tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Translocation, Genetic D014178 20 associated lipids
HIV Infections D015658 20 associated lipids
Ataxia D001259 20 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Hyperglycemia D006943 21 associated lipids
Anemia D000740 21 associated lipids
Vomiting D014839 21 associated lipids
Bacterial Infections D001424 21 associated lipids
Erythema D004890 22 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Hypersensitivity D006967 22 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Cystitis D003556 23 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Ascites D001201 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Brain Diseases D001927 27 associated lipids
Endotoxemia D019446 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Obesity D009765 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Catalepsy D002375 30 associated lipids
Dermatitis D003872 30 associated lipids
Drug Eruptions D003875 30 associated lipids
Proteinuria D011507 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Liver Diseases D008107 31 associated lipids
Diarrhea D003967 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Stroke D020521 32 associated lipids
Memory Disorders D008569 33 associated lipids
Uremia D014511 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Ierardi E et al. Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance. 2001 Aliment. Pharmacol. Ther. pmid:11207512
Romano C et al. Oral tacrolimus (FK 506) in refractory paediatric ulcerative colitis. 2010 Aliment. Pharmacol. Ther. pmid:20148798
Itoh S et al. Inhibition of CN (protein phosphatase-2B) suppresses Ca2+-mediated acid secretion in rats. 2002 Aliment. Pharmacol. Ther. pmid:11966520
Firpi RJ et al. Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent. 2004 Aliment. Pharmacol. Ther. pmid:15113371
Herrlinger KR et al. Infliximab as rescue medication for patients with severe ulcerative/indeterminate colitis refractory to tacrolimus. 2010 Aliment. Pharmacol. Ther. pmid:20175769
Schwrer H et al. Pantoprazole and cyclosporine or tacrolimus. 2001 Aliment. Pharmacol. Ther. pmid:11284790
Högenauer C et al. Effect of oral tacrolimus (FK 506) on steroid-refractory moderate/severe ulcerative colitis. 2003 Aliment. Pharmacol. Ther. pmid:12940927
Trotter JF et al. Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients. 2005 Aliment. Pharmacol. Ther. pmid:15963078
Laharie D and Poullenot F Letter: which patient profile for tacrolimus in ulcerative colitis? 2016 Aliment. Pharmacol. Ther. pmid:27137730
Lawrance IC and Copeland TS Rectal tacrolimus in the treatment of resistant ulcerative proctitis. 2008 Aliment. Pharmacol. Ther. pmid:18761706
Liberal R et al. Expert clinical management of autoimmune hepatitis in the real world. 2017 Aliment. Pharmacol. Ther. pmid:28004405
Segal JP et al. Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. 2017 Aliment. Pharmacol. Ther. pmid:28008631
Yamamoto T et al. Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. 2016 Aliment. Pharmacol. Ther. pmid:27040167
Taylor KM and Sparrow MP Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. 2016 Aliment. Pharmacol. Ther. pmid:27040166
Haagsma EB et al. Inflammatory bowel disease after liver transplantation: the effect of different immunosuppressive regimens. 2003 Aliment. Pharmacol. Ther. pmid:12848624
Nakase H et al. Cytomegalovirus affects clinical outcome of infliximab in ulcerative colitis refractory to tacrolimus. 2010 Aliment. Pharmacol. Ther. pmid:20636704
Ortiz de Frutos FJ [New horizons in the treatment of atopic dermatitis]. Allergol Immunopathol (Madr) pmid:11988144
Mori F et al. Increase of natural killer cells in children with liver transplantation-acquired food allergy. Allergol Immunopathol (Madr) pmid:29456038
Regueiro-García A et al. Haploidentical stem cell transplantation in a boy with chronic granulomatous disease. Allergol Immunopathol (Madr) pmid:29373243
Inoue Y et al. Food allergy after cord blood stem cell transplantation with tacrolimus therapy in two patients who developed veno-occlusive disease. 2012 Allergol Int pmid:22722810
Tsuji T et al. Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. 2016 Allergol Int pmid:26666476
Miyachi Y et al. Suplatast/tacrolimus combination therapy for refractory facial erythema in adult patients with atopic dermatitis: a meta-analysis study. 2007 Allergol Int pmid:17582208
Ebihara N et al. Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension. 2012 Allergol Int pmid:22361511
Yamamoto M et al. A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice. 2007 Allergol Int pmid:17460441
Wollenberg A et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. 2008 Allergy pmid:18445188
Jensen JM et al. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis. 2012 Allergy pmid:22142306
Bieber T et al. Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis. 2007 Allergy pmid:17298428
Wollenberg A et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. 2008 Allergy pmid:18592619
Bergstrand H and Lundquist B Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. 1992 Allergy pmid:1280915
Kaufmann R et al. Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. 2006 Allergy pmid:16436149
Oldhoff JM et al. Modulation of the atopy patch test: tacrolimus 0.1% compared with triamcinolone acetonide 0.1%. 2006 Allergy pmid:16629794
Simon D et al. Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment. 2005 Allergy pmid:15932386
Leonardi S et al. Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. 2006 Nov-Dec Allergy Asthma Proc pmid:17176789
Pacor ML et al. Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis. 2006 Nov-Dec Allergy Asthma Proc pmid:17176790
Rico MJ and Lawrence I Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. 2002 May-Jun Allergy Asthma Proc pmid:12125507
Szema AM Angioedema in a child with a liver transplant, intussusception, and normal c4 levels. 2010 Jul-Aug Allergy Asthma Proc pmid:20615276
Kay AB Immunosuppressive agents in chronic severe asthma. 1994 May-Jun Allergy Proc pmid:7523242
Wilhelmi E et al. Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. 2002 May-Jun Altern Lab Anim pmid:12106005
Mcauliffe EP Is tacrolimus the best therapy for atopic dermatitis? 2003 Am Fam Physician pmid:12751651
Lane JE and Johnson J Persistent penile patch. 2008 Am Fam Physician pmid:19007056
Russell JJ Topical tacrolimus: a new therapy for atopic dermatitis. 2002 Am Fam Physician pmid:12469964
Berke R et al. Atopic dermatitis: an overview. 2012 Am Fam Physician pmid:22962911
Hitzeman N and Kinnevey C Topical Tacrolimus for Eczema. 2016 Am Fam Physician pmid:27929217
Baran DA et al. Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. 2004 Am J Cardiovasc Drugs pmid:14967063
Ramirez R et al. Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. 2017 Am J Case Rep pmid:28465499
Kawamura H et al. Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. 2017 Am J Case Rep pmid:28411286
Udomkarnjananun S et al. An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. 2018 Am J Case Rep pmid:29654227
Cheer SM and Plosker GL Tacrolimus ointment. A review of its therapeutic potential as a topical therapy in atopic dermatitis. 2001 Am J Clin Dermatol pmid:11770393
Iskedjian M et al. Topical calcineurin inhibitors in the treatment of atopic dermatitis: a meta-analysis of current evidence. 2004 Am J Clin Dermatol pmid:15301573
Tjioe M et al. Topical macrolide immunomodulators: a role in the treatment of vitiligo? 2006 Am J Clin Dermatol pmid:16489839