Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kim HC et al. | Primary immunosuppression with tacrolimus in kidney transplantation: three-year follow-up in a single center. | 2004 | Transplant. Proc. | pmid:15518753 |
Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
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Jin KB et al. | The production of reactive oxygen species in tacrolimus-treated glial cells. | 2008 | Transplant. Proc. | pmid:18929834 |
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Jain A et al. | Steroid withdrawal under tacrolimus for primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis after liver transplantation and long-term survival. | 2002 | Transplant. Proc. | pmid:12176467 |
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Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
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Nakazato P et al. | Early experience with FK 506 induction immunosuppression--suggestion for using oral FK 506. | 1991 | Transplant. Proc. | pmid:1721345 |
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Numakura K et al. | Incidence and risk factors of clinical characteristics, tacrolimus pharmacokinetics, and related genomic polymorphisms for posttransplant diabetes mellitus in the early stage of renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919487 |
Velio P et al. | Combined orthotopic liver-small bowel transplantation or small bowel transplantation in pigs: relations between survival, rejection, and mucosal morphometry. | 1997 | Transplant. Proc. | pmid:9142295 |
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Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
Yura H et al. | Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9838577 |
Ueda D et al. | Influence of FK 506 on renal blood flow. | 1991 | Transplant. Proc. | pmid:1721377 |
Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
Thomson AW et al. | The influence of FK 506 on the thymus: implications of drug-induced injury to thymic epithelial cells. | 1991 | Transplant. Proc. | pmid:1703361 |
Perico N et al. | FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat. | 1991 | Transplant. Proc. | pmid:1721378 |
Kato T et al. | Mycophenolate mofetil rescue therapy in patients with chronic hepatic allograft rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083158 |
Song Z et al. | Protective effect of FK-506 in pig-to-rat islet xenotransplantation is abrogated by prednisolone. | 2000 | Transplant. Proc. | pmid:10936332 |
Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
Mueller AR et al. | Is the use of marginal liver grafts justified? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083160 |
Miki T et al. | Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation. | 2000 | Transplant. Proc. | pmid:10936339 |
Morozumi K et al. | Electron-microscopic peritubular capillary lesion is a specific and useful diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesions in the cyclosporine era. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123167 |
Nanmoku K et al. | Effects of immunosuppressants on the progression of hepatitis C in hepatitis C virus-positive renal transplantation and the usefulness of interferon therapy. | 2008 | Transplant. Proc. | pmid:18790241 |
Zipperle S et al. | Impaired T-cell IL-10 secretion and CD4 helper function in liver transplant patients treated with tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123208 |
Nishioka T et al. | Arterial stiffness after successful renal transplantation. | 2008 | Transplant. Proc. | pmid:18790249 |
Sola E et al. | Low-dose and rapid steroid withdrawal in renal transplant patients treated with tacrolimus and mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12176537 |
Chien YS et al. | Incidence and risk factors of new-onset diabetes mellitus after renal transplantation. | 2008 | Transplant. Proc. | pmid:18790250 |
Moons P et al. | Steroids may compromise quality of life of renal transplant recipients on a tacrolimus-based regimen. | 2002 | Transplant. Proc. | pmid:12176538 |
Utsugi R et al. | Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniature swine renal allografts treated with a 12-day course of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266727 |
Pelekanou V et al. | FK 506 and rapamycin do not affect platelet aggregation or mitochondrial function. | 1991 | Transplant. Proc. | pmid:1721408 |
Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
Schorlemmer HU et al. | Coadministration of malononitrilamides and tacrolimus induces tolerance in a rat skin allograft model. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083529 |
Fishbein T et al. | Isolated intestinal transplantation in adults with nonreconstructible GI tracts. | 2000 | Transplant. Proc. | pmid:10995925 |
Wen J et al. | Tripterygium wilfordii hook f increase the blood concentration of tacrolimus. | 2008 | Transplant. Proc. | pmid:19100464 |
van Gelder T et al. | ATP-binding cassette transporters and calcineurin inhibitors: potential clinical implications. | 2001 | Transplant. Proc. | pmid:11377580 |
Fieguth HG et al. | Tacrolimus for treatment of bronchiolitis obliterans syndrome after unilateral and bilateral lung transplantation. | 2002 | Transplant. Proc. | pmid:12176613 |
Chang HR et al. | Sirolimus addition is beneficial for renal allograft dysfunction due to simultaneous acute rejection episode and calcineurin inhibitor nephrotoxicity. | 2004 | Transplant. Proc. | pmid:15621119 |
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Quiroga I et al. | Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267261 |
Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
Jiang H et al. | Prolonged cardiac allograft survival in sensitized rats by low-dose FK 506 in combination with splenectomy. | 1991 | Transplant. Proc. | pmid:1721439 |
Sato K et al. | Comparative study of FK 506, cyclosporine, and triple regimen immunosuppression with FK 506, cyclosporine, and mizoribine. | 1991 | Transplant. Proc. | pmid:1721440 |
Makowka L et al. | The effect of FK-506 on hyperacute rejection in presensitized rats. | 1987 | Transplant. Proc. | pmid:2445082 |
Katayama Y et al. | Immunosuppressive effects of FK 506 in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1721441 |
Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
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Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
Yonan NA et al. | Tracheal allograft transplantation in rats: the role of immunosuppressive agents in development of obliterative airway disease. | 1998 | Transplant. Proc. | pmid:9723443 |
Greenstein SM et al. | Nifedipine prevents tacrolimus-induced intestinal hemodynamic and functional impairments. | 1998 | Transplant. Proc. | pmid:9745540 |
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Ben-Ari Z et al. | Conversion of liver allograft recipients from cyclosporine A to FK 506 immunosuppressive therapy. | 2000 | Transplant. Proc. | pmid:10856553 |
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Soh KS et al. | Simultaneous liver and kidney transplantation from different living donors. | 2012 | Transplant. Proc. | pmid:22410057 |