Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Breuer K et al. | Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis. | 2005 | Am J Clin Dermatol | pmid:15799678 |
Kalavala M and Dohil MA | Calcineurin inhibitors in pediatric atopic dermatitis: a review of current evidence. | 2011 | Am J Clin Dermatol | pmid:21067248 |
Yang LP and Curran MP | Spotlight on topical pimecrolimus in pediatric atopic dermatitis. | 2010 | Am J Clin Dermatol | pmid:20509720 |
Cheer SM and Plosker GL | Tacrolimus ointment. A review of its therapeutic potential as a topical therapy in atopic dermatitis. | 2001 | Am J Clin Dermatol | pmid:11770393 |
Ozden MG et al. | Topical pimecrolimus 1% cream for resistant seborrheic dermatitis of the face: an open-label study. | 2010 | Am J Clin Dermatol | pmid:20000875 |
Patel TS et al. | Cancer concerns with topical immunomodulators in atopic dermatitis: overview of data and recommendations to clinicians. | 2007 | Am J Clin Dermatol | pmid:17645374 |
Mertens JS et al. | Morphea and Eosinophilic Fasciitis: An Update. | 2017 | Am J Clin Dermatol | pmid:28303481 |
Frankel HC and Qureshi AA | Comparative effectiveness of topical calcineurin inhibitors in adult patients with atopic dermatitis. | 2012 | Am J Clin Dermatol | pmid:22263704 |
Iskedjian M et al. | Topical calcineurin inhibitors in the treatment of atopic dermatitis: a meta-analysis of current evidence. | 2004 | Am J Clin Dermatol | pmid:15301573 |
Siegfried EC et al. | Topical calcineurin inhibitors and lymphoma risk: evidence update with implications for daily practice. | 2013 | Am J Clin Dermatol | pmid:23703374 |
Tjioe M et al. | Topical macrolide immunomodulators: a role in the treatment of vitiligo? | 2006 | Am J Clin Dermatol | pmid:16489839 |
Valdivielso-Ramos M et al. | Significant improvement in extensive lichen sclerosus with tacrolimus ointment and PUVA. | 2008 | Am J Clin Dermatol | pmid:18429647 |
Wellington K and Noble S | Pimecrolimus: a review of its use in atopic dermatitis. | 2004 | Am J Clin Dermatol | pmid:15663345 |
Cook BA and Warshaw EM | Role of topical calcineurin inhibitors in the treatment of seborrheic dermatitis: a review of pathophysiology, safety, and efficacy. | 2009 | Am J Clin Dermatol | pmid:19222250 |
Ingram JR et al. | Impact of topical calcineurin inhibitors on quality of life in patients with atopic dermatitis. | 2009 | Am J Clin Dermatol | pmid:19489656 |
Reitamo S et al. | Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis. | 2002 | Am J Clin Dermatol | pmid:12113647 |
Wellington K and Jarvis B | Spotlight on topical pimecrolimus in atopic dermatitis. | 2002 | Am J Clin Dermatol | pmid:12113651 |
Ellis CN et al. | Cost effectiveness of management of mild-to-moderate atopic dermatitis with 1% pimecrolimus cream in children and adolescents 2-17 years of age. | 2006 | Am J Clin Dermatol | pmid:16605293 |
Wollina U | The role of topical calcineurin inhibitors for skin diseases other than atopic dermatitis. | 2007 | Am J Clin Dermatol | pmid:17492844 |
Kasper RC et al. | Anetoderma arising in cutaneous B-cell lymphoproliferative disease. | 2001 | Am J Dermatopathol | pmid:11285407 |
Roche, FDA announce new drug-interaction warnings for mibefradil. | 1998 | Am J Health Syst Pharm | pmid:9492249 | |
Ku YM et al. | Compatibility of tacrolimus injection with cimetidine hydrochloride injection in 0.9% sodium chloride injection. | 1995 | Am J Health Syst Pharm | pmid:8528874 |
Greanya ED et al. | Pharmacokinetics of tacrolimus and mycophenolate mofetil in renal transplant recipients on a corticosteroid-free regimen. | 2012 | Am J Health Syst Pharm | pmid:22215359 |
Heavner MS et al. | Clinical outcomes associated with conversion from brand-name to generic tacrolimus in hospitalized kidney transplant recipients. | 2013 | Am J Health Syst Pharm | pmid:23943182 |
Curtin BF et al. | Unusually late-onset mycophenolate mofetil-related colitis. | 2014 | Am J Health Syst Pharm | pmid:25320135 |
Bonhomme-Faivre L et al. | Effect of the ABCB1 3435C>T polymorphism on tacrolimus concentrations and dosage requirements in liver transplant recipients. | 2009 | Am J Health Syst Pharm | pmid:19729569 |
Lee JH et al. | Stability of tacrolimus solutions in polyolefin containers. | 2016 | Am J Health Syst Pharm | pmid:26796907 |
Tacrolimus. | 2001 | Am J Health Syst Pharm | pmid:11794952 | |
Lee B et al. | Appropriate timing of tacrolimus concentration measurements in the emergency department. | 2016 | Am J Health Syst Pharm | pmid:27543574 |
Jacobson PA et al. | Stability of tacrolimus in an extemporaneously compounded oral liquid. | 1997 | Am J Health Syst Pharm | pmid:9117806 |
Utecht KN et al. | Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors. | 2006 | Am J Health Syst Pharm | pmid:17106006 |
Kelly PA et al. | Tacrolimus: a new immunosuppressive agent. | 1995 | Am J Health Syst Pharm | pmid:7552894 |
MacDonald AS and Sketris IS | Tacrolimus in transplantation. | 1995 | Am J Health Syst Pharm | pmid:7552906 |
Johnson CE et al. | Stability of tacrolimus with morphine sulfate, hydromorphone hydrochloride, and ceftazidime during simulated intravenous coadministration. | 1999 | Am J Health Syst Pharm | pmid:10030533 |
Pennington CA and Park JM | Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. | 2015 | Am J Health Syst Pharm | pmid:25631834 |
Tsapepas DS et al. | Managing the atazanavir-tacrolimus drug interaction in a renal transplant recipient. | 2011 | Am J Health Syst Pharm | pmid:21200061 |
Myers AL et al. | Stability of tacrolimus injection diluted in 0.9% sodium chloride injection and stored in Excel bags. | 2016 | Am J Health Syst Pharm | pmid:27919876 |
Grouzmann E et al. | Misleading tacrolimus concentration value in blood taken from a catheter used for tacrolimus administration. | 2008 | Am J Health Syst Pharm | pmid:18216007 |
Taormina D et al. | Stability and sorption of FK 506 in 5% dextrose injection and 0.9% sodium chloride injection in glass, polyvinyl chloride, and polyolefin containers. | 1992 | Am J Hosp Pharm | pmid:1373936 |
Min DI et al. | Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. | 1992 | Am J Hosp Pharm | pmid:1282779 |
Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
Przepiorka D et al. | Blood tacrolimus concentration unchanged by plasmapheresis. | 1994 | Am J Hosp Pharm | pmid:7524318 |
Matsunami H et al. | New technique for measuring tacrolimus concentrations in blood. | 1994 | Am J Hosp Pharm | pmid:7510929 |
Pezze JL and Whiteman K | Transplantation's newest weapon FK 506. | 1991 | Am J Nurs | pmid:1716857 |
Yang GS et al. | Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. | 2000 | Am J Otol | pmid:10912694 |
Tulaci KG et al. | The effect of tacrolimus on facial nerve injury: Histopathological findings in a rabbit model. | Am J Otolaryngol | pmid:27465503 | |
Knott PD et al. | Induction with T-cell receptor antibody leads to long-term laryngeal allograft function. | 2008 Nov-Dec | Am J Otolaryngol | pmid:19144301 |
Laifer SA et al. | Pregnancy after cardiac transplantation. | 1994 | Am J Perinatol | pmid:7519426 |
Lee J et al. | Inpatient rehabilitation challenges in a quadrimembral amputee after bilateral hand transplantation. | 2011 | Am J Phys Med Rehabil | pmid:21765280 |
Reams BD and Palmer SM | Sublingual tacrolimus for immunosuppression in lung transplantation: a potentially important therapeutic option in cystic fibrosis. | 2002 | Am J Respir Med | pmid:14720063 |
Moon BJ et al. | Effect of chronic rhinosinusitis on liver transplant patients. | 2009 Sep-Oct | Am J Rhinol Allergy | pmid:19807981 |
Shin JH et al. | The effect of topical FK506 (tacrolimus) in a mouse model of allergic rhinitis. | 2012 Mar-Apr | Am J Rhinol Allergy | pmid:22487280 |
Vearrier D et al. | Mutism and persistent dysarthria due to tacrolimus-based immunosuppression following allogeneic liver transplantation. | 2011 | Am J Ther | pmid:20535006 |
Yang A and Wang B | Sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids: focus on acute rejection, patient and graft survival. | Am J Ther | pmid:23921809 | |
Pariser D | Topical corticosteroids and topical calcineurin inhibitors in the treatment of atopic dermatitis: focus on percutaneous absorption. | 2009 May-Jun | Am J Ther | pmid:19262357 |
Sathyan S et al. | Prevention of recurrent episodes of rhabdomyolysis with tacrolimus in a transplant recipient with myopathy. | Am J Ther | pmid:23429166 | |
Liu JY et al. | Tacrolimus Versus Cyclosporine as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. | Am J Ther | pmid:25299636 | |
Haroon N et al. | Tacrolimus Toxicity With Minimal Clinical Manifestations: A Case Report and Literature Review. | Am J Ther | pmid:25730156 | |
Nunokawa T et al. | Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report. | Am J Ther | pmid:22836123 | |
Liu JY et al. | Sirolimus Versus Tacrolimus as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. | Am J Ther | pmid:25569597 | |
Cohen SM | Current immunosuppression in liver transplantation. | 2002 Mar-Apr | Am J Ther | pmid:11897926 |
Yousuf Bhat Z et al. | Colchicine-Induced Myopathy in a Tacrolimus-Treated Renal Transplant Recipient: Case Report and Literature Review. | Am J Ther | pmid:24732905 | |
Azizian M et al. | Augmentation of ischemia/reperfusion injury to endothelial cells by cyclosporin A. | 2004 | Am Surg | pmid:15156953 |
Henderson CN et al. | Continuous Abdominal Irrigation for Treatment of Tertiary Peritonitis in the Immunosuppressed Patient after Solid Organ Transplant: A Novel Approach. | 2017 | Am Surg | pmid:28424115 |
Rojas-GarcÃa P et al. | Breast fibroadenomas associated with immunosuppressive drugs. | 2010 | Am Surg | pmid:21418766 |
Kodama M et al. | FK506 therapy of experimental autoimmune myocarditis after onset of the disease. | 1993 | Am. Heart J. | pmid:7504393 |
Chieffo A et al. | Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents. | 2009 | Am. J. Cardiol. | pmid:19962471 |
Chang RK et al. | Marked left ventricular hypertrophy in children on tacrolimus (FK506) after orthotopic liver transplantation. | 1998 | Am. J. Cardiol. | pmid:9604971 |
Klauss V et al. | Cyclosporine versus tacrolimus (FK 506) for prevention of cardiac allograft vasculopathy. | 2000 | Am. J. Cardiol. | pmid:10955391 |
Herzberg GZ et al. | Usefulness of tacrolimus versus cyclosporine after pediatric heart transplantation. | 1998 | Am. J. Cardiol. | pmid:9723652 |
Hisamura F et al. | Synergistic effect of green tea polyphenols on their protection against FK506-induced cytotoxicity in renal cells. | 2008 | Am. J. Chin. Med. | pmid:18543393 |
Chung SY et al. | Ginkgo biloba leaf extract (EGb761) combined with neuroprotective agents reduces the infarct volumes of gerbil ischemic brain. | 2006 | Am. J. Chin. Med. | pmid:17080546 |
Stickle DF et al. | Effects of sterilizing gamma irradiation on bloodspot newborn screening tests and whole blood cyclosporine and tacrolimus measurements. | 2003 | Am. J. Clin. Pathol. | pmid:12580001 |
Wang E et al. | Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly. | 2011 | Am. J. Clin. Pathol. | pmid:21228370 |
Burke MT et al. | Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients. | 2015 | Am. J. Clin. Pathol. | pmid:25780003 |
Lower DR et al. | Comparison of CEDIA FK506 assay with HPLC/MS/MS in a large cohort of pediatric patients. | 2013 | Am. J. Clin. Pathol. | pmid:23690122 |
Rudi J et al. | Prevalence of serum antibodies to Helicobacter pylori and to CagA protein in liver transplant recipients. | 1997 | Am. J. Gastroenterol. | pmid:9317070 |
Van Thiel DH et al. | Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7532912 |
Baumgart DC et al. | Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease--a long-term follow-up. | 2006 | Am. J. Gastroenterol. | pmid:16573777 |
Sandborn WJ | Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. | 1997 | Am. J. Gastroenterol. | pmid:9149205 |
Van Thiel DH et al. | Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7537444 |
Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
Nara M et al. | Effect of oral itraconazole on the pharmacokinetics of tacrolimus in a hematopoietic stem cell transplant recipient with CYP3A5*3/*3. | 2010 | Am. J. Hematol. | pmid:20568249 |
Lekakis LJ et al. | BK virus nephropathy after allogeneic stem cell transplantation: a case report and literature review. | 2009 | Am. J. Hematol. | pmid:19208419 |
Hammerstrom AE et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. | 2013 | Am. J. Hematol. | pmid:23460378 |
Abdel-Azim H et al. | Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. | 2015 | Am. J. Hematol. | pmid:26242764 |
Uehara T et al. | Successful control of Epstein-Barr virus (EBV)-infected cells by allogeneic nonmyeloablative stem cell transplantation in a patient with the lethal form of chronic active EBV infection. | 2004 | Am. J. Hematol. | pmid:15282671 |
Nakamae H et al. | Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation. | 2006 | Am. J. Hematol. | pmid:16755559 |
Bolaños-Meade J et al. | Lymphocytic pneumonitis as the manifestation of acute graft-versus-host disease of the lung. | 2005 | Am. J. Hematol. | pmid:15929116 |
Ninan MJ and Datta YH | Post-transplant lymphoproliferative disorder presenting as multiple myeloma. | 2010 | Am. J. Hematol. | pmid:20578201 |
Mach-Pascual S et al. | Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. | 1996 | Am. J. Hematol. | pmid:8701950 |
Uehara T et al. | A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. | 2002 | Am. J. Hematol. | pmid:12221672 |
Cohen DL et al. | Pulse wave analysis to assess vascular compliance changes in stable renal transplant recipients. | 2004 | Am. J. Hypertens. | pmid:15001192 |
Zhang W and Victor RG | Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. | 2000 | Am. J. Hypertens. | pmid:10981550 |
Taler SJ et al. | Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. | 1995 | Am. J. Hypertens. | pmid:7544983 |
Revelo MP et al. | A 14-year-old boy with kidney allograft failure in the first month after transplantation. | 2000 | Am. J. Kidney Dis. | pmid:11007695 |
Al-Awwa IA et al. | Importance of allograft biopsy in renal transplant recipients: correlation between clinical and histological diagnosis. | 1998 | Am. J. Kidney Dis. | pmid:9631859 |
Lum EL et al. | Acute Kidney Allograft Rejection Precipitated by Lenalidomide Treatment for Multiple Myeloma. | 2017 | Am. J. Kidney Dis. | pmid:28189378 |
Mathis AS and Friedman GS | Coadministration of digoxin with itraconazole in renal transplant recipients. | 2001 | Am. J. Kidney Dis. | pmid:11157404 |
Grinyó JM et al. | Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27889299 |