tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grinyó JM and Petruzzelli S | Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations. | 2014 | Expert Rev Clin Immunol | pmid:25407098 |
| Uchida J et al. | Effects of conversion from a twice-daily tacrolimus to a once-daily tacrolimus on glucose metabolism in stable kidney transplant recipients. | 2014 | Transplant. Proc. | pmid:24656005 |
| Zaltzman JS et al. | A randomized cross-over comparison of short-term exposure of once-daily extended release tacrolimus and twice-daily tacrolimus on renal function in healthy volunteers. | 2014 | Transpl. Int. | pmid:25160518 |
| Weng LC et al. | Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24656004 |
| Gérard C et al. | Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach. | 2014 | AAPS J | pmid:24526611 |
| Filler G | Finding the optimal therapeutic window for tacrolimus. | 2014 | Pediatr Transplant | pmid:25345999 |
| Méndez A et al. | Pharmacokinetic study of conversion from tacrolimus twice-daily to tacrolimus once-daily in stable lung transplantation. | 2014 | Transplantation | pmid:24492423 |
| Moss MC et al. | Lithium use for bipolar disorder post renal transplant: is mood stabilization without toxicity possible? | 2014 | Transplantation | pmid:24492429 |
| Hinchliffe E et al. | Therapeutic drug monitoring of ciclosporin A and tacrolimus in heart lung transplant patients using dried blood spots. | 2014 | Ann. Clin. Biochem. | pmid:23939194 |
| Isoda K et al. | The proton pump inhibitor lansoprazole, but not rabeprazole, the increased blood concentrations of calcineurin inhibitors in Japanese patients with connective tissue diseases. | 2014 | Intern. Med. | pmid:24990333 |
| Buendia JA et al. | Effects of combinational CYP3A5 6986A>G polymorphism in graft liver and native intestine on the pharmacokinetics of tacrolimus in liver transplant patients: a meta-analysis. | 2014 | Ther Drug Monit | pmid:24378577 |
| Eid L et al. | Late acute rejection: incidence, risk factors, and effect on graft survival and function. | 2014 | Pediatr Transplant | pmid:24372967 |
| Basu B | Ofatumumab for rituximab-resistant nephrotic syndrome. | 2014 | N. Engl. J. Med. | pmid:24670185 |
| Fukushima A et al. | Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement. | 2014 | Br J Ophthalmol | pmid:24695688 |
| Schellekens J et al. | The Maastricht Transplant Center: clinical setting and epitope searches in HLA class II molecules: does the structural localization of a polymorphic site contribute to its immunogenicity? | 2014 | Transpl. Immunol. | pmid:25240735 |
| Parks AC et al. | Long-term clearance of linear porokeratosis with tacrolimus, 0.1%, ointment. | 2014 | JAMA Dermatol | pmid:24553841 |
| Xu C et al. | Tacrolimus reversibly reduces insulin secretion, induces insulin resistance, and causes islet cell damage in rats. | 2014 | Int J Clin Pharmacol Ther | pmid:24755137 |
| Caraveo G et al. | Calcineurin determines toxic versus beneficial responses to α-synuclein. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25122673 |
| Gajanayake T et al. | A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. | 2014 | Sci Transl Med | pmid:25122638 |
| Gionchetti P and Rizzello F | IBD. Sequential rescue therapy in steroid-refractory ulcerative colitis. | 2014 | Nat Rev Gastroenterol Hepatol | pmid:25023033 |
| Shimizu M et al. | Treatment of refractory polyarticular juvenile idiopathic arthritis with tacrolimus. | 2014 | Rheumatology (Oxford) | pmid:25065006 |
| Marits P et al. | Evaluation of T and B lymphocyte function in clinical practice using a flow cytometry based proliferation assay. | 2014 | Clin. Immunol. | pmid:24909732 |
| Uesugi M et al. | Impact of cytochrome P450 3A5 polymorphism in graft livers on the frequency of acute cellular rejection in living-donor liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:24911663 |
| Al-Harbi NO et al. | Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue. | 2014 | Biomed Res Int | pmid:24987695 |
| Saracino A et al. | Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation. | 2014 | Transplant. Proc. | pmid:25242754 |
| Zhu H et al. | Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. | 2014 | Mol Med Rep | pmid:24912495 |
| Van Laecke S et al. | The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. | 2014 | Transpl. Int. | pmid:24909487 |
| Trkulja V et al. | Effect of cyclosporine on steady-state pharmacokinetics of MPA in renal transplant recipients is not affected by the MPA formulation: analysis based on therapeutic drug monitoring data. | 2014 | Ther Drug Monit | pmid:24518562 |
| Sánchez L et al. | Topical tacrolimus for recurrent penile Crohn's disease. | 2014 | J Crohns Colitis | pmid:24815787 |
| Reynolds BC et al. | Use of belatacept to maintain adequate early immunosuppression in calcineurin-mediated microangiopathic hemolysis post-renal transplant. | 2014 | Pediatr Transplant | pmid:24815506 |
| Wang J and Fan H | [Assessment of P70S6 kinase phosphorylation after liver transplantation by phospho-flow cytometry]. | 2014 | Zhonghua Yi Xue Za Zhi | pmid:25623311 |
| Heilman RL et al. | Delayed allograft inflammation following alemtuzumab induction for kidney transplantation. | 2013 Sep-Oct | Clin Transplant | pmid:23924146 |
| Benoit S and Hamm H | Psoriasis from a prosthesis: unusual Koebner phenomenon in a girl with autoamputation of the leg. | 2013 Sep-Oct | Pediatr Dermatol | pmid:23360396 |
| Zahdi MR et al. | Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. | 2013 Sep-Oct | An Bras Dermatol | pmid:24173187 |
| Riva N et al. | [Pharmacovigilance of calcineurin inhibitor in peidatric kidney and liver transplantation]. | 2013 Nov-Dec | Farm Hosp | pmid:24256007 |
| Brodrick B et al. | Influence of treatments on prognosis for vulvar lichen sclerosus: facts and controversies. | 2013 Nov-Dec | Clin. Dermatol. | pmid:24160287 |
| Bloom RD et al. | A randomized, crossover pharmacokinetic study comparing generic tacrolimus vs. the reference formulation in subpopulations of kidney transplant patients. | 2013 Nov-Dec | Clin Transplant | pmid:24118450 |
| Labirua-Iturburu A et al. | Calcineurin inhibitors in a cohort of patients with antisynthetase-associated interstitial lung disease. | 2013 May-Jun | Clin. Exp. Rheumatol. | pmid:23465087 |
| Chen SY et al. | Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism--a prospective, randomized, controlled study. | 2013 May-Jun | Clin Transplant | pmid:23432535 |
| Ramirez CB et al. | Completely steroid-free immunosuppression in liver transplantation: a randomized study. | 2013 May-Jun | Clin Transplant | pmid:23621629 |
| Krishna N et al. | Tacrolimus-induced paranoid delusions and fugue-like state. | 2013 May-Jun | Gen Hosp Psychiatry | pmid:22959421 |
| He L et al. | Treatment of idiopathic membranous nephropathy with combination of low-dose tacrolimus and corticosteroids. | 2013 May-Jun | J. Nephrol. | pmid:22956434 |
| Kanzelmeyer NK et al. | Correlations with six-month protocol biopsy findings in pediatric transplant recipients on low- and regular-dose CNI regimens. | 2013 Mar-Apr | Clin Transplant | pmid:23414365 |
| Tiwari R et al. | Enhancements in healthcare information technology systems: customizing vendor-supplied clinical decision support for a high-risk patient population. | 2013 Mar-Apr | J Am Med Inform Assoc | pmid:22813760 |
| Albekairy A et al. | Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients. | 2013 Mar-Apr | Saudi J Gastroenterol | pmid:23481136 |
| LaMattina JC et al. | Native kidney function following liver transplantation using calcineurin inhibitors: single-center analysis with 20 years of follow-up. | 2013 Mar-Apr | Clin Transplant | pmid:23294013 |
| Alfson ED et al. | Lysis of catatonic withdrawal by propofol in a bone-marrow transplant recipient with adenovirus limbic encephalitis. | 2013 Mar-Apr | Psychosomatics | pmid:22705183 |
| Yoshida EM et al. | Canadian national retrospective chart review comparing the long term effect of cyclosporine vs. tacrolimus on clinical outcomes in patients with post-liver transplantation hepatitis C virus infection. | 2013 Mar-Apr | Ann Hepatol | pmid:23396740 |
| Castillo G et al. | [Acute cellular rejection in a liver transplantation patient due to changing the brand of a generic immunosuppressant]. | 2013 Jul-Sep | Rev Gastroenterol Mex | pmid:23866966 |
| Bechstein WO et al. | A comparative, randomized trial of concentration-controlled sirolimus combined with reduced-dose tacrolimus or standard-dose tacrolimus in renal allograft recipients. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953523 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Weiler N et al. | Tacrolimus effects and side effects after liver transplantation: is there a difference between immediate and extended release? | 2013 Jul-Aug | Transplant. Proc. | pmid:23953543 |
| Stringa P et al. | Ischemic preconditioning and tacrolimus pretreatment as strategies to attenuate intestinal ischemia-reperfusion injury in mice. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953566 |
| Tachibana A et al. | Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes. | 2013 Jul-Aug | Xenotransplantation | pmid:23683097 |
| Favi E et al. | Tacrolimus plus mycophenolate mofetil vs. cyclosporine plus everolimus in deceased donor kidney transplant recipients: three-yr results of a single-center prospective clinical trial. | 2013 Jul-Aug | Clin Transplant | pmid:23710603 |
| Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
| Satyanarayan HS et al. | Efficacy and tolerability of combined treatment with NB-UVB and topical tacrolimus versus NB-UVB alone in patients with vitiligo vulgaris: a randomized intra-individual open comparative trial. | 2013 Jul-Aug | Indian J Dermatol Venereol Leprol | pmid:23760325 |
| Babalola O and Strober BE | Treatment of atopic dermatitis in pregnancy. | 2013 Jul-Aug | Dermatol Ther | pmid:23914886 |
| Conti R et al. | Jessner-Kanof disease: two effective and sure therapeutic options. | 2013 Jul-Aug | Dermatol Ther | pmid:23914897 |
| Chakkera HA et al. | Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375287 |
| Tian Ch et al. | B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375291 |
| Yao B et al. | The incidence of posttransplantation diabetes mellitus during follow-up in kidney transplant recipients and relationship to Fok1 vitamin D receptor polymorphism. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375298 |
| Miyazaki T et al. | Two case reports of successful withdrawal of mycofenolate mofetil after living donor lobar lung transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375323 |
| Chang HY et al. | Long-term follow-up of arrhythmia characteristics and clinical outcomes in heart transplant patients. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375324 |
| Al Nahdi N et al. | First successful treatment of post-liver transplant hepatitis C fibrosing cholestatic hepatitis with boceprevir, peginterferon and ribavirin in a pre-transplant null responder. | 2013 Jan-Feb | Ann Hepatol | pmid:23293209 |
| Seco-Melantuche R et al. | [Incidence of drug-induced thrombocytopenia in hospitalized patients]. | 2013 Jan-Feb | Farm Hosp | pmid:23461497 |
| Rao V et al. | A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimus. | 2013 Jan-Feb | Transplant. Proc. | pmid:23267806 |
| Langone A et al. | Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure level? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry. | 2013 Jan-Feb | Clin Transplant | pmid:22861144 |
| Shiba H et al. | Switching from tacrolimus to cyclosporine A to prevent primary biliary cirrhosis recurrence after living-donor liver transplantation. | 2013 Apr-Jun | Int Surg | pmid:23701152 |
| Adamu B et al. | New-onset diabetes after renal transplantation: a case series as seen in a Nigerian kidney transplant population. | 2013 Apr-Jun | Niger J Clin Pract | pmid:23563475 |
| Cangemi G et al. | Comparison of antibody-conjugated magnetic immunoassay and liquid chromatography-tandem mass spectrometry for the measurement of cyclosporine and tacrolimus in whole blood. | 2013 Apr-Jun | Int J Immunopathol Pharmacol | pmid:23755756 |
| Landy J and Hart AL | Commentary: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336680 |
| Heavner MS et al. | Clinical outcomes associated with conversion from brand-name to generic tacrolimus in hospitalized kidney transplant recipients. | 2013 | Am J Health Syst Pharm | pmid:23943182 |
| Øzbay LA et al. | The effects of calcineurin inhibitors on prostanoid synthesis: a randomized cross-over study in healthy humans. | 2013 | Transpl. Int. | pmid:23190385 |
| Gaber AO et al. | Acute rejection characteristics from a prospective, randomized, double-blind, placebo-controlled multicenter trial of early corticosteroid withdrawal. | 2013 | Transplantation | pmid:23423269 |
| Ricciardelli I et al. | Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. | 2013 | Am. J. Transplant. | pmid:24266973 |
| Chen YP et al. | [The clinical efficacy and safety of tacrolimus in patients with myasthenia gravis]. | 2013 | Zhonghua Nei Ke Za Zhi | pmid:24266997 |
| Ogawa K et al. | A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. | 2013 | Xenobiotica | pmid:23153054 |
| Zuo XC et al. | Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine. | 2013 | Drug Metab. Pharmacokinet. | pmid:23438946 |
| Barraclough KA et al. | A differential impact of mycophenolic acid, prednisolone, and tacrolimus exposure on sCD30 levels in adult kidney transplant recipients. | 2013 | Ther Drug Monit | pmid:23503451 |
| Kim BR et al. | A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation. | 2013 | Sao Paulo Med J | pmid:23903271 |
| Sánchez Ferreiro AV and Muñoz Bellido L | [Tacrolimus in the treatment of atopic kerato-conjunctivitis]. | 2013 | Arch Soc Esp Oftalmol | pmid:23886369 |
| Kapoor K et al. | Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70. | 2013 | J. Biol. Chem. | pmid:24064216 |
| de Heus C et al. | Analysis of EGF receptor oligomerization by homo-FRET. | 2013 | Methods Cell Biol. | pmid:24143984 |
| Radu CD et al. | Cotton-made cellulose support for anti-allergic pajamas. | 2013 | Carbohydr Polym | pmid:23618296 |
| First MR et al. | New-onset diabetes after transplantation (NODAT): an evaluation of definitions in clinical trials. | 2013 | Transplantation | pmid:23619735 |
| Lehner GM and Linek M | A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. | 2013 | Vet. Dermatol. | pmid:24118370 |
| Zhu L et al. | A limited sampling strategy for tacrolimus in liver transplant patients. | 2013 | Int J Clin Pharmacol Ther | pmid:23547852 |
| Yadav DK et al. | Tacrolimus-induced severe cholestasis complicating renal transplantation. | 2013 | Ren Fail | pmid:23560366 |
| Saint-Marcoux F et al. | Lessons from routine dose adjustment of tacrolimus in renal transplant patients based on global exposure. | 2013 | Ther Drug Monit | pmid:23666572 |
| Spierings N et al. | CYP3A5 genotype had no impact on intrapatient variability of tacrolimus clearance in renal transplant recipients. | 2013 | Ther Drug Monit | pmid:23666583 |
| Fan L et al. | Tacrolimus is an alternative therapy option for the treatment of adult steroid-resistant nephrotic syndrome: a prospective, multicenter clinical trial. | 2013 | Int Urol Nephrol | pmid:22684795 |
| Dufty NE et al. | Pharmacokinetic interaction of maraviroc with tacrolimus in a patient coinfected with HIV and hepatitis B virus following hepatic transplant due to hepatocellular carcinoma. | 2013 | J. Antimicrob. Chemother. | pmid:23249840 |
| Kymionis GD et al. | Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. | 2013 | Cornea | pmid:23770977 |
| Yan L et al. | Immunomodulatory effectiveness of tacrolimus in preventing epidural scar adhesion after laminectomy in rat model. | 2013 | Eur. J. Pharmacol. | pmid:23220162 |
| Kurasawa T et al. | Successful treatment of class IV+V lupus nephritis with combination therapy of high-dose corticosteroids, tacrolimus and intravenous cyclophosphamide. | 2013 | Intern. Med. | pmid:23676603 |
| Güngör S et al. | Squamous cell carcinoma on the lower lip after using topical calcineurin inhibitor. | 2013 | J Dtsch Dermatol Ges | pmid:23763692 |
| Kuypers DR et al. | Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring. | 2013 | Transplantation | pmid:23263559 |
| Kitahama M et al. | Efficacy of adjunct tacrolimus treatment in patients with rheumatoid arthritis with inadequate responses to methotrexate. | 2013 | Mod Rheumatol | pmid:22975732 |
| Chhabra D et al. | Impact of calcineurin-inhibitor conversion to mTOR inhibitor on renal allograft function in a prednisone-free regimen. | 2013 | Am. J. Transplant. | pmid:24007570 |