tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dumont FJ et al. | Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. | 1990 | J. Immunol. | pmid:1688572 |
| Murase N et al. | Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506. | 1990 | Transplant. Proc. | pmid:1689906 |
| Hoffman AL et al. | The effect of FK 506 on small intestine allotransplantation in the rat. | 1990 | Transplant. Proc. | pmid:1689907 |
| Lee KK et al. | Successful orthotopic small bowel transplantation with short-term FK 506 immunosuppressive therapy. | 1990 | Transplant. Proc. | pmid:1689908 |
| Ueda Y et al. | Induction of graft acceptance after dog kidney or liver transplantation. | 1990 | Transplant. Proc. | pmid:1689909 |
| Tropschug M et al. | Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding. | 1990 | Nature | pmid:1696687 |
| Randall T | New antirejection drugs anticipated. | 1990 | JAMA | pmid:1696999 |
| Metcalfe S et al. | FK 506 and cyclosporine A: early effects on activation and gene induction in mouse spleen cells. | 1990 | Transplant. Proc. | pmid:1697107 |
| Morris RE et al. | A study of the contrasting effects of cyclosporine, FK 506, and rapamycin on the suppression of allograft rejection. | 1990 | Transplant. Proc. | pmid:1697111 |
| Hara S et al. | The effects of a new immunosuppressive agent, FK506, on the glomerular injury in rats with accelerated nephrotoxic serum glomerulonephritis. | 1990 | Clin. Immunol. Immunopathol. | pmid:1700936 |
| Murase N et al. | Effect of FK 506 on spontaneous diabetes in BB rats. | 1990 | Diabetes | pmid:1700959 |
| Kawashima H and Mochizuki M | Effects of a new immunosuppressive agent, FK 506, on the efferent limb of the immune responses. | 1990 | Exp. Eye Res. | pmid:1701148 |
| Siekierka JJ et al. | The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase. | 1990 | J. Biol. Chem. | pmid:1701173 |
| Collier SJ | Immunosuppressive drugs. | 1989-1990 | Curr. Opin. Immunol. | pmid:2484794 |
| McCauley J et al. | Treatment of cyclosporin-induced haemolytic uraemic syndrome with FK506. | 1989 Dec 23-30 | Lancet | pmid:2481200 |
| Ochiai T et al. | Comparative studies on the immunosuppressive activity of FK506, 15-deoxyspergualin, and cyclosporine. | 1989 | Transplant. Proc. | pmid:2468228 |
| Yasunami Y et al. | Effects of a novel immunosuppressive agent, FK-506, on islet allograft survival in the rat. | 1989 | Transplant. Proc. | pmid:2468234 |
| Kobayashi C et al. | Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506. | 1989 | Transplant. Proc. | pmid:2468254 |
| Aoki M et al. | [Histological observations of immunosuppressive effects of FK-506 in canine lung allotransplantation]. | 1989 | Bull Chest Dis Res Inst Kyoto Univ | pmid:2482787 |
| Kay JE and Benzie CR | T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506. | 1989 | Immunol. Lett. | pmid:2483716 |