tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Macario-Barrel A et al. | [Mouth ulcers in patients receiving tacrolimus]. | 2001 | Ann Dermatol Venereol | pmid:11908135 |
| Trotter JF et al. | Living donor liver transplant recipients achieve relatively higher immunosuppressant blood levels than cadaveric recipients. | 2002 | Liver Transpl. | pmid:11910565 |
| Taber DJ et al. | Tacrolimus dosing requirements and concentrations in adult living donor liver transplant recipients. | 2002 | Liver Transpl. | pmid:11910566 |
| Trull A et al. | Influence of albumin supplementation on tacrolimus and cyclosporine therapy early after liver transplantation. | 2002 | Liver Transpl. | pmid:11910567 |
| Gornet JM et al. | Severe CPT-11-induced diarrhea in presence of FK-506 following liver transplantation for hepatocellular carcinoma. | 2001 Nov-Dec | Anticancer Res. | pmid:11911319 |
| Sugiura R | [Functional analysis of calcineurin-mediated signalling pathway using fission yeast as a model system]. | 2002 | Nippon Yakurigaku Zasshi | pmid:11915517 |
| Segarra A et al. | Combined therapy of tacrolimus and corticosteroids in cyclosporin-resistant or -dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow-up. | 2002 | Nephrol. Dial. Transplant. | pmid:11917061 |
| Ikezumi Y et al. | FK506 ameliorates proteinuria and glomerular lesions induced by anti-Thy 1.1 monoclonal antibody 1-22-3. | 2002 | Kidney Int. | pmid:11918741 |
| Tamura S et al. | Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. | 2002 | J Pharm Sci | pmid:11920757 |
| Oettinger-Barak O et al. | Periodontal changes in liver cirrhosis and post-transplantation patients. II: radiographic findings:. | 2002 | J. Periodontol. | pmid:11922262 |
| Shimomura M et al. | Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus. | 2002 | J. Surg. Res. | pmid:11922737 |
| Bueno OF et al. | Calcineurin and hypertrophic heart disease: novel insights and remaining questions. | 2002 | Cardiovasc. Res. | pmid:11922891 |
| Fuchinoue S et al. | Kidney transplantation after liver transplantation from the same donor: four cases of successful steroid withdrawal. | 2002 | Transplantation | pmid:11923698 |
| Lauzurica R et al. | Tacrolimus-associated severe bilateral corneal ulcer after renal transplantation. | 2002 | Transplantation | pmid:11923710 |
| Bolley R et al. | Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort. | 2002 | Transplantation | pmid:11923712 |
| Panickar KS et al. | Differential response of neural cells to trauma-induced free radical production in vitro. | 2002 | Neurochem. Res. | pmid:11926270 |
| Vitulo P et al. | Efficacy of tacrolimus rescue therapy in refractory acute rejection after lung transplantation. | 2002 | J. Heart Lung Transplant. | pmid:11927219 |
| Wellington K and Jarvis B | Topical pimecrolimus: a review of its clinical potential in the management of atopic dermatitis. | 2002 | Drugs | pmid:11929333 |
| Jacobsohn DA and Vogelsang GB | Novel pharmacotherapeutic approaches to prevention and treatment of GVHD. | 2002 | Drugs | pmid:11929336 |
| Drosos AA | Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy. | 2002 | Drugs | pmid:11929337 |
| Nishino K et al. | Suppression of experimental immune-mediated blepharoconjunctivitis in Brown Norway rats by topical application of FK506. | 2002 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:11931080 |
| Armenti VT et al. | National Transplantation Pregnancy Registry looks at outcomes with Neoral and Tacrolimus. | 2000 | Nephrol News Issues | pmid:11933431 |
| Schwarz NT et al. | Protective effects of ex vivo graft radiation and tacrolimus on syngeneic transplanted rat small bowel motility. | 2002 | Surgery | pmid:11935132 |
| Shapiro AM et al. | Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in non-obese diabetic mice. | 2002 | Diabetologia | pmid:11935154 |
| Goffin E et al. | Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation. | 2002 | Transpl. Int. | pmid:11935163 |
| Nör JE et al. | Ablation of microvessels in vivo upon dimerization of iCaspase-9. | 2002 | Gene Ther. | pmid:11938459 |
| Regentin R et al. | Production of a novel FK520 analog in Streptomyces hygroscopicus: improving titer while minimizing impurities. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:11938465 |
| Udina E and Navarro X | [Immunophilins: neuroprotective agents and promoters of neural regeneration]. | 2002 | Neurologia | pmid:11940408 |
| Reich K et al. | Evidence for a role of Langerhans cell-derived IL-16 in atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11941319 |
| Passos E et al. | Ocular toxicity of intravitreal tacrolimus. | 2002 Mar-Apr | Ophthalmic Surg Lasers | pmid:11942546 |
| Chen GF et al. | [Peripheral nerve regeneration under immunosuppression]. | 2002 | Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi | pmid:11944523 |
| Li ZY et al. | Dimerizer-induced proliferation of genetically modified hepatocytes. | 2002 | Mol. Ther. | pmid:11945069 |
| Turton-Weeks S et al. | Pretransplant evaluation of a patient with acute intermittent porphyria. | 2001 | Prog Transplant | pmid:11949465 |
| Schwertfeger E et al. | Contractile effects of tacrolimus in human and rat isolated renal arteries. | 2001 | J Auton Pharmacol | pmid:11952876 |
| Xie H et al. | [Effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer]. | 2002 | Zhonghua Yan Ke Za Zhi | pmid:11955293 |
| Deppe CE et al. | Cyclosporine a and FK506 inhibit transcriptional activity of the human mineralocorticoid receptor: a cell-based model to investigate partial aldosterone resistance in kidney transplantation. | 2002 | Endocrinology | pmid:11956176 |
| Robichaud GA et al. | Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells. | 2002 | J. Biol. Chem. | pmid:11956207 |
| Trompeter R et al. | Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation. | 2002 | Pediatr. Nephrol. | pmid:11956848 |
| Son IJ et al. | Pharmacokinetic changes of intravenous tacrolimus in rats with uranyl nitrate-induced acute renal failure. | 2000 Nov-Dec | Res. Commun. Mol. Pathol. Pharmacol. | pmid:11958289 |
| Macleod MR and Butcher SP | Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition. | 2002 | Neurosci. Lett. | pmid:11958839 |
| Norris CM et al. | Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture. | 2002 | Neuroscience | pmid:11958864 |
| Latorre A et al. | Clinical management of renal transplant patients with hepatitis C virus infection treated with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:11959186 |
| Urbizu JM et al. | Immunosuppression using tacrolimus/mycophenolate versus neoral/mycophenolate following kidney transplantation: a single-center experience. | 2002 | Transplant. Proc. | pmid:11959197 |
| Pascual J and Ortuño J | Simple tacrolimus-based immunosuppressive regimens following renal transplantation: a large multicenter comparison between double and triple therapy. | 2002 | Transplant. Proc. | pmid:11959198 |
| Pascual J et al. | One-center comparison between primary immunosuppression based on neoral cyclosporine and tacrolimus for renal transplantation. | 2002 | Transplant. Proc. | pmid:11959200 |
| Herrero JC et al. | Role of immunosuppressive treatments based on mycophenolate mofetil in posttransplantation renal surgical complications. | 2002 | Transplant. Proc. | pmid:11959201 |
| Facundo C et al. | Results of a triple induction regime with tacrolimus, mycophenolate mofetil, and prednisone in renal transplantation. | 2002 | Transplant. Proc. | pmid:11959203 |
| GarcÃa-Meseguer C et al. | Efficacy and safety of basiliximab in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:11959206 |
| Machado PG et al. | Use of reduced dose of OKT3 (2.5 mg) after renal transplantation. | 2002 | Transplant. Proc. | pmid:11959207 |
| Asensio M et al. | Experience with tacrolimus as primary immunosuppressor in pediatric liver transplant. | 2002 | Transplant. Proc. | pmid:11959208 |
| Rafecas A et al. | Immunosuppression with calcineurin inhibitors and polyclonal antibodies in liver transplantation. | 2002 | Transplant. Proc. | pmid:11959209 |
| Lladó L et al. | Prospective evaluation of a quadruple therapy based on tacrolimus after liver transplantation. | 2002 | Transplant. Proc. | pmid:11959210 |
| Mollevà DG et al. | Late xenograft rejection: comparison between liver and heart xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959212 |
| Crespo-Leiro MG et al. | Replacement of cyclosporine by tacrolimus for immunosuppression in heart transplant patients: safety and efficacy. | 2002 | Transplant. Proc. | pmid:11959213 |
| Sgrosso JL et al. | Histopathological findings in heart transplant patients under tacrolimus-mycophenolate mofetil versus cyclosporine microemulsion-azathioprine. | 2002 | Transplant. Proc. | pmid:11959214 |
| Alarcón-Zurita A et al. | Steroids withdrawal after 3 months of successful renal transplantation using a tacrolimus- and mycophenolate-based immunosuppression. | 2002 | Transplant. Proc. | pmid:11959216 |
| Lauzurica R et al. | Monotherapy with tacrolimus and corticosteroid withdrawal. | 2002 | Transplant. Proc. | pmid:11959217 |
| Sgrosso JL et al. | Tacrolimus pharmacokinetics in heart transplant. | 2002 | Transplant. Proc. | pmid:11959225 |
| Roman A et al. | Preliminary results of rescue therapy with tacrolimus and mycophenolate mofetil in lung transplanted patients with bronchiolitis obliterans. | 2002 | Transplant. Proc. | pmid:11959227 |
| Morell Ginestà M et al. | Histology and immunopathology of heart and liver xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959305 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients treated with tacrolimus. | 2002 | Transplant. Proc. | pmid:11959335 |
| Pahl A et al. | Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. | 2002 | Br. J. Pharmacol. | pmid:11959794 |
| Bloom RD et al. | Association of hepatitis C with posttransplant diabetes in renal transplant patients on tacrolimus. | 2002 | J. Am. Soc. Nephrol. | pmid:11961026 |
| Vanderhoof JA and Young RJ | Autoimmune enteropathy in a child: response to infliximab therapy. | 2002 | J. Pediatr. Gastroenterol. Nutr. | pmid:11964960 |
| Fujimura Y and Owen RL | Tacrolimus (FK506) and cyclosporine reduce the uptake and transport of particles into rabbit Peyer's patches. | 2002 | Transplantation | pmid:11965030 |
| Ciancio G et al. | Daclizumab induction, tacrolimus, mycophenolate mofetil and steroids as an immunosuppression regimen for primary kidney transplant recipients. | 2002 | Transplantation | pmid:11965039 |
| Itoh S et al. | Inhibition of CN (protein phosphatase-2B) suppresses Ca2+-mediated acid secretion in rats. | 2002 | Aliment. Pharmacol. Ther. | pmid:11966520 |
| Sugawara Y et al. | Correlation between optimal tacrolimus doses and the graft weight in living donor liver transplantation. | 2002 | Clin Transplant | pmid:11966779 |
| Gonwa TA et al. | Immunosuppression for delayed or slow graft function in primary cadaveric renal transplantation: use of low dose tacrolimus therapy with post-operative administration of anti-CD25 monoclonal antibody. | 2002 | Clin Transplant | pmid:11966785 |
| Ignatescu MC et al. | Influence of mycophenolic acid and tacrolimus on homocysteine metabolism. | 2002 | Kidney Int. | pmid:11967042 |
| Ahmad SM et al. | Successful treatment of acute ocular graft-versus-host disease with tacrolimus (FK506). | 2002 | Cornea | pmid:11973400 |
| Abdelhadi M et al. | Structural skeletal impairment induced by immunosuppressive therapy in rats: cyclosporine A vs tacrolimus. | 2002 | Transpl. Int. | pmid:11976740 |
| Müller WE et al. | Histocompatibility reaction in tissue and cells of the marine sponge Suberites domuncula in vitro and in vivo: central role of the allograft inflammatory factor 1. | 2002 | Immunogenetics | pmid:11976791 |
| Ueno T et al. | Evaluation of osteogenic/chondrogenic cellular proliferation and differentiation in the xenogeneic periosteal graft. | 2002 | Ann Plast Surg | pmid:11981197 |
| Chow KM et al. | Good metabolic control using tacrolimus-based immunosuppressants in primary cadaveric renal transplantation in Chinese--a preliminary report. | 2002 | Clin Transplant | pmid:11982613 |
| Reimer J et al. | Quality of life in kidney recipients: comparison of tacrolimus and cyclosporine-microemulsion. | 2002 | Clin Transplant | pmid:11982615 |
| Stratta RJ et al. | A multicenter, open-label, comparative trial of two daclizumab dosing strategies vs. no antibody induction in combination with tacrolimus, mycophenolate mofetil, and steroids for the prevention of acute rejection in simultaneous kidney-pancreas transplant recipients: interim analysis. | 2002 | Clin Transplant | pmid:11982617 |
| Al-Daraji WI et al. | Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. | 2002 | J. Invest. Dermatol. | pmid:11982754 |
| Danovitch GM | How should the immunosuppressive regimen be managed in patients with established chronic allograft failure? | 2002 | Kidney Int. Suppl. | pmid:11982816 |
| Strauss G et al. | Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs. | 2002 | Clin. Exp. Immunol. | pmid:11985515 |
| Krishnadasan B et al. | Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus. | 2002 | J. Thorac. Cardiovasc. Surg. | pmid:11986604 |
| Reinhard T et al. | [Topical Fk506 in inflammatory corneal and conjunctival diseases. A pilot study]. | 2002 | Klin Monbl Augenheilkd | pmid:11987039 |
| Ortiz de Frutos FJ | [New horizons in the treatment of atopic dermatitis]. | Allergol Immunopathol (Madr) | pmid:11988144 | |
| Chen QS et al. | Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus. | 2002 | Neurobiol Learn Mem | pmid:11991763 |
| Minematsu T et al. | Quantitative relationship between myocardial concentration of tacrolimus and QT prolongation in guinea pigs: pharmacokinetic/pharmacodynamic model incorporating a site of adverse effect. | 2001 | J Pharmacokinet Pharmacodyn | pmid:11999291 |
| Reding R et al. | Efficacy and pharmacokinetics of tacrolimus oral suspension in pediatric liver transplant recipients. | 2002 | Pediatr Transplant | pmid:12000467 |
| Wang SJ | Interaction between FK 506 and isoproterenol in the modulation of glutamate release from cerebrocortical nerve terminals. | 2002 | Neuroreport | pmid:12004204 |
| Granot E et al. | Markers of oxidative stress in cyclosporine-treated and tacrolimus-treated children after liver transplantation. | 2002 | Liver Transpl. | pmid:12004347 |
| Deters M et al. | Simultaneous quantification of sirolimus, everolimus, tacrolimus and cyclosporine by liquid chromatography-mass spectrometry (LC-MS). | 2002 | Clin. Chem. Lab. Med. | pmid:12005219 |
| Grand AG et al. | Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice. | 2002 | J. Neurosurg. | pmid:12005401 |
| Henthorn DC et al. | A GAL4-based yeast three-hybrid system for the identification of small molecule-target protein interactions. | 2002 | Biochem. Pharmacol. | pmid:12007565 |
| Skuk D et al. | Efficacy of myoblast transplantation in nonhuman primates following simple intramuscular cell injections: toward defining strategies applicable to humans. | 2002 | Exp. Neurol. | pmid:12009764 |
| Sulaiman OA et al. | FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic schwann cell denervation. | 2002 | Exp. Neurol. | pmid:12009765 |
| Logan AJ et al. | Upper gastrointestinal complications after renal transplantation: a 3-yr sequential study. | 2002 | Clin Transplant | pmid:12010137 |
| Abouljoud MS et al. | Neoral rescue therapy in transplant patients with intolerance to tacrolimus. | 2002 | Clin Transplant | pmid:12010138 |
| Cantin B et al. | Mycophenolic acid concentrations in long-term heart transplant patients: relationship with calcineurin antagonists and acute rejection. | 2002 | Clin Transplant | pmid:12010143 |
| Muscella A et al. | Muscarinic acetylcholine receptor activation induces Ca2+ mobilization and Na+/K+-ATPase activity inhibition in eel enterocytes. | 2002 | J. Endocrinol. | pmid:12010640 |
| Welm BE et al. | Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. | 2002 | J. Cell Biol. | pmid:12011115 |
| Ahn SC et al. | A tactic for screening inhibitors of interleukin-2 production. | 2002 | Anal. Biochem. | pmid:12018952 |
| Heering P et al. | Hemolytic uremic syndrome after renal transplantation: immunosuppressive therapy with rapamycin. | 2002 | Nephron | pmid:12021541 |