| MeSH term | MeSH ID | Detail |
|---|---|---|
| Denys-Drash Syndrome | D030321 | 1 associated lipids |
| Hypophosphatemia | D017674 | 1 associated lipids |
| Moyamoya Disease | D009072 | 1 associated lipids |
| Latent Tuberculosis | D055985 | 1 associated lipids |
| Leukoplakia | D007971 | 1 associated lipids |
| Oculomotor Nerve Diseases | D015840 | 1 associated lipids |
| Scorpion Stings | D065008 | 1 associated lipids |
| Esophageal Perforation | D004939 | 1 associated lipids |
| Mediastinitis | D008480 | 2 associated lipids |
| Coproporphyria, Hereditary | D046349 | 1 associated lipids |
| Ileus | D045823 | 3 associated lipids |
| Rectal Diseases | D012002 | 1 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Manzanares C et al. | Influence of hepatitis C virus infection on FK 506 blood levels in renal transplant patients. | 1998 | Transplant. Proc. | pmid:9636513 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Kamińska D et al. | Significant infections after hand transplantation in a Polish population. | 2014 | Transplant. Proc. | pmid:25380943 |
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Youhua Z et al. | Clinical study of FK 506 in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11119900 |
| TuÄŸcu M et al. | Tacrolimus-Induced Diabetic Ketoacidosis and Effect of Switching to Everolimus: A Case Report. | 2015 | Transplant. Proc. | pmid:26093759 |
| Klintmalm GB et al. | Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679828 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
| Venkataramanan R et al. | Pharmacokinetics of FK 506 in transplant patients. | 1991 | Transplant. Proc. | pmid:1721261 |
| Regazzi MB et al. | Interaction between FK 506 and diltiazem in an animal model. | 1996 | Transplant. Proc. | pmid:8623215 |
| Brook NR et al. | Prograf produces a molecular environment favoring antifibrosis, an effect reversed by the addition of rapamune. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808577 |
| Second International Workshop on FK 506. A potential breakthrough in immunosuppression: clinical implications. October 31, 1989, Barcelona, Spain. Proceedings. | 1990 | Transplant. Proc. | pmid:1689897 | |
| Shitrit D et al. | Tacrolimus-induced hemolytic uremic syndrome case presentation in a lung transplant recipient. | 2003 | Transplant. Proc. | pmid:12644073 |
| Ma A et al. | Immunological evaluation of combination therapy with tacrolimus and sirolimus on long-term allograft survival in nonhuman primates. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808578 |
| Crespo-Leiro MG et al. | Replacement of cyclosporine by tacrolimus for immunosuppression in heart transplant patients: safety and efficacy. | 2002 | Transplant. Proc. | pmid:11959213 |
| Bechstein WO et al. | A comparative, randomized trial of concentration-controlled sirolimus combined with reduced-dose tacrolimus or standard-dose tacrolimus in renal allograft recipients. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953523 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Qu W et al. | Correlation Between Immunosuppressive Therapy and CD4(+) T-Cell Intracellular Adenosine Triphosphate Levels in Liver Transplant Recipients. | Transplant. Proc. | pmid:27569951 | |
| Ringe B et al. | Tacrolimus and mycophenolate mofetil in clinical liver transplantation: experience with a steroid-sparing concept. | 1998 | Transplant. Proc. | pmid:9636573 |
| Lopes CT et al. | Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice. | 2008 | Transplant. Proc. | pmid:18455036 |
| Imamura M et al. | FK 506 inhibits severe graft-versus-host disease without mediating cytokine balance and/or cytotoxic molecules. | 2000 | Transplant. Proc. | pmid:11120238 |
| Kim SJ et al. | Randomized trial of tacrolimus versus cyclosporine in steroid withdrawal in living donor renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518759 |
| Schreiber SL et al. | Immunophilin-ligand complexes as probes of intracellular signaling pathways. | 1991 | Transplant. Proc. | pmid:1721293 |
| Forsythe J | Tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. The European Multicentre Tacrolimus/MMF Study Group. | 1999 | Transplant. Proc. | pmid:10576049 |
| Ullman KS et al. | Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes. | 1991 | Transplant. Proc. | pmid:1721294 |
| Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
| Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
| Burg M et al. | Enteric-coated mycophenolate sodium reduces gastrointestinal symptoms in renal transplant patients. | 2009 | Transplant. Proc. | pmid:20005359 |
| Schneeberger H et al. | Tacrolimus as a primary immunosuppressive therapy in cadaveric renal transplantation: five years' experience at a single center. | 1998 | Transplant. Proc. | pmid:9636642 |
| Yamazaki R et al. | Interindividual variation of maximal blood levels of tacrolimus after its oral administration in hematopoietic cell transplant recipients. | 2009 | Transplant. Proc. | pmid:19545738 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
| Foroncewicz B et al. | Anti-CD25 and tacrolimus therapy may not prevent early primary biliary cirrhosis recurrence after liver transplantation: two case reports. | 2003 | Transplant. Proc. | pmid:14529924 |
| Reggiani P et al. | A "steroid-free" tacrolimus and low-dose mycophenolate mofetil primary immunosuppression does not prevent early acute rejection after liver transplantation. | 2005 | Transplant. Proc. | pmid:15919435 |
| Moreno Gonzales M et al. | Sublingual Tacrolimus in Liver Transplantation: A Valid Option? | Transplant. Proc. | pmid:27569953 | |
| Moscicka M et al. | The effect of cyclosporine and tacrolimus on indigenous bacterial flora in human skin grafts. | 2003 | Transplant. Proc. | pmid:14529942 |
| Bahra M et al. | Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft loss. | 2005 | Transplant. Proc. | pmid:15919436 |
| Kai N et al. | A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. | 1992 | Transplant. Proc. | pmid:1376511 |
| Langrehr JM et al. | Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. | 1995 | Transplant. Proc. | pmid:7533373 |
| Kim SW et al. | Decreased formation of nitric oxide in rats treated with FK506. | 2003 | Transplant. Proc. | pmid:12591357 |
| Kim HC et al. | Primary immunosuppression with tacrolimus in renal transplantation: a single center experience. | 2003 | Transplant. Proc. | pmid:12591370 |
| Nakata S et al. | Immunosuppressive effect of FK 506 on cytotoxic T lymphocytes and delayed-type hypersensitivity in rats. | 1991 | Transplant. Proc. | pmid:1721325 |
| Ennaifer R et al. | Nodular hyperplasia of the gastrointestinal tract after liver transplantation: role of immunosuppressive therapy? A case report. | 2015 | Transplant. Proc. | pmid:25891739 |
| Maes BD and Vanrenterghem YF | Cyclosporine: advantages versus disadvantages vis-Ã -vis tacrolimus. | 2004 | Transplant. Proc. | pmid:15041305 |
| Jonas S et al. | Cyclosporine-based quadruple induction therapy versus tacrolimus-based dual immunosuppression after liver transplantation: ten-year follow-up. | 2002 | Transplant. Proc. | pmid:12176459 |
| Chen JW et al. | Ten-year results of a randomised prospective study of FK506 versus cyclosporine in management of primary orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176460 |
| Tsuchida Y et al. | Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. | 1997 | Transplant. Proc. | pmid:9142252 |
| Costa A et al. | Small bowel myoelectrical activity after transplantation in pigs: motility versus ACR score. | 1997 | Transplant. Proc. | pmid:9142281 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Fontana I et al. | Severe rhabdomyolysis and acute renal failure in a kidney transplant patient treated with tacrolimus and chimaeric CD25 monoclonal antibody. | 2004 | Transplant. Proc. | pmid:15110640 |
| Woodside KJ et al. | Conversion from cyclosporine to tacrolimus results in improved creatinine but does not alter lipid profile. | 2005 | Transplant. Proc. | pmid:15919491 |
| Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
| Dahmen U et al. | Onset of liver regeneration after subtotal resection is inhibited by the use of new immunosuppressive drugs. | 2002 | Transplant. Proc. | pmid:12270412 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in adult cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721358 |
| Nalesnik MA et al. | Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population. | 1991 | Transplant. Proc. | pmid:1703335 |
| Takahara S et al. | Excellent results following 3 years of tacrolimus immunosuppression in kidney transplantation recipients in Japan: overall analysis of more than 1000 patients. | 2002 | Transplant. Proc. | pmid:12176500 |
| Lo CM et al. | Use of FK506 as primary or rescue therapy after liver transplantation in Hong Kong. | 1998 | Transplant. Proc. | pmid:9838571 |
| Reichenspurner H et al. | Tacrolimus-based immunosuppressive protocols in lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083062 |
| Khanna A et al. | Cardiac changes at autopsy in adult liver transplant recipients under tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123118 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Takagishi K et al. | Effects of FK-506 on collagen arthritis in mice. | 1989 | Transplant. Proc. | pmid:2468205 |
| Schmidt RJ et al. | Hemolytic-uremic syndrome in a renal transplant recipient on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721390 |
| Arita C et al. | Effect of FK 506 (FR 900506) on collagen arthritis in rats: a preliminary report. | 1989 | Transplant. Proc. | pmid:2468206 |
| Tze WJ et al. | Effect of FK 506 on glucose metabolism and insulin secretion in normal rats. | 1991 | Transplant. Proc. | pmid:1721391 |
| Bilbao I et al. | Comparison between tacrolimus and neoral cyclosporine administered by oral route in liver transplantation. | 2001 | Transplant. Proc. | pmid:11377472 |
| van Duijnhoven EM et al. | Evidence that fasting does not significantly affect trough levels of tacrolimus in stable renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176552 |
| Castel MA et al. | Primary immunosuppression and outcome differences after heart transplantation: tacrolimus versus cyclosporine. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839245 |
| Ji SM et al. | Conversion from cyclosporine to tacrolimus for chronic allograft nephropathy. | 2007 | Transplant. Proc. | pmid:17580148 |
| Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
| Weinbroum AA et al. | Lack of cumulative effect of tacrolimus and low flow on a rat isolated liver. | 2001 | Transplant. Proc. | pmid:11543812 |
| Zuckermann A et al. | Benefit of mycophenolate mofetil in patients with cyclosporine A-induced nephropathy after lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083518 |
| Ohdan H et al. | Prolongation of hamster-to-rat liver xenograft survival by donor bone marrow augmentation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123589 |
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| Boggs S et al. | FK 506 has no short-term effects on endogenous or exogenous myeloid reconstitution in irradiated mice. | 1991 | Transplant. Proc. | pmid:1721420 |
| Ogawa N et al. | Suppressive effects of combination therapy with mizoribine and FK 506 on the development of accelerated coronary artery disease and myocardial rejection after heart transplantation. | 1996 | Transplant. Proc. | pmid:8658710 |
| Soran A et al. | Renal retransplantation in elderly recipients under tacrolimus-based immunosuppression. | 2000 | Transplant. Proc. | pmid:10812157 |
| Formica RN et al. | Sirolimus-based immunosuppression with reduce dose cyclosporine or tacrolimus after renal transplantation. | 2003 | Transplant. Proc. | pmid:12742475 |
| Baran DA et al. | Can initial tacrolimus trough levels be predicted from clinical variables? | 2004 | Transplant. Proc. | pmid:15621157 |
| Hasegawa A et al. | Optimal use of tacrolimus in living donor renal transplantation in children. | 2002 | Transplant. Proc. | pmid:12176635 |
| El-Sabrout R et al. | Rejection-free protocol using sirolimus-tacrolimus combination for pediatric renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176636 |
| Eun SC et al. | Prolongation of the rat composite tissue allograft survival by the combination of tolerogenic immature dendritic cells and short-term treatment with FK506. | 2013 | Transplant. Proc. | pmid:23769045 |
| van den Berg AP et al. | Prediction of the inhibition of IL-2 production by calcineurin inhibitors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267197 |
| Wu M et al. | Cyclosporine and tacrolimus alter renin-angiotesin system in mouse medullary-thick ascending limb cultured cells. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267198 |
| Liu W et al. | Transfusion of endothelial cells with lentivirus-mediated expression of fas ligand prolonged survival of rat liver allograft. | 2012 | Transplant. Proc. | pmid:22664023 |
| Otto C et al. | Selective immunosuppression with FK 506, anti-IL-2R, and anti-ICAM-1 monoclonal antibodies: contrasting effects after liver and small bowel transplantation in rats. | 1998 | Transplant. Proc. | pmid:9723426 |
| Chen H et al. | Combined effect of rapamycin and FK 506 in prolongation of small bowel graft survival in the mouse. | 1998 | Transplant. Proc. | pmid:9745497 |
| Halloran PF et al. | Calcineurin and the biological effect of cyclosporine and tacrolimus. | 1998 | Transplant. Proc. | pmid:9723430 |
| Matevossian E et al. | Nitric oxide inhibition and consecutive Aspisol application show a prolonged survival of orthotopic transplanted livers in a rat model. | 2008 | Transplant. Proc. | pmid:18555092 |
| Walgenbach KJ et al. | Upregulation of basic fibroblast growth factor during chronic rejection of rat intestinal allografts and its downregulation by FK 506. | 1998 | Transplant. Proc. | pmid:9745501 |
| Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
| Thomson AW et al. | Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study. | 1991 | Transplant. Proc. | pmid:1721452 |
| Mohsin N et al. | Low tacrolimus dose requirements in renal transplant recipients in the omani population: implications for pharmacogenetics? | 2005 | Transplant. Proc. | pmid:16213259 |
| Sainsbury TS et al. | Differential effects of FK 506 and cyclosporine on hair regrowth in the DEBR model of alopecia areata. | 1991 | Transplant. Proc. | pmid:1721453 |
| Todo S et al. | Effect of FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450416 |
| Treede H et al. | Incidence and spectrum of infections in lung transplanted patients: comparison of four different immunosuppressive protocols. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267444 |
| Chen H et al. | FK 506 and rapamycin in combination are not antagonistic but produce extended small bowel graft survival in the mouse. | 1998 | Transplant. Proc. | pmid:9636419 |
| Yoshimura R et al. | A comparative study between cyclosporine and FK 506 effects on renal microsomal P-450. | 1991 | Transplant. Proc. | pmid:1703686 |
| Hartwig T et al. | Low-dose sirolimus and tacrolimus in kidney transplantation: first results of a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750383 |
| Pridöhl O et al. | Low-dose immunosuppression with FK 506 and sirolimus after liver transplantation: 1-year results. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750384 |