tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gaweco AS et al. | Distinct intragraft cytokine gene expression patterns during acute hepatic rejection under cyclosporine versus FK 506 primary immunosuppression. | 1994 | Transplant. Proc. | pmid:7527948 |
| Mathieu C et al. | Potential role of 1,25(OH)2 vitamin D3 as a dose-reducing agent for cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7527950 |
| Ramos-Cebrián M et al. | Conversion from tacrolimus to cyclosporine could improve control of posttransplant diabetes mellitus after renal transplantation. | 2007 | Transplant. Proc. | pmid:17889154 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Valdivia LA et al. | Hamster-to-rat liver xenografts protect extrahepatic organs from rejection. | 1993 | Transplant. Proc. | pmid:7679816 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Yasunami Y et al. | Acceptance of donor-specific islet allografts in rat by intraportal preimmunization with islets and FK 506. | 1994 | Transplant. Proc. | pmid:7513467 |
| Murase N et al. | Effect of FK 506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat. | 1993 | Transplant. Proc. | pmid:7679817 |
| Ueki M et al. | Functional and morphologic characterization of renal subcapsular islet isografts in rats treated with FK 506. | 1994 | Transplant. Proc. | pmid:7513469 |
| Alejandro R et al. | Combined liver-islet allotransplantation in man under FK 506. | 1991 | Transplant. Proc. | pmid:1703712 |
| Ito T et al. | The mechanism of tolerance induced by a perioperative injection of bone marrow cells and a brief course of FK 506. | 1991 | Transplant. Proc. | pmid:1703716 |
| GarcÃa Meseguer C et al. | Anti-HLA antibodies posttransplantation in children: do we know what it means? | 2009 Jul-Aug | Transplant. Proc. | pmid:19715846 |
| Kedzierska K et al. | Oxidative stress indices in rats under immunosuppression. | 2011 | Transplant. Proc. | pmid:22172876 |
| Pascual J and Ortuño J | Simple tacrolimus-based immunosuppressive regimens following renal transplantation: a large multicenter comparison between double and triple therapy. | 2002 | Transplant. Proc. | pmid:11959198 |
| Lian Y et al. | Suppression of Delayed Xenograft Rejection by Resveratrol in a Hamster-to-Rat Cardiac Transplantation Model. | Transplant. Proc. | pmid:28736027 | |
| Grewal HP et al. | Corticosteroid cessation 1 week following renal transplantation using tacrolimus/mycophenolate mofetil based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636558 |
| Garcia C et al. | Collaborative Brazilian Pediatric Renal Transplant Registry (CoBrazPed-RTx): A Report From 2004 to 2013. | 2015 | Transplant. Proc. | pmid:26036492 |
| Ohara K et al. | Toxicologic evaluation of FK 506. | 1990 | Transplant. Proc. | pmid:1689910 |
| Nalesnik MA et al. | The effect of FK 506 and CyA on the Lewis rat renal ischemia model. | 1990 | Transplant. Proc. | pmid:1689911 |
| Vathsala A et al. | Inhibition of apoptosis in anti-CD3-treated peripheral blood lymphocytes by immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120034 |
| Shibata T et al. | Does FK 506 accelerate the development of coronary artery disease in the transplanted heart as well as the native heart? | 1993 | Transplant. Proc. | pmid:7680147 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120037 |
| Oltean M et al. | Transplantation of preconditioned intestinal grafts is associated with lower inflammatory activation and remote organ injury in rats. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908278 |
| Alessiani M et al. | FK778 and tacrolimus combination therapy to control acute rejection after pig intestinal transplantation. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908288 |
| Wu YM et al. | Interaction between FK 506 and cyclosporine in dogs. | 1991 | Transplant. Proc. | pmid:1721281 |
| Bora F et al. | Drug interaction between tacrolimus and ertapenem in renal transplantation recipients. | 2012 | Transplant. Proc. | pmid:23195020 |
| Horimoto H et al. | Hepatocyte xenotransplantation for Nagase's analbuminemic rats: the effect of FK506. | 1996 | Transplant. Proc. | pmid:8623421 |
| Crespo-Leiro MG | Calcineurin inhibitors in heart transplantation. | 2005 | Transplant. Proc. | pmid:16386614 |
| Tan HP et al. | Steroid-free tacrolimus monotherapy after pretransplantation thymoglobulin or Campath and laparoscopy in living donor renal transplantation. | 2005 | Transplant. Proc. | pmid:16387087 |
| McAlister VC et al. | Cost of liver transplantation using tacrolimus. | 1998 | Transplant. Proc. | pmid:9636611 |
| Lipson DA et al. | Conversion to tacrolimus (FK506) from cyclosporine after orthotopic lung transplantation. | 1998 | Transplant. Proc. | pmid:9636612 |
| Wiebe K et al. | FK506 rescue therapy in lung transplantation. | 1998 | Transplant. Proc. | pmid:9636613 |
| Lentine KL et al. | Variation in Comedication Use According to Kidney Transplant Immunosuppressive Regimens: Application of Integrated Registry and Pharmacy Claims Data. | Transplant. Proc. | pmid:26915843 | |
| Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
| Woo J et al. | Effects of FK 506 and low concentration cyclosporine on human lymphocyte activation antigen expression: a flow cytometric analysis. | 1990 | Transplant. Proc. | pmid:1697113 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Kita J et al. | Effects of tacrolimus on small and large bowel anastomoses in the rat. | 1999 | Transplant. Proc. | pmid:10578292 |
| Woo J et al. | Kinetics of early T-cell repopulation in the mouse following syngeneic bone marrow transplantation: FK 506 causes a maturational defect of CD4+ CD8- T cells. | 1991 | Transplant. Proc. | pmid:1721313 |
| Kato T et al. | Steroid-free induction and preemptive antiviral therapy for liver transplant recipients with hepatitis C: a preliminary report from a prospective randomized study. | 2005 | Transplant. Proc. | pmid:15848674 |
| Ebbs A et al. | Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration. | 2002 | Transplant. Proc. | pmid:12176404 |
| Gagliano N et al. | A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblasts. | 2008 | Transplant. Proc. | pmid:18589121 |
| Petan JA et al. | Physiochemical properties of generic formulations of tacrolimus in Mexico. | 2008 | Transplant. Proc. | pmid:18589125 |
| Bäckman L et al. | Steroid-free immunosuppression in kidney transplant recipients and prograf monotherapy: an interim analysis of a prospective multicenter trial. | 2006 | Transplant. Proc. | pmid:17098029 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Nakazato P et al. | Early experience with FK 506 induction immunosuppression--suggestion for using oral FK 506. | 1991 | Transplant. Proc. | pmid:1721345 |
| Takahashi K et al. | Successful results after 5 years of tacrolimus therapy in ABO-incompatible kidney transplantation in Japan. | 2005 | Transplant. Proc. | pmid:15919471 |
| Nakamura K et al. | The lymphocytotoxic crossmatch in liver transplantation: a clinicopathologic analysis. | 1991 | Transplant. Proc. | pmid:1721346 |
| Foroncewicz B et al. | Safety and efficacy of steroid-free immunosuppression with tacrolimus and daclizumab in liver transplant recipients: 6-year follow-up in a single center. | 2009 | Transplant. Proc. | pmid:19857686 |
| Lin YH et al. | The 4-week serum creatinine level predicts long-term renal dysfunction after adult living donor liver transplantation. | 2012 | Transplant. Proc. | pmid:22483492 |
| Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
| Naraghi RM et al. | Long-term follow-up of tacrolimus rescue therapy for renal allograft rejection. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123013 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Ueda D et al. | Influence of FK 506 on renal blood flow. | 1991 | Transplant. Proc. | pmid:1721377 |
| Pisitkun T et al. | The roles of C4 and AUC0-4 in monitoring of tacrolimus in stable kidney transplant patients. | 2002 | Transplant. Proc. | pmid:12493410 |
| Thomson AW et al. | The influence of FK 506 on the thymus: implications of drug-induced injury to thymic epithelial cells. | 1991 | Transplant. Proc. | pmid:1703361 |
| Veroux P et al. | Tacrolimus-induced neurotoxicity in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12493415 |
| Guleria S et al. | Generic tacrolimus (Pan Graf) in renal transplantation: an experience of 155 recipients in India. | 2008 | Transplant. Proc. | pmid:18790202 |
| Tanabe K et al. | Improved outcome of minor-mismatched living renal allografts under tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176528 |
| Takeuchi H et al. | Evidence of different pharmacokinetics between cyclosporine and tacrolimus in renal transplant recipients: why cyclosporine is monitored by C2 level and tacrolimus by trough level. | 2008 | Transplant. Proc. | pmid:18790203 |
| Scolari MP et al. | Acute rejection after renal transplantation with tacrolimus-based therapy in conditions of normal clinical practice. | 2002 | Transplant. Proc. | pmid:12176529 |
| Chen WY et al. | Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28219593 |
| Rastellini C et al. | Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083278 |
| Rao AS et al. | Immune modulation in organ allograft recipients by single or multiple donor bone marrow infusions. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083302 |
| Kato H et al. | Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27320564 |
| Millis JM et al. | Tacrolimus treatment of steroid-resistant rejection provides economic advantages compared with OKT3 therapy. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123421 |
| Corry RJ et al. | Pancreas transplantation with enteric drainage under tacrolimus induction therapy. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123457 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| Yokoyama I et al. | Decreased Fas antigen expression of cultured hepatocytes with FK 506. | 1996 | Transplant. Proc. | pmid:8962237 |
| Shinozuka H et al. | Effect of FK 506 on experimental liver carcinogenesis. | 1991 | Transplant. Proc. | pmid:1721407 |
| Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
| Pelekanou V et al. | FK 506 and rapamycin do not affect platelet aggregation or mitochondrial function. | 1991 | Transplant. Proc. | pmid:1721408 |
| Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
| Nagashima N et al. | Immunocompetence assay for net effect of combined immunosuppression. | 2001 | Transplant. Proc. | pmid:11377556 |
| Baran DA et al. | Tacrolimus and cardiac transplantation: a comparison of monotherapy and steroid-dependent patients. | 2002 | Transplant. Proc. | pmid:12176599 |
| Calconi G and Vianello A | One-year follow-up of a large European trial comparing dual versus triple tacrolimus-based immunosuppressive regimens following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267173 |
| Lang M et al. | Combined liver-kidney transplantation: long-term follow-up in 18 patients. | 1998 | Transplant. Proc. | pmid:9723313 |
| Ersoy A et al. | Diabetic ketoacidosis following development of de novo diabetes in renal transplant recipient associated with tacrolimus. | 2004 | Transplant. Proc. | pmid:15251345 |
| Minematsu T et al. | Effect of hematocrit on pharmacokinetics of tacrolimus in adult living donor liver transplant recipients. | 2004 | Transplant. Proc. | pmid:15251372 |
| Sato K et al. | Comparative study of FK 506, cyclosporine, and triple regimen immunosuppression with FK 506, cyclosporine, and mizoribine. | 1991 | Transplant. Proc. | pmid:1721440 |
| Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
| Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
| Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
| Markus BH et al. | Daclizumab induction therapy in combination with tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267354 |
| Laftavi MR et al. | The role of antibiotic prophylaxis in the new era of immunosuppression. | 2011 | Transplant. Proc. | pmid:21440753 |
| Langrehr JM et al. | IL-2 receptor antibody induction increases the risk for chronic rejection after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267360 |
| González MG et al. | Comparison of post-liver transplantation electrocardiographic alterations between cyclosporine- and tacrolimus-treated patients. | 1999 | Transplant. Proc. | pmid:10500652 |
| González-Pinto I et al. | Usefulness of the switch to tacrolimus in liver transplantation. | 1999 | Transplant. Proc. | pmid:10500653 |
| Tsujimura K et al. | Effect of Influenza Vaccine in Patients With Kidney Transplant. | 2018 | Transplant. Proc. | pmid:30316375 |
| Shullo MA et al. | Elevated tacrolimus levels associated with intravenous azithromycin and ceftriaxone: a case report. | 2010 | Transplant. Proc. | pmid:20620540 |
| Rao V et al. | A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimus. | 2013 Jan-Feb | Transplant. Proc. | pmid:23267806 |
| Kahu J et al. | Impact of mycophenolate mofetil intolerance on early results of kidney transplantation. | 2005 | Transplant. Proc. | pmid:16298571 |
| Wong YT et al. | Audit of diabetes in a renal transplant population. | 2005 | Transplant. Proc. | pmid:16298573 |
| Suarez Benjumea A et al. | Hepatitis C Virus in Kidney Transplant Recipients: A Problem on the Path to Eradication. | 2016 | Transplant. Proc. | pmid:27932111 |
| Xie L et al. | Pretransplantation Risk Factors Associated With New-onset Diabetes After Living-donor Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27931572 |
| Eghtesad B et al. | Use of tacrolimus as the primary immunosuppression after renal transplant in Native Americans and Hispanics. | 1998 | Transplant. Proc. | pmid:9636500 |
| Turner CD et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a 4-year experience with an aggressive approach. | 1998 | Transplant. Proc. | pmid:9636501 |
| Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |