Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hanafusa T et al. | Long-term impact of hepatitis virus infection on kidney transplant recipients and a pilot study of the effects of interferon alpha on chronic hepatitis C. | 1995 | Transplant. Proc. | pmid:7533440 |
Bundick RV et al. | The effect of cyclosporin A, FK506, and rapamycin on the murine chronic graft-versus-host response--an in vivo model of Th2-like activity. | 1995 | Clin. Exp. Immunol. | pmid:7533681 |
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Tumlin JA et al. | Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. | 1995 | Am. J. Physiol. | pmid:7485542 |
Furukawa F et al. | FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice. | 1995 | Arch. Dermatol. Res. | pmid:7487142 |
Marumo T et al. | Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. | 1995 | Hypertension | pmid:7536714 |
Lapa e Silva JR et al. | Modulation of the bronchial inflammation in sensitized guinea-pigs by FK506, nedocromil sodium and dexamethasone. | 1995 | Eur. Respir. J. | pmid:7489798 |
Schwaninger M et al. | Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. | 1995 | J. Biol. Chem. | pmid:7536740 |
Shackleton CR et al. | Lack of correlation between the magnitude of preservation injury and the incidence of acute rejection, need for OKT3, and conversion to FK506 in cyclosporine-treated primary liver allograft recipients. | 1995 | Transplantation | pmid:7570950 |
Min Z and Jones NF | Limb transplantation in rats: immunosuppression with FK-506. | 1995 | J Hand Surg Am | pmid:7536766 |
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Lyons WE et al. | Neuronal regeneration enhances the expression of the immunophilin FKBP-12. | 1995 | J. Neurosci. | pmid:7536825 |
Thomson AW and Bonham CA | Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV infection. | 1995 | Adv. Exp. Med. Biol. | pmid:7572394 |
Wortis HH et al. | B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7536930 |
Paterson JM et al. | Control of a novel adenylyl cyclase by calcineurin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575502 |
Bang H et al. | Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7536932 |
Masaki Y et al. | Cellular basis of acquired immunologic tolerance following total bowel transplantation in rats. I. Relation between donor lymphocyte chimerism and host-cell-mediated immunity. | 1995 | Transplant. Proc. | pmid:7536971 |
Masaki Y et al. | Cellular basis of immunologic tolerance following total bowel transplantation in rats. II. Dominant role of suppressor T cells in adoptive transfer of acquired tolerance to vascularized allografts. | 1995 | Transplant. Proc. | pmid:7536972 |
Kaufman DB et al. | The successful use of tacrolimus (FK506) in a pancreas/kidney transplant recipient with recurrent cyclosporine-associated hemolytic uremic syndrome. | 1995 | Transplantation | pmid:7541579 |
McDiarmid SV et al. | The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7541834 |
Dix SP et al. | Re: Severe interaction between methotrexate and a macrolide-like antibiotic. | 1995 | J. Natl. Cancer Inst. | pmid:7563209 |
Kawasaki M et al. | [Immunosuppression and the problems in partial liver transplantation]. | 1995 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:8963785 |
Teraoka S et al. | [Present status and problems in clinical application of tacrolimus(FK506)]. | 1995 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:8963787 |
Kanda T et al. | Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7542339 |
Canzanello VJ et al. | Renal sodium handling with cyclosporin A and FK506 after orthotopic liver transplantation. | 1995 | J. Am. Soc. Nephrol. | pmid:7542491 |
Garrett-Engele P et al. | Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. | 1995 | Mol. Cell. Biol. | pmid:7542741 |
Baughman G et al. | FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. | 1995 | Mol. Cell. Biol. | pmid:7542743 |
Columbo M et al. | Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins. | 1995 | J. Immunol. | pmid:7538541 |
Pearlman DA and Connelly PR | Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. | 1995 | J. Mol. Biol. | pmid:7538591 |
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Freeman DJ et al. | Stability of FK 506 in whole blood samples. | 1995 | Ther Drug Monit | pmid:7542810 |
Strumph P et al. | The effect of FK506 on glycemic response as assessed by the hyperglycemic clamp technique. | 1995 | Transplantation | pmid:7542815 |
Dumont FJ et al. | Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. | 1995 | Cell. Immunol. | pmid:7538911 |
Theopold U et al. | FKBP39, a Drosophila member of a family of proteins that bind the immunosuppressive drug FK506. | 1995 | Gene | pmid:7538962 |
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Bronsther O et al. | Liver transplantation for HBV-related disease under immunosuppression with tacrolimus: an experience with 78 consecutive cases. | 1995 | J Okla State Med Assoc | pmid:7539077 |
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Hoshino H et al. | Effects of FK506 on an experimental model of colitis in rats. | 1995 | Aliment. Pharmacol. Ther. | pmid:7544633 |
Mori A et al. | IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. | 1995 | Int. Immunol. | pmid:7540862 |
Firdaous I et al. | HPLC-microparticle enzyme immunoassay specific for tacrolimus in whole blood of hepatic and renal transplant patients. | 1995 | Clin. Chem. | pmid:7544705 |
Tashiro H et al. | Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. | 1995 | Cell Transplant | pmid:7540919 |
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Hikita N et al. | Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat. | 1995 | Curr. Eye Res. | pmid:7540967 |
Takizawa H et al. | Activated immunocompetent cells in rat colitis mucosa induced by dextran sulfate sodium and not complete but partial suppression of colitis by FK506. | 1995 | Digestion | pmid:7544748 |
Cardenas ME et al. | Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. | 1995 | EMBO J. | pmid:7540976 |
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Madsen KL et al. | FK506 increases permeability in rat intestine by inhibiting mitochondrial function. | 1995 | Gastroenterology | pmid:7540994 |
Yang WM et al. | Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity. | 1995 | J. Biol. Chem. | pmid:7541038 |
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Lauerma AI | Immunomodulation of contact dermatitis. | 1995 | Curr. Probl. Dermatol. | pmid:7587333 |
Cardenas ME et al. | Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. | 1995 | Curr. Opin. Nephrol. Hypertens. | pmid:8591053 |
Wera S et al. | Cyclosporin A, rapamycin and FK506 decrease prolactin release from rat pituitary cells in primary culture. | 1995 | Endocr. Res. | pmid:7588431 |
Cameron AM et al. | Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. | 1995 | Cell | pmid:8521476 |
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Farcasanu IC et al. | Protein phosphatase 2B of Saccharomyces cerevisiae is required for tolerance to manganese, in blocking the entry of ions into the cells. | 1995 | Eur. J. Biochem. | pmid:7588708 |
Mugiya S et al. | Renal blood flow, fibrinolysis, and platelet aggregation following tacrolimus (FK 506) treatment in rats. | 1995 | Thromb. Res. | pmid:8533130 |
Stemmer PM et al. | Factors responsible for the Ca(2+)-dependent inactivation of calcineurin in brain. | 1995 | FEBS Lett. | pmid:7589543 |
Kaplan A et al. | The effects of cyclosporin A and FK506 on proliferation and IL-8 production of cultured human keratinocytes. | 1995 | J. Dermatol. Sci. | pmid:8534611 |
Hadad SJ et al. | FK 506: effects on glomerular hemodynamics and on mesangial cells in culture. | 1995 | Kidney Int. | pmid:7564092 |
Zhu X et al. | Enhancing and suppressive effects of immunosuppressants cyclosporin A, FK506, and KM2210 on the colony formation of murine bone marrow cells. | 1995 | Ann. Hematol. | pmid:8534762 |
Ockenfels HM et al. | Tyrosine phosphorylation in psoriatic T cells is modulated by drugs that induce or improve psoriasis. | 1995 | Dermatology (Basel) | pmid:8534940 |
Orengo CA et al. | Structural similarity between the pleckstrin homology domain and verotoxin: the problem of measuring and evaluating structural similarity. | 1995 | Protein Sci. | pmid:8535234 |
Vilquin JT et al. | FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. | 1995 | Hum. Gene Ther. | pmid:8573612 |
Sano T et al. | FK506 and cyclosporin A inhibit granulocyte/macrophage colony-stimulating factor production by mononuclear cells in asthma. | 1995 | Eur. Respir. J. | pmid:8575571 |