tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Mouth Diseases D009059 5 associated lipids
Meningococcal Infections D008589 3 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mycobacterium Infections D009164 7 associated lipids
Sarcoidosis D012507 13 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Hyperglycemia D006943 21 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Skin Neoplasms D012878 12 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Postoperative Complications D011183 5 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Neoplasm Recurrence, Local D009364 5 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Morales-Molina JA et al. Alcohol ingestion and topical tacrolimus: a disulfiram-like interaction? 2005 Ann Pharmacother pmid:15755786
Copacia JA et al. 70% Ethanol for Decontamination of Central Venous Lines Exposed to Calcineurin Inhibitors. 2018 Ann Pharmacother pmid:28838253
Teshima D et al. Increased topical tacrolimus absorption in generalized leukemic erythroderma. 2003 Ann Pharmacother pmid:14519034
Hui RL et al. Association between exposure to topical tacrolimus or pimecrolimus and cancers. 2009 Ann Pharmacother pmid:19903860
Mathis AS Comment: delayed wound healing with sirolimus after liver transplant. 2003 Ann Pharmacother pmid:12639183
Shaeffer MS et al. Interaction between FK506 and erythromycin. 1994 Ann Pharmacother pmid:7513563
Su VCh et al. Impact of Mycophenolate Mofetil Dose Reduction on Allograft Outcomes in Kidney Transplant Recipients on Tacrolimus-Based Regimens: A Systematic Review. 2011 Ann Pharmacother pmid:21304036
Chenhsu RY et al. Renal allograft dysfunction associated with rifampin-tacrolimus interaction. 2000 Ann Pharmacother pmid:10669182
Coley KC et al. Lack of tacrolimus-induced cardiomyopathy. 2001 Ann Pharmacother pmid:11573873
Takahashi K et al. Lansoprazole-tacrolimus interaction in Japanese transplant recipient with CYP2C19 polymorphism. 2004 Ann Pharmacother pmid:15010519
Guerra AA et al. Cyclosporine versus tacrolimus in immunosuppressive maintenance regimens in renal transplants in Brazil: survival analysis from 2000 to 2004. 2010 Ann Pharmacother pmid:20009005
Hebert MF and Lam AY Diltiazem increases tacrolimus concentrations. 1999 Ann Pharmacother pmid:10410178
Pierce DA and Reeves-Daniel AM Ranolazine-tacrolimus interaction. 2010 Ann Pharmacother pmid:20876828
Lam S et al. Corticosteroid interactions with cyclosporine, tacrolimus, mycophenolate, and sirolimus: fact or fiction? 2008 Ann Pharmacother pmid:18594053
Hooks MA Tacrolimus, a new immunosuppressant--a review of the literature. 1994 Ann Pharmacother pmid:7518710
Morris RG Immunosuppressant drug monitoring: is the laboratory meeting clinical expectations? 2005 Ann Pharmacother pmid:15590877
Skaehill PA Tacrolimus in dermatologic disorders. 2001 Ann Pharmacother pmid:11346066
French AE et al. Milk transfer and neonatal safety of tacrolimus. 2003 Ann Pharmacother pmid:12773068
Gianni LM and Sulli MM Topical tacrolimus in the treatment of atopic dermatitis. 2001 Jul-Aug Ann Pharmacother pmid:11485148
Seifeldin RA et al. Nifedipine interaction with tacrolimus in liver transplant recipients. 1997 Ann Pharmacother pmid:9161650
Kaushik P et al. Miller fisher variant of guillain-barre syndrome requiring a cardiac pacemaker in a patient on tacrolimus after liver transplantation. 2005 Ann Pharmacother pmid:15855240
Page RL et al. Potential elevation of tacrolimus trough concentrations with concomitant metronidazole therapy. 2005 Ann Pharmacother pmid:15855244
Bax K et al. Rapid resolution of tacrolimus intoxication-induced AKI with a corticosteroid and phenytoin. 2014 Ann Pharmacother pmid:25104567
Ibrahim RB et al. Tacrolimus-clarithromycin interaction in a patient receiving bone marrow transplantation. 2002 Ann Pharmacother pmid:12452763
Schonder KS et al. Tacrolimus and lopinavir/ritonavir interaction in liver transplantation. 2003 Ann Pharmacother pmid:14632538
Outeda Macías M et al. Tacrolimus-itraconazole interaction in a kidney transplant patient. 2000 Ann Pharmacother pmid:10772445
Chisholm MA and Middleton MD Modified-release tacrolimus. 2006 Ann Pharmacother pmid:16449540
Hiraoka S et al. Readministration of calcineurin inhibitors for ulcerative colitis. 2012 Ann Pharmacother pmid:23032660
Ibrahim RB et al. Tacrolimus disposition in the ascitic fluid of a bone marrow transplant patient. 2010 Ann Pharmacother pmid:20371750
Thompson PA and Mosley CA Tacrolimus-phenytoin interaction. 1996 Ann Pharmacother pmid:8740340
Guilbeau JM Delayed wound healing with sirolimus after liver transplant. 2002 Ann Pharmacother pmid:12196058
Capone D et al. Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient. 1999 Ann Pharmacother pmid:10534229
Lee TJ and Kennedy LA Tacrolimus: an alternative for graft-versus-host disease prevention. 2000 Ann Pharmacother pmid:10917386
Auzéric M et al. [Designing a tool to describe drug interactions and adverse events for learning and clinical routine]. 2009 Ann Pharm Fr pmid:19900608
Blanchet B [Therapeutic monitoring of immunosuppressive drugs: interest of calcineurin activity assessment in liver transplantation]. 2008 Ann Pharm Fr pmid:18570908
Ferlicot S et al. [Smooth muscle mesentery associated with Epstein-Barr virus (EBV). Report of a case in a child with a liver transplant under FK506 regimen]. 1999 Ann Pathol pmid:10320913
Hanf W et al. [An unusual native kidney neoplasm presenting in a kidney graft recipient]. 2012 Ann Pathol pmid:23010406
Goldust M et al. Treatment of seborrheic dermatitis: the efficiency of sertaconazole 2% cream vs. tacrolimus 0.03% cream. 2013 Ann Parasitol pmid:24171300
Yalçindag FN et al. Effectiveness of tacrolimus in high-risk limbal allo-graft transplantation. 2008 Fall-Winter Ann Ophthalmol (Skokie) pmid:19230352
Yalçindağ FN et al. Penetration of topically applied tacrolimus into the aqueous humor in Behçet's disease. 2007 Ann Ophthalmol (Skokie) pmid:17914200
Ikitimur B et al. Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. 2015 Ann Noninvasive Electrocardiol pmid:25367596
Qin X et al. Multi-center Performance Evaluations of Tacrolimus and Cyclosporine Electrochemiluminescence Immunoassays in the Asia-Pacific Region. 2018 Ann Lab Med pmid:29214751
Al Nahdi N et al. First successful treatment of post-liver transplant hepatitis C fibrosing cholestatic hepatitis with boceprevir, peginterferon and ribavirin in a pre-transplant null responder. 2013 Jan-Feb Ann Hepatol pmid:23293209
Forns X et al. Efficacy of telaprevir-based therapy in stable liver transplant patients with chronic genotype 1 hepatitis C. Ann Hepatol pmid:27236150
Norero B et al.  Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key. Ann Hepatol pmid:28051798
Yoshida EM et al. Canadian national retrospective chart review comparing the long term effect of cyclosporine vs. tacrolimus on clinical outcomes in patients with post-liver transplantation hepatitis C virus infection. 2013 Mar-Apr Ann Hepatol pmid:23396740
Vassal O et al. [Bacterial parotitis in an immunocompromised patient in adult ICU]. 2013 Ann Fr Anesth Reanim pmid:23948025
Abbott KC et al. Differing manifestations of hepatitis C and tacrolimus on hospitalized diabetes mellitus occurring after kidney transplantation. 2005 Ann Epidemiol pmid:16118000
Moncourier M et al. [Granulomatous periocular eruption]. Ann Dermatol Venereol pmid:28410769
Elloudi S et al. [Frontal fibrosing alopecia: A prospective study of 20 cases]. Ann Dermatol Venereol pmid:28258757
Mirkamali A et al. [Ulcerated necrobiosis lipoidica: successful treatment with topical tacrolimus and hydroxychloroquine]. 2010 Aug-Sep Ann Dermatol Venereol pmid:20804904
Parodi A et al. Treatment of rosacea. 2011 Ann Dermatol Venereol pmid:22183101
Schmutz JL et al. [Pimecrolimus and vaccinations]. 2007 Jun-Jul Ann Dermatol Venereol pmid:17702119
Alquier-Bouffard A et al. [Chronic actinic dermatitis: treatment with topical tacrolimus (two cases)]. 2007 Jun-Jul Ann Dermatol Venereol pmid:17657183
Schmutz JL [No increased risk of cancer under pimecrolimus]. 2016 Ann Dermatol Venereol pmid:26708204
Parodi A et al. [Treatment of rosacea]. 2011 Ann Dermatol Venereol pmid:21907876
Mahé E et al. [Plane warts in areas of atopic dermatitis treated with tacrolimus ointment]. 2006 Aug-Sep Ann Dermatol Venereol pmid:17053745
Girault PY et al. [Topical tacrolimus in chronic actinic dermatitis]. 2008 Ann Dermatol Venereol pmid:18929923
Rouxel AM et al. [Tacrolimus mouthwash as second-line treatment for erosive oral lichen planus]. 2010 Ann Dermatol Venereol pmid:20932447
Schmutz JL et al. [Contact allergy with tacrolimus then pimecrolimus]. 2008 Ann Dermatol Venereol pmid:18342086
Skowron F et al. [Important systemic absorption of topical tacrolimus during treatment of severe pemphigus vulgaris]. 2005 Ann Dermatol Venereol pmid:15924053
Martel J et al. [Subcutaneous mycosis due to Scopulariopsis brevicaulis in an immunocompromised patient]. 2001 Ann Dermatol Venereol pmid:11275588
Nouchi A et al. [Treatment of angiolymphoid hyperplasia with eosinophilia (ALHE) using topical tacrolimus: Two cases]. 2015 Ann Dermatol Venereol pmid:25778634
Reynaert G et al. [Streptococcal impetigo at topical tacrolimus application sites in a woman with atopic dermatitis]. 2007 Ann Dermatol Venereol pmid:17389853
Paul C [Science, marketing and pharmacovigilance: the example of topical calcineurin inhibitors]. 2007 Ann Dermatol Venereol pmid:18033059
Al Gain M et al. [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. 2015 Ann Dermatol Venereol pmid:25683011
Chiheb S et al. [Behçet's disease]. 2003 Jun-Jul Ann Dermatol Venereol pmid:13679709
Baubion E et al. [Oral lichen planus and treatment with topical tacrolimus rinse]. 2009 Ann Dermatol Venereol pmid:19328313
Schmutz JL et al. [Kaposi's sarcoma in an AIDS patient after application of tacrolimus (Protopic)]. 2006 Ann Dermatol Venereol pmid:16800194
Henno A et al. [Improvement of Netherton syndrome associated erythroderma in two adult sisters through use of topical pimecrolimus]. 2006 Ann Dermatol Venereol pmid:16495860
Michel JL and Gain P [Topical tacrolimus treatment for ocular cicatricial pemphigoid]. 2006 Ann Dermatol Venereol pmid:16508602
Lacour JP [Topical tacrolimus in dermatology: what can one expect?]. 2001 Ann Dermatol Venereol pmid:11908129
Macario-Barrel A et al. [Mouth ulcers in patients receiving tacrolimus]. 2001 Ann Dermatol Venereol pmid:11908135
Firmin D et al. [Tacrolimus ointment in the treatment of chronic cutaneous graft-versus-host disease]. 2008 Ann Dermatol Venereol pmid:18374862
Ferraro V et al. [Efficacy of topical tacrolimus in Hailey-Hailey disease]. 2006 Ann Dermatol Venereol pmid:16760841
Fery-Blanco C et al. [Disseminated molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus: efficacy of cidofovir]. 2007 Ann Dermatol Venereol pmid:17507844
Schmutz J et al. [Gingival hypertrophy and tacrolimus]. 2000 Jun-Jul Ann Dermatol Venereol pmid:10930868
Lübbe J and Saurat JH [A monograph on topical tacrolimus (Protopic]. 2003 Ann Dermatol Venereol pmid:12700537
de Prost Y [The value of topical immunosuppressors in the treatment of atopic dermatitis in children]. 2005 Ann Dermatol Venereol pmid:15984296
Nicolie B [What is the treatment for atopic dermatitis flares in children?]. 2005 Ann Dermatol Venereol pmid:15984308
de Prost Y [Can the precautionary principle obstruct therapeutic progress?]. 2005 Aug-Sep Ann Dermatol Venereol pmid:16230911
Martin D et al. [First case in the world of autoreplantation of a limb associated with oral administration of an immunosupressant agent (FK 506-Tacrolimus)]. 2005 Ann Chir Plast Esthet pmid:16087038
Panis Y and Valleur P [Small intestine transplantation. Experimental and clinical results]. 1993 Ann Chir pmid:7504899
Busque S et al. [Hypertrichosis and gingival hypertrophy regression in renal transplants following the substitution of cyclosporin by tacrolimus]. 1999 Ann Chir pmid:10584376
Philippe F et al. [Drug eluting stents: from evidence based medicine to clinical practice]. 2005 Ann Cardiol Angeiol (Paris) pmid:16104621
Sahu MK et al. High blood tacrolimus and hyperkalemia in a heart transplant patient. Ann Card Anaesth pmid:28393798
Wüthrich B et al. Atopic eczema: genetics or environment? 2007 Ann Agric Environ Med pmid:18247450
Elisaf M and Mikhailidis DP Statins and renal function. 2002 Sep-Oct Angiology pmid:12365855
Brittain DE et al. Total synthesis of antascomicin B. 2005 Angew. Chem. Int. Ed. Engl. pmid:15806607
Lee KB et al. Direct monitoring of the inhibition of protein-protein interactions in cells by translocation of PKCδ fusion proteins. 2011 Angew. Chem. Int. Ed. Engl. pmid:21290501
McKenzie KM et al. Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe. 2004 Angew. Chem. Int. Ed. Engl. pmid:15300693
Feng S et al. A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. 2014 Angew. Chem. Int. Ed. Engl. pmid:24841150
Althoff EA and Cornish VW A bacterial small-molecule three-hybrid system. 2002 Angew. Chem. Int. Ed. Engl. pmid:12203581
Brooksbank RL et al. Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. 1998 Anesthesiology pmid:9743407
Chini EN and Walker H FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. 2000 Anesthesiology pmid:10781282
Lang-Lazdunski L et al. The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. 2001 Anesth. Analg. pmid:11323353
Siniscalchi A et al. Opioid-induced hyperalgesia and rapid opioid detoxification after tacrolimus administration. 2008 Anesth. Analg. pmid:18227327
Georgiou GK et al. Calcineurin inhibitors and male fertility after renal transplantation - a review. 2016 Andrologia pmid:26341518
Brecht S et al. FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. 2009 Anat Rec (Hoboken) pmid:19728359
Kim SK et al. Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion. 2012 Analyst pmid:22822477