Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid:8615615 | ||||
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Soda M et al. | Association Between Tacrolimus Pharmacokinetics and Cytochrome P450 3A5 and Multidrug Resistance Protein 1 Exon 21 Polymorphisms. | Transplant. Proc. | pmid:28736028 | |
Mac Guad R et al. | Effects of CYP3A5 Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:26915847 | |
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pmid:19200227 | ||||
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Wei KC and Lai PC | Combination of everolimus and tacrolimus: a potentially effective regimen for recalcitrant psoriasis. | Dermatol Ther | pmid:25285355 | |
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Park J et al. | Persistent generalized lichen nitidus successfully treated with 0.03% tacrolimus ointment. | Eur J Dermatol | pmid:24184632 | |
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Menéndez Valladares P et al. | [Increased lipoprotein(a) in a paediatric patient associated with nephrotic syndrome]. | Clin Investig Arterioscler | pmid:27623226 | |
Yang A and Wang B | Sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids: focus on acute rejection, patient and graft survival. | Am J Ther | pmid:23921809 | |
Mackesy MM et al. | Immunosuppressant-induced acneiform eruption of the breast. | Breast J | pmid:25229395 | |
Pan W et al. | Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery. | Int J Nanomedicine | pmid:27578973 | |
Errichetti E et al. | Annular elastolytic giant cell granuloma treated with topical pimecrolimus. | Indian J Dermatol Venereol Leprol | pmid:25201861 | |
Sathyan S et al. | Prevention of recurrent episodes of rhabdomyolysis with tacrolimus in a transplant recipient with myopathy. | Am J Ther | pmid:23429166 | |
Huang CT et al. | Higher Variability of Tacrolimus Trough Level Increases Risk of Acute Rejection in Kidney Transplant Recipients. | Transplant. Proc. | pmid:27569931 | |
Ge J et al. | Impact of FOXP3 Polymorphisms on the Blood Level of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:27569929 | |
Yigitaslan S et al. | The Effect of P-Glycoprotein Inhibition and Activation on the Absorption and Serum Levels of Cyclosporine and Tacrolimus in Rats. | Adv Clin Exp Med | pmid:27627555 | |
Kathuria S et al. | Segmental vitiligo: a randomized controlled trial to evaluate efficacy and safety of 0.1% tacrolimus ointment vs 0.05% fluticasone propionate cream. | Indian J Dermatol Venereol Leprol | pmid:22199063 | |
Hirohata A et al. | Oral tacrolimus for the treatment of generalized morphea. | Eur J Dermatol | pmid:26679400 | |
Ortiz de Frutos FJ | [New horizons in the treatment of atopic dermatitis]. | Allergol Immunopathol (Madr) | pmid:11988144 | |
Gómez-Sánchez ME et al. | Intralymphatic Histiocytosis: A Report of 2 Cases. | Actas Dermosifiliogr | pmid:28256202 | |
López-Oliva MO et al. | Switch to belatacept in kidney graft recipients. | Nefrologia | pmid:28233569 | |
Jefferson J et al. | Follicular Mucinosis in a Male Adolescent with a History of Acute Myelogenous Leukemia and Graft-versus-Host Disease. | Pediatr Dermatol | pmid:26645410 | |
Sarvary E et al. | De novo Prograf versus de novo Advagraf: are trough level profile curves similar? | Transplant. Proc. | pmid:25131131 | |
Borda B et al. | Early histopathological changes in new-onset diabetes after kidney transplantation. | Transplant. Proc. | pmid:25131129 | |
Porubsky M et al. | Excellent outcomes can be achieved in young pancreas transplant alone recipients by addition of sirolimus to maintenance immunosuppression regimen. | Transplant. Proc. | pmid:25131074 | |
Lasa J and Olivera P | EFFICACY OF TACROLIMUS FOR INDUCTION OF REMISSION IN PATIENTS WITH MODERATE-TO-SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS. | Arq Gastroenterol | pmid:28327826 | |
Tulaci KG et al. | The effect of tacrolimus on facial nerve injury: Histopathological findings in a rabbit model. | Am J Otolaryngol | pmid:27465503 | |
Liu JY et al. | Tacrolimus Versus Cyclosporine as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. | Am J Ther | pmid:25299636 | |
Cakici O et al. | Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus. | An Bras Dermatol | pmid:28300917 | |
pmid:9123014 | ||||
Lima RS et al. | Granuloma faciale: a good therapeutic response with the use of topical tacrolimus. | An Bras Dermatol | pmid:26560220 | |
Alokaily F et al. | Takayasu's arteritis and liver transplantation: Association and implications. | Saudi J Gastroenterol | pmid:26458863 | |
Haroon N et al. | Tacrolimus Toxicity With Minimal Clinical Manifestations: A Case Report and Literature Review. | Am J Ther | pmid:25730156 | |
Krzyżowska K et al. | No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients. | Transplant. Proc. | pmid:30056895 | |
Zmonarski S et al. | Expression of PBMC TLR4 in Renal Graft Recipients Who Experienced Delayed Graft Function Reflects Dynamic Balance Between Blood and Tissue Compartments and Helps Select a Problematic Patient. | Transplant. Proc. | pmid:30056893 | |
Kubiça TF et al. | Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates. | Braz J Infect Dis | pmid:27697432 | |
Zulim LFDC et al. | Comparison of the efficacy of 0.03% tacrolimus eye drops diluted in olive oil and linseed oil for the treatment of keratoconjunctivitis sicca in dogs. | Arq Bras Oftalmol | pmid:29995121 | |
Kim K et al. | Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104132 | |
Yamamoto T et al. | Efficacy of Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome Recurrence and Antibody-Mediated Rejection Progress After Renal Transplantation With Preformed Donor-Specific Antibodies: Case Report. | Transplant. Proc. | pmid:28104125 | |
Dogra PM et al. | Tacrolimus for treatment of toxic epidermal necrolysis. | Indian J Dermatol Venereol Leprol | pmid:26515857 | |
pmid:11334064 | ||||
Park JS et al. | Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells. | Int J Immunopathol Pharmacol | pmid:29873267 | |
Ülkümen PK et al. | Annular lichenoid dermatitis of youth in a 15-year-old boy: Topical tacrolimus as a treatment option. | Indian J Dermatol Venereol Leprol | pmid:27279324 | |
pmid:10773614 | ||||
Takahashi Y et al. | Pharmacokinetic Profile of Twice- and Once-daily Tacrolimus in Pediatric Kidney Transplant Recipients. | Transplant. Proc. | pmid:28104153 | |
Shi Y et al. | Comparison of Mizoribine and Mycophenolate Mofetil With a Tacrolimus-Based Immunosuppressive Regimen in Living-Donor Kidney Transplantation Recipients: A Retrospective Study in China. | Transplant. Proc. | pmid:28104150 | |
Pan D et al. | Tacrolimus-associated Diffuse Gastrointestinal Ulcerations and Pathergy: A Case Report. | Transplant. Proc. | pmid:28104141 | |
Ash MM and Jolly PS | A Case Report of the Resolution of Multiple Recalcitrant Verrucae in a Renal Transplant Recipient After a Mycophenolate Mofetil Dose Reduction. | Transplant. Proc. | pmid:28104140 | |
Nayeri A et al. | Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. | Transplant. Proc. | pmid:28104136 | |
Tahir W et al. | Diffuse Alveolar haemorrhage: a fatal complication after alemtuzumab induction therapy in renal transplantation. | Transplant. Proc. | pmid:25645795 | |
Dedhia P et al. | Eculizumab and Belatacept for De Novo Atypical Hemolytic Uremic Syndrome Associated With CFHR3-CFHR1 Deletion in a Kidney Transplant Recipient: A Case Report. | Transplant. Proc. | pmid:28104134 | |
Jiménez-Pérez M et al. | Everolimus plus mycophenolate mofetil as initial immunosuppression in liver transplantation. | Transplant. Proc. | pmid:25645779 | |
Zhang J et al. | Chemotherapy for De Novo Gastric Adenocarcinoma After Deceased Orthotopic Liver Transplantation: A Case Report. | Transplant. Proc. | pmid:28104131 | |
Polanco N et al. | Everolimus-based immunosuppression therapy for BK virus nephropathy. | Transplant. Proc. | pmid:25645770 | |
Britto-Williams P and Pansare M | Management of chronic idiopathic urticaria in childhood: are we on the same page? | J Allergy Clin Immunol Pract | pmid:24565627 | |
Nunokawa T et al. | Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report. | Am J Ther | pmid:22836123 | |
Nojima M et al. | Immunosuppression Modification by Everolimus With Minimization of Calcineurin Inhibitors Recovers Kidney Graft Function Even in Patients With Very Late Conversion and Also With Poor Graft Function. | Transplant. Proc. | pmid:28104155 | |
Paul GM et al. | Qualitative analysis of the deposit of collagen in bladder suture of rats treated with tacrolimus combined with mycophenolate-mofetil. | Int Braz J Urol | pmid:24856494 | |
Ishida S et al. | Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104127 | |
López-Vilella R et al. | Incidence of development of obesity after heart transplantation according to the calcineurin inhibitor. | Transplant. Proc. | pmid:25645789 | |
pmid:8986461 | ||||
Forns X et al. | Efficacy of telaprevir-based therapy in stable liver transplant patients with chronic genotype 1 hepatitis C. | Ann Hepatol | pmid:27236150 | |
Tinoco R et al. | [A case of de novo inflammatory bowel disease after liver transplantation for cryptogenic cirrhosis]. | Gastroenterol Hepatol | pmid:26321322 | |
Ito T et al. | Therapeutic Effect of Sirolimus for Lymphangioleiomyomatosis Remaining in the Abdominopelvic Region After Lung Transplantation: A Case Report. | Transplant. Proc. | pmid:26915883 | |
Liu JY et al. | Sirolimus Versus Tacrolimus as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. | Am J Ther | pmid:25569597 | |
Norero B et al. | Â Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key. | Ann Hepatol | pmid:28051798 | |
Hirata Y et al. | Antibody Drug Treatment for Steroid-Resistant Rejection After Pediatric Living Donor Liver Transplantation: A Single-Center Experience. | Transplant. Proc. | pmid:29407332 | |
Back JH et al. | Antiproteinuric Effects of Green Tea Extract on Tacrolimus-Induced Nephrotoxicity in Mice. | Transplant. Proc. | pmid:26293093 | |
Shingaki S et al. | Graft-versus-host Disease-free, Relapse-free Survival After HLA-identical Sibling Peripheral Blood Stem Cell Transplantation With Tacrolimus-based Graft-versus-host Disease Prophylaxis in Japanese Patients. | Transplant. Proc. | pmid:29407317 | |
Kim SH et al. | Outcomes of Early Conversion From Prograf to Generic Tacrolimus in Adult Living Donor Liver Transplant Recipients. | Transplant. Proc. | pmid:26293073 | |
Manzia TM et al. | Ab initio Everolimus-based Versus Standard Calcineurin Inhibitor Immunosuppression Regimen in Liver Transplant Recipients. | Transplant. Proc. | pmid:29407305 | |
Falconer SJ et al. | Early or Late Conversion From Tac-BD to Tac-BD in Renal Transplantation: When is the Right Time? | Transplant. Proc. | pmid:26293044 | |
Clark K et al. | Oxidative Stress Induces Disruption of the Axon Initial Segment. | ASN Neuro | pmid:29228786 | |
Dall'Agnol DJ et al. | Effects of immunosuppressive drugs on gastrointestinal transit of rats: effects of tacrolimus, cyclosporine, and prednisone. | Transplant. Proc. | pmid:25131057 | |
Byun JW et al. | A successful helium-neon laser and topical tacrolimus combination therapy in one child with vitiligo. | Dermatol Ther | pmid:26278617 | |
Mori F et al. | Increase of natural killer cells in children with liver transplantation-acquired food allergy. | Allergol Immunopathol (Madr) | pmid:29456038 | |
Hoverson K et al. | Dermestid Dermatitis in a 2-Year-Old Girl: Case Report and Review of the Literature. | Pediatr Dermatol | pmid:26250481 | |
pmid:28590598 | ||||
Torres A et al. | Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study). | Nefrologia | pmid:27133898 | |
pmid:28422431 | ||||
Yousuf Bhat Z et al. | Colchicine-Induced Myopathy in a Tacrolimus-Treated Renal Transplant Recipient: Case Report and Literature Review. | Am J Ther | pmid:24732905 | |
pmid:11111152 | ||||
Regueiro-GarcÃa A et al. | Haploidentical stem cell transplantation in a boy with chronic granulomatous disease. | Allergol Immunopathol (Madr) | pmid:29373243 | |
Lythgoe M and Abraham S | Tacrolimus: an effective treatment in refractory psoriatic arthritis following biologic failure. | Clin. Exp. Rheumatol. | pmid:26211753 | |
Leon L et al. | Successfull Simultaneous Pancreas Kidney transplantation in a patient with Congenital Partial Lipodystrophy. | Nefrologia | pmid:27006329 | |
Al-Amri AM et al. | Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. | Middle East Afr J Ophthalmol | pmid:26957853 |