Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mercuri A et al. | In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions. | 2016 | Int J Pharm | pmid:27737809 |
Ochi H et al. | Notalgia paresthetica: treatment with topical tacrolimus. | 2016 | J Eur Acad Dermatol Venereol | pmid:25388817 |
Chen YF et al. | Tacrolimus inhibits vasoconstriction by increasing Ca(2+) sparks in rat aorta. | 2016 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:26838733 |
Kravljaca M et al. | The importance of MDR1 gene polymorphisms for tacrolimus dosage. | 2016 | Eur J Pharm Sci | pmid:26705892 |
Herden U et al. | Early Initiation of Everolimus After Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:26842532 |
Early CR et al. | Effect of metronidazole use on tacrolimus concentrations in transplant patients treated for Clostridium difficile. | 2016 | Transpl Infect Dis | pmid:27501504 |
Chen Y et al. | Clinicopathological features and prognosis of Kimura's disease with renal involvement in Chinese patients. | 2016 | Clin. Nephrol. | pmid:27142199 |
Hermans C et al. | Atypical discrete papular lichen myxedematosus associated with monoclonal gammopathy: report of four cases and review of the literature. | 2016 | J Eur Acad Dermatol Venereol | pmid:27422288 |
Kato H et al. | Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27320564 |
Shin J et al. | Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. | 2016 | Skelet Muscle | pmid:26949511 |
Gambarino S et al. | Human Cytomegalovirus Impact on mir-146a Expression Levels in Kidney Transplant Patients. | 2016 | Viral Immunol. | pmid:27077822 |
Mettang T | Uremic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578082 |
Xie L et al. | Pretransplantation Risk Factors Associated With New-onset Diabetes After Living-donor Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27931572 |
Song GW et al. | A Pilot Study of the Pharmacokinetics of the Modified-Release Once-Daily Tacrolimus Formulation Administered to Living-Donor Liver Transplant Recipients. | 2016 | Exp Clin Transplant | pmid:26976646 |
Hu YN et al. | High-dose calcineurin inhibitor-free everolimus as a maintenance regimen for heart transplantation may be a risk factor for Pneumocystis pneumonia. | 2017 | Transpl Infect Dis | pmid:28425200 |
Epperla N et al. | Impact of treatment and outcomes for patients with posttransplant drug-associated thrombotic microangiopathy. | 2017 | Transfusion | pmid:28836275 |
Müller EG et al. | Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. | 2017 | Arq Bras Oftalmol | pmid:28832739 |
Nishimoto M et al. | Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. | 2017 | Br J Clin Pharmacol | pmid:28407449 |
Charlton M et al. | Everolimus Is Associated With Less Weight Gain Than Tacrolimus 2 Years After Liver Transplantation: Results of a Randomized Multicenter Study. | 2017 | Transplantation | pmid:28817434 |
Moura Penteado LA et al. | Evaluation of the effect of tacrolimus on periodontitis induced in rats. | 2017 | Arch. Oral Biol. | pmid:28399470 |
Ghaffari R et al. | Tacrolimus Eye Drops as Adjunct Therapy in Severe Corneal Endothelial Rejection Refractory to Corticosteroids. | 2017 | Cornea | pmid:28817391 |
Desai VCA et al. | Comparative Effectiveness of Tacrolimus-Based Steroid Sparing versus Steroid Maintenance Regimens in Kidney Transplantation: Results from Discrete Event Simulation. | 2017 | Med Decis Making | pmid:28384413 |
Huh KH et al. | De novo low-dose sirolimus versus mycophenolate mofetil in combination with extended-release tacrolimus in kidney transplant recipients: a multicentre, open-label, randomized, controlled, non-inferiority trial. | 2017 | Nephrol. Dial. Transplant. | pmid:28810721 |
Bao LQ et al. | Tacrolimus prevents murine cerebral malaria. | 2017 | Immunology | pmid:27546479 |
Sato K et al. | Early post-transplant hyperbilirubinemia is a possible predictive factor for developing neurological complications in pediatric living donor liver transplant patients receiving tacrolimus. | 2017 | Pediatr Transplant | pmid:27804185 |
van der Merwe Y et al. | An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat. | 2017 | EBioMedicine | pmid:29208469 |
Baluch A et al. | Successful management of Mycobacterium haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient. | 2017 | Transpl Infect Dis | pmid:27775824 |
Chakkera HA et al. | Calcineurin Inhibitors: Pharmacologic Mechanisms Impacting Both Insulin Resistance and Insulin Secretion Leading to Glucose Dysregulation and Diabetes Mellitus. | 2017 | Clin. Pharmacol. Ther. | pmid:27804122 |
Arns W et al. | Pharmacokinetics and Clinical Outcomes of Generic Tacrolimus (Hexal) Versus Branded Tacrolimus in De Novo Kidney Transplant Patients: A Multicenter, Randomized Trial. | 2017 | Transplantation | pmid:28658202 |
Taber DJ et al. | Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation. | 2017 | Transplantation | pmid:28658199 |
Cong M et al. | Novel oleyl amine-modified polymannuronic acid micelle loading tacrolimus for therapy of allergic conjunctivitis. | 2017 | Int. J. Biol. Macromol. | pmid:28655660 |
Suda M et al. | Effectiveness of multi-target therapy in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with early-stage interstitial lung disease. | 2017 | Scand. J. Rheumatol. | pmid:28649889 |
Li X et al. | Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. | 2017 | J. Am. Soc. Nephrol. | pmid:27807213 |
Agarwal SK et al. | Impact of type of calcineurin inhibitor on post-transplant tuberculosis: Single-center study from India. | 2017 | Transpl Infect Dis | pmid:27775825 |
Jin J et al. | Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats. | 2017 | Korean J. Intern. Med. | pmid:27688296 |
Zaza G et al. | Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen. | 2017 | PLoS ONE | pmid:28542523 |
Neustadtl AL et al. | Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. | 2017 | Neuroreport | pmid:28542068 |
Schulte K et al. | Late conversion from tacrolimus to a belatacept-based immuno-suppression regime in kidney transplant recipients improves renal function, acid-base derangement and mineral-bone metabolism. | 2017 | J. Nephrol. | pmid:28540602 |
Gouvêa ALF et al. | BK polyomavirus nephropathy in two kidney transplant patients with distinct diagnostic strategies for BK virus and similar clinical outcomes: two case reports. | 2017 | J Med Case Rep | pmid:28535782 |
DaSilva I et al. | Rituximab for Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome in Adults: A Retrospective, Multicenter Study in Spain. | 2017 | BioDrugs | pmid:28534103 |
Baron PW et al. | Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. | 2017 | Ann. Transplant. | pmid:28533501 |
Trasi NS et al. | Evaluation of the Crystallization Tendency of Commercially Available Amorphous Tacrolimus Formulations Exposed to Different Stress Conditions. | 2017 | Pharm. Res. | pmid:28687987 |
Torres IB et al. | Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants. | 2017 | Transpl. Int. | pmid:28667664 |
Miyamoto T et al. | Comparison of cyclosporine and tacrolimus combined with mycophenolate mofetil in prophylaxis for graft-versus-host disease after reduced-intensity umbilical cord blood transplantation. | 2017 | Int. J. Hematol. | pmid:27686673 |
Fai D et al. | Duration of response in vitiligo lesions after narrowband UVB phototherapy combined with tacrolimus ointment. | 2017 | G Ital Dermatol Venereol | pmid:28621124 |
Efe C et al. | Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis. | 2017 | Clin. Gastroenterol. Hepatol. | pmid:28603052 |
Liu G et al. | FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells. | 2017 | Cell. Mol. Neurobiol. | pmid:27572744 |
Shah SZA et al. | Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters. | 2017 | Neurotherapeutics | pmid:28083805 |
Kanate AS et al. | Recipient Immune Modulation with Atorvastatin for Acute Graft-versus-Host Disease Prophylaxis after Allogeneic Transplantation. | 2017 | Biol. Blood Marrow Transplant. | pmid:28412518 |
Nambu M et al. | A calcineurin antifungal strategy with analogs of FK506. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28412204 |
Kawamura H et al. | Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. | 2017 | Am J Case Rep | pmid:28411286 |
Sadati MS et al. | Recalcitrant cases of pyoderma gangrenosum, responding dramatically to systemic tacrolimus. | 2017 | G Ital Dermatol Venereol | pmid:28409579 |
Tang J et al. | Application of Machine-Learning Models to Predict Tacrolimus Stable Dose in Renal Transplant Recipients. | 2017 | Sci Rep | pmid:28176850 |
Ikebe T et al. | Hemophagocytic lymphohistiocytosis following influenza vaccination in a patient with aplastic anemia undergoing allogeneic bone marrow stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:28054244 |
Harada S et al. | Complete remission of angiolymphoid hyperplasia with eosinophilia using topical tacrolimus. | 2017 | Eur J Dermatol | pmid:28007668 |
Zheng X et al. | Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice. | 2017 | Eur. J. Oral Sci. | pmid:27935130 |
Ikeguchi R et al. | Recipient bone marrow-derived stromal cells prolong graft survival in a rat hind limb allotransplantation model. | 2017 | Microsurgery | pmid:27859595 |
Ito A et al. | Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3. | 2017 | Biochem. Genet. | pmid:28324194 |
Sauer R et al. | Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution. | 2017 | J. Neurol. Sci. | pmid:28320193 |
Hayashi Y et al. | Neuropathological findings from an autopsied case showing posterior reversible encephalopathy syndrome-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation. | 2017 | J. Neurol. Sci. | pmid:28320172 |
Sinha A et al. | Mycophenolate mofetil is inferior to tacrolimus in sustaining remission in children with idiopathic steroid-resistant nephrotic syndrome. | 2017 | Kidney Int. | pmid:28318625 |
Genvigir FDV et al. | Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients. | 2017 | Pharmacotherapy | pmid:28316087 |
Mertens JS et al. | Morphea and Eosinophilic Fasciitis: An Update. | 2017 | Am J Clin Dermatol | pmid:28303481 |
Xiang DM et al. | [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. | 2017 | Zhonghua Yan Ke Za Zhi | pmid:28412805 |
Lepelley M et al. | [Pharmacokinetic drug interaction between miconazole mucoadhesive tablet and tacrolimus: About 3Â case-reports in transplant patients]. | 2017 | Therapie | pmid:28214069 |
Saeki K et al. | Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. | 2017 | Am. J. Respir. Crit. Care Med. | pmid:28199133 |
Manocha GD et al. | Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. | 2017 | Mol Neurodegener | pmid:28196514 |
Sikma MA et al. | High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28132082 |
Ayar Y et al. | Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. | 2017 | Transplant. Proc. | pmid:28219583 |
Pengcheng W et al. | Validation of Donor-Specific Tolerance of Intestinal Transplant by a Secondary Heart Transplantation Model. | 2017 | Exp Clin Transplant | pmid:28122485 |
Keller F et al. | Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients
. | 2017 | Clin. Nephrol. | pmid:28025957 |
Kannegieter NM et al. | The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function. | 2017 | PLoS ONE | pmid:28122021 |
Sukma Dewi I et al. | Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. | 2017 | PLoS ONE | pmid:28125729 |
Ren L et al. | Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients. | 2017 | Pharmacogenomics | pmid:28084894 |
Zhu LB et al. | Efficacy and Safety of Tacrolimus Versus Cyclophosphamide for Primary Membranous Nephropathy: A Meta-Analysis. | 2017 | Drugs | pmid:28084563 |
TruneÄka P | Once-daily tacrolimus in liver transplantation: a 'me-too drug', or a therapeutic advantage. | 2017 | Curr Opin Organ Transplant | pmid:28079558 |
Riva N et al. | Adequate exposure to tacrolimus with sublingual administration in pediatric liver transplant patients. | 2017 | Int J Clin Pharmacol Ther | pmid:28079516 |
Ericson JE et al. | A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation. | 2017 | Ther Drug Monit | pmid:28081041 |
Li R et al. | Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis. | 2017 | Photodermatol Photoimmunol Photomed | pmid:27696531 |
Billing H et al. | Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial. | 2017 | Ther Drug Monit | pmid:28030534 |
Rozen-Zvi B et al. | Association of the combination of time-weighted variability of tacrolimus blood level and exposure to low drug levels with graft survival after kidney transplantation. | 2017 | Nephrol. Dial. Transplant. | pmid:28025383 |
Miyazaki D et al. | Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases. | 2017 | Ophthalmology | pmid:28017421 |
Müller F et al. | Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. | 2017 | Eur J Pharm Biopharm | pmid:28012989 |
Ordóñez-Robles M et al. | Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28983826 |
Qi JC et al. | Tacrolimus protects vascular endothelial cells from injuries caused by Ox-LDL by regulating endoplasmic reticulum stress. | 2017 | Eur Rev Med Pharmacol Sci | pmid:28975964 |
Kitazawa F et al. | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. | 2017 | Ann. Transplant. | pmid:28947731 |
Dabrowska-Zamojcin E et al. | KCNJ11 and KCNQ1 Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus. | 2017 | Folia Biol. (Praha) | pmid:28805561 |
Hirano Y et al. | Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. | 2017 | Ann. Transplant. | pmid:28798289 |
De Majumdar S et al. | A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis. | 2017 | Curr. Mol. Med. | pmid:28782485 |
Kim MJ et al. | The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis. | 2017 | J. Korean Med. Sci. | pmid:28776347 |
Kaneko T et al. | Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility. | 2017 | J Nippon Med Sch | pmid:29279557 |
Mussin N et al. | Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. | 2017 | J. Korean Med. Sci. | pmid:28776332 |
Higashi H et al. | First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. | 2017 | World J. Gastroenterol. | pmid:28210092 |
Yu MY et al. | Short-term anti-proteinuric effect of tacrolimus is not related to preservation of the glomerular filtration rate in IgA nephropathy: A 5-year follow-up study. | 2017 | PLoS ONE | pmid:29155873 |
Alloway RR et al. | Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. | 2017 | PLoS Med. | pmid:29135993 |
Singh AR et al. | Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study. | 2017 | J Laryngol Otol | pmid:27917729 |
Furukawa T et al. | A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis. | 2017 | Rinsho Shinkeigaku | pmid:28132975 |
Veenhof H et al. | Clinical Validation of Simultaneous Analysis of Tacrolimus, Cyclosporine A, and Creatinine in Dried Blood Spots in Kidney Transplant Patients. | 2017 | Transplantation | pmid:27906832 |
Tourret J et al. | Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli. | 2017 | Transplantation | pmid:27681266 |
Larche M and McGonagle D | A case of resistant spondyloarthritis (SpA) that responded to tacrolimus and mycophenolate treatment initiated at the time of renal transplantation for unrelated renal failure. | 2017 | Scand. J. Rheumatol. | pmid:26971928 |