| MeSH term | MeSH ID | Detail |
|---|---|---|
| Denys-Drash Syndrome | D030321 | 1 associated lipids |
| Hypophosphatemia | D017674 | 1 associated lipids |
| Moyamoya Disease | D009072 | 1 associated lipids |
| Latent Tuberculosis | D055985 | 1 associated lipids |
| Leukoplakia | D007971 | 1 associated lipids |
| Oculomotor Nerve Diseases | D015840 | 1 associated lipids |
| Scorpion Stings | D065008 | 1 associated lipids |
| Esophageal Perforation | D004939 | 1 associated lipids |
| Mediastinitis | D008480 | 2 associated lipids |
| Coproporphyria, Hereditary | D046349 | 1 associated lipids |
| Ileus | D045823 | 3 associated lipids |
| Rectal Diseases | D012002 | 1 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qin J et al. | Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases. | 2012 | Br J Radiol | pmid:22496071 |
| Ahn KJ et al. | Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity. | 2003 | Br J Radiol | pmid:14711782 |
| Murphy GJ et al. | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. | 2003 | Br J Surg | pmid:12808614 |
| Middleton SJ et al. | Adult small intestinal transplantation in England and Wales. | 2003 | Br J Surg | pmid:12808622 |
| Morris-Stiff GJ et al. | Sequential changes in plasma selenium concentration after cadaveric renal transplantation. | 2004 | Br J Surg | pmid:14991636 |
| Wilson CH et al. | Randomized clinical trial of daclizumab induction and delayed introduction of tacrolimus for recipients of non-heart-beating kidney transplants. | 2005 | Br J Surg | pmid:15856479 |
| Waller JR et al. | Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia. | 2002 | Br J Surg | pmid:12390379 |
| Brook NR et al. | Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection. | 2003 | Br J Surg | pmid:12905557 |
| Jain S et al. | Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury. | 2000 | Br J Surg | pmid:11091246 |
| Bicknell GR et al. | Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants. | 2000 | Br J Surg | pmid:11091247 |
| White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
| Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
| Andersson Y et al. | Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo. | 2009 | Br. J. Cancer | pmid:19773757 |
| Chambers CA | Topical tacrolimus for cutaneous lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12752154 |
| Ludwig E et al. | New treatment modalities for granuloma faciale. | 2003 | Br. J. Dermatol. | pmid:14511001 |
| Vecchietti G et al. | Topical tacrolimus (FK506) for relapsing erosive stomatitis in paraneoplastic pemphigus. | 2003 | Br. J. Dermatol. | pmid:12752158 |
| Bens G et al. | Topical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption. | 2003 | Br. J. Dermatol. | pmid:12890237 |
| Reich K et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Br. J. Dermatol. | pmid:9892935 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Schmitt J et al. | Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials. | 2011 | Br. J. Dermatol. | pmid:20819086 |
| Sugiura H et al. | An open study of a lotion formulation to improve tolerance of tacrolimus in facial atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11736904 |
| Calza AM and Lübbe J | Tacrolimus ointment-associated alcohol intolerance in infants receiving ethanol-containing medication. | 2005 | Br. J. Dermatol. | pmid:15787832 |
| Rigopoulos D et al. | Pimecrolimus cream 1% vs. betamethasone 17-valerate 0.1% cream in the treatment of seborrhoeic dermatitis. A randomized open-label clinical trial. | 2004 | Br. J. Dermatol. | pmid:15541087 |
| Clayton TH and Harrison PV | Successful treatment of chronic ulcerated necrobiosis lipoidica with 0.1% topical tacrolimus ointment. | 2005 | Br. J. Dermatol. | pmid:15787840 |
| RodrÃguez GarcÃa F et al. | Generalized pustular psoriasis successfully treated with topical tacrolimus. | 2005 | Br. J. Dermatol. | pmid:15787845 |
| Remitz A et al. | Tacrolimus ointment improves psoriasis in a microplaque assay. | 1999 | Br. J. Dermatol. | pmid:10417522 |
| Braza TJ et al. | Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. | 2003 | Br. J. Dermatol. | pmid:12828755 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
| Charman C | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. | 2017 | Br. J. Dermatol. | pmid:28858382 |
| Lan CC et al. | FK506 (tacrolimus) and endothelin combined treatment induces mobility of melanoblasts: new insights into follicular vitiligo repigmentation induced by topical tacrolimus on sun-exposed skin. | 2011 | Br. J. Dermatol. | pmid:21039414 |
| Esquivel-Pedraza L et al. | Treatment of oral lichen planus with topical pimecrolimus 1% cream. | 2004 | Br. J. Dermatol. | pmid:15099380 |
| Sorgentini C et al. | Lichen striatus in an adult: successful treatment with tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15099383 |
| Dissemond J et al. | Pimecrolimus in an adhesive ointment as a new treatment option for oral lichen planus. | 2004 | Br. J. Dermatol. | pmid:15099387 |
| Harth W and Linse R | Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. | 2004 | Br. J. Dermatol. | pmid:15099394 |
| Kanekura T et al. | Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12588393 |
| Vente C et al. | Erosive mucosal lichen planus: response to topical treatment with tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233234 |
| Lyon CC et al. | Recalcitrant pyoderma gangrenosum treated with systemic tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233300 |
| Jolles S et al. | Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum. | 1999 | Br. J. Dermatol. | pmid:10233301 |
| Anstey A | Therapeutic advances and shift in disease paradigm for atopic dermatitis. | 2008 | Br. J. Dermatol. | pmid:19036027 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Griffiths CE | Ascomycin: an advance in the management of atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298524 |
| Fujimoto N et al. | Facial lichen striatus: successful treatment with tacrolimus ointment. | 2003 | Br. J. Dermatol. | pmid:12653755 |
| Harper J et al. | First experience of topical SDZ ASM 981 in children with atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298537 |
| Ueda M et al. | Successful treatment of amyopathic dermatomyositis with topical tacrolimus. | 2003 | Br. J. Dermatol. | pmid:12653761 |
| Luger T et al. | SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298538 |
| Lan CC et al. | FK506 independently upregulates transforming growth factor beta and downregulates inducible nitric oxide synthase in cultured human keratinocytes: possible mechanisms of how tacrolimus ointment interacts with atopic skin. | 2004 | Br. J. Dermatol. | pmid:15377358 |
| Fricain JC et al. | Long-term efficacy of topical tacrolimus on oral lesions of chronic graft-versus-host disease. | 2007 | Br. J. Dermatol. | pmid:17300261 |
| Vissers WH et al. | Topical treatment of mild to moderate plaque psoriasis with 0.3% tacrolimus gel and 0.5% tacrolimus cream: the effect on SUM score, epidermal proliferation, keratinization, T-cell subsets and HLA-DR expression. | 2008 | Br. J. Dermatol. | pmid:18284400 |
| Reitamo S et al. | 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. | 2004 | Br. J. Dermatol. | pmid:15030341 |
| Chuh AA | The application of topical tacrolimus in vesicular pemphigoid. | 2004 | Br. J. Dermatol. | pmid:15030368 |
| Ormerod AD | Topical tacrolimus and pimecrolimus and the risk of cancer: how much cause for concern? | 2005 | Br. J. Dermatol. | pmid:16181449 |
| Lan CC et al. | FK506 inhibits tumour necrosis factor-alpha secretion in human keratinocytes via regulation of nuclear factor-kappaB. | 2005 | Br. J. Dermatol. | pmid:16181452 |
| Vukmanovic-Stejic M et al. | Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:16181456 |
| Martin-Munoz MF et al. | Topical treatment tacrolimus and food allergy. | 2005 | Br. J. Dermatol. | pmid:16181473 |
| Gollnick H et al. | Pimecrolimus cream 1% in the long-term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial. | 2008 | Br. J. Dermatol. | pmid:18341665 |
| Hjelmgren J et al. | Cost-effectiveness of tacrolimus ointment vs. standard treatment in patients with moderate and severe atopic dermatitis: a health-economic model simulation based on a patient survey and clinical trial data. | 2007 | Br. J. Dermatol. | pmid:17263826 |
| Reitamo S et al. | A 4-year follow-up study of atopic dermatitis therapy with 0.1% tacrolimus ointment in children and adult patients. | 2008 | Br. J. Dermatol. | pmid:18637898 |
| Rigopoulos D et al. | Efficacy and safety of tacrolimus ointment 0.1% vs. betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study. | 2009 | Br. J. Dermatol. | pmid:19120329 |
| Oranje AP et al. | Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. | 2009 | Br. J. Dermatol. | pmid:18795918 |
| Wataya-Kaneda M et al. | A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity. | 2011 | Br. J. Dermatol. | pmid:21692771 |
| Spergel JM et al. | Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17573885 |
| Bäumer W et al. | Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis. | 2005 | Br. J. Dermatol. | pmid:16029339 |
| Niwa Y et al. | Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin. | 2003 | Br. J. Dermatol. | pmid:14632799 |
| Ko MJ and Chu CY | Topical tacrolimus therapy for localized bullous pemphigoid. | 2003 | Br. J. Dermatol. | pmid:14632824 |
| Wollenberg A et al. | Economic evaluation of maintenance treatment with tacrolimus 0.1% ointment in adults with moderate to severe atopic dermatitis. | 2008 | Br. J. Dermatol. | pmid:18782316 |
| Doss N et al. | Superiority of tacrolimus 0.1% ointment compared with fluticasone 0.005% in adults with moderate to severe atopic dermatitis of the face: results from a randomized, double-blind trial. | 2009 | Br. J. Dermatol. | pmid:19416227 |
| Thaçi D et al. | Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of a randomized, multicentre, comparative study. | 2008 | Br. J. Dermatol. | pmid:18782319 |
| Böhm M et al. | Resolution of lichen aureus in a 10-year-old child after topical pimecrolimus. | 2004 | Br. J. Dermatol. | pmid:15327576 |
| Leung DY et al. | Effects of pimecrolimus cream 1% in the treatment of patients with atopic dermatitis who demonstrate a clinical insensitivity to topical corticosteroids: a randomized, multicentre vehicle-controlled trial. | 2009 | Br. J. Dermatol. | pmid:19416245 |
| Hickey JR et al. | Does topical tacrolimus induce lentigines in children with atopic dermatitis? A report of three cases. | 2005 | Br. J. Dermatol. | pmid:15656817 |
| Mancuso G and Berdondini RM | Localized scleroderma: response to occlusive treatment with tacrolimus ointment. | 2005 | Br. J. Dermatol. | pmid:15656828 |
| Langeland T and Engh V | Topical use of tacrolimus and squamous cell carcinoma on the penis. | 2005 | Br. J. Dermatol. | pmid:15656830 |
| Kreuter A et al. | Pimecrolimus 1% cream for perianal atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15656832 |
| Fiorentino DF et al. | The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes. | 2011 | Br. J. Dermatol. | pmid:21166661 |
| Lewis FM and Neill SM | Safety of calcineurin inhibitors in the management of lichen sclerosis. | 2007 | Br. J. Dermatol. | pmid:17535239 |
| Neckermann G et al. | Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981. | 2000 | Br. J. Dermatol. | pmid:10792216 |
| Queille-Roussel C et al. | The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. | 2001 | Br. J. Dermatol. | pmid:11260007 |
| Ramsay HM and Harden PN | Cyclosporin-induced flushing in a renal transplant recipient resolving after substitution with tacrolimus. | 2000 | Br. J. Dermatol. | pmid:10792253 |
| Rao A and Bunker C | Efficacy and safety of tacrolimus ointment 0.1% vs. betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study. | 2010 | Br. J. Dermatol. | pmid:20353455 |
| Ellis C et al. | International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. | 2003 | Br. J. Dermatol. | pmid:12694268 |
| Oji V et al. | Topical pimecrolimus: a novel therapeutic option for Netherton syndrome. | 2005 | Br. J. Dermatol. | pmid:16225628 |
| Connolly M and Kennedy C | Exfoliative cheilitis successfully treated with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15270904 |
| Healy E et al. | Cost-effectiveness of tacrolimus ointment in adults and children with moderate and severe atopic dermatitis: twice-weekly maintenance treatment vs. standard twice-daily reactive treatment of exacerbations from a third party payer (U.K. National Health Service) perspective. | 2011 | Br. J. Dermatol. | pmid:21083544 |
| Tzung TY and Wu JC | Topical calcineurin inhibitors in treating Jessner's lymphocytic infiltration of the skin: report of a case. | 2005 | Br. J. Dermatol. | pmid:15727667 |
| Poole CD et al. | Health-related utility among adults with atopic dermatitis treated with 0.1% tacrolimus ointment as maintenance therapy over the long term: findings from the Protopic CONTROL study. | 2009 | Br. J. Dermatol. | pmid:19754867 |
| Chu CY | The use of 1% pimecrolimus cream for the treatment of steroid-induced rosacea. | 2005 | Br. J. Dermatol. | pmid:15727676 |
| Park CW et al. | Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948978 |
| Gottlieb AB et al. | Oral pimecrolimus in the treatment of moderate to severe chronic plaque-type psoriasis: a double-blind, multicentre, randomized, dose-finding trial. | 2005 | Br. J. Dermatol. | pmid:15948985 |
| Bhol KC and Schechter PJ | Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948987 |
| Reitamo S et al. | A multicentre, randomized, double-blind, controlled study of long-term treatment with 0.1% tacrolimus ointment in adults with moderate to severe atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948994 |
| Bos JD | Topical tacrolimus and pimecrolimus are not associated with skin atrophy. | 2002 | Br. J. Dermatol. | pmid:11903264 |
| Wolff K et al. | Efficacy and tolerability of three different doses of oral pimecrolimus in the treatment of moderate to severe atopic dermatitis: a randomized controlled trial. | 2005 | Br. J. Dermatol. | pmid:15948996 |
| Rigopoulos D et al. | Pimecrolimus 1% cream in the treatment of disseminated granuloma annulare. | 2005 | Br. J. Dermatol. | pmid:15949015 |
| Kirtschig G et al. | Successful treatment of erosive vulvovaginal lichen planus with topical tacrolimus. | 2002 | Br. J. Dermatol. | pmid:12207624 |
| Feldmann KA et al. | Is topical tacrolimus effective in alopecia areata universalis? | 2002 | Br. J. Dermatol. | pmid:12410729 |
| Sigurgeirsson B and Luger T | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. | 2017 | Br. J. Dermatol. | pmid:28940181 |
| Ho N et al. | A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0·1% vs. clobetasol propionate 0·05% in childhood vitiligo. | 2011 | Br. J. Dermatol. | pmid:21457214 |
| Rigopoulos D et al. | Tacrolimus ointment 0.1% in pityriasis alba: an open-label, randomized, placebo-controlled study. | 2006 | Br. J. Dermatol. | pmid:16792767 |
| Weissenbacher S et al. | Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial. | 2007 | Br. J. Dermatol. | pmid:17493072 |