograft rejection: 5-year follow-up. | 1999 | Transplant. Proc. | pmid:10576052 |
| Tanida I et al. | Yeast cyclophilin-related gene encodes a nonessential second peptidyl-prolyl cis-trans isomerase associated with the secretory pathway. | 1991 | Transplant. Proc. | pmid:1721297 |
| Ichimaru N et al. | Risk factors and incidence for lipid abnormalities in kidney transplant patients. | 2015 | Transplant. Proc. | pmid:25891708 |
| Nicoluzzi J et al. | One hundred pancreas transplants performed in a Brazilian institution. | 2009 | Transplant. Proc. | pmid:20005382 |
| Kolonko A et al. | Improved kidney graft function after conversion from twice daily tacrolimus to a once daily prolonged-release formulation. | 2011 | Transplant. Proc. | pmid:21996198 |
| Imai K et al. | Pancreaticoduodenal allotransplantation with the use of FK 506, cyclosporine, and triple-regimen immunosuppression. | 1990 | Transplant. Proc. | pmid:1697117 |
| Tai HC et al. | Urachal adenocarcinoma following kidney transplantation: the first case report. | 2009 | Transplant. Proc. | pmid:19545760 |
| Wilusz M et al. | Effect of immunosuppressive therapy on the serum fatty acids of phospholipids fraction in patients after heart transplantation. | 2014 | Transplant. Proc. | pmid:25380928 |
| Wojewodzka J et al. | Inhibition of formation of synapses between dendritic cells and lymphocytes in skin lymph in an allogeneic reaction by cyclosporine and tacrolimus. | 2003 | Transplant. Proc. | pmid:14529947 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Ge J et al. | Impact of FOXP3 Polymorphisms on the Blood Level of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:27569929 | |
| Masuda S et al. | Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients. | 2005 | Transplant. Proc. | pmid:15919446 |
| Ogasa N et al. | Successful transplantation of newborn rat intestine as a free graft. | 1992 | Transplant. Proc. | pmid:1376514 |
| Suga A et al. | Diabetes mellitus after renal transplantation under tacrolimus-based immunosuppression. | 2003 | Transplant. Proc. | pmid:12591391 |
| Fay JW et al. | FK 506-based immunosuppression for prevention of graft versus host disease after unrelated donor marrow transplantation. | 1995 | Transplant. Proc. | pmid:7533383 |
| Liu B et al. | Single-center experience: tacrolimus and mycophenolate mofetil in early stage of kidney transplantation with liver dysfunction. | 2003 | Transplant. Proc. | pmid:12591396 |
| Hultsch T and Hohman RJ | Categorizing receptor-signaling pathways with FK 506 and rapamycin. | 1991 | Transplant. Proc. | pmid:1721328 |
| Yang SS et al. | A single center, open-label, randomized pilot study to evaluate the safety and efficacy of tacrolimus modified release, Advagraf, versus tacrolimus twice daily, Prograf, in stable renal recipients (single). | 2015 | Transplant. Proc. | pmid:25891697 |
| Ogino S et al. | Conversion from tacrolimus to cyclosporine microemulsion therapy in liver transplant recipients. | 2004 | Transplant. Proc. | pmid:15041357 |
| Timmermann W et al. | A randomised trial comparing the efficacy and safety of tacrolimus with microemulsified cyclosporine after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176463 |
| Hassoun Z et al. | The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176464 |
| Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
| Gozdowska J et al. | Safety and tolerance of sodium mycophenolate in patients after renal transplantation--an observational study. | 2009 | Transplant. Proc. | pmid:19857665 |
| Viganò J et al. | The role of basiliximab induction therapy in adult-to-adult living-related transplantation and deceased donor liver transplantation: a comparative retrospective analysis of a single-center series. | 2008 Jul-Aug | Transplant. Proc. | pmid:18675099 |
| Zegarska J et al. | Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496443 |
| Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
| Hohage H et al. | Switching immunosuppression from cyclosporine to tacrolimus improves long-term kidney function: a 6-year study. | 2005 | Transplant. Proc. | pmid:15919497 |
| Weber M et al. | Decreased rejection episodes in African-American renal transplant recipients receiving mycophenolate mofetil/tacrolimus therapy. | 1997 | Transplant. Proc. | pmid:9414883 |
| Gelens MA et al. | Do blood pressure and arterial wall properties change after conversion from cyclosporine to tacrolimus? | 2005 | Transplant. Proc. | pmid:15919498 |
| Hanafusa T et al. | Long-term impact of hepatitis virus infection on kidney transplant recipients and a pilot study of the effects of interferon alpha on chronic hepatitis C. | 1995 | Transplant. Proc. | pmid:7533440 |
| Shapiro R et al. | FK 506 in clinical kidney transplantation. | 1991 | Transplant. Proc. | pmid:1721361 |
| Jiménez O et al. | Defining the initial doses of sirolimus and tacrolimus in the period immediately after renal transplantation. | 2003 | Transplant. Proc. | pmid:12962758 |
| Teebken OE et al. | Primary immunosuppression with tacrolimus and mycophenolate mofetil versus cyclosporine and azathioprine in heart transplant recipients. | 2002 | Transplant. Proc. | pmid:12072335 |
| Kociszewska-Najman B et al. | Congenital Infections in Neonates of Women With Liver or Kidney Transplants. | 2016 | Transplant. Proc. | pmid:27496446 |
| Burke GW et al. | Randomized trial of three different immunosuppressive regimens to prevent chronic renal allograft rejection. | 2002 | Transplant. Proc. | pmid:12176505 |
| Feitoza CQ et al. | A role for HO-1 in renal function impairment in animals subjected to ischemic and reperfusion injury and treated with immunosuppressive drugs. | 2007 | Transplant. Proc. | pmid:17362747 |
| Goh BL et al. | FK506 rescue therapy for acute renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9838574 |
| Melk A et al. | P-glycoprotein expression in patients before and after kidney transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083115 |
| Thomson AW et al. | The influence of FK 506 on the thymus: implications of drug-induced injury to thymic epithelial cells. | 1991 | Transplant. Proc. | pmid:1703361 |
| Villanueva ME et al. | Alemtuzumab induction with tacrolimus monotherapy in de novo renal transplantation. | 2008 | Transplant. Proc. | pmid:18790198 |
| Katoh H et al. | Effectiveness of 15-deoxyspergualin on steroid-resistant acute rejection in living related liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123125 |
| Rilo HL et al. | Effect of FK 506 on function of human islets of Langerhans. | 1991 | Transplant. Proc. | pmid:1721393 |
| Carroll PB et al. | Synexin: a target protein for toxic effects of cyclosporine and FK 506 in endocrine cells. | 1991 | Transplant. Proc. | pmid:1721394 |
| Gerhardt U et al. | High QT dispersion in tacrolimus-treated kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377482 |
| Toda F et al. | Tacrolimus trough level adjustment after administration of fluconazole to kidney recipients. | 2002 | Transplant. Proc. | pmid:12176555 |
| Lauro A et al. | Rejection episodes and 3-year graft survival under sirolimus and tacrolimus treatment after adult intestinal transplantation. | 2007 | Transplant. Proc. | pmid:17580204 |
| Yamashita K et al. | Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083526 |
| Yu X et al. | Different effect of cyclosporine and tacrolimus on renal expression of P-glycoprotein in human kidney transplantation. | 2008 | Transplant. Proc. | pmid:19100412 |
| Zhou J et al. | Sirolimus-based immunosuppression therapy in liver transplantation for patients with hepatocellular carcinoma exceeding the Milan criteria. | 2008 | Transplant. Proc. | pmid:19100435 |
| Morrissey PE et al. | Factors contributing to acute rejection in renal transplantation: the role of noncompliance. | 2005 | Transplant. Proc. | pmid:15964334 |
| Alkhunaizi AM et al. | Breast fibroadenomas in renal transplant recipients. | 2004 Jul-Aug | Transplant. Proc. | pmid:15350492 |
| Murase N et al. | Lymphocyte traffic and graft-versus-host disease after fully allogeneic small bowel transplantation. | 1991 | Transplant. Proc. | pmid:1721424 |
| Takeda M et al. | Pretreatment with splenectomy and FK506 in xeno-lung transplantation. | 1996 | Transplant. Proc. | pmid:8658728 |
| Flechner SM | Minimizing calcineurin inhibitor drugs in renal transplantation. | 2003 | Transplant. Proc. | pmid:12742481 |
| Wiseman AC et al. | Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience. | 2003 | Transplant. Proc. | pmid:12742482 |
| El-Sabrout R et al. | Improved lipid profile and blood sugar control in pediatric renal transplant recipients using sirolimus-tacrolimus combination. | 2002 | Transplant. Proc. | pmid:12176638 |
| Moura Neto A et al. | Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation. | 2018 | Transplant. Proc. | pmid:29661439 |
| Webb NJ et al. | Pharmacokinetics of tacrolimus in paediatric renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176639 |
| Felipe CR et al. | Choosing the right dose of new immunossuppressive drugs for new populations: importance of pharmacokinetic studies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267207 |
| Koc-Zorawska E et al. | Vascular adhesion protein-1, a novel molecule, in kidney and heart allograft recipients. | 2013 | Transplant. Proc. | pmid:23769096 |
| Evans NJ et al. | The expression of endothelin and inducible nitric oxide synthase in human renal allografts and their role in chronic renal allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267247 |
| Busuttil RW and Holt CD | Tacrolimus is superior to cyclosporine in liver transplantation. | 1998 | Transplant. Proc. | pmid:9723432 |
| Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
| Gasser M et al. | Effect of selective immunosuppression with FK 506, anti-IL-2R, and anti-ICAM-1 MAb in rat small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745510 |
| Jonas S et al. | Five-year follow-up of tacrolimus as primary immunosuppressant after liver transplantation. | 1998 | Transplant. Proc. | pmid:9723433 |
| Dutta S et al. | Liposomal tacrolimus and intestinal drug concentration. | 1998 | Transplant. Proc. | pmid:9745533 |
| Pankewycz O et al. | Conversion to low-dose tacrolimus or rapamycin 3 months after kidney transplantation: a prospective, protocol biopsy-guided study. | 2011 | Transplant. Proc. | pmid:21440749 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Kanbay M et al. | Influence of cyclosporine and tacrolimus on serum uric acid levels in stable kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:16213325 |
| Mochizuki M et al. | A multicenter clinical open trial of FK 506 in refractory uveitis, including Behçet's disease. Japanese FK 506 Study Group on Refractory Uveitis. | 1991 | Transplant. Proc. | pmid:1721456 |
| Lee CM et al. | Monotherapy with tacrolimus for heart and liver transplant: a case report. | 2014 | Transplant. Proc. | pmid:24767396 |
| Kahl A et al. | Long-term prednisolone withdrawal after pancreas and kidney transplantation in patients treated with ATG, tacrolimus, and mycophenolate mofetil. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267473 |
| Sessa A et al. | Cardiovascular risk factors in renal transplant patients after switch from standard tacrolimus to prolonged-release tacrolimus. | 2012 | Transplant. Proc. | pmid:22974866 |
| Calne RY | Immunosuppression for organ grafting. | 1991 | Transplant. Proc. | pmid:1714646 |
| Rieber J et al. | Effects of tacrolimus and cyclosporine on the coronary microcirculation after heart transplantation: a prospective study with serial intracoronary flow measurements. | 1998 | Transplant. Proc. | pmid:9636446 |
| Kanatani T et al. | Experimental limb transplantation, part III: induction of tolerance in the rigorous strain combination of Brown Norway donor to Lewis recipient. | 2004 | Transplant. Proc. | pmid:15686745 |
| Sakr MF et al. | Protective effect of FK 506 against hepatic ischemia in rats. | 1991 | Transplant. Proc. | pmid:1703689 |