| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| López Lago AM et al. | Evolution of hepatorenal syndrome after orthotopic liver transplantation: comparative analysis with patients who developed acute renal failure in the early postoperative period of liver transplantation. | 2007 | Transplant. Proc. | pmid:17889176 |
| Loinaz C et al. | A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 randomized liver transplant recipients: midterm efficacy and safety. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750472 |
| Rostaing L et al. | Early posttransplantation renal hemodynamics in FK 506-treated kidney recipients with or without prior induction therapy. | 1998 | Transplant. Proc. | pmid:9636519 |
| Perrakis A et al. | Impact of the conversion of the immunosuppressive regimen from prograf to advagraf or to sirolimus in long-term stable liver transplant recipients: indications, safety, and outcome. | 2011 | Transplant. Proc. | pmid:22172830 |
| Crespo M et al. | De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715848 |
| Sancho Calabuig A et al. | Very low-grade proteinuria at 3 months posttransplantation is an earlier marker of graft survival. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715850 |
| Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
| Wong KM et al. | Tacrolimus versus cyclosporine as primary prophylactic therapy after cadaveric renal transplant: two-year survival study. | 2000 | Transplant. Proc. | pmid:11119907 |
| Porayko MK et al. | Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7679835 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |
| Iwasaki K et al. | Pharmacokinetic study of FK 506 in the rat. | 1991 | Transplant. Proc. | pmid:1721268 |
| Andersson J et al. | FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro. | 1992 | Transplant. Proc. | pmid:1371621 |
| Takada S et al. | HGF prevents tacrolimus (FK 506)-induced nephrotoxicity in SHR rats. | 1996 | Transplant. Proc. | pmid:8623236 |
| Vilalta R et al. | Rapamycin use and rapid withdrawal of calcineurin inhibitors in pediatric renal transplantation. | 2003 | Transplant. Proc. | pmid:12644102 |
| Monden M et al. | A potent immunosuppressive effect of FK 506 in orthotopic liver transplantation in primates. | 1990 | Transplant. Proc. | pmid:1689904 |
| Ciancio G et al. | Efficacy and safety of daclizumab induction for primary kidney transplant recipients in combination with tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2003 | Transplant. Proc. | pmid:12644172 |
| Morell Ginestà M et al. | Histology and immunopathology of heart and liver xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959305 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients treated with tacrolimus. | 2002 | Transplant. Proc. | pmid:11959335 |
| Klupp J et al. | Risk and benefit of antibody induction therapy in combination with tacrolimus immunosuppression after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636585 |
| Steinmueller T et al. | Effect of CsA versus FK 506 on insulin sensitivity and insulin response using a modeling technique. | 1998 | Transplant. Proc. | pmid:9636589 |
| Miura S et al. | The beneficial effects of FK 506 on living-related renal transplantation in presensitized recipients. | 1999 | Transplant. Proc. | pmid:10455940 |
| Ringe B et al. | Replacement of corticosteroids by mycophenolate mofetil in liver graft recipients on initial tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11120285 |
| Birk PE et al. | Preliminary experience with FK 506 in pediatric renal transplant recipients: a single-center report. | 1996 | Transplant. Proc. | pmid:8623493 |
| Alloway RR et al. | Conversion from cyclosporine to tacrolimus in kidney, kidney/pancreas, and pancreas alone transplant recipients: the Memphis experience. | 1996 | Transplant. Proc. | pmid:8623494 |
| Dumont FJ et al. | Up-regulation of gene expression by FK 506. | 1991 | Transplant. Proc. | pmid:1721300 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Koefoed-Nielsen PB et al. | Comparison of the temporal profile of calcineurin inhibition by cyclosporine and tacrolimus in renal transplant patients. | 2005 | Transplant. Proc. | pmid:15919449 |
| Kusne S et al. | Infectious complications after small bowel transplantation in adults. | 1994 | Transplant. Proc. | pmid:7518153 |
| Akioka K et al. | Abdominal pain is a critical complication of mycophenolate mofetil in renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12591411 |
| Jain A et al. | Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients. | 1992 | Transplant. Proc. | pmid:1376518 |
| Watanabe K et al. | Factors influencing long-term operational tolerance in dogs treated with fractionated lymphoid irradiation, donor bone marrow cell infusion and FK506. | 1995 | Transplant. Proc. | pmid:7533389 |
| Kitamura T et al. | Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation: a case report. | 2003 | Transplant. Proc. | pmid:12591458 |
| Masutani H et al. | Suppression of the histologic changes of GVHD by FK 506 in rat small bowel transplantation. | 1992 | Transplant. Proc. | pmid:1376519 |
| Wennberg L et al. | Efficacy of various immunosuppressive drugs in preventing pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:7533391 |
| Borg AJ and Kumagai M | FK 506 and xenogeneic human anti-porcine cellular reactivity. | 1991 | Transplant. Proc. | pmid:1721332 |
| Fung J et al. | A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine. | 1991 | Transplant. Proc. | pmid:1721333 |
| Jain A et al. | Steroid withdrawal under tacrolimus for primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis after liver transplantation and long-term survival. | 2002 | Transplant. Proc. | pmid:12176467 |
| Lladó L et al. | Prospective study of a tacrolimus-based quadruple immunosuppressive regimen: evaluation of safety and efficacy. | 2002 | Transplant. Proc. | pmid:12176468 |
| Fleck PR et al. | Tacrolimus use in kidney-pancreas recipients is associated with less acute renal dysfunction than cyclosporine. | 1998 | Transplant. Proc. | pmid:9865299 |
| Niel OR et al. | Long-term glomerular filtration rate in liver allograft recipients according to the type of calcineurin inhibitors. | 2009 | Transplant. Proc. | pmid:19857743 |
| Regazzi MB et al. | Pharmacokinetics of FK506 and mycophenolic acid in experimental and clinical intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142302 |
| Rifai K et al. | Severe hearing loss after liver transplantation. | 2005 | Transplant. Proc. | pmid:15919504 |
| Oltean M et al. | FK506 donor pretreatment improves intestinal graft microcirculation and morphology by concurrent inhibition of early NF-kappaB activation and augmented HSP72 synthesis. | 2005 | Transplant. Proc. | pmid:15919508 |
| Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
| Jensen CW et al. | Pediatric renal transplantation under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721364 |
| Solà R et al. | Tacrolimus in induction immunosuppressive treatment in renal transplantation: comparison with cyclosporine. | 2003 | Transplant. Proc. | pmid:12962763 |
| Pascual J et al. | Comparison between a two-drug regimen with tacrolimus and steroids and a triple one with azathioprine in kidney transplantation: results of a European trial with 3-year follow up. | 2003 | Transplant. Proc. | pmid:12962764 |
| Ciancio G et al. | Effect of daclizumab, tacrolimus and mycophenolate mofetil in racial minority first renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176508 |
| Charpentier B | A three arm study comparing immediate tacrolimus therapy with ATG induction therapy followed by either tacrolimus or cyclosporine in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176511 |
| Deuse T et al. | Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection? | 2007 | Transplant. Proc. | pmid:17362784 |
| Yura H et al. | Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9838577 |
| Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
| Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
| Kato T et al. | Mycophenolate mofetil rescue therapy in patients with chronic hepatic allograft rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083158 |
| Watanabe K et al. | Prolongation effect of FK506 on the survival of 3-day preserved kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9838579 |
| Mueller AR et al. | Is the use of marginal liver grafts justified? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083160 |
| Karakulska-Prystupiuk E et al. | Pericarditis in Patients With Chronic Graft-vs-Host Disease. | 2018 | Transplant. Proc. | pmid:30177139 |
| Takeuchi H et al. | Evidence of different pharmacokinetics between cyclosporine and tacrolimus in renal transplant recipients: why cyclosporine is monitored by C2 level and tacrolimus by trough level. | 2008 | Transplant. Proc. | pmid:18790203 |
| Morozumi K et al. | Electron-microscopic peritubular capillary lesion is a specific and useful diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesions in the cyclosporine era. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123167 |
| Morris RE et al. | Immunopharmacology of FK-506. | 1989 | Transplant. Proc. | pmid:2468201 |
| Zipperle S et al. | Impaired T-cell IL-10 secretion and CD4 helper function in liver transplant patients treated with tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123208 |
| Carroll PB et al. | FK 506-associated diabetes mellitus in the pediatric transplant population is a rare complication. | 1991 | Transplant. Proc. | pmid:1721396 |
| Freise CE et al. | Similar clinical presentation of neurotoxicity following FK 506 and cyclosporine in a liver transplant recipient. | 1991 | Transplant. Proc. | pmid:1721397 |
| McGrath JS and Shehata M | The effect of differing immunosuppressive regimes on the functional and morphologic changes in a rat renal allograft model of chronic rejection. | 2001 | Transplant. Proc. | pmid:11377499 |
| Koefoed-Nielsen PB and Jørgensen KA | Alterations in calcineurin phosphatase activity in tacrolimus-treated renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176559 |
| Gasser M et al. | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266759 |
| Jiang H et al. | Inhibition of IL-10 by FK 506 may be responsible for overcoming ongoing allograft rejection in the rat. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083538 |
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| Dresske B et al. | Synergistic impact of "WOFIE" on the immunosuppressive potency of FK 506 in a heterotopic heart transplantation model in the rat. | 1999 | Transplant. Proc. | pmid:10331001 |
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| Fukuzawa M et al. | Effect of donor-specific transfusion and FK 506 on small intestine allotransplantation. | 1991 | Transplant. Proc. | pmid:1721427 |
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| Sindhi R et al. | Pharmacodynamics of sirolimus in transplanted children receiving tacrolimus. | 2002 | Transplant. Proc. | pmid:12176644 |
| Quiroga I et al. | Differential homocysteine levels in renal transplant patients receiving neoral versus tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267261 |
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| Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
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| Yonan NA et al. | Tracheal allograft transplantation in rats: the role of immunosuppressive agents in development of obliterative airway disease. | 1998 | Transplant. Proc. | pmid:9723443 |
| Greenstein SM et al. | Nifedipine prevents tacrolimus-induced intestinal hemodynamic and functional impairments. | 1998 | Transplant. Proc. | pmid:9745540 |
| Xu M et al. | FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9723447 |
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| McCauley J et al. | FK 506 in the management of transplant-related nephrotic syndrome and steroid-resistant nephrotic syndrome. | 1991 | Transplant. Proc. | pmid:1721459 |
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| Stempfle HU et al. | Rapid trabecular bone loss after cardiac transplantation using FK506 (tacrolimus)-based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636459 |
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