Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chambraud B et al. | Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10051602 |
Briesewitz R et al. | Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10051576 |
Clardy J | Borrowing to make ends meet. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10051553 |
Yamaguchi Y et al. | Peroxynitrite formation during rat hepatic allograft rejection. | 1999 | Hepatology | pmid:10051479 |
Chen HY et al. | Prediction of tacrolimus blood levels by using the neural network with genetic algorithm in liver transplantation patients. | 1999 | Ther Drug Monit | pmid:10051054 |
Zucker K et al. | Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation. | 1999 | Ther Drug Monit | pmid:10051052 |
Regazzi MB et al. | Clinical pharmacokinetics of tacrolimus in heart transplant recipients. | 1999 | Ther Drug Monit | pmid:10051048 |
Dolinski KJ and Heitman J | Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. | 1999 | Genetics | pmid:10049913 |
Johnson CE et al. | Stability of tacrolimus with morphine sulfate, hydromorphone hydrochloride, and ceftazidime during simulated intravenous coadministration. | 1999 | Am J Health Syst Pharm | pmid:10030533 |
Vyas S et al. | Outcome of twin pregnancy in a renal transplant recipient treated with tacrolimus. | 1999 | Transplantation | pmid:10030303 |