tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gaweco AS et al. | Distinct intragraft cytokine gene expression patterns during acute hepatic rejection under cyclosporine versus FK 506 primary immunosuppression. | 1994 | Transplant. Proc. | pmid:7527948 |
| Mathieu C et al. | Potential role of 1,25(OH)2 vitamin D3 as a dose-reducing agent for cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7527950 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Valdivia LA et al. | Hamster-to-rat liver xenografts protect extrahepatic organs from rejection. | 1993 | Transplant. Proc. | pmid:7679816 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Yasunami Y et al. | Acceptance of donor-specific islet allografts in rat by intraportal preimmunization with islets and FK 506. | 1994 | Transplant. Proc. | pmid:7513467 |
| Meier-Kriesche HU and Kaplan B | Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared to Sandimmune. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750465 |
| Murase N et al. | Effect of FK 506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat. | 1993 | Transplant. Proc. | pmid:7679817 |
| Ueki M et al. | Functional and morphologic characterization of renal subcapsular islet isografts in rats treated with FK 506. | 1994 | Transplant. Proc. | pmid:7513469 |
| Loinaz C et al. | A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 randomized liver transplant recipients: midterm efficacy and safety. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750472 |
| Alejandro R et al. | Combined liver-islet allotransplantation in man under FK 506. | 1991 | Transplant. Proc. | pmid:1703712 |
| Ito T et al. | The mechanism of tolerance induced by a perioperative injection of bone marrow cells and a brief course of FK 506. | 1991 | Transplant. Proc. | pmid:1703716 |
| Rostaing L et al. | Early posttransplantation renal hemodynamics in FK 506-treated kidney recipients with or without prior induction therapy. | 1998 | Transplant. Proc. | pmid:9636519 |
| Braun F et al. | Primary tacrolimus immunosuppression in kidney recipients considered "higher immunological risk". | 2000 | Transplant. Proc. | pmid:11119893 |
| Kamińska D et al. | Significant infections after hand transplantation in a Polish population. | 2014 | Transplant. Proc. | pmid:25380943 |
| Marin-Gomez LM et al. | Evaluation of clinical safety of conversion to Advagraf therapy in liver transplant recipients: observational study. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715867 |
| Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
| Shoji T et al. | Long-term acceptance of porcine pulmonary allografts without chronic rejection. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808551 |
| Ortiz de Urbina J et al. | Advagraf de novo in liver transplantation: a single-center experience. | 2011 | Transplant. Proc. | pmid:21486583 |
| Qu W et al. | Correlation Between Immunosuppressive Therapy and CD4(+) T-Cell Intracellular Adenosine Triphosphate Levels in Liver Transplant Recipients. | Transplant. Proc. | pmid:27569951 | |
| Francavilla A et al. | FK 506 as a growth control factor. | 1990 | Transplant. Proc. | pmid:1689912 |
| Todo S et al. | Intestinal transplantation in humans under FK 506. | 1993 | Transplant. Proc. | pmid:7680148 |
| Habucky K et al. | The pharmacodynamics of pentobarbital following FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721282 |
| Fujikawa K et al. | Effects of tacrolimus on rat thymic epithelial cells. | 2000 | Transplant. Proc. | pmid:11120046 |
| Sung RS et al. | Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats. | 1996 | Transplant. Proc. | pmid:8623427 |
| Steinmueller T et al. | Effect of CsA versus FK 506 on insulin sensitivity and insulin response using a modeling technique. | 1998 | Transplant. Proc. | pmid:9636589 |
| Miura S et al. | The beneficial effects of FK 506 on living-related renal transplantation in presensitized recipients. | 1999 | Transplant. Proc. | pmid:10455940 |
| Hossain MA et al. | Effect of the immunosuppressants FK506 and D-allose on allogenic orthotopic liver transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120048 |
| Jordan ML et al. | Tacrolimus-based immunosuppression in pediatric renal transplantation. | 1999 | Transplant. Proc. | pmid:10576039 |
| Kliem V et al. | Conversion to tacrolimus for acute corticosteroid- and antibody-resistant rejection following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576041 |
| Gonzalez-Molina M et al. | Mycophenolate mofetil and tacrolimus reduce mortality after deceased donor kidney transplantation. | 2012 | Transplant. Proc. | pmid:23146459 |
| Nakamuta M et al. | Cyclosporine suppresses cell growth and collagen production in hepatic stellate cells. | 2005 | Transplant. Proc. | pmid:16387179 |
| Kim HC et al. | Primary immunosuppression with tacrolimus in kidney transplantation: three-year follow-up in a single center. | 2004 | Transplant. Proc. | pmid:15518753 |
| Yeung S et al. | Primary immunosuppression with tacrolimus and low-dose mycophenolate mofetil in renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518754 |
| Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
| Miyazawa H et al. | Mechanisms of hamster kidney graft rejection in the rat. | 1994 | Transplant. Proc. | pmid:7518111 |
| Propper DJ et al. | Low-dose FK 506 inhibits sensitisation after blood transfusions. | 1990 | Transplant. Proc. | pmid:1697114 |
| Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
| Morozumi K et al. | Diagnosis of chronic rejection using peritubular and glomerular capillary lesions. | 1996 | Transplant. Proc. | pmid:8644331 |
| McCarthy SA et al. | Effects of FK 506 and cyclosporine on T-cell tolerance: inhibition of a "protective" mechanism that regulates activation-induced apoptosis in developing thymocytes. | 1991 | Transplant. Proc. | pmid:1721314 |
| Curro G et al. | Transient ischemic attack after rizatriptan administration in a liver transplant recipient: a case report. | 2006 | Transplant. Proc. | pmid:17112920 |
| Uchida H et al. | Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. | 1999 | Transplant. Proc. | pmid:10578297 |
| Jin KB et al. | The production of reactive oxygen species in tacrolimus-treated glial cells. | 2008 | Transplant. Proc. | pmid:18929834 |
| Yang YJ et al. | Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. | 2008 | Transplant. Proc. | pmid:18589147 |
| Jain A et al. | Steroid withdrawal under tacrolimus for primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis after liver transplantation and long-term survival. | 2002 | Transplant. Proc. | pmid:12176467 |
| Lladó L et al. | Prospective study of a tacrolimus-based quadruple immunosuppressive regimen: evaluation of safety and efficacy. | 2002 | Transplant. Proc. | pmid:12176468 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Brunet M et al. | Therapeutic drug monitoring of tacrolimus in kidney transplantation: 9-month follow-up. | 1998 | Transplant. Proc. | pmid:9865298 |
| Nakazato P et al. | Early experience with FK 506 induction immunosuppression--suggestion for using oral FK 506. | 1991 | Transplant. Proc. | pmid:1721345 |
| Fleck PR et al. | Tacrolimus use in kidney-pancreas recipients is associated with less acute renal dysfunction than cyclosporine. | 1998 | Transplant. Proc. | pmid:9865299 |
| Nakamura K et al. | The lymphocytotoxic crossmatch in liver transplantation: a clinicopathologic analysis. | 1991 | Transplant. Proc. | pmid:1721346 |
| Krämer BK et al. | Cardiovascular risk estimates and risk factors in renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919488 |
| Velio P et al. | Combined orthotopic liver-small bowel transplantation or small bowel transplantation in pigs: relations between survival, rejection, and mucosal morphometry. | 1997 | Transplant. Proc. | pmid:9142295 |
| Regazzi MB et al. | Pharmacokinetics of FK506 and mycophenolic acid in experimental and clinical intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142302 |
| Moro JA et al. | Randomized prospective study of the evolution of renal function depending on the anticalcineurin used. | 2008 | Transplant. Proc. | pmid:19010143 |
| Fukuhara N et al. | Long-term outcome of tacrolimus in cadaveric kidney transplantation from non-heart-beating donors. | 2002 | Transplant. Proc. | pmid:12176492 |
| Gruttadauria S et al. | Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182762 |
| Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
| Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
| Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
| Perico N et al. | FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat. | 1991 | Transplant. Proc. | pmid:1721378 |
| Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
| Mueller AR et al. | Is the use of marginal liver grafts justified? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083160 |
| Miki T et al. | Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation. | 2000 | Transplant. Proc. | pmid:10936339 |
| Zipperle S et al. | Impaired T-cell IL-10 secretion and CD4 helper function in liver transplant patients treated with tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123208 |
| Nishioka T et al. | Arterial stiffness after successful renal transplantation. | 2008 | Transplant. Proc. | pmid:18790249 |
| Sola E et al. | Low-dose and rapid steroid withdrawal in renal transplant patients treated with tacrolimus and mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12176537 |
| Chien YS et al. | Incidence and risk factors of new-onset diabetes mellitus after renal transplantation. | 2008 | Transplant. Proc. | pmid:18790250 |
| Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
| Gasser M et al. | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266759 |
| Tai J et al. | In vivo and in vitro effect of FK 506 on rat Leydig cell function. | 1991 | Transplant. Proc. | pmid:1721409 |
| Sato Y et al. | FK 506 suppresses class II antigen expression in regenerating livers following partial hepatectomy in the rat. | 1992 | Transplant. Proc. | pmid:1379761 |
| Jiang H et al. | Inhibition of IL-10 by FK 506 may be responsible for overcoming ongoing allograft rejection in the rat. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083538 |
| Alessiani M et al. | Correlations between functional changes and different grades of acute rejection in swine small bowel allografts. | 2000 | Transplant. Proc. | pmid:10995933 |
| Kahan BD | High variability of drug exposure: a biopharmaceutic risk factor for chronic rejection. | 1998 | Transplant. Proc. | pmid:9723224 |
| Weir MR | Optimizing early de novo immunosuppression with sirolimus. | 2008 | Transplant. Proc. | pmid:19100903 |
| Chang HR et al. | Sirolimus addition is beneficial for renal allograft dysfunction due to simultaneous acute rejection episode and calcineurin inhibitor nephrotoxicity. | 2004 | Transplant. Proc. | pmid:15621119 |
| Khwaja K et al. | Pancreas transplantation in cross-match-positive recipients using cyclosporine- or tacrolimus-based immunosuppression. | 2002 | Transplant. Proc. | pmid:12176621 |
| Quiroga I et al. | Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267261 |
| Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
| Sato K et al. | Comparative study of FK 506, cyclosporine, and triple regimen immunosuppression with FK 506, cyclosporine, and mizoribine. | 1991 | Transplant. Proc. | pmid:1721440 |
| Katayama Y et al. | Immunosuppressive effects of FK 506 in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1721441 |
| Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
| Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
| Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
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| Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
| Fukuoka N et al. | Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation. | 2010 | Transplant. Proc. | pmid:20832577 |
| Yonan NA et al. | Tracheal allograft transplantation in rats: the role of immunosuppressive agents in development of obliterative airway disease. | 1998 | Transplant. Proc. | pmid:9723443 |
| Greenstein SM et al. | Nifedipine prevents tacrolimus-induced intestinal hemodynamic and functional impairments. | 1998 | Transplant. Proc. | pmid:9745540 |
| Xu M et al. | FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9723447 |
| Maroun T et al. | Rejection therapy with tacrolimus in renal transplantation: preliminary results of a collaborative multicenter study in 45 patients. Groupe Cooperatif de Transplantation D'ile de France (GCIF). | 1998 | Transplant. Proc. | pmid:9745576 |
| Valenzuela M et al. | Early steroid withdrawal in pediatric renal transplantation at a single center: preliminary report. | 2008 | Transplant. Proc. | pmid:19010242 |
| Ito Y et al. | Complete replacement of tracheal epithelia by the host promotes spontaneous acceptance of orthotopic tracheal allografts in rats. | 2004 | Transplant. Proc. | pmid:15561264 |
| Owen ER et al. | Peripheral nerve regeneration in human hand transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267484 |
| Ben-Ari Z et al. | Conversion of liver allograft recipients from cyclosporine A to FK 506 immunosuppressive therapy. | 2000 | Transplant. Proc. | pmid:10856553 |
| Stempfle HU et al. | Rapid trabecular bone loss after cardiac transplantation using FK506 (tacrolimus)-based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636459 |
| Soh KS et al. | Simultaneous liver and kidney transplantation from different living donors. | 2012 | Transplant. Proc. | pmid:22410057 |
| Wojciechowski D et al. | Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923623 |