tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Misra DP et al. | Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. | 2014 | BMJ Case Rep | pmid:25398925 |
| Takahashi K et al. | Safety and efficacy of once-daily modified-release tacrolimus in kidney transplant recipients: interim analysis of multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24655975 |
| Wu MJ et al. | Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5. | 2014 | Transplant. Proc. | pmid:24655974 |
| Leung EK et al. | Clinical evaluation of the QMS® Tacrolimus immunoassay. | 2014 | Clin. Chim. Acta | pmid:24518359 |
| Qi R et al. | FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. | 2014 | Ren Fail | pmid:24512120 |
| Thölking G et al. | The tacrolimus metabolism rate influences renal function after kidney transplantation. | 2014 | PLoS ONE | pmid:25340655 |
| Pulsipher MA et al. | The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. | 2014 | Blood | pmid:24497539 |
| Peng ZG and Tian J | Higher Serum Trough Levels of Tacrolimus Increase 5-Year Allograft Survival in Antibody Positive Renal Transplant Patients. | 2014 | Clin Transpl | pmid:26281147 |
| Filler G et al. | Similar MPA exposure on modified release and regular tacrolimus. | 2014 | Ther Drug Monit | pmid:24365986 |
| Jain A et al. | Delayed introduction of tacrolimus postliver transplant with intravenous mycophenolate mofetil preserves renal function without incurring rejection. | 2014 | Transplantation | pmid:25285953 |
| Sugiyama K et al. | Immune monitoring with a lymphocyte adenosine triphosphate assay in kidney transplant recipients treated with a calcineurin inhibitor. | 2014 | Exp Clin Transplant | pmid:24907718 |
| Lankarani KB et al. | New onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:23902591 |
| Ichinose K et al. | [Rare case of systemic lupus erythematosus with encapsulating peritoneal sclerosis during hemodialysis]. | 2014 | Nihon Jinzo Gakkai Shi | pmid:24730352 |
| Thorat A et al. | Effects of converting tacrolimus formulation from twice-daily to once-daily in liver transplantation recipients. | 2014 | Biomed Res Int | pmid:25121091 |
| Griffith RD et al. | Cells to surgery quiz: September 2014. | 2014 | J. Invest. Dermatol. | pmid:25120152 |
| Van der Hauwaert C et al. | Expression profiles of genes involved in xenobiotic metabolism and disposition in human renal tissues and renal cell models. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25036895 |
| Helenius-Hietala J et al. | Oral mucosal health in liver transplant recipients and controls. | 2014 | Liver Transpl. | pmid:24142471 |
| Dai YJ et al. | Effect of pharmacological intervention on MIP-1α, MIP-1β and MCP-1 expression in patients with psoriasis vulgaris. | 2014 | Asian Pac J Trop Med | pmid:25063291 |
| Di Stasio D et al. | Oral lichen planus: a narrative review. | 2014 | Front Biosci (Elite Ed) | pmid:24896212 |
| Nikitin AV | [Mechanisms of nephrotoxic action of immunodepressants, calcineurine inhibitors]. | 2014 | Antibiot. Khimioter. | pmid:25051716 |
| Sun J et al. | [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:24985179 |
| Hayashi T and Harada N | Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation. | 2014 | FEBS J. | pmid:25158681 |
| Savikko J et al. | Different effects of tacrolimus and cyclosporine on PDGF induction and chronic allograft injury: evidence for improved kidney graft outcome. | 2014 | Transpl. Immunol. | pmid:25158212 |
| Kim YE and Eun SC | Effect of FK506 ointment (Protopic) on rat skin allograft model. | 2014 | Transplant. Proc. | pmid:24815165 |
| Lee KM and Eun SC | Experimental canine facial transplantation. | 2014 | Transplant. Proc. | pmid:24815162 |
| Osmola-Mańkowska A et al. | Topical tacrolimus vs medium-dose ultraviolet A1 phototherapy in the treatment of atopic dermatitis - a preliminary study in relation to parameters of the epidermal barrier function and high-frequency ultrasonography. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25555886 |
| Upadhyay V et al. | Rapid and sensitive UPLC-MS-MS determination of tacrolimus in Wistar rats and human blood. | 2014 | J Chromatogr Sci | pmid:23264321 |
| Hilgers M and Megahed M | [Oral lichen planus. Insight into the pathogenesis and therapeutic options]. | 2014 | Hautarzt | pmid:24722910 |
| Shipkova M et al. | Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. | 2014 | Clin. Biochem. | pmid:24721684 |
| Lin BW et al. | Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25491293 |
| Kharfan-Dabaja M et al. | Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease in people receiving allogeneic hematopoietic stem cell transplantation. | 2014 | Cochrane Database Syst Rev | pmid:25061777 |
| Heilman RL et al. | Delayed allograft inflammation following alemtuzumab induction for kidney transplantation. | 2013 Sep-Oct | Clin Transplant | pmid:23924146 |
| Benoit S and Hamm H | Psoriasis from a prosthesis: unusual Koebner phenomenon in a girl with autoamputation of the leg. | 2013 Sep-Oct | Pediatr Dermatol | pmid:23360396 |
| Zahdi MR et al. | Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. | 2013 Sep-Oct | An Bras Dermatol | pmid:24173187 |
| Riva N et al. | [Pharmacovigilance of calcineurin inhibitor in peidatric kidney and liver transplantation]. | 2013 Nov-Dec | Farm Hosp | pmid:24256007 |
| Brodrick B et al. | Influence of treatments on prognosis for vulvar lichen sclerosus: facts and controversies. | 2013 Nov-Dec | Clin. Dermatol. | pmid:24160287 |
| Bloom RD et al. | A randomized, crossover pharmacokinetic study comparing generic tacrolimus vs. the reference formulation in subpopulations of kidney transplant patients. | 2013 Nov-Dec | Clin Transplant | pmid:24118450 |
| Labirua-Iturburu A et al. | Calcineurin inhibitors in a cohort of patients with antisynthetase-associated interstitial lung disease. | 2013 May-Jun | Clin. Exp. Rheumatol. | pmid:23465087 |
| Chen SY et al. | Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism--a prospective, randomized, controlled study. | 2013 May-Jun | Clin Transplant | pmid:23432535 |
| Ramirez CB et al. | Completely steroid-free immunosuppression in liver transplantation: a randomized study. | 2013 May-Jun | Clin Transplant | pmid:23621629 |
| Krishna N et al. | Tacrolimus-induced paranoid delusions and fugue-like state. | 2013 May-Jun | Gen Hosp Psychiatry | pmid:22959421 |
| He L et al. | Treatment of idiopathic membranous nephropathy with combination of low-dose tacrolimus and corticosteroids. | 2013 May-Jun | J. Nephrol. | pmid:22956434 |
| Kanzelmeyer NK et al. | Correlations with six-month protocol biopsy findings in pediatric transplant recipients on low- and regular-dose CNI regimens. | 2013 Mar-Apr | Clin Transplant | pmid:23414365 |
| Tiwari R et al. | Enhancements in healthcare information technology systems: customizing vendor-supplied clinical decision support for a high-risk patient population. | 2013 Mar-Apr | J Am Med Inform Assoc | pmid:22813760 |
| Albekairy A et al. | Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients. | 2013 Mar-Apr | Saudi J Gastroenterol | pmid:23481136 |
| LaMattina JC et al. | Native kidney function following liver transplantation using calcineurin inhibitors: single-center analysis with 20 years of follow-up. | 2013 Mar-Apr | Clin Transplant | pmid:23294013 |
| Alfson ED et al. | Lysis of catatonic withdrawal by propofol in a bone-marrow transplant recipient with adenovirus limbic encephalitis. | 2013 Mar-Apr | Psychosomatics | pmid:22705183 |
| Yoshida EM et al. | Canadian national retrospective chart review comparing the long term effect of cyclosporine vs. tacrolimus on clinical outcomes in patients with post-liver transplantation hepatitis C virus infection. | 2013 Mar-Apr | Ann Hepatol | pmid:23396740 |
| Castillo G et al. | [Acute cellular rejection in a liver transplantation patient due to changing the brand of a generic immunosuppressant]. | 2013 Jul-Sep | Rev Gastroenterol Mex | pmid:23866966 |
| Bechstein WO et al. | A comparative, randomized trial of concentration-controlled sirolimus combined with reduced-dose tacrolimus or standard-dose tacrolimus in renal allograft recipients. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953523 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Weiler N et al. | Tacrolimus effects and side effects after liver transplantation: is there a difference between immediate and extended release? | 2013 Jul-Aug | Transplant. Proc. | pmid:23953543 |
| Stringa P et al. | Ischemic preconditioning and tacrolimus pretreatment as strategies to attenuate intestinal ischemia-reperfusion injury in mice. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953566 |
| Tachibana A et al. | Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes. | 2013 Jul-Aug | Xenotransplantation | pmid:23683097 |
| Favi E et al. | Tacrolimus plus mycophenolate mofetil vs. cyclosporine plus everolimus in deceased donor kidney transplant recipients: three-yr results of a single-center prospective clinical trial. | 2013 Jul-Aug | Clin Transplant | pmid:23710603 |
| Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
| Satyanarayan HS et al. | Efficacy and tolerability of combined treatment with NB-UVB and topical tacrolimus versus NB-UVB alone in patients with vitiligo vulgaris: a randomized intra-individual open comparative trial. | 2013 Jul-Aug | Indian J Dermatol Venereol Leprol | pmid:23760325 |
| Babalola O and Strober BE | Treatment of atopic dermatitis in pregnancy. | 2013 Jul-Aug | Dermatol Ther | pmid:23914886 |
| Conti R et al. | Jessner-Kanof disease: two effective and sure therapeutic options. | 2013 Jul-Aug | Dermatol Ther | pmid:23914897 |
| Chakkera HA et al. | Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375287 |
| Tian Ch et al. | B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375291 |
| Yao B et al. | The incidence of posttransplantation diabetes mellitus during follow-up in kidney transplant recipients and relationship to Fok1 vitamin D receptor polymorphism. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375298 |
| Miyazaki T et al. | Two case reports of successful withdrawal of mycofenolate mofetil after living donor lobar lung transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375323 |
| Chang HY et al. | Long-term follow-up of arrhythmia characteristics and clinical outcomes in heart transplant patients. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375324 |
| Al Nahdi N et al. | First successful treatment of post-liver transplant hepatitis C fibrosing cholestatic hepatitis with boceprevir, peginterferon and ribavirin in a pre-transplant null responder. | 2013 Jan-Feb | Ann Hepatol | pmid:23293209 |
| Seco-Melantuche R et al. | [Incidence of drug-induced thrombocytopenia in hospitalized patients]. | 2013 Jan-Feb | Farm Hosp | pmid:23461497 |
| Rao V et al. | A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimus. | 2013 Jan-Feb | Transplant. Proc. | pmid:23267806 |
| Langone A et al. | Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure level? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry. | 2013 Jan-Feb | Clin Transplant | pmid:22861144 |
| Shiba H et al. | Switching from tacrolimus to cyclosporine A to prevent primary biliary cirrhosis recurrence after living-donor liver transplantation. | 2013 Apr-Jun | Int Surg | pmid:23701152 |
| Adamu B et al. | New-onset diabetes after renal transplantation: a case series as seen in a Nigerian kidney transplant population. | 2013 Apr-Jun | Niger J Clin Pract | pmid:23563475 |
| Cangemi G et al. | Comparison of antibody-conjugated magnetic immunoassay and liquid chromatography-tandem mass spectrometry for the measurement of cyclosporine and tacrolimus in whole blood. | 2013 Apr-Jun | Int J Immunopathol Pharmacol | pmid:23755756 |
| Tanoue Y and Tominaga R | [Donor heart preservation with University of Wisconsin solution and immunosuppressive therapy with drip-infusion of tacrolimus]. | 2013 | Kyobu Geka | pmid:23985403 |
| Schmidt KJ et al. | Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - authors' reply. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336691 |
| Picard N | The pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on "Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus". | 2013 | Xenobiotica | pmid:23339626 |
| Mattar T et al. | Effect of rhBMP-2 and VEGF in a vascularized bone allotransplant experimental model based on surgical neoangiogenesis. | 2013 | J. Orthop. Res. | pmid:23192572 |
| Hao D et al. | Lymphocytic infiltration of the eyelid: two cases responding to tacrolimus and topical glucocorticoid. | 2013 | Acta Derm. Venereol. | pmid:23423497 |
| Borro JM et al. | Long-term success of combined kidney-lung transplantation in a patient with cystic fibrosis. | 2013 | Arch. Bronconeumol. | pmid:23427867 |
| Fang Y et al. | T-cell acute lymphoblastic leukaemia after liver transplantation: post-transplant lymphoproliferative disorder or coincidental de novo leukaemia? | 2013 | Hematol Oncol | pmid:22618860 |
| Frassetto L et al. | Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. | 2013 | Biopharm Drug Dispos | pmid:24030928 |
| Muthukumar T et al. | HIV-infected kidney graft recipients managed with an early corticosteroid withdrawal protocol: clinical outcomes and messenger RNA profiles. | 2013 | Transplantation | pmid:23503504 |
| Manojlovic Z et al. | Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. | 2013 | PLoS ONE | pmid:23755290 |
| Pawinski T et al. | Development and validation of limited sampling strategies for the estimation of mycophenolic acid area under the curve in adult kidney and liver transplant recipients receiving concomitant enteric-coated mycophenolate sodium and tacrolimus. | 2013 | Ther Drug Monit | pmid:24192641 |
| Perez-Simón JA et al. | The combination of sirolimus plus tacrolimus improves outcome after reduced-intensity conditioning, unrelated donor hematopoietic stem cell transplantation compared with cyclosporine plus mycofenolate. | 2013 | Haematologica | pmid:23065527 |
| Nakagaki T et al. | FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. | 2013 | Autophagy | pmid:23800841 |
| Hengge UR | [Off-label indications for topical tacrolimus]. | 2013 | Hautarzt | pmid:24150824 |
| Choi JY and Kwon OJ | Post-transplant diabetes mellitus: is it associated with poor allograft outcomes in renal transplants? | 2013 | Transplant. Proc. | pmid:24156999 |
| RodrÃguez-Perálvarez M et al. | Tacrolimus exposure after liver transplantation in randomized controlled trials: too much for too long. | 2013 | Am. J. Transplant. | pmid:23621166 |
| Lee JT et al. | Calcineurin inhibitors and Clostridium difficile infection in adult lung transplant recipients: the effect of cyclosporine versus tacrolimus. | 2013 | J. Surg. Res. | pmid:23566442 |
| O'Connell PJ et al. | Multicenter Australian trial of islet transplantation: improving accessibility and outcomes. | 2013 | Am. J. Transplant. | pmid:23668890 |
| Russ GR et al. | Efficacy of sotrastaurin plus tacrolimus after de novo kidney transplantation: randomized, phase II trial results. | 2013 | Am. J. Transplant. | pmid:23668931 |
| Pulzer A et al. | Calcineurin inhibitor dose-finding before kidney transplantation in HIV patients. | 2013 | Transpl. Int. | pmid:23227980 |
| Slatinska J et al. | Long-term follow-up of stable kidney transplant recipients after conversion from tacrolimus twice daily immediate release to tacrolimus once-daily prolonged release: a large single-center experience. | 2013 | Transplant. Proc. | pmid:23726604 |
| Grabczewska Z et al. | Neither cyclosporine nor tacrolimus deteriorate endothelial function in renal transplant recipients assessed with reactive hyperernia index. | 2013 | Transplant. Proc. | pmid:23726621 |
| Ban YH et al. | Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit. | 2013 | Mol Biosyst | pmid:23223556 |
| Ciancio G et al. | A randomized pilot study of donor stem cell infusion in living-related kidney transplant recipients receiving alemtuzumab. | 2013 | Transplantation | pmid:23903014 |
| Wang Z et al. | L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/Hâ‚‚S pathway. | 2013 | Neuroscience | pmid:23376738 |
| Cantisani C et al. | Generalized morphea successfully treated with tacrolimus 0.1% ointment. | 2013 | J Drugs Dermatol | pmid:23377321 |
| Herbst S et al. | A new and clinically relevant murine model of solid-organ transplant aspergillosis. | 2013 | Dis Model Mech | pmid:23264562 |
| Millán O et al. | Intracellular IFN-γ and IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients. | 2013 | Cytokine | pmid:23265966 |
| Pham PT and Reddy UG | Transplantation: Immunosuppression and risk of polyomavirus BK replication. | 2013 | Nat Rev Nephrol | pmid:23399577 |