tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oka K et al. | A case of tacrolimus nephrotoxicity appearing in a second renal transplantation patient. | 2001 | Clin Transplant | pmid:11791792 |
| Iguchi S et al. | Intratubular calcification in a post-renal transplanted patient with secondary hyperparathyroidism. | 2001 | Clin Transplant | pmid:11791796 |
| D'Antiga L et al. | Late cellular rejection in paediatric liver transplantation: aetiology and outcome. | 2002 | Transplantation | pmid:11792983 |
| Butani L et al. | Effect of felodipine on tacrolimus pharmacokinetics in a renal transplant recipient. | 2002 | Transplantation | pmid:11793001 |
| Boots JM et al. | Single-center experience with tacrolimus versus cyclosporine-Neoral in renal transplant recipients. | 2001 | Transpl. Int. | pmid:11793034 |
| Chang RW et al. | European randomised trial of dual versus triple tacrolimus-based regimens for control of acute rejection in renal allograft recipients. | 2001 | Transpl. Int. | pmid:11793035 |
| Lo A et al. | Initial clinical experience with interleukin-2 receptor antagonist induction in combination with tacrolimus, mycophenolate mofetil and steroids in simultaneous kidney-pancreas transplantation. | 2001 | Transpl. Int. | pmid:11793037 |
| Venkiteswaran K et al. | Tacrolimus, cyclosporine and plasma lipoproteins in renal transplant recipients. | 2001 | Transpl. Int. | pmid:11793038 |
| Hymes LC and Warshaw BL | Tacrolimus rescue therapy for children with acute renal transplant rejection. | 2001 | Pediatr. Nephrol. | pmid:11793086 |
| Tanaka K et al. | Effects of immunophilin ligands on hydrogen peroxide-induced apoptosis in C6 glioma cells. | 2002 | Synapse | pmid:11793428 |
| Tacrolimus. | 2001 | Am J Health Syst Pharm | pmid:11794952 | |
| Jain A et al. | A prospective randomized trial of mycophenolate mofetil in liver transplant recipients with hepatitis C. | 2002 | Liver Transpl. | pmid:11799484 |
| Turvey SE | Atopic diseases of childhood. | 2001 | Curr. Opin. Pediatr. | pmid:11801897 |
| Itagaki F et al. | Effect of ascites on tacrolimus disposition in a liver transplant recipient. | 2001 | Ther Drug Monit | pmid:11802097 |
| Zylber-Katz E and Granot E | Abrupt increase of tacrolimus blood levels during an episode of Shigella infection in a child after liver transplantation. | 2001 | Ther Drug Monit | pmid:11802098 |
| Espino G et al. | Assessment of myocardial hypertrophy by echocardiography in adult patients receiving tacrolimus or cyclosporine therapy for prevention of acute GVHD. | 2001 | Bone Marrow Transplant. | pmid:11803349 |
| Girman P et al. | The effect of bone marrow transplantation on survival of allogeneic pancreatic islets with short-term tacrolimus conditioning in rats. | 2001 | Ann. Transplant. | pmid:11803619 |
| Olyaei AJ et al. | Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies. | 2001 | Curr Opin Crit Care | pmid:11805539 |
| Holt DW et al. | International Federation of Clinical Chemistry/International Association of Therapeutic Drug Monitoring and Clinical Toxicology working group on immunosuppressive drug monitoring. | 2002 | Ther Drug Monit | pmid:11805724 |
| Nghiem P et al. | Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. | 2002 | J. Am. Acad. Dermatol. | pmid:11807435 |
| Suga Y et al. | Topical tacrolimus for chronic actinic dermatitis. | 2002 | J. Am. Acad. Dermatol. | pmid:11807453 |
| Yoshimasu T et al. | Topical FK506 (tacrolimus) therapy for facial erythematous lesions of cutaneous lupus erythematosus and dermatomyositis. | 2002 Jan-Feb | Eur J Dermatol | pmid:11809595 |
| Li TK et al. | Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin. | 2002 | J. Cell. Biochem. | pmid:11813252 |
| Pascual MA et al. | Progress in understanding humoral rejection in kidney transplantation: implications for patient management. | 2001 Jul-Aug | Nefrologia | pmid:11816504 |
| Peces R et al. | [Hemolytic anemia caused by graft-versus-host reaction in ABO-nonidentical renal transplants from blood group O donors]. | 2001 Jul-Aug | Nefrologia | pmid:11816517 |
| Cho ML et al. | Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes. | 2002 | Arthritis Rheum. | pmid:11817607 |
| Sugden PH | Signalling pathways in cardiac myocyte hypertrophy. | 2001 | Ann. Med. | pmid:11817656 |
| Kotanko P et al. | Rhabdomyolysis and acute renal graft impairment in a patient treated with simvastatin, tacrolimus, and fusidic acid. | 2002 | Nephron | pmid:11818715 |
| Iyer KR et al. | Late graft loss and long-term outcome after isolated intestinal transplantation in children. | 2002 | J. Pediatr. Surg. | pmid:11819189 |
| Bennett PC et al. | Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick. | 2002 | Brain Res. | pmid:11821011 |
| Homma M et al. | Effects of lansoprazole and rabeprazole on tacrolimus blood concentration: case of a renal transplant recipient with CYP2C19 gene mutation. | 2002 | Transplantation | pmid:11821750 |
| Hopt UT | [New developments in immunosuppressive therapy]. | 2001 | Kongressbd Dtsch Ges Chir Kongr | pmid:11824327 |
| Ponseti JM et al. | [Tacrolimus (FK506) in the treatment of prednisone-resistant myasthenia gravis. Preliminary results of 20 cases]. | 2002 | Med Clin (Barc) | pmid:11825555 |
| Yoshida EM | Post-liver transplantation immunosuppression: the song does not remain the same. | 2002 | Can. J. Gastroenterol. | pmid:11826341 |
| Zhang W | Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy. | 2002 | Cardiovasc. Res. | pmid:11827679 |
| Mazzone PJ et al. | The humoral immune response to influenza vaccination in lung transplant patients. | 2001 | Eur. Respir. J. | pmid:11829104 |
| Okabe H et al. | Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction. | 2002 | J. Pharm. Pharmacol. | pmid:11829131 |
| MacDonald A | Improving tolerability of immunosuppressive regimens. | 2001 | Transplantation | pmid:11833142 |
| Kato Y et al. | Effect of epidermal growth factor on intestinal adaptation after allogeneic small bowel transplantation in rats. | 2002 | Life Sci. | pmid:11833743 |
| Van Leent EJ et al. | Low systemic exposure after repeated topical application of Pimecrolimus (Elidel), SD Z ASM 981) in patients with atopic dermatitis. | 2002 | Dermatology (Basel) | pmid:11834853 |
| Lü L et al. | [Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats]. | 1999 | Zhonghua Yan Ke Za Zhi | pmid:11835769 |
| Garcia M et al. | Efficacy of early immunosuppressive therapy in a child with carbamazepine-associated vanishing bile duct and Stevens-Johnson syndromes. | 2002 | Dig. Dis. Sci. | pmid:11837721 |
| Kruszka SJ and Gherman RB | Successful pregnancy outcome in a lung transplant recipient with tacrolimus immunosuppression. A case report. | 2002 | J Reprod Med | pmid:11838314 |
| Takeda Y et al. | Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy. | 2002 | Circulation | pmid:11839620 |
| Clemons PA et al. | Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. | 2002 | Chem. Biol. | pmid:11841938 |
| Tsoulfas G and Geller DA | NF-kappaB in transplantation: friend or foe? | 2001 | Transpl Infect Dis | pmid:11844153 |
| Brenner BC et al. | Mechanisms of L-selectin-induced activation of the nuclear factor of activated T lymphocytes (NFAT). | 2002 | Biochem. Biophys. Res. Commun. | pmid:11846396 |
| Cruz MC et al. | Calcineurin is essential for survival during membrane stress in Candida albicans. | 2002 | EMBO J. | pmid:11847103 |
| Tada H et al. | Effects of thymic hormone on reactive oxygen species-scavengers and renal function in tacrolimus-induced nephrotoxicity. | 2002 | Life Sci. | pmid:11848304 |
| Baboolal K et al. | Molecular and structural consequences of early renal allograft injury. | 2002 | Kidney Int. | pmid:11849412 |
| Fauvel H et al. | Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11850335 |
| Suehiro A et al. | Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation. | 2002 | Bone Marrow Transplant. | pmid:11850703 |
| O'Connell PJ et al. | Identification of functional type 1 ryanodine receptors in mouse dendritic cells. | 2002 | FEBS Lett. | pmid:11852053 |
| Wu Y and Anderson ME | Reduced repolarization reserve in ventricular myocytes from female mice. | 2002 | Cardiovasc. Res. | pmid:11861046 |
| Keshavarz R et al. | Diabetic ketoacidosis in a child on FK506 immunosuppression after a liver transplant. | 2002 | Pediatr Emerg Care | pmid:11862133 |
| Kato T et al. | Intestinal and multivisceral transplantation. | 2002 | World J Surg | pmid:11865353 |
| Parasrampuria DA et al. | Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. | 2002 | J Clin Pharmacol | pmid:11865967 |
| Okoshi Y et al. | [A case of FK 506-induced leukoencephalopathy]. | 2002 | No To Shinkei | pmid:11868353 |
| Tanaka K et al. | GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum. | 2002 | Neurosci. Lett. | pmid:11872253 |
| Lawrence MC et al. | NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. | 2002 | Diabetes | pmid:11872668 |
| Choi SH et al. | A case of persistent anemia in a renal transplant recipient: association with parvovirus B19 infection. | 2002 | Scand. J. Infect. Dis. | pmid:11874173 |
| Kosch M et al. | Relationship between muscle sympathetic nerve activity and large artery mechanical vessel wall properties in renal transplant patients. | 2002 | J. Hypertens. | pmid:11875318 |
| Dunn SE et al. | Calcineurin and skeletal muscle growth. | 2002 | Nat. Cell Biol. | pmid:11875443 |
| Sarahrudi K et al. | The value of switching from cyclosporine to tacrolimus in the treatment of refractory acute rejection and obliterative bronchiolitis after lung transplantation. | 2002 | Transpl. Int. | pmid:11875609 |
| Lytton SD et al. | Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs. | 2002 | Clin. Exp. Immunol. | pmid:11876753 |
| Lü L and Zhang W | [Immunopathologic studies on the effects of immunosuppressant FK 506 on penetrating keratoplasty rejection model in rat]. | 1998 | Zhonghua Yan Ke Za Zhi | pmid:11877144 |
| Israni A et al. | Conversion to tacrolimus for the treatment of cyclosporine-associated nephrotoxicity in heart transplant recipients. | 2002 | Am. J. Kidney Dis. | pmid:11877596 |
| Cron RQ | HIV-1, NFAT, and cyclosporin: immunosuppression for the immunosuppressed? | 2001 | DNA Cell Biol. | pmid:11879569 |
| Toyonaga T et al. | Sudden onset of diabetes with ketoacidosis in a patient treated with FK506/tacrolimus. | 2002 | Diabetes Res. Clin. Pract. | pmid:11879716 |
| Pascual J | [Toward an evidence-based immunosuppression]. | 2001 | Nefrologia | pmid:11881421 |
| McCluskey A et al. | Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. | 2002 | J. Med. Chem. | pmid:11881984 |
| Lanzetta M et al. | Hand transplantation: ethics, immunosuppression and indications. | 2001 | J Hand Surg Br | pmid:11884098 |
| Merle M | Some aspects of hand transplantation. | 2001 | J Hand Surg Br | pmid:11884103 |
| Barone GW et al. | Increased early rejection rate after conversion from tacrolimus in kidney and pancreas transplantation. | 2002 | JOP | pmid:11884766 |
| Paty BW et al. | Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets. | 2002 | Transplantation | pmid:11884930 |
| Präst I et al. | Nerve cells in transplanted pancreatic islets: no effects of cyclosporin or tacrolimus on immediate neuronal survival. | 2001 | Ups. J. Med. Sci. | pmid:11888070 |
| del Mar Fernández De Gatta M et al. | Immunosuppressive therapy for paediatric transplant patients: pharmacokinetic considerations. | 2002 | Clin Pharmacokinet | pmid:11888332 |
| Margreiter R | Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study. | 2002 | Lancet | pmid:11888584 |
| Stempfle HU et al. | The role of tacrolimus (FK506)-based immunosuppression on bone mineral density and bone turnover after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriol. | 2002 | Transplantation | pmid:11889427 |
| Panz VR et al. | Diabetogenic effect of tacrolimus in South African patients undergoing kidney transplantation1. | 2002 | Transplantation | pmid:11889436 |
| Nishigaki F et al. | FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5. | 2002 | Eur. J. Pharmacol. | pmid:11890899 |
| Beltrani VS | Tacrolimus ointment: advancing the treatment of atopic dermatitis. | 2001 | Curr Allergy Asthma Rep | pmid:11892051 |
| Tang WX et al. | Role of FKBP12.6 in cADPR-induced activation of reconstituted ryanodine receptors from arterial smooth muscle. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11893565 |
| Cohen SM | Current immunosuppression in liver transplantation. | 2002 Mar-Apr | Am J Ther | pmid:11897926 |
| Allen BR | Tacrolimus ointment: its place in the therapy of atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11897982 |
| Reitamo S et al. | Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11898004 |
| Reitamo S et al. | Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11898005 |
| Doi M et al. | Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor. | 2002 | Circulation | pmid:11901051 |
| Vögelin E et al. | Long-term viability of articular cartilage after microsurgical whole-joint transplantation and immunosuppression with rapamycin, mycophenolate mofetil, and tacrolimus. | 2002 | J Hand Surg Am | pmid:11901390 |
| Bos JD | Topical tacrolimus and pimecrolimus are not associated with skin atrophy. | 2002 | Br. J. Dermatol. | pmid:11903264 |
| Fuhrer DK et al. | Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel. | 2001 | Diabetes Obes Metab | pmid:11903410 |
| Ishikawa K et al. | Mycobacterium tuberculosis infection of bilateral cervical lymph nodes after renal transplantation. | 2001 | Int. J. Urol. | pmid:11903693 |
| Sakanoue M et al. | Tacrolimus, a specific inhibitor of calcineurin, modifies the locomotor activity of quinpirole, but not that of SKF82958, in male rats. | 2002 | Eur. J. Pharmacol. | pmid:11906716 |
| Holt S and Moore K | Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. | 2002 | Transplantation | pmid:11907407 |
| Yang H et al. | Liposomal encapsulation significantly enchances the immunosuppressive effect of tacrolimus in a discordant islet xenotransplant model. | 2002 | Transplantation | pmid:11907415 |
| Klein IH et al. | Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. | 2002 | Transplantation | pmid:11907418 |
| Vincenti F et al. | A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years. | 2002 | Transplantation | pmid:11907427 |
| Eichenfield LF et al. | Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents. | 2002 | J. Am. Acad. Dermatol. | pmid:11907497 |
| Dé Tran QH et al. | Tacrolimus in dermatology. | 2001 Jul-Aug | J Cutan Med Surg | pmid:11907845 |
| Lacour JP | [Topical tacrolimus in dermatology: what can one expect?]. | 2001 | Ann Dermatol Venereol | pmid:11908129 |