tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cho JH et al. | Development of novel fast-dissolving tacrolimus solid dispersion-loaded prolonged release tablet. | 2014 | Eur J Pharm Sci | pmid:24388864 |
| Smoter P et al. | Risk factors of acute renal failure after orthotopic liver transplantation: single-center experience. | 2014 | Transplant. Proc. | pmid:25380918 |
| Frassetto LA et al. | Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. | 2014 | Transplantation | pmid:24389906 |
| Lerut JP et al. | Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study. | 2014 | Ann. Surg. | pmid:25379858 |
| Hitzler JK et al. | Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. | 2014 | Pediatr Blood Cancer | pmid:24391118 |
| Wu Y et al. | Increased macrophage activation inhibited by tacrolimus in the kidney of diabetic rats. | 2014 | Nephron Exp. Nephrol. | pmid:25376933 |
| Levitsky J and Feng S | Sirolimus and mTOR inhibitors in liver transplantation: the wheel has come full circle. | 2014 | Am. J. Transplant. | pmid:24620373 |
| Catalano G et al. | Everolimus-based immunosuppression in a case of ABO-incompatible liver transplantation with calcineurin inhibitor-related posterior occipital syndrome. | 2014 | Transpl. Int. | pmid:24606320 |
| Zhang Y et al. | Genome-wide identification and analysis of FK506-binding protein gene family in peach (Prunus persica). | 2014 | Gene | pmid:24342662 |
| Muhetaer G et al. | Clinical significance of peripheral blood lymphocyte sensitivity to glucocorticoids for the differentiation of high-risk patients with decreased allograft function after glucocorticoid withdrawal in renal transplantation. | 2014 | Clin Ther | pmid:25037282 |
| Shin BH et al. | Regulation of anti-HLA antibody-dependent natural killer cell activation by immunosuppressive agents. | 2014 | Transplantation | pmid:24342979 |
| Tavira B et al. | [Pharmacogenetics of tacrolimus: from bench to bedside?]. | 2014 | Nefrologia | pmid:24463861 |
| Qin XL et al. | Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. | 2014 | Phytomedicine | pmid:24462213 |
| Asrani SK et al. | De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial. | 2014 | Am. J. Transplant. | pmid:24456026 |
| Nevers W et al. | Safety of tacrolimus in pregnancy. | 2014 | Can Fam Physician | pmid:25316742 |
| Oellerich M et al. | Use of graft-derived cell-free DNA as an organ integrity biomarker to reexamine effective tacrolimus trough concentrations after liver transplantation. | 2014 | Ther Drug Monit | pmid:24452066 |
| Wang J et al. | Molecular mechanisms of FK506-induced hypertension in solid organ transplantation patients. | 2014 | Chin. Med. J. | pmid:25316243 |
| Ducroux E et al. | Hidradenitis suppurativa after renal transplantation: complete remission after switching from oral cyclosporine to oral tacrolimus. | 2014 | J. Am. Acad. Dermatol. | pmid:25437996 |
| Khorrami A et al. | Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol-induced myocardial infarction. | 2014 | Daru | pmid:25312839 |
| Shimizu M et al. | Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis. | 2014 | Rheumatology (Oxford) | pmid:24609060 |
| Golubović B et al. | Total plasma protein effect on tacrolimus elimination in kidney transplant patients--population pharmacokinetic approach. | 2014 | Eur J Pharm Sci | pmid:24184751 |
| Hu YM et al. | Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24610957 |
| Bäckman L and Persson CA | An observational study evaluating tacrolimus dose, exposure, and medication adherence after conversion from twice- to once-daily tacrolimus in liver and kidney transplant recipients. | 2014 | Ann. Transplant. | pmid:24637379 |
| Mai HL et al. | IL-7 receptor blockade following T cell depletion promotes long-term allograft survival. | 2014 | J. Clin. Invest. | pmid:24569454 |
| Tokuoka H et al. | Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons. | 2014 | Neurosci. Lett. | pmid:24291696 |
| Boran M et al. | Determining renal resistive and pulsatility indexes long-term after kidney transplantation in kidney transplant recipients on cyclosporine a-, tacrolimus-, or sirolimus-based regimens. | 2014 | Transplant. Proc. | pmid:24935296 |
| Fuchs U et al. | Clinical outcome in heart transplant recipients receiving everolimus in combination with dosage reduction of the calcineurin inhibitor cyclosporine A or tacrolimus. | 2014 | Transpl. Immunol. | pmid:24932812 |
| Motomura H et al. | Inhibitory effect of tacrolimus on progression of joint damage in patients with rheumatoid arthritis. | 2014 | Int J Rheum Dis | pmid:24251619 |
| Han N et al. | Population pharmacokinetic-pharmacogenetic model of tacrolimus in the early period after kidney transplantation. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24238261 |
| Yasukochi Y et al. | Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments. | 2014 | Asian Pac. J. Allergy Immunol. | pmid:25268342 |
| Zhang L et al. | Ambrisentan improves the outcome of rats with liver transplantation partially through reducing nephrotoxicity. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25268107 |
| Donnadieu B et al. | Central retinal vein occlusion-associated tacrolimus after liver transplantation. | 2014 | Transplantation | pmid:25955343 |
| Rangel EB | Tacrolimus in pancreas transplant: a focus on toxicity, diabetogenic effect and drug-drug interactions. | 2014 | Expert Opin Drug Metab Toxicol | pmid:25255841 |
| Sharp WW et al. | Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. | 2014 | FASEB J. | pmid:24076965 |
| Al-Harbi NO et al. | Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren. | 2014 | Toxicol. Mech. Methods | pmid:25199528 |
| Wilusz M et al. | Effect of immunosuppressive therapy on the serum fatty acids of phospholipids fraction in patients after heart transplantation. | 2014 | Transplant. Proc. | pmid:25380928 |
| Notaro E et al. | Dose conversion factor between cyclosporine and tacrolimus in pediatric heart transplant recipients. | 2014 | J. Heart Lung Transplant. | pmid:24854566 |
| Lan CC et al. | Tacrolimus abrogates TGF-β1-induced type I collagen production in normal human fibroblasts through suppressing p38MAPK signalling pathway: implications on treatment of chronic atopic dermatitis lesions. | 2014 | J Eur Acad Dermatol Venereol | pmid:23301526 |
| Burroughs LM et al. | Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial. | 2014 | Biol. Blood Marrow Transplant. | pmid:25196857 |
| Guy-Viterbo V et al. | Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. | 2014 | Pharmacogenomics | pmid:25141896 |
| Cavalli RC et al. | Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus. | 2014 | Acta Cir Bras | pmid:25140592 |
| Mabe S et al. | Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells. | 2014 | Sci Rep | pmid:25135216 |
| Sol Fustiñana M et al. | Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory. | 2014 | Learn. Mem. | pmid:25135196 |
| Elens L et al. | Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. | 2014 | Ther Drug Monit | pmid:24061445 |
| Imataki O et al. | Reversible cerebral vasoconstriction syndrome resulted in cerebral infarction after allogeneic stem cell transplantation: a case report. | 2014 | Ann. Hematol. | pmid:24061786 |
| Hagihara Y et al. | Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease. | 2014 | J Crohns Colitis | pmid:24011513 |
| Kilinc S et al. | The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats. | 2014 | Int Urol Nephrol | pmid:24014133 |
| Gürkan A et al. | Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. | 2014 | Arch. Oral Biol. | pmid:24581850 |
| Spasovski G and Masin-Spasovska J | How to improve the survival of the kidney transplant - is it only the pharmaceutical management? | 2014 | Expert Opin Pharmacother | pmid:24617949 |
| Shen T et al. | A modified protocol with rituximab and intravenous immunoglobulin in emergent ABO-incompatible liver transplantation for acute liver failure. | 2014 | HBPD INT | pmid:25100124 |
| Wang B et al. | Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats. | 2014 | J Ethnopharmacol | pmid:25091466 |
| Bao J and Liang H | Tacrolimus-induced permanent asymptomatic pontine myelinolysis after liver transplantation. | 2014 | Intern. Med. | pmid:25088893 |
| Verghese PS et al. | Calcineurin inhibitors in HLA-identical living related donor kidney transplantation. | 2014 | Nephrol. Dial. Transplant. | pmid:24414376 |
| Da-Long S et al. | Tacrolimus on Kimura's disease: a case report. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:22939325 |
| Kyriakou A et al. | Therapeutic efficacy of topical calcineurin inhibitors in plasma cell balanitis: case series and review of the literature. | 2014 | Dermatology (Basel) | pmid:24434685 |
| Thapa RK and Yoo BK | Evaluation of the effect of tacrolimus-loaded liquid crystalline nanoparticles on psoriasis-like skin inflammation. | 2014 | J Dermatolog Treat | pmid:23210668 |
| Viecelli A et al. | Diagnostic and management dilemma of a pancreas-kidney transplant recipient with aplastic anaemia. | 2014 | BMJ Case Rep | pmid:25257886 |
| Yamazoe K et al. | Efficacy and safety of systemic tacrolimus in high-risk penetrating keratoplasty after graft failure with systemic cyclosporine. | 2014 | Cornea | pmid:25255133 |
| Jaksch P et al. | Alemtuzumab in lung transplantation: an open-label, randomized, prospective single center study. | 2014 | Am. J. Transplant. | pmid:25039364 |
| Segarra-Medrano A et al. | Evolution of antibody titre against the M-type phospholipase A2 receptor and clinical response in idiopathic membranous nephropathy patients treated with tacrolimus. | 2014 | Nefrologia | pmid:25036063 |
| Bax K et al. | Rapid resolution of tacrolimus intoxication-induced AKI with a corticosteroid and phenytoin. | 2014 | Ann Pharmacother | pmid:25104567 |
| John K et al. | Role of dendritic cells in the context of acute cellular rejection: comparison between tacrolimus- or cyclosporine A-treated heart transplanted recipients. | 2014 | Cytometry B Clin Cytom | pmid:24668729 |
| Dessilly G et al. | ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. | 2014 | PLoS ONE | pmid:24621983 |
| Falconer SJ et al. | Conversion from twice-daily to once-daily tacrolimus in simultaneous pancreas-kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24935313 |
| Terada Y et al. | Intestinal P-glycoprotein expression is multimodally regulated by intestinal ischemia-reperfusion. | 2014 | J Pharm Pharm Sci | pmid:24934555 |
| Goring SM et al. | A network meta-analysis of the efficacy of belatacept, cyclosporine and tacrolimus for immunosuppression therapy in adult renal transplant recipients. | 2014 | Curr Med Res Opin | pmid:24628478 |
| Mai S et al. | In vitro and in vivo release characteristics of Tacrolimus (FK506) from an episcleral drug-delivery implant. | 2014 | J Ocul Pharmacol Ther | pmid:24933028 |
| Urbanowicz T et al. | Comparison of conventional tacrolimus versus prolong release formula as initial therapy in heart transplantation. | 2014 | Ann. Transplant. | pmid:24949728 |
| Nomura H et al. | A patient with lupus miliaris disseminatus faciei treated successfully with a combination of oral metronidazole and topical tacrolimus. | 2014 | J. Dermatol. | pmid:24931738 |
| Fuchs U et al. | Incidence of malignant neoplasia after heart transplantation--a comparison between cyclosporine a and tacrolimus. | 2014 | Ann. Transplant. | pmid:24953848 |
| Rahman Z et al. | Near-infrared and fourier transform infrared chemometric methods for the quantification of crystalline tacrolimus from sustained-release amorphous solid dispersion. | 2014 | J Pharm Sci | pmid:24931728 |
| Elamin S et al. | Co-administration of ketoconazole and tacrolimus to kidney transplant recipients: cost minimization and potential metabolic benefits. | 2014 | Saudi J Kidney Dis Transpl | pmid:24969193 |
| Gibbs BF et al. | Highly specific targeting of human leukocytes using gold nanoparticle-based biologically active conjugates. | 2014 | J Biomed Nanotechnol | pmid:24804546 |
| Richards KR et al. | Tacrolimus trough level at discharge predicts acute rejection in moderately sensitized renal transplant recipients. | 2014 | Transplantation | pmid:24784360 |
| Cutler C et al. | Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT. | 2014 | Blood | pmid:24982504 |
| Liu Z et al. | Tacrolimus-based versus cyclosporine-based immunosuppression in hepatitis C virus-infected patients after liver transplantation: a meta-analysis and systematic review. | 2014 | PLoS ONE | pmid:25198195 |
| Katayama M et al. | Preliminary study of interaction of clarithromycin with tacrolimus in cats. | 2014 | J. Vet. Med. Sci. | pmid:25099737 |
| Shihab F et al. | Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. | 2014 | Transpl. Immunol. | pmid:24861504 |
| Almeida-Paulo GN et al. | Limited sampling strategies for tacrolimus exposure (AUC0-24) prediction after Prograf(®) and Advagraf(®) administration in children and adolescents with liver or kidney transplants. | 2014 | Transpl. Int. | pmid:24861353 |
| Kahvecioglu S et al. | Effects of calcineurin inhibitors on paraoxonase and arylesterase activity after a kidney transplant. | 2014 | Exp Clin Transplant | pmid:24447269 |
| Marin-Casino M et al. | Significant tacrolimus and dronedarone interaction in a kidney transplant recipient. | 2014 | Transplantation | pmid:25243519 |
| Chamienia A et al. | Open prospective study to evaluate cardiovascular risk factors and renal function in 2 dosage regimens of tacrolimus combined with mycophenolate mofetil and steroids in renal transplant patients: 5-year results. | 2014 | Transplant. Proc. | pmid:25380901 |
| Doren EL and Aya-ay ML | Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids. | 2014 | Aesthet Surg J | pmid:24448967 |
| Lee CM et al. | Monotherapy with tacrolimus for heart and liver transplant: a case report. | 2014 | Transplant. Proc. | pmid:24767396 |
| Lin YH and Pratt MR | A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells. | 2014 | Chembiochem | pmid:24615791 |
| Abe T et al. | Risk factors for development of new-onset diabetes mellitus and progressive impairment of glucose metabolism after living-donor liver transplantation. | 2014 | Transplant. Proc. | pmid:24767367 |
| Mita A et al. | Optimal initial dose of orally administered once-daily extended-release tacrolimus following intravenous tacrolimus therapy after liver transplantation. | 2014 | Transplant. Proc. | pmid:24767351 |
| Jin L et al. | Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats. | 2014 | PLoS ONE | pmid:24959755 |
| Hashi S et al. | Assessment of four methodologies (microparticle enzyme immunoassay, chemiluminescent enzyme immunoassay, affinity column-mediated immunoassay, and flow injection assay-tandem mass spectrometry) for measuring tacrolimus blood concentration in Japanese liver transplant recipients. | 2014 | Transplant. Proc. | pmid:24767342 |
| Wan XC and Dimov V | Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. | 2014 | Expert Opin Drug Metab Toxicol | pmid:24490943 |
| Zhang X et al. | Profiling of drug binding proteins by monolithic affinity chromatography in combination with liquid chromatography-tandem mass spectrometry. | 2014 | J Chromatogr A | pmid:25064533 |
| Chen C et al. | Rapid construction of a Bacterial Artificial Chromosomal (BAC) expression vector using designer DNA fragments. | 2014 | Plasmid | pmid:25454071 |
| Olson KA et al. | Toxic tacrolimus levels after application of topical tacrolimus and use of occlusive dressings in two bone marrow transplant recipients with cutaneous graft-versus-host disease. | 2014 | Pharmacotherapy | pmid:24700567 |
| Momohara S et al. | Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort. | 2014 | J. Rheumatol. | pmid:24692532 |
| Lin Q et al. | Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus. | 2014 | J. Invest. Dermatol. | pmid:24682043 |
| DÃaz-GarcÃa C et al. | Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory. | 2014 | Fertil. Steril. | pmid:25439799 |
| Tsunashima D et al. | Assessment of tacrolimus absorption from the human intestinal tract: open-label, randomized, 4-way crossover study. | 2014 | Clin Ther | pmid:24680768 |
| Ibrahim O et al. | The role of infliximab in the treatment of superficial granulomatous pyoderma of the head and neck. | 2014 | J. Am. Acad. Dermatol. | pmid:25438004 |
| Kraaij MD et al. | Human monocytes produce interferon-gamma upon stimulation with LPS. | 2014 | Cytokine | pmid:24680476 |
| Sawamoto K et al. | Mechanisms of lower maintenance dose of tacrolimus in obese patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24670405 |