tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hiraoka A et al. | Phase III study comparing tacrolimus (FK506) with cyclosporine for graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11509936 |
| McAlister VC et al. | Orthotopic liver transplantation using low-dose tacrolimus and sirolimus. | 2001 | Liver Transpl. | pmid:11510015 |
| Terui T et al. | Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells. | 2001 | J. Invest. Dermatol. | pmid:11511299 |
| Tatekawa Y et al. | Intragraft expression of p38 and activated p38 MAPK (mitogen-activated protein kinase) in rat small bowel transplantation. | 2001 | Transpl. Int. | pmid:11512052 |
| Hochleitner BW et al. | Increased tacrolimus levels during diarrhea. | 2001 | Transpl. Int. | pmid:11512055 |
| Marx SO and Marks AR | Bench to bedside: the development of rapamycin and its application to stent restenosis. | 2001 | Circulation | pmid:11514367 |
| Hiraga K et al. | A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11515543 |
| Taupin JL et al. | Functional quantification of cyclosporine A and FK506 in human whole blood by flow cytometry, using the green fluorescent protein as an interleukin-2 reporter gene. | 2001 | J. Immunol. Methods | pmid:11516757 |
| Cole O et al. | The effect of different immunosuppressants on alloantigen dependent and independent factors involved in the development of chronic rejection in an animal model. | 2001 | Ann R Coll Surg Engl | pmid:11518369 |
| Suzuki K et al. | FK506 facilitates chemical kindling induced by pentylenetetrazole in rats. | 2001 | Epilepsy Res. | pmid:11518629 |
| Hashida T and Inui K | [Therapeutic drug monitoring of immunosuppresants]. | 2001 | Rinsho Byori | pmid:11519126 |
| Morioka M et al. | Intravenously injected FK506 failed to inhibit hippocampal calcineurin. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520068 |
| Dmitrewski J et al. | Metabolic and hormonal effects of tacrolimus (FK506) or cyclosporin immunosuppression following renal transplantation. | 2001 | Diabetes Obes Metab | pmid:11520309 |
| Behrend M | Adverse gastrointestinal effects of mycophenolate mofetil: aetiology, incidence and management. | 2001 | Drug Saf | pmid:11522119 |
| Staatz C et al. | Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation. | 2001 | Nephrol. Dial. Transplant. | pmid:11522877 |
| Anneser JM et al. | Immunosuppressant FK506 does not exert beneficial effects in symptomatic G93A superoxide dismutase-1 transgenic mice. | 2001 | Neuroreport | pmid:11522944 |
| Lhoëst G et al. | In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry. | 2001 | J Mass Spectrom | pmid:11523088 |
| Szabo G et al. | Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells. | 2001 | J. Investig. Med. | pmid:11523700 |
| Abu-Elmagd K et al. | Clinical intestinal transplantation: a decade of experience at a single center. | 2001 | Ann. Surg. | pmid:11524593 |
| Riboldi-Tunnicliffe A et al. | Crystal structure of Mip, a prolylisomerase from Legionella pneumophila. | 2001 | Nat. Struct. Biol. | pmid:11524681 |
| Freyschmidt-Paul P et al. | Treatment of alopecia areata in C3H/HeJ mice with the topical immunosuppressant FK506 (Tacrolimus). | 2001 Sep-Oct | Eur J Dermatol | pmid:11525945 |
| Tremblay JP and Vilquin JT | [Transplantation of normal or genetically modified myoblasts for the treatment of hereditary or acquired diseases]. | 2001 | J. Soc. Biol. | pmid:11530497 |
| Ikegame K et al. | Lethal adenovirus infection in a patient who had undergone nonmyeloablative stem cell transplantation. | 2001 | Int. J. Hematol. | pmid:11530814 |
| Elinav H et al. | Plasma oxidizability and plasma carbonyls, markers of oxidative stress, in liver transplant patients. | 2001 | Transplant. Proc. | pmid:11543789 |
| Mor E et al. | Homocysteine levels among transplant recipients: effect of immunosuppressive protocols. | 2001 | Transplant. Proc. | pmid:11543802 |
| Weinbroum AA et al. | Lack of cumulative effect of tacrolimus and low flow on a rat isolated liver. | 2001 | Transplant. Proc. | pmid:11543812 |
| Kovalev GI et al. | An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation. | 2001 | J. Immunol. | pmid:11544316 |
| Berg UB et al. | Renal function before and long after liver transplantation in children. | 2001 | Transplantation | pmid:11544422 |
| Aw MM et al. | Calcineurin-inhibitor related nephrotoxicity- reversibility in paediatric liver transplant recipients. | 2001 | Transplantation | pmid:11544444 |
| Mann J | Natural products as immunosuppressive agents. | 2001 | Nat Prod Rep | pmid:11548050 |
| Furukawa M et al. | MRI in seven cases of tacrolimus (FK-506) encephalopathy: utility of FLAIR and diffusion-weighted imaging. | 2001 | Neuroradiology | pmid:11548166 |
| Lübbe J | Topical tacrolimus for atopic dermatitis: euphoria and vigilance. | 2001 | Dermatology (Basel) | pmid:11549790 |
| Kawakami T et al. | Safe and effective treatment of refractory facial lesions in atopic dermatitis using topical tacrolimus following corticosteroid discontinuation. | 2001 | Dermatology (Basel) | pmid:11549797 |
| Aker S et al. | Different effects of cyclosporine a and FK506 on potassium transport systems in MDCK cells. | 2001 | Exp. Nephrol. | pmid:11549851 |
| Moody BR and Sengelmann RD | Topical tacrolimus in the treatment of bovine collagen hypersensitivity. | 2001 | Dermatol Surg | pmid:11553165 |
| Dunn SE et al. | Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. | 2001 | J. Biol. Chem. | pmid:11555650 |
| Carmody M et al. | FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels. | 2001 | FEBS Lett. | pmid:11557049 |
| Schlitt HJ et al. | Replacement of calcineurin inhibitors with mycophenolate mofetil in liver-transplant patients with renal dysfunction: a randomised controlled study. | 2001 | Lancet | pmid:11558484 |
| Stewart SF et al. | Mycophenolate mofetil monotherapy in liver transplantation. | 2001 | Lancet | pmid:11558493 |
| Choi CJ and Nghiem P | Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients. | 2001 | Arch Dermatol | pmid:11559218 |
| Cacciarelli TV et al. | Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients. | 2001 | Pediatr Transplant | pmid:11560756 |
| Letko E et al. | Treatment of ocular cicatricial pemphigoid with tacrolimus (FK 506). | 2001 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:11561793 |
| Laham G et al. | [Acute peripheral demyelinating polyneuropathy and acute renal failure after administration of FK506]. | 2001 | Medicina (B Aires) | pmid:11563175 |
| Briggs WA et al. | Lymphocyte suppression by glucocorticoids with cyclosporine, tacrolimus, pentoxifylline, and mycophenolic acid. | 1999 | J Clin Pharmacol | pmid:11563403 |
| Nakao A et al. | Impact of tacrolimus and bone marrow augmentation on intestinal allograft survival and intragraft cytokine expression in rats. | 2001 | J Med | pmid:11563819 |
| Sindhi R et al. | Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus. | 2001 | Transplantation | pmid:11571449 |
| Takamatsu Y et al. | Intravenous cyclosporine and tacrolimus caused anaphylaxis but oral cyclosporine capsules were tolerated in an allogeneic bone marrow transplant recipient. | 2001 | Bone Marrow Transplant. | pmid:11571519 |
| Coley KC et al. | Lack of tacrolimus-induced cardiomyopathy. | 2001 | Ann Pharmacother | pmid:11573873 |
| Gingras AC et al. | Control of translation by the target of rapamycin proteins. | 2001 | Prog. Mol. Subcell. Biol. | pmid:11575159 |
| Dumont FJ | Treatment of transplant rejection: are the traditional immunosuppressants good enough? | 2001 | Curr Opin Investig Drugs | pmid:11575705 |
| Fujimoto H et al. | Immunomodulatory constituents from an Ascomycete, Eupenicillium crustaceum, and revised absolute structure of macrophorin D. | 2001 | J. Nat. Prod. | pmid:11575965 |
| Bayle F | [Focus on Islets of Langerhans transplantation]. | 2001 | Presse Med | pmid:11577579 |
| Thervet E | [Minimization of immunosuppression]. | 2001 | Presse Med | pmid:11577589 |
| Oettinger-Barak O et al. | Periodontal changes in liver cirrhosis and post-transplantation patients. I: clinical findings. | 2001 | J. Periodontol. | pmid:11577956 |
| Lawrence MC et al. | Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells. | 2001 | Mol. Endocrinol. | pmid:11579208 |
| Al-Uzri A et al. | Posttransplant diabetes mellitus in pediatric renal transplant recipients: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). | 2001 | Transplantation | pmid:11579294 |
| Mourad G et al. | Induction versus noninduction in renal transplant recipients with tacrolimus-based immunosuppression. | 2001 | Transplantation | pmid:11579299 |
| Staatz CE et al. | Population pharmacokinetics of tacrolimus in children who receive cut-down or full liver transplants. | 2001 | Transplantation | pmid:11579300 |
| Selzner N et al. | Conversion from cyclosporine to FK506 in adult liver transplant recipients: a combined North American and European experience. | 2001 | Transplantation | pmid:11579301 |
| Savoldo B et al. | Generation of autologous Epstein-Barr virus-specific cytotoxic T cells for adoptive immunotherapy in solid organ transplant recipients. | 2001 | Transplantation | pmid:11579304 |
| Jain A et al. | A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone and mycophenolate mofetil in primary adult liver transplantation: a single center report. | 2001 | Transplantation | pmid:11579306 |
| Sloper CM et al. | Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts. | 2001 | Ophthalmology | pmid:11581059 |
| Simpson D | New developments in the prophylaxis and treatment of graft versus host disease. | 2001 | Expert Opin Pharmacother | pmid:11583062 |
| Assmann T et al. | Topical tacrolimus for the treatment of inflammatory skin diseases. | 2001 | Expert Opin Pharmacother | pmid:11583067 |
| Ichimaru N et al. | Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus. | 2001 | Atherosclerosis | pmid:11583721 |
| Hricik DE | Safety and efficacy of TOR inhibitors and other immunosuppressive regimens in African-American renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11583939 |
| Pescovitz MD and Govani M | Sirolimus and mycophenolate mofetil for calcineurin-free immunosuppression in renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11583940 |
| First MR | Strategies to minimize immunological and nonimmunological risk factors in the renal transplant population. | 2001 | Transplantation | pmid:11585240 |
| Koomans HA and Ligtenberg G | Mechanisms and consequences of arterial hypertension after renal transplantation. | 2001 | Transplantation | pmid:11585243 |
| Patel S et al. | Prevalence and causes of low bone density and fractures in kidney transplant patients. | 2001 | J. Bone Miner. Res. | pmid:11585351 |
| Chau TN et al. | Histological patterns of rejection using oral microemulsified cyclosporine and tacrolimus (FK506) as monotherapy induction after orthotopic liver transplantation. | 2001 | Liver | pmid:11589769 |
| Sezen SF et al. | Immunophilin ligand FK506 is neuroprotective for penile innervation. | 2001 | Nat. Med. | pmid:11590407 |
| Morissette P et al. | In vivo higher glucuronidation of mycophenolic acid in male than in female recipients of a cadaveric kidney allograft and under immunosuppressive therapy with mycophenolate mofetil. | 2001 | Ther Drug Monit | pmid:11591897 |
| Naka Y et al. | Effects of dexamethasone and FK506 on Helicobacter pylori-induced gastritis and bacterial viability in Mongolian gerbils. | 2001 Jan-Dec | J. Physiol. Paris | pmid:11595473 |
| Dipchand AI et al. | Mycophenolic acid levels in pediatric heart transplant recipients receiving mycophenolate mofetil. | 2001 | J. Heart Lung Transplant. | pmid:11595558 |
| Christ B et al. | Interactions of sildenafil and tacrolimus in men with erectile dysfunction after kidney transplantation. | 2001 | Urology | pmid:11597545 |
| Bultynck G et al. | The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different. | 2001 | J. Biol. Chem. | pmid:11598113 |
| Hardinger KL et al. | Renal allograft outcomes in African American versus Caucasian transplant recipients in the tacrolimus era. | 2001 | Surgery | pmid:11602906 |
| Dello Strologo L et al. | Renal hemodynamic effect of tacrolimus in renal transplanted children. | 2001 | Pediatr. Nephrol. | pmid:11605779 |
| Serrano AL et al. | Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11606756 |
| Bornhövd E et al. | Macrolactam immunomodulators for topical treatment of inflammatory skin diseases. | 2001 | J. Am. Acad. Dermatol. | pmid:11606925 |
| Wang M et al. | Inhibition of nitric oxide synthase induces intestinal mucosal damage and increases mortality in rats treated by FK506. | 2001 | Exp. Toxicol. Pathol. | pmid:11665854 |
| Fernández-Miranda C et al. | Determinants of increased plasma homocysteine in 221 stable liver transplant patients. | 2001 | Clin. Chem. | pmid:11673376 |
| Carreras CW et al. | An FKBP12 binding assay based upon biotinylated FKBP12. | 2001 | Anal. Biochem. | pmid:11673895 |
| Mimura T et al. | [Treatment of steroid-resistant polymyositis and dermatomyositis]. | 2001 | Nippon Rinsho | pmid:11676154 |
| Kimikawa M et al. | Effective oral administration of tacrolimus in renal transplant recipients. | 2001 | Clin Transplant | pmid:11678958 |
| Chisholm MA et al. | Impact of clinical pharmacy services on renal transplant patients' compliance with immunosuppressive medications. | 2001 | Clin Transplant | pmid:11678959 |
| Arii T et al. | Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: therapeutic time window for FK506 in transient focal ischemia. | 2001 | Neurol. Res. | pmid:11680517 |
| Sakuma Y et al. | High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination. | 2001 | Transpl. Immunol. | pmid:11680570 |
| Deters M et al. | Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat. | 2001 | Dig. Dis. Sci. | pmid:11680585 |
| Onoe H et al. | [Interaction of immunophilin FKBP and intracellular Ca2+ release channels]. | 2001 | Fukuoka Igaku Zasshi | pmid:11681278 |
| Suehiro E et al. | The immunophilin ligand FK506 attenuates the axonal damage associated with rapid rewarming following posttraumatic hypothermia. | 2001 | Exp. Neurol. | pmid:11681852 |
| Dietemann J et al. | Comparison of ELISA method versus MEIA method for daily practice in the therapeutic monitoring of tacrolimus. | 2001 | Nephrol. Dial. Transplant. | pmid:11682676 |
| Barri YM et al. | Polyoma viral infection in renal transplantation: the role of immunosuppressive therapy. | 2001 | Clin Transplant | pmid:11683817 |
| Baan CC et al. | Conversion from cyclosporin A to tacrolimus is safe and decreases blood pressure, cholesterol levels and TGF-beta 1 type I receptor expression. | 2001 | Clin Transplant | pmid:11683823 |
| Geba GP et al. | Topical tacrolimus and cyclosporin A differentially inhibit early and late effector phases of cutaneous delayed-type and immunoglobulin E hypersensitivity. | 2001 | Immunology | pmid:11683964 |
| Ovuworie CA et al. | Vascular endothelial function in cyclosporine and tacrolimus treated renal transplant recipients. | 2001 | Transplantation | pmid:11685108 |
| Oz HS et al. | Provocative effects of the immunosuppressants rapamycin, tacrolimus, and dexamethasone on pneumonitis in contrast to the anti- pneumonitis effects of mycophenolate mofetil. | 2001 | Transplantation | pmid:11685124 |
| Mazariegos GV et al. | Conversion from cyclosporin to tacrolimus in paediatric liver transplant recipients. | 2001 | Paediatr Drugs | pmid:11688597 |
| Tucker CL and Fields S | A yeast sensor of ligand binding. | 2001 | Nat. Biotechnol. | pmid:11689849 |