tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Christians U et al. | High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients. | 1991 | Transplant. Proc. | pmid:1721262 |
| Shapiro R et al. | Outcome after steroid withdrawal in renal transplant patients receiving tacrolimus-based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636557 |
| Okamoto M et al. | Beneficial effect of multiple drug therapy including tacrolimus in clinical renal transplantation. | 2000 | Transplant. Proc. | pmid:11119905 |
| Hashikura Y et al. | Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623218 |
| Tian Ch et al. | B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375291 |
| Ochiai M et al. | Islet toxicity of FK506 measured in canine autografts. | 1998 | Transplant. Proc. | pmid:9532224 |
| Yao B et al. | The incidence of posttransplantation diabetes mellitus during follow-up in kidney transplant recipients and relationship to Fok1 vitamin D receptor polymorphism. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375298 |
| Zeevi A et al. | Bioassay of plasma specimens from liver transplant patients on FK 506 immunosuppression. | 1990 | Transplant. Proc. | pmid:1689902 |
| Ruiz MC et al. | Effect of early versus delayed calcineurin inhibitor treatment on delayed graft function. | 2003 | Transplant. Proc. | pmid:12644096 |
| Imventarza O et al. | Renal transplantation in baboons under FK 506. | 1990 | Transplant. Proc. | pmid:1689903 |
| Fraile P et al. | Non-skin solid tumors as a cause of morbidity and mortality after liver transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715943 |
| Roman A et al. | Preliminary results of rescue therapy with tacrolimus and mycophenolate mofetil in lung transplanted patients with bronchiolitis obliterans. | 2002 | Transplant. Proc. | pmid:11959227 |
| Rath T and Küpper M | Comparison of inosine-monophosphate-dehydrogenase activity in patients with enteric-coated mycophenolate sodium or mycophenolate mofetil after renal transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715967 |
| Sigal NH et al. | Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506? | 1991 | Transplant. Proc. | pmid:1721295 |
| Lipson DA et al. | Conversion to tacrolimus (FK506) from cyclosporine after orthotopic lung transplantation. | 1998 | Transplant. Proc. | pmid:9636612 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressives. | 2000 | Transplant. Proc. | pmid:11120282 |
| Vanrenterghem Y | Vascular rejection with tacrolimus and potential long-term graft outcome. | 1999 | Transplant. Proc. | pmid:10576054 |
| Iaria G et al. | Prospective study of switch from cyclosporine to tacrolimus for fibroadenomas of the breast in kidney transplantation. | 2010 | Transplant. Proc. | pmid:20534252 |
| Woodle ES | A prospective, randomized, multicenter, double-blind study of early corticosteroid cessation versus long-term maintenance of corticosteroid therapy with tacrolimus and mycophenolate mofetil in primary renal transplant recipients: one year report. | 2005 | Transplant. Proc. | pmid:15848538 |
| López-Montenegro Soria MA et al. | Genetic polymorphisms and individualized tacrolimus dosing. | 2010 | Transplant. Proc. | pmid:20970601 |
| Nowacka-Cieciura E et al. | Late conversion to everolimus complicated with necrotizing glomerulonephritis in a renal allograft recipient: case report. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249576 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
| Ricordi C et al. | Effect of FK 506 on human pancreatic islets following renal subcapsular transplantation in diabetic nude mice. | 1992 | Transplant. Proc. | pmid:1376512 |
| Vargas V et al. | Alpha-interferon for acute hepatitis C in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533374 |
| Cooper MH et al. | Evaluation of the influence of FK 506, rapamycin, and cyclosporine on processing and presentation of particulate antigen by macrophages: assessment of a drug "carry-over" effect. | 1991 | Transplant. Proc. | pmid:1721326 |
| Didlake R and Grogan J | Effect of FK 506 on rat leukocyte chemotaxis. | 1991 | Transplant. Proc. | pmid:1721327 |
| Nakamura K et al. | Renal transplant recipient experiencing pneumatosis cystoides intestinalis: a case report. | 2003 | Transplant. Proc. | pmid:12591410 |
| Akioka K et al. | Abdominal pain is a critical complication of mycophenolate mofetil in renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12591411 |
| Takeuchi H et al. | Optimal dose and target trough level in cyclosporine and tacrolimus conversion in renal transplantation as evaluated by lymphocyte drug sensitivity and pharmacokinetic parameters. | 2005 | Transplant. Proc. | pmid:15919452 |
| Hohage H et al. | Differential effects of cyclosporine and tacrolimus on mycophenolate pharmacokinetics in patients with impaired kidney function. | 2005 | Transplant. Proc. | pmid:15919453 |
| Sarvary E et al. | De novo Prograf versus de novo Advagraf: are trough level profile curves similar? | Transplant. Proc. | pmid:25131131 | |
| Borda B et al. | Early histopathological changes in new-onset diabetes after kidney transplantation. | Transplant. Proc. | pmid:25131129 | |
| Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
| Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
| Scantlebury VP et al. | Outcome of kidney transplantation in African-Americans using tacrolimus. | 1997 | Transplant. Proc. | pmid:9414906 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in pediatric cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721359 |
| Oğütmen B et al. | Transforming growth factor-beta1, vascular endothelial growth factor, and bone morphogenic protein-7 expression in tacrolimus-induced nephrotoxicity in rats. | 2006 | Transplant. Proc. | pmid:16549155 |
| Armitage JM et al. | A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1703336 |
| Branco KC et al. | The impact of tacrolimus as rescue therapy in children using a double immunosuppressive regimen after heart transplantation. | 2012 | Transplant. Proc. | pmid:23026625 |
| Prates LC et al. | Pain syndrome induced by calcineurin inhibitor and resolved by conversion to sirolimus in a child after kidney transplantation: a case report. | 2012 | Transplant. Proc. | pmid:23026634 |
| Sánchez-Fructuoso AI et al. | Daclizumab induction as an immunosuppressive regimen for renal transplant recipients from non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12962759 |
| Valente G et al. | Conversion from twice-daily to once-daily tacrolimus in stable liver transplant patients: effectiveness in a real-world setting. | 2013 | Transplant. Proc. | pmid:23622676 |
| Zhu Y et al. | Prolongation of canine renal allograft survival by combining tacrolimus with antimetabolic agents. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123011 |
| Nishimoto Y et al. | Real-time monitoring for detecting rejection using strain gauge force transducers in porcine small bowel transplantation. | 2004 | Transplant. Proc. | pmid:15050153 |
| Miyazawa H et al. | Graft immunomodulation by donor irradiation and recipient-specific bone marrow cells in rat small bowel transplantation. | 2002 | Transplant. Proc. | pmid:12072357 |
| Platz KP et al. | Immunosuppressive power and limitations of FK 506 for prevention and treatment of graft-vs-host disease after small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907933 |
| Coupes BM et al. | Tacrolimus monotherapy in renal transplantation: four-year data. | 2002 | Transplant. Proc. | pmid:12176506 |
| Iaria G et al. | Switch from twice-daily tacrolimus (Prograf) to once-daily prolonged-release tacrolimus (Advagraf) in kidney transplantation. | 2011 | Transplant. Proc. | pmid:21620043 |
| Guy S et al. | Successful treatment of acute severe graft-versus-host-disease in a pancreas-after-kidney transplant recipient: case report. | 2014 | Transplant. Proc. | pmid:25179161 |
| Stratta RJ | Optimal immunosuppression in pancreas transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083263 |
| Rastellini C et al. | Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083278 |
| Arita C et al. | Effect of FK 506 (FR 900506) on collagen arthritis in rats: a preliminary report. | 1989 | Transplant. Proc. | pmid:2468206 |
| Tze WJ et al. | Effect of FK 506 on glucose metabolism and insulin secretion in normal rats. | 1991 | Transplant. Proc. | pmid:1721391 |
| Morimoto T et al. | Blood levels of FK506 after intramuscular and intravenous administration in dogs. | 1989 | Transplant. Proc. | pmid:2468207 |
| Doi R et al. | Mechanisms by which FK 506 affects exocrine pancreas in rats. | 1991 | Transplant. Proc. | pmid:1721392 |
| Walgenbach KJ et al. | Immunocytes of composite tissue allografts express elevated levels of TGF beta mRNA and protein during chronic rejection. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123418 |
| Millis JM et al. | Tacrolimus treatment of steroid-resistant rejection provides economic advantages compared with OKT3 therapy. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123421 |
| Platz KP et al. | Incidence and outcome of chronic rejection in CyA- and FK 506-treated patients. | 1996 | Transplant. Proc. | pmid:8962235 |
| Klupp J et al. | New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus. | 2001 | Transplant. Proc. | pmid:11377491 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| Pozzetto U et al. | Effects of immunosuppressive regimens on plasma levels of transforming growth factor-beta 1 in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176558 |
| Mao PC et al. | Trends in the use of immunosuppressive agents by outpatients after renal transplantation at a medical center in southern Taiwan. | 2012 | Transplant. Proc. | pmid:22310611 |
| Vincenti F | Tacrolimus (FK 506) in kidney transplantation: five-year survival results of the U.S. multicenter, randomized, comparative trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267172 |
| Cooper MH et al. | Prolonged prevention of acute graft-versus-host disease after allogeneic bone marrow transplantation by donor pretreatment using FK 506. | 1991 | Transplant. Proc. | pmid:1721421 |
| Yoshida Y et al. | Effect of lipoprostaglandin E1 in concordant xenografts. | 1996 | Transplant. Proc. | pmid:8658716 |
| Ash MM and Jolly PS | A Case Report of the Resolution of Multiple Recalcitrant Verrucae in a Renal Transplant Recipient After a Mycophenolate Mofetil Dose Reduction. | Transplant. Proc. | pmid:28104140 | |
| Zhou S et al. | Tacrolimus enhances the invasion potential of hepatocellular carcinoma cells and promotes lymphatic metastasis in a rat model of hepatocellular carcinoma: involvement of vascular endothelial growth factor-C. | 2011 | Transplant. Proc. | pmid:21911157 |
| Sicilia-Castro D et al. | Reconstruction of a severe facial defect by allotransplantation in neurofibromatosis type 1: a case report. | 2011 | Transplant. Proc. | pmid:21911174 |
| Kiberd BA et al. | Impact of mycophenolate mofetil loading on drug exposure in the early posttransplant period. | 2005 | Transplant. Proc. | pmid:15964408 |
| Lagget M et al. | Disappearance of diabetes mellitus after conversion from FK 506 to Neoral in two liver transplanted patients. | 1998 | Transplant. Proc. | pmid:9723312 |
| Hummel AD et al. | Application of artificial neural networks in renal transplantation: classification of nephrotoxicity and acute cellular rejection episodes. | 2010 | Transplant. Proc. | pmid:20304167 |
| Kanatani T et al. | Donor leukocytes combine with immunosuppressive drug therapy to prolong limb allograft survival. | 2005 | Transplant. Proc. | pmid:15964421 |
| Gnatta D et al. | Use of tacrolimus and the development of posttransplant diabetes mellitus: a Brazilian single-center, observational study. | 2010 | Transplant. Proc. | pmid:20304169 |
| Holt DW et al. | Therapeutic monitoring of sirolimus: its contribution to optimal prescription. | 2003 | Transplant. Proc. | pmid:12742490 |
| Trotter JF | Sirolimus in liver transplantation. | 2003 | Transplant. Proc. | pmid:12742496 |
| Ventura E et al. | Calcineurin Inhibitor Determination in Whole Blood With the RXL Dimension Analyzer: A Useful Tool for Immunosuppressive Drug Monitoring. | 2009 | Transplant. Proc. | pmid:19328963 |
| Sundberg AK et al. | Conversion from cyclosporine to tacrolimus is preferred by pediatric renal transplant recipients: a focus on opinions and outcomes. | 2002 | Transplant. Proc. | pmid:12176640 |
| Li ZY et al. | Analytical performance of the Abbott Architect i2000 tacrolimus assay in Chinese patients after renal transplantation. | 2010 | Transplant. Proc. | pmid:21168731 |
| Ojogho ON et al. | Mycophenolate mofetil without antibody induction in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12176641 |
| van der Laan LJ et al. | Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus. | 2010 | Transplant. Proc. | pmid:21168740 |
| Veroux M et al. | Caspofungin in the treatment of azole-refractory esophageal candidiasis in kidney transplant recipients. | 2006 | Transplant. Proc. | pmid:16757256 |
| Gruttadauria S et al. | A safe immunosuppressive protocol in adult-to-adult living related liver transplantation. | 2006 | Transplant. Proc. | pmid:16757278 |
| Nanmoku K et al. | Steroid Withdrawal Using Everolimus in ABO-Incompatible Kidney Transplant Recipients With Post-Transplant Diabetes Mellitus. | 2018 | Transplant. Proc. | pmid:29631750 |
| Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Llull R et al. | Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. | 1995 | Transplant. Proc. | pmid:7544504 |
| Langrehr JM et al. | IL-2 receptor antibody induction increases the risk for chronic rejection after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267360 |
| Rao B et al. | Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases. | 2016 | Transplant. Proc. | pmid:27109983 |
| Chang HK et al. | Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital. | 2016 | Transplant. Proc. | pmid:27109981 |
| Fujino Y et al. | FK 506 treatment of experimental autoimmune uveoretinitis in primates. | 1991 | Transplant. Proc. | pmid:1721454 |
| González-Pinto I et al. | Usefulness of the switch to tacrolimus in liver transplantation. | 1999 | Transplant. Proc. | pmid:10500653 |
| Miyagawa S et al. | Mechanism of unresponsiveness in rats induced by a short course of FK 506 or CyA. | 1991 | Transplant. Proc. | pmid:1703687 |
| Carroll PB et al. | Effect of the immunosuppressant FK 506 on insulin release from adult rat islets of Langerhans. | 1991 | Transplant. Proc. | pmid:1703688 |
| Morris-Stiff G et al. | Preoperative induction with tacrolimus does not have a detrimental effect on primary graft function in adult cadaveric renal transplantation. | 1998 | Transplant. Proc. | pmid:9636499 |
| Eghtesad B et al. | Use of tacrolimus as the primary immunosuppression after renal transplant in Native Americans and Hispanics. | 1998 | Transplant. Proc. | pmid:9636500 |
| Scholler G et al. | Comparison of cyclosporine A and FK506 with regard to complaints and psychosocial characteristics before and after liver transplantation. | 1997 | Transplant. Proc. | pmid:9270822 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |