tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garg V et al. | Proglycosomes: A novel nano-vesicle for ocular delivery of tacrolimus. | 2017 | Colloids Surf B Biointerfaces | pmid:28575739 |
| Jogiraju VK et al. | Application of physiologically based pharmacokinetic modeling to predict drug disposition in pregnant populations. | 2017 | Biopharm Drug Dispos | pmid:28474821 |
| David-Neto E et al. | Longitudinal Pharmacokinetics of Everolimus When Combined With Low-level of Tacrolimus in Elderly Renal Transplant Recipients. | 2017 | Transplantation | pmid:27798513 |
| Yuan D et al. | Effect of Vitamin D and Tacrolimus Combination Therapy on IgA Nephropathy. | 2017 | Med. Sci. Monit. | pmid:28659572 |
| Devaux S et al. | RhoA Inhibitor Treatment At Acute Phase of Spinal Cord Injury May Induce Neurite Outgrowth and Synaptogenesis. | 2017 | Mol. Cell Proteomics | pmid:28659490 |
| Qazi Y et al. | Efficacy and Safety of Everolimus Plus Low-Dose Tacrolimus Versus Mycophenolate Mofetil Plus Standard-Dose Tacrolimus in De Novo Renal Transplant Recipients: 12-Month Data. | 2017 | Am. J. Transplant. | pmid:27775865 |
| Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
| Sharma N et al. | Myositis-associated Interstitial Lung Disease: Predictors of Failure of Conventional Treatment and Response to Tacrolimus in a US Cohort. | 2017 | J. Rheumatol. | pmid:28864644 |
| Pinsk V et al. | Complete Reversion of Familial Adenomatous Polyposis Phenotype Associated with Tacrolimus and Mycophenolate Mofetil Treatment Following Kidney Transplantation. | 2017 | Anticancer Res. | pmid:28551651 |
| Jin SE et al. | Evaluation of tacrolimus sorption to PVC- and non-PVC-based tubes in administration sets: Pump method vs. drip method. | 2017 | Int J Pharm | pmid:28549974 |
| Berntsen HF et al. | The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. | 2017 | Toxicology | pmid:29037868 |
| Henderson CN et al. | Continuous Abdominal Irrigation for Treatment of Tertiary Peritonitis in the Immunosuppressed Patient after Solid Organ Transplant: A Novel Approach. | 2017 | Am Surg | pmid:28424115 |
| Chen B et al. | Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder. | 2017 | Sci Rep | pmid:28400553 |
| Vanhove T et al. | Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients. | 2017 | Clin. Pharmacol. Ther. | pmid:28437851 |
| Alvarez-ElÃas AC et al. | A Retrospective Study on Mycophenolic Acid Drug Interactions: Effect of Prednisone, Sirolimus, and Tacrolimus With MPA. | 2017 | Ther Drug Monit | pmid:28437284 |
| Alhamad T et al. | Targeting High Calcineurin Inhibitor Levels After Acute Rejection With Less Tremor: A New Strategy. | 2017 | Transplantation | pmid:28422926 |
| Saeki H | Management of Atopic Dermatitis in Japan. | 2017 | J Nippon Med Sch | pmid:28331140 |
| Marini BL et al. | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 2017 | J Oncol Pharm Pract | pmid:26970572 |
| Kasahara M et al. | Living donor liver transplantation during the first 3 months of life. | 2017 | Liver Transpl. | pmid:28220684 |
| Chen WY et al. | Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28219593 |
| Regunath H et al. | Early diagnosis of Ehrlichia ewingii infection in a lung transplant recipient by peripheral blood smear. | 2017 | Transpl Infect Dis | pmid:28036138 |
| Shoughy SS and Tabbara KF | Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis. | 2017 | Br J Ophthalmol | pmid:28137823 |
| Onodera M et al. | ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis. | 2017 | J. Gastroenterol. Hepatol. | pmid:28135009 |
| Kirpalani A et al. | Idiosyncratic drug reactions and membranous glomerulopathy. | 2017 | BMJ Case Rep | pmid:28137906 |
| Viklicky O et al. | Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial. | 2017 | PLoS ONE | pmid:28085915 |
| Naniwa T et al. | Efficacy of add-on tacrolimus on methotrexate to maintain clinical remission after rediscontinuation of a tumor necrosis factor inhibitor in rheumatoid arthritis patients who relapsed shortly after discontinuation of the same tumor necrosis factor inhibitor due to clinical remission. | 2017 | Mod Rheumatol | pmid:27143107 |
| Pimentel AL et al. | Diagnostic accuracy of glycated hemoglobin for post-transplantation diabetes mellitus after kidney transplantation: systematic review and meta-analysis. | 2017 | Nephrol. Dial. Transplant. | pmid:28088775 |
| Yang D et al. | JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature. | 2017 | Transpl Infect Dis | pmid:28036142 |
| Xu D et al. | Tacrolimus improves proteinuria remission in adults with cyclosporine A-resistant or -dependent minimal change disease. | 2017 | Nephrology (Carlton) | pmid:28035723 |
| Igata S et al. | Acute right heart failure caused by tacrolimus after renal transplantation: Serial observation by speckle tracking and Doppler echocardiography. | 2017 | Echocardiography | pmid:29178293 |
| Sathyasaikumar KV et al. | Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. | 2017 | Neuroscience | pmid:29031603 |
| Cohen L et al. | A novel presentation of Mycobacterium avium complex in a recipient of a lung transplant: a case report. | 2017 | J Med Case Rep | pmid:28844207 |
| Dang W et al. | Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. | 2017 | Antimicrob. Agents Chemother. | pmid:28807916 |
| Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
| Hasegawa J et al. | Preemptive anti-cytomegalovirus therapy in high-risk (donor-positive, recipient-negative cytomegalovirus serostatus) kidney transplant recipients. | 2017 | Int. J. Infect. Dis. | pmid:28986314 |
| Olariu R et al. | Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation. | 2017 | J. Surg. Res. | pmid:28985877 |
| Dardis G et al. | Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. | 2017 | Dev. Dyn. | pmid:28577298 |
| Jain A et al. | Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis. | 2016 | J Control Release | pmid:27725194 |
| Stienstra NA et al. | Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. | 2016 | Ther Drug Monit | pmid:27805928 |
| Quist SR et al. | Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis. | 2016 | Acta Derm. Venereol. | pmid:26911315 |
| Prytula A et al. | Tacrolimus Predose Concentration Is Associated With Hypertension in Pediatric Liver Transplant Recipients. | 2016 | J. Pediatr. Gastroenterol. Nutr. | pmid:26910645 |
| Wang X et al. | Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro. | 2016 | Mol Nutr Food Res | pmid:27061233 |
| Tang J et al. | ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts. | 2016 | Cell. Physiol. Biochem. | pmid:27771715 |
| Ghareeb M and Akhlaghi F | Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27771258 |
| Pathak S et al. | Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method. | 2016 | Chem. Pharm. Bull. | pmid:26833445 |
| Jannot AS et al. | A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26829596 |
| Sayar E et al. | The Ineffectiveness of Tacrolimus in an Infant With a Mutation in the IL-10 Receptor. | 2016 | J. Clin. Gastroenterol. | pmid:26828243 |
| Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
| Gathogo E et al. | Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. | 2016 | Transplantation | pmid:26413990 |
| Sienkiewicz B et al. | The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation. | 2016 | Pharmazie | pmid:29441922 |
| Borges-Costa J et al. | Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient. | 2016 | BMJ Case Rep | pmid:26759393 |
| Cortes X et al. | Successful use of infliximab and tacrolimus combination therapy in a patient with ulcerative colitis refractory to infliximab dose intensification plus azathioprine. | 2016 | Int J Clin Pharmacol Ther | pmid:26754306 |
| Vanhove T et al. | Clinical determinants of calcineurin inhibitor disposition: a mechanistic review. | 2016 | Drug Metab. Rev. | pmid:26912097 |
| Bae JM et al. | Repigmentation of poliosis in a patient with segmental vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27317537 |
| Tamhankar MA et al. | Tacrolimus-induced cerebral blindness in a liver transplant patient. | 2016 | Indian J Ophthalmol | pmid:23619482 |
| Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
| Wang J et al. | Evaluation of mycophenolate mofetil or tacrolimus in children with steroid sensitive but frequently relapsing or steroid-dependent nephrotic syndrome. | 2016 | Nephrology (Carlton) | pmid:26697959 |
| Yang Y et al. | STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. | 2016 | Neuroreport | pmid:26694943 |
| Ganetsky A et al. | Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:26691423 |
| Åžavk E | Neurologic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578080 |
| Okuda K et al. | Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. | 2016 | PLoS ONE | pmid:27501378 |
| Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Delli K et al. | Comment on: 'Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature' by Ribero et al. (2015). | 2016 | J Eur Acad Dermatol Venereol | pmid:26616360 |
| Zhang Y et al. | Effect of FK506 on apoptosis of facial motor neurons in rats and its possible mechanism. | 2016 | Eur Arch Otorhinolaryngol | pmid:25784181 |
| Ibrahim MA et al. | Study of intercurrent infection pattern in hepatitis C seropositive renal transplant recipients, relationship with T-cell function. | 2016 | Ren Fail | pmid:27418152 |
| Bessa AB et al. | Prospective Randomized Trial Investigating the Influence of Pharmaceutical Care on the Intra-Individual Variability of Tacrolimus Concentrations Early After Kidney Transplant. | 2016 | Ther Drug Monit | pmid:27414973 |
| Mehraj V et al. | The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. | 2016 | EBioMedicine | pmid:27397514 |
| MacDonald C et al. | Acute kidney injury after heart transplant in young children: risk factors and outcomes. | 2016 | Pediatr. Nephrol. | pmid:26559064 |
| Pastor-Clerigues A et al. | Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test. | 2016 | Curr. Eye Res. | pmid:26554729 |
| Mittal A et al. | Pilot Study to Evaluate the Efficacy and Safety of Oral Tacrolimus in Adult Patients With Refractory Severe Plaque Psoriasis. | 2016 | J Cutan Med Surg | pmid:26553734 |
| Vanhove T et al. | Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. | 2016 | Br J Clin Pharmacol | pmid:27501475 |
| Roblin E et al. | Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. | 2016 | Pediatr Transplant | pmid:26750745 |
| Dunyak BM and Gestwicki JE | Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. | 2016 | J. Med. Chem. | pmid:27409354 |
| Stiehl SR et al. | Tacrolimus interaction with dexmedetomidine--a case report. | 2016 | Pediatr Transplant | pmid:26493547 |
| Sun W et al. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. | 2016 | Pflugers Arch. | pmid:27318696 |
| Kang SW et al. | Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK. | 2016 | Mech. Ageing Dev. | pmid:26704447 |
| Yoshimura N et al. | Effectiveness of the Combination of Everolimus and Tacrolimus With High Dosage of Mizoribine for Living Donor-Related Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234736 |
| Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
| Baek CH et al. | Usefulness of Tacrolimus without Basiliximab in Well-Matched Living-Donor Renal Transplant Recipients in Korea. | 2016 | Exp Clin Transplant | pmid:27228054 |
| Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
| Hannah J et al. | Tacrolimus use in lupus nephritis: A systematic review and meta-analysis. | 2016 | Autoimmun Rev | pmid:26427983 |
| Schmidt KJ et al. | Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues. | 2016 | J Crohns Colitis | pmid:26419459 |
| Sommerer C and Giese T | Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:26418701 |
| Prytuła AA et al. | The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients. | 2016 | Clin Pharmacokinet | pmid:27138785 |
| Yamamoto T et al. | Letter: which patient profile for tacrolimus in ulcerative colitis? Authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27137731 |
| Laharie D and Poullenot F | Letter: which patient profile for tacrolimus in ulcerative colitis? | 2016 | Aliment. Pharmacol. Ther. | pmid:27137730 |
| Kim MJ et al. | Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy. | 2016 | PLoS ONE | pmid:27930655 |
| Wei Q et al. | Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma. | 2016 | Gut Liver | pmid:27074818 |
| Wowro SJ et al. | Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells. | 2016 | Int. Immunopharmacol. | pmid:26613512 |
| Adler M et al. | A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. | 2016 | J. Am. Soc. Nephrol. | pmid:26260164 |
| Saeki H et al. | Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016. | 2016 | J. Dermatol. | pmid:27076388 |
| Ueda Y and Uemoto S | Decreased tacrolimus concentration following a temporal increase during interferon-free therapy with asunaprevir and daclatasvir in patients with recurrent hepatitis C after liver transplantation. | 2016 | Transpl. Int. | pmid:26270021 |
| Jung H and Oh ES | FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression. | 2016 | Pigment Cell Melanoma Res | pmid:27060922 |
| Brito-Costa A et al. | Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation: The Potential Influence of Immunosuppressive Agents. | 2016 | Transplantation | pmid:27136260 |
| Hitzeman N and Kinnevey C | Topical Tacrolimus for Eczema. | 2016 | Am Fam Physician | pmid:27929217 |
| Myers AL et al. | Stability of tacrolimus injection diluted in 0.9% sodium chloride injection and stored in Excel bags. | 2016 | Am J Health Syst Pharm | pmid:27919876 |
| Saadi A and Schmahmann JD | Pearls & Oy-sters: Tacrolimus neurotoxicity presenting as an isolated brainstem lesion. | 2016 | Neurology | pmid:26976521 |
| Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
| Thervet É | [Applied pharmacogenetic]. | 2016 | Nephrol. Ther. | pmid:26972091 |