Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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van den Berg JW et al. | New immunosuppressive drugs and lung transplantation: last or least? | 1999 | Thorax | pmid:10335012 |
Henley SA et al. | Lipids increase after solitary pancreas transplantation. | 1999 | Diabetes Care | pmid:10333952 |
Iwamoto H et al. | Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration. | 1999 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:10333108 |
Okamoto H | The CD38-cyclic ADP-ribose signaling system in insulin secretion. | 1999 | Mol. Cell. Biochem. | pmid:10331647 |
Dresske B et al. | Synergistic impact of "WOFIE" on the immunosuppressive potency of FK 506 in a heterotopic heart transplantation model in the rat. | 1999 | Transplant. Proc. | pmid:10331001 |
Nakamura H et al. | Induction of autologous graft-versus-host disease after autologous peripheral blood stem cell transplantation. | 1999 | J. Allergy Clin. Immunol. | pmid:10329849 |
Tian J and Karin M | Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). | 1999 | J. Biol. Chem. | pmid:10329725 |
Kohyama T et al. | A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils. | 1999 | Mol. Cell Biol. Res. Commun. | pmid:10329481 |
Schmidt RH et al. | Haemolytic-uraemic syndrome after tacrolimus rescue therapy for cortisone-resistant rejection. | 1999 | Nephrol. Dial. Transplant. | pmid:10328486 |
Ruzicka T et al. | Tacrolimus: the drug for the turn of the millennium? | 1999 | Arch Dermatol | pmid:10328199 |
Garrity ER et al. | Suggested guidelines for the use of tacrolimus in lung-transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10328140 |
Raofi V et al. | A prospective randomized trial comparing the efficacy of tacrolimus versus cyclosporine in black recipients of primary cadaveric renal transplants. | 1999 | Am. J. Surg. | pmid:10326847 |
Ferlicot S et al. | [Smooth muscle mesentery associated with Epstein-Barr virus (EBV). Report of a case in a child with a liver transplant under FK506 regimen]. | 1999 | Ann Pathol | pmid:10320913 |
Morioka M et al. | Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia. | 1999 | Brain Res. | pmid:10320733 |
Genazzani AA et al. | Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318964 |
Remy I and Michnick SW | Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318894 |
Stratta RJ et al. | Evolution in pancreas transplantation techniques: simultaneous kidney-pancreas transplantation using portal-enteric drainage without antilymphocyte induction. | 1999 | Ann. Surg. | pmid:10235529 |
Akahane M et al. | Osteogenic phenotype expression of allogeneic rat marrow cells in porous hydroxyapatite ceramics. | 1999 | J. Bone Miner. Res. | pmid:10234577 |
Mollison KW et al. | A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases. | 1999 | J. Invest. Dermatol. | pmid:10233764 |
Jolles S et al. | Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum. | 1999 | Br. J. Dermatol. | pmid:10233301 |
Lyon CC et al. | Recalcitrant pyoderma gangrenosum treated with systemic tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233300 |
Vente C et al. | Erosive mucosal lichen planus: response to topical treatment with tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233234 |
Johnston A and Holt DW | Therapeutic drug monitoring of immunosuppressant drugs. | 1999 | Br J Clin Pharmacol | pmid:10233195 |
Uno T et al. | Pharmacokinetic advantages of a newly developed tacrolimus oil-in-water-type emulsion via the enteral route. | 1999 | Lipids | pmid:10230718 |
Göthel SF and Marahiel MA | Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. | 1999 | Cell. Mol. Life Sci. | pmid:10228556 |
Torocsik HV et al. | FK506-induced leukoencephalopathy in children with organ transplants. | 1999 | Neurology | pmid:10227644 |
Taylor DO et al. | A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus. | 1999 | J. Heart Lung Transplant. | pmid:10226898 |
Charco R et al. | Serum cholesterol changes in long-term survivors of liver transplantation: a comparison between cyclosporine and tacrolimus therapy. | 1999 | Liver Transpl Surg | pmid:10226111 |
Herr I et al. | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. | 1999 | Brain Res. | pmid:10224298 |
Ferrari D et al. | P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells. | 1999 | J. Biol. Chem. | pmid:10224077 |
Green MD and Michaels MG | Tacrolimus: effects and side effects. | 1999 | Pediatr. Infect. Dis. J. | pmid:10223694 |
Knoll GA and Bell RC | Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. | 1999 | BMJ | pmid:10213717 |
Jani A et al. | Modulation of cell-mediated immunity prolongs adenovirus-mediated transgene expression in sciatic nerve. | 1999 | Hum. Gene Ther. | pmid:10210146 |
Lütkes P et al. | [Quality of life following transplantation. The impact ofa new immunosuppressive substance]. | 1999 | Zentralbl Chir | pmid:10209841 |
Cetinkale O et al. | Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury. | 1999 | Burns | pmid:10208383 |
Hortelano S et al. | Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. | 1999 | Br. J. Pharmacol. | pmid:10205001 |
Nagasaki Y et al. | Reversal of hypopigmentation in phenylketonuria mice by adenovirus-mediated gene transfer. | 1999 | Pediatr. Res. | pmid:10203136 |
Sloper CM et al. | Tacrolimus (FK506) in the treatment of posterior uveitis refractory to cyclosporine. | 1999 | Ophthalmology | pmid:10201592 |
De Lima JJ et al. | Effects of FK506 in rat and human resistance arteries. | 1999 | Kidney Int. | pmid:10201018 |
Mollison KW et al. | Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases. | 1998 | Curr. Pharm. Des. | pmid:10197049 |
Azuma N et al. | Immunosuppression with FK506 in rat arterial allografts: fate of allogeneic endothelial cells. | 1999 | J. Vasc. Surg. | pmid:10194498 |
Meiser BM et al. | Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: importance of mycophenolic acid therapeutic drug monitoring. | 1999 | J. Heart Lung Transplant. | pmid:10194038 |
Fansa H et al. | The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting. | 1999 | J Hand Surg Br | pmid:10190602 |
Zhang W et al. | Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. | 1999 | Circ. Res. | pmid:10189360 |
Yasutsune T et al. | Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery. | 1999 | Br. J. Pharmacol. | pmid:10188984 |
Antoniou EA et al. | Immunosuppressive effect of combination schedules of brequinar with leflunomide or tacrolimus on rat cardiac allotransplantation. | 1999 | Microsurgery | pmid:10188834 |
Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
Hemenway CS and Heitman J | Calcineurin. Structure, function, and inhibition. | 1999 | Cell Biochem. Biophys. | pmid:10099825 |
Shapiro R et al. | Posttransplant diabetes in pediatric recipients on tacrolimus. | 1999 | Transplantation | pmid:10096540 |
Nogueira JM et al. | A comparison of recipient renal outcomes with laparoscopic versus open live donor nephrectomy. | 1999 | Transplantation | pmid:10096529 |