tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Park JY et al. | Monitoring the status of T-cell activation in a microfluidic system. | 2011 | Analyst | pmid:21623432 |
| Menotta M et al. | Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. | 2015 | Anal. Chim. Acta | pmid:26073814 |
| Gómez-RÃos GA et al. | Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS). | 2018 | Anal. Chim. Acta | pmid:29254576 |
| Wada A et al. | Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. | 2014 | Anal. Chem. | pmid:24380432 |
| Hopper JT and Oldham NJ | Alkali metal cation-induced destabilization of gas-phase protein-ligand complexes: consequences and prevention. | 2011 | Anal. Chem. | pmid:21863818 |
| Sage L | Fishing for MAGIC targets. | 2005 | Anal. Chem. | pmid:16285140 |
| Murakami Y et al. | On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506). | 2004 | Anal. Biochem. | pmid:15464959 |
| Sellar KJ et al. | Spectrophotometric assay for calcineurin activity in leukocytes isolated from human blood. | 2006 | Anal. Biochem. | pmid:16979577 |
| Cañadas O et al. | Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A. | 2005 | Anal. Biochem. | pmid:15802130 |
| Carreras CW et al. | An FKBP12 binding assay based upon biotinylated FKBP12. | 2001 | Anal. Biochem. | pmid:11673895 |
| Ahn SC et al. | A tactic for screening inhibitors of interleukin-2 production. | 2002 | Anal. Biochem. | pmid:12018952 |
| Park JW et al. | Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP. | 2009 | Anal. Biochem. | pmid:19539594 |
| Sonatore LM et al. | The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. | 1996 | Anal. Biochem. | pmid:8811923 |
| Blanchet B et al. | Determination of serine/threonine protein phosphatase type 2B PP2B in lymphocytes by HPLC. | 2003 | Anal. Biochem. | pmid:12479828 |
| Ohtsu Y et al. | Selective ligand purification using high-performance affinity beads. | 2005 | Anal. Biochem. | pmid:15745744 |
| Rupprecht KR et al. | Development of a dot-blot assay for screening monoclonal antibodies to low-molecular-mass drugs. | 2010 | Anal. Biochem. | pmid:20696124 |
| Nozaki K et al. | Elimination technique for alkali metal ion adducts from an electrospray ionization process using an on-line ion suppressor. | 2010 | Anal Sci | pmid:20543506 |
| den Burger JC et al. | Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22899246 |
| Neu V et al. | On-line solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry for the quantitative analysis of tacrolimus in whole blood hemolyzate. | 2012 | Anal Bioanal Chem | pmid:22797715 |
| Takahashi T et al. | Isolating the whole complex of target proteins of FK506 using affinity resins from novel solid phases. | 2006 | Anal Bioanal Chem | pmid:16601955 |
| Tomás ML | [Immunosuppressive agents: side effects]. | 1997 | An R Acad Nac Med (Madr) | pmid:9616947 |
| Navas López VM et al. | [Safety and efficacy of oral tacrolimus in the treatment of paediatric inflammatory bowel disease]. | 2009 | An Pediatr (Barc) | pmid:19427822 |
| Zahdi MR et al. | Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. | 2013 Sep-Oct | An Bras Dermatol | pmid:24173187 |
| Delgado L et al. | Zoon's plasma cell balanitis: a report of two cases treated with pimecrolimus. | 2011 Jul-Aug | An Bras Dermatol | pmid:22068766 |
| Viana Fde O et al. | Acral lichen sclerosus et atrophicus--case report. | 2011 Jul-Aug | An Bras Dermatol | pmid:22068779 |
| Cakici O et al. | Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus. | An Bras Dermatol | pmid:28300917 | |
| Lima RS et al. | Granuloma faciale: a good therapeutic response with the use of topical tacrolimus. | An Bras Dermatol | pmid:26560220 | |
| Sisti A et al. | Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. | 2016 | An Bras Dermatol | pmid:27192518 |
| Tamler C et al. | Tacrolimus 0,1% ointment in the treatment of vitiligo: a series of cases. | 2011 Jan-Feb | An Bras Dermatol | pmid:21437550 |
| Holmgren G et al. | Successful pregnancies and fatherhood in familial amyloidotic polyneuropathy (FAP Val30Met) patients with liver transplantation. | 2004 | Amyloid | pmid:15478469 |
| Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
| Kyles AE et al. | Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. | 2000 | Am. J. Vet. Res. | pmid:10951980 |
| Kyles AE et al. | Pharmacokinetics of tacrolimus after multidose oral administration and efficacy in the prevention of allograft rejection in cats with renal transplants. | 2003 | Am. J. Vet. Res. | pmid:12856780 |
| Arango C et al. | A 29-year-old renal transplant recipient with acute respiratory failure. | 2012 | Am. J. Trop. Med. Hyg. | pmid:22665592 |
| Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
| Kandaswamy R et al. | A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients--an interim analysis. | 2005 | Am. J. Transplant. | pmid:15888064 |
| Frassetto LA et al. | Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. | 2007 | Am. J. Transplant. | pmid:17949460 |
| Xu H et al. | The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. | 2014 | Am. J. Transplant. | pmid:24472192 |
| Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
| Zafrani L et al. | Incidence, risk factors and clinical consequences of neutropenia following kidney transplantation: a retrospective study. | 2009 | Am. J. Transplant. | pmid:19538494 |
| Krämer BK et al. | Tacrolimus once daily (ADVAGRAF) versus twice daily (PROGRAF) in de novo renal transplantation: a randomized phase III study. | 2010 | Am. J. Transplant. | pmid:20840480 |
| TruneÄka P et al. | Once-daily prolonged-release tacrolimus (ADVAGRAF) versus twice-daily tacrolimus (PROGRAF) in liver transplantation. | 2010 | Am. J. Transplant. | pmid:20840481 |
| Ekberg H et al. | Calcineurin inhibitor minimization in the Symphony study: observational results 3 years after transplantation. | 2009 | Am. J. Transplant. | pmid:19563339 |
| Wang Q et al. | Biodegradable microsphere-loaded tacrolimus enhanced the effect on mice islet allograft and reduced the adverse effect on insulin secretion. | 2004 | Am. J. Transplant. | pmid:15084166 |
| Schubert M et al. | Pharmacokinetics of sirolimus and tacrolimus in pediatric transplant patients. | 2004 | Am. J. Transplant. | pmid:15084173 |
| ter Meulen CG et al. | Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a prospective, randomized, multicenter study. | 2004 | Am. J. Transplant. | pmid:15084178 |
| Mehra MR et al. | Immunosuppression in cardiac transplantation: science, common sense and the heart of the matter. | 2006 | Am. J. Transplant. | pmid:16686745 |
| Grimm M et al. | Superior prevention of acute rejection by tacrolimus vs. cyclosporine in heart transplant recipients--a large European trial. | 2006 | Am. J. Transplant. | pmid:16686762 |
| Budde K et al. | Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. | 2014 | Am. J. Transplant. | pmid:25278376 |
| Sis B et al. | Reproducibility studies on arteriolar hyaline thickening scoring in calcineurin inhibitor-treated renal allograft recipients. | 2006 | Am. J. Transplant. | pmid:16686769 |
| Duncan FJ et al. | Clinically relevant immunosuppressants influence UVB-induced tumor size through effects on inflammation and angiogenesis. | 2007 | Am. J. Transplant. | pmid:17941958 |
| Hu X et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. | 2016 | Am. J. Transplant. | pmid:26749344 |
| Cameron AM et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. | 2016 | Am. J. Transplant. | pmid:26748958 |
| Böhmig GA et al. | Immunoadsorption in severe C4d-positive acute kidney allograft rejection: a randomized controlled trial. | 2007 | Am. J. Transplant. | pmid:17109725 |
| Budde K et al. | Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients. | 2010 | Am. J. Transplant. | pmid:20121745 |
| Bouamar R et al. | Tacrolimus predose concentrations do not predict the risk of acute rejection after renal transplantation: a pooled analysis from three randomized-controlled clinical trials(†). | 2013 | Am. J. Transplant. | pmid:23480233 |
| Busque S et al. | The PROMISE study: a phase 2b multicenter study of voclosporin (ISA247) versus tacrolimus in de novo kidney transplantation. | 2011 | Am. J. Transplant. | pmid:21943027 |
| Artz MA et al. | Conversion from cyclosporine to tacrolimus improves quality-of-life indices, renal graft function and cardiovascular risk profile. | 2004 | Am. J. Transplant. | pmid:15147428 |
| Hamdy AF et al. | Comparison of sirolimus with low-dose tacrolimus versus sirolimus-based calcineurin inhibitor-free regimen in live donor renal transplantation. | 2005 | Am. J. Transplant. | pmid:16162204 |
| Kaufman DB et al. | Alemtuzumab induction and prednisone-free maintenance immunotherapy in kidney transplantation: comparison with basiliximab induction--long-term results. | 2005 | Am. J. Transplant. | pmid:16162205 |
| Naesens M et al. | Tacrolimus exposure and evolution of renal allograft histology in the first year after transplantation. | 2007 | Am. J. Transplant. | pmid:17608835 |
| Schwarz A et al. | Polyoma virus nephropathy in native kidneys after lung transplantation. | 2005 | Am. J. Transplant. | pmid:16162212 |
| Shemesh E et al. | The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. | 2017 | Am. J. Transplant. | pmid:28321975 |
| Van Laecke S et al. | Posttransplantation hypomagnesemia and its relation with immunosuppression as predictors of new-onset diabetes after transplantation. | 2009 | Am. J. Transplant. | pmid:19624560 |
| Pirenne J et al. | Tolerance of liver transplant patients to strenuous physical activity in high-altitude. | 2004 | Am. J. Transplant. | pmid:15023147 |
| Heisel O et al. | New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysis. | 2004 | Am. J. Transplant. | pmid:15023151 |
| Hardinger KL et al. | Pharmacokinetics of tacrolimus in kidney transplant recipients: twice daily versus once daily dosing. | 2004 | Am. J. Transplant. | pmid:15023155 |
| Suwelack B et al. | Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy. | 2004 | Am. J. Transplant. | pmid:15023160 |
| Bryan CF et al. | Long-term survival of kidneys transplanted from live A2 donors to O and B recipients. | 2007 | Am. J. Transplant. | pmid:17359511 |
| Vincenti F et al. | Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. | 2007 | Am. J. Transplant. | pmid:17359512 |
| Diaz-Siso JR et al. | Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. | 2015 | Am. J. Transplant. | pmid:25777324 |
| Rodriguez-Rodriguez AE et al. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats. | 2013 | Am. J. Transplant. | pmid:23651473 |
| Klintmalm GB et al. | Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. | 2014 | Am. J. Transplant. | pmid:25041339 |
| Jaksch P et al. | Alemtuzumab in lung transplantation: an open-label, randomized, prospective single center study. | 2014 | Am. J. Transplant. | pmid:25039364 |
| Neuberger JM et al. | Delayed introduction of reduced-dose tacrolimus, and renal function in liver transplantation: the 'ReSpECT' study. | 2009 | Am. J. Transplant. | pmid:19120077 |
| Momper JD et al. | The impact of conversion from prograf to generic tacrolimus in liver and kidney transplant recipients with stable graft function. | 2011 | Am. J. Transplant. | pmid:21714845 |
| TruneÄŒka P et al. | Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. | 2015 | Am. J. Transplant. | pmid:25707487 |
| Adam R et al. | Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. | 2015 | Am. J. Transplant. | pmid:25703527 |
| Asrani SK and O'Leary JG | Can one pill a day keep rejection away? | 2015 | Am. J. Transplant. | pmid:25703394 |
| Lemahieu WP et al. | CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. | 2004 | Am. J. Transplant. | pmid:15307840 |
| Oetting WS et al. | Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. | 2016 | Am. J. Transplant. | pmid:26485092 |
| Badri P et al. | Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvir. | 2015 | Am. J. Transplant. | pmid:25708713 |
| Larson TS et al. | Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimus. | 2006 | Am. J. Transplant. | pmid:16468960 |
| Vitko S et al. | Tacrolimus combined with two different dosages of sirolimus in kidney transplantation: results of a multicenter study. | 2006 | Am. J. Transplant. | pmid:16468962 |
| Woywodt A et al. | Different preparations of tacrolimus and medication errors. | 2008 | Am. J. Transplant. | pmid:18786238 |
| Servais A et al. | Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. | 2011 | Am. J. Transplant. | pmid:21672152 |
| Carenco C et al. | Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. | 2015 | Am. J. Transplant. | pmid:25648361 |
| Mulay AV et al. | Impact of immunosuppressive medication on the risk of renal allograft failure due to recurrent glomerulonephritis. | 2009 | Am. J. Transplant. | pmid:19353768 |
| Bourdeaux C et al. | Living-related versus deceased donor pediatric liver transplantation: a multivariate analysis of technical and immunological complications in 235 recipients. | 2007 | Am. J. Transplant. | pmid:17173657 |
| Heller T et al. | Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients. | 2007 | Am. J. Transplant. | pmid:17532750 |
| Schrepfer S et al. | Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease. | 2007 | Am. J. Transplant. | pmid:17532751 |
| Rostaing L et al. | Alefacept combined with tacrolimus, mycophenolate mofetil and steroids in de novo kidney transplantation: a randomized controlled trial. | 2013 | Am. J. Transplant. | pmid:23730730 |
| Posselt AM et al. | Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. | 2010 | Am. J. Transplant. | pmid:20659093 |
| Ciancio G et al. | Advantage of rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous pancreas kidney transplants: randomized, single-center trial at 10 years. | 2012 | Am. J. Transplant. | pmid:22946986 |
| Jacobson PA et al. | Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs. | 2012 | Am. J. Transplant. | pmid:22947444 |
| De Simone P et al. | Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial. | 2012 | Am. J. Transplant. | pmid:22882750 |
| Echeverri GJ et al. | Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. | 2009 | Am. J. Transplant. | pmid:19775318 |
| Gaston RS et al. | Fixed- or controlled-dose mycophenolate mofetil with standard- or reduced-dose calcineurin inhibitors: the Opticept trial. | 2009 | Am. J. Transplant. | pmid:19459794 |
| Lake JR et al. | Addition of MMF to dual immunosuppression does not increase the risk of malignant short-term death after liver transplantation. | 2005 | Am. J. Transplant. | pmid:16303011 |
| Miller LW | Cardiovascular toxicities of immunosuppressive agents. | 2002 | Am. J. Transplant. | pmid:12392286 |