tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Denys-Drash Syndrome D030321 1 associated lipids
Hypophosphatemia D017674 1 associated lipids
Moyamoya Disease D009072 1 associated lipids
Latent Tuberculosis D055985 1 associated lipids
Leukoplakia D007971 1 associated lipids
Oculomotor Nerve Diseases D015840 1 associated lipids
Scorpion Stings D065008 1 associated lipids
Esophageal Perforation D004939 1 associated lipids
Mediastinitis D008480 2 associated lipids
Coproporphyria, Hereditary D046349 1 associated lipids
Ileus D045823 3 associated lipids
Rectal Diseases D012002 1 associated lipids
Angiolymphoid Hyperplasia with Eosinophilia D000796 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Authors Title Published Journal PubMed Link
Garg V et al. Topical tacrolimus nanoemulsion, a promising therapeutic approach for uveitis. 2013 Med. Hypotheses pmid:24018283
Gökceoğlu AU et al. Circulating endothelial cells in pediatric renal transplant recipients. 2013 Pediatr. Nephrol. pmid:24018796
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Carcas-Sansuán AJ et al. Conversion from Prograf to Advagraf in adolescents with stable liver transplants: comparative pharmacokinetics and 1-year follow-up. 2013 Liver Transpl. pmid:23894093
Howell J et al. Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signaling after liver transplantation. 2013 Liver Transpl. pmid:23894100
Danielsen AA et al. Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. 2013 J. Biol. Chem. pmid:23382378
Zhang CW et al. [Establishment of a real-time PCR assay for simultaneously detecting human BKV and CMV DNA and its application in renal transplantation recipients]. 2013 Bing Du Xue Bao pmid:23895006
Cardona M et al. [Association of everolimus with tacrolimus during the first year after heart transplantation: initial experience]. 2013 Med Clin (Barc) pmid:23384432
Yildirim R et al. Treatment of pure red-cell aplasia with cyclosporine in a renal transplant patient. 2013 Exp Clin Transplant pmid:22891934
März AM et al. Large FK506-binding proteins shape the pharmacology of rapamycin. 2013 Mol. Cell. Biol. pmid:23358420
Danby SG and Cork MJ The effects of pimecrolimus on the innate immune response in atopic dermatitis. 2013 Br. J. Dermatol. pmid:23362967
Chen W et al. Outcomes of tacrolimus therapy in adults with refractory membranous nephrotic syndrome: a prospective, multicenter clinical trial. 2013 Am. J. Med. Sci. pmid:22627258
Mizuno S et al. Immunological aspects in late phase of living donor liver transplant patients: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity. 2013 Clin. Dev. Immunol. pmid:24187567
Uesugi M et al. Influence of cytochrome P450 (CYP) 3A4*1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients. 2013 Biol. Pharm. Bull. pmid:24189425
Nakase H [Tacrolimus therapy for patients with ulcerative colitis]. 2013 Nihon Shokakibyo Gakkai Zasshi pmid:24189819
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Nakane S [Calcineurin inhibitors and IVIg in the treatment of myasthenia gravis]. 2013 Rinsho Shinkeigaku pmid:24291970
Kaczmarek I et al. Tacrolimus with mycophenolate mofetil or sirolimus compared with calcineurin inhibitor-free immunosuppression (sirolimus/mycophenolate mofetil) after heart transplantation: 5-year results. 2013 J. Heart Lung Transplant. pmid:23415313
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Kovacs D et al. Follow up of lung transplant recipients using an electronic nose. 2013 J Breath Res pmid:23445553
Gijsen VM et al. Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review. 2013 Pediatr Transplant pmid:23448292
Okamoto M et al. Successful treatment with tacrolimus in a case of lung-dominant connective tissue disease. 2013 Intern. Med. pmid:23448773
Li H et al. Immunosuppressant-related hip pain after orthotopic liver transplant. 2013 Exp Clin Transplant pmid:22813534
Laftavi MR et al. African American renal transplant recipients (RTR) require higher tacrolimus doses to achieve target levels compared to white RTR: does clotrimazole help? 2013 Transplant. Proc. pmid:24314941
Marente VC et al. Modigraf administration through jejunostomy in liver transplant recipient: case report. 2013 Transplant. Proc. pmid:24314992
Telkes G et al. Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil: a case report. 2013 Transplant. Proc. pmid:24315002
Azzi JR et al. Calcineurin inhibitors: 40 years later, can't live without ... 2013 J. Immunol. pmid:24319282
König S et al. Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle. 2013 Am. J. Physiol. Heart Circ. Physiol. pmid:24056904
Praehauser C et al. Risk factors and outcome of expanded-criteria donor kidney transplants in patients with low immunological risk. 2013 Swiss Med Wkly pmid:24222631
Sun JY et al. [Association of CYP3A5 and MDR1 genetic polymorphisms with the blood concentration of tacrolimus in Chinese liver and renal transplant recipients]. 2013 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:24059111
Kim CR and Lee DY Combination of narrow-band ultraviolet B and topical tacrolimus is effective for segmental vitiligo. 2013 Int. J. Dermatol. pmid:24073911
Ali FR and Lyon CC Tacrolimus toxicity following topical treatment of perianal Crohn's disease: an admonitory anecdote. 2013 J Crohns Colitis pmid:24076430
Choe JY et al. Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes. 2013 Arthritis Res. Ther. pmid:23406906
Orange DE et al. Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. 2013 Elife pmid:23390586
Roan JN et al. Dose-normalization for exposure to mycophenolic acid and the early clinical outcome in patients taking tacrolimus after heart transplantation. 2013 Ann. Transplant. pmid:23792500
Tanaka T et al. Evaluation of immune function under conversion from Prograf to Advagraf in living donor liver transplantation. 2013 Ann. Transplant. pmid:23792533
Pérez-López FR et al. EMAS clinical guide: vulvar lichen sclerosus in peri and postmenopausal women. 2013 Maturitas pmid:23291001
Tsuchiya T et al. Comparison of pharmacokinetics and pathology for low-dose tacrolimus once-daily and twice-daily in living kidney transplantation: prospective trial in once-daily versus twice-daily tacrolimus. 2013 Transplantation pmid:23792649
Ercan Z et al. Kaposi's sarcoma in the early post-transplant period in a kidney transplant recipient. 2013 Nefrologia pmid:24241380
Skytte DM et al. Some transformations of tacrolimus, an immunosuppressive drug. 2013 Eur J Pharm Sci pmid:23238171
Kosugi K et al. A longitudinal study of the effect of experimental osteoporosis on bone trabecular structure in the rat mandibular condyle. 2013 Cranio pmid:23795404
Issa N et al. Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. 2013 Am. J. Nephrol. pmid:23796509
Honda A et al. Omission of day-11 MTX, in combination with tacrolimus, is not associated with increased risk of acute graft-versus-host disease after allo-BMT. 2013 Bone Marrow Transplant. pmid:22751000
Ceresa CD et al. Mesenchymal stromal cells promote bowel regeneration after intestinal transplantation: myth to mucosa. 2013 Transpl. Int. pmid:23869998
Pitarch G and Giner F Periorbital necrobiosis lipoidica. 2013 Actas Dermosifiliogr pmid:23871211
Mouzaki M et al. Basiliximab with delayed introduction of calcineurin inhibitors as a renal-sparing protocol following liver transplantation in children with renal impairment. 2013 Pediatr Transplant pmid:24118898
Vannaprasaht S et al. Personalized tacrolimus doses determined by CYP3A5 genotype for induction and maintenance phases of kidney transplantation. 2013 Clin Ther pmid:24120259
Prud'homme GJ et al. GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. 2013 Transplantation pmid:23851932
Hilbrands R et al. Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts. 2013 Transplantation pmid:23857001
Wang SE et al. Hepatic veno-occlusive disease related to tacrolimus after pancreas transplantation. 2013 J Chin Med Assoc pmid:23602212
Fujii H et al. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. 2013 Cell Rep pmid:23602566
Hodge G et al. Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome. 2013 Clin. Exp. Immunol. pmid:23607447
Yin ZQ et al. Effects of topical tacrolimus 0.03% on long-term suberythemal ultraviolet B-irradiated epidermal Langerhans cells in mice. 2013 J Eur Acad Dermatol Venereol pmid:22471949
Hammerstrom AE et al. Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. 2013 Am. J. Hematol. pmid:23460378
Sung J et al. Alemtuzumab induction with tacrolimus monotherapy in 25 pediatric renal transplant recipients. 2013 Pediatr Transplant pmid:24164824
Im MS et al. Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. 2013 Exp Clin Transplant pmid:23075084
Briem-Richter A et al. Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation. 2013 Pediatr Transplant pmid:24164827
Shayani S et al. Thrombotic microangiopathy associated with sirolimus level after allogeneic hematopoietic cell transplantation with tacrolimus/sirolimus-based graft-versus-host disease prophylaxis. 2013 Biol. Blood Marrow Transplant. pmid:23078784
Sheu JJ et al. Innate immune response after acute myocardial infarction and pharmacomodulatory action of tacrolimus in reducing infarct size and preserving myocardial integrity. 2013 J. Biomed. Sci. pmid:24165293
McDiarmid SV Adolescence: challenges and responses. 2013 Liver Transpl. pmid:24166838
Li J et al. Evaluation of mycophenolic acid exposure using a limited sampling strategy in renal transplant recipients. 2013 Am. J. Nephrol. pmid:23689735
Jensen JM et al. Effects of pimecrolimus compared with triamcinolone acetonide cream on skin barrier structure in atopic dermatitis: a randomized, double-blind, right-left arm trial. 2013 Acta Derm. Venereol. pmid:23571785
Gorgan M et al. Pulmonary hemorrhage with capillaritis secondary to mycophenolate mofetil in a heart-transplant patient. 2013 Arch. Pathol. Lab. Med. pmid:24168511
Lower DR et al. Comparison of CEDIA FK506 assay with HPLC/MS/MS in a large cohort of pediatric patients. 2013 Am. J. Clin. Pathol. pmid:23690122
Vafadari R et al. Tacrolimus inhibits NF-κB activation in peripheral human T cells. 2013 PLoS ONE pmid:23573283
Dai Y et al. Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation. 2013 Int J Nanomedicine pmid:23690687
Sinha R and Marks SD Tacrolimus toxicity secondary to diarrhoea in nephrotic syndrome. 2013 Acta Paediatr. pmid:23573873
Takada Y et al. Randomized, multicenter trial comparing tacrolimus plus mycophenolate mofetil to tacrolimus plus steroids in hepatitis C virus-positive recipients of living donor liver transplantation. 2013 Liver Transpl. pmid:23696054
Keating GM and Lyseng-Williamson KA Everolimus: a guide to its use in liver transplantation. 2013 BioDrugs pmid:23696253
Trotter JF et al. Early use of renal-sparing agents in liver transplantation: a closer look. 2013 Liver Transpl. pmid:23696464
Matsumoto A et al. [A case of tacrolimus plus intensive LCAP therapy combination for refractory ulcerative colitis]. 2013 Nihon Shokakibyo Gakkai Zasshi pmid:23558127
Muramatsu H and Nagai K Streptomyces tsukubensis sp. nov., a producer of the immunosuppressant tacrolimus. 2013 J. Antibiot. pmid:23299187
Yamaguchi K et al. Limited sampling strategy for the estimation of mycophenolic acid area under the concentration-time curve treated in Japanese living-related renal transplant recipients with concomitant extended-release tacrolimus. 2013 Biol. Pharm. Bull. pmid:23558676
van Maarseveen E and van Zuilen AD Pretransplantation pharmacokinetic assessments to predict posttransplantation dosing requirements in renal transplant recipients: what is known? 2013 Clin. Pharmacol. Ther. pmid:23299646
Zheng S et al. Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. 2013 Br J Clin Pharmacol pmid:23528073
Ishii T et al. Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506. 2013 FASEB J. pmid:23241312
Nwaba A et al. Tacrolimus-induced thrombotic microangiopathy in orthotopic liver transplant patients: case series of four patients. 2013 Intern Med J pmid:23441660
Hofmann M et al. Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy. 2013 Arch. Dermatol. Res. pmid:23242470
Koop DR et al. Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23548676
Kita J et al. Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach. 2013 Mod Rheumatol pmid:22669596
Lewis RE et al. Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. 2013 J. Infect. Dis. pmid:23242544
Nakagawa Y et al. Induction of rapid apoptosis for class I MHC molecule-restricted CD8(+) HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo. 2013 Int. Immunol. pmid:22945875
Ayer J and Young HS Pimecrolimus for psoriasis. 2013 Expert Opin Pharmacother pmid:23461536
Schneeberger S et al. Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. 2013 Ann. Surg. pmid:23001085
Pinelli NR et al. Coadministration of liraglutide with tacrolimus in kidney transplant recipients: a case series. 2013 Diabetes Care pmid:24065848
Huang D et al. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. 2013 J. Ind. Microbiol. Biotechnol. pmid:23779221
McNeil C Preventing graft-versus-host disease: transplanters glimpse hope beyond immunosuppressants. 2013 J. Natl. Cancer Inst. pmid:23781000
Ramser EM et al. Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. 2013 Mol. Biol. Cell pmid:23783030
Bien CG et al. Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. 2013 Epilepsia pmid:23216622
Niioka T et al. Pharmaceutical and genetic determinants for interindividual differences of tacrolimus bioavailability in renal transplant recipients. 2013 Eur. J. Clin. Pharmacol. pmid:23733010
Tanaka Y et al. Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study. 2013 Mod Rheumatol pmid:23271170
Murase S Signal transducer and activator of transcription 3 (STAT3) degradation by proteasome controls a developmental switch in neurotrophin dependence. 2013 J. Biol. Chem. pmid:23733189
Borrego-Utiel FJ et al. Painful gynaecomastia secondary to cyclosporine A and tacrolimus in a patient with focal segmental glomerulosclerosis. 2013 Nefrologia pmid:24241383
Sha T et al. Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice. 2013 Int. Immunopharmacol. pmid:23142502
Boyer NL et al. Tacrolimus-associated thrombotic microangiopathy in a lung transplant recipient. 2013 BMJ Case Rep pmid:23396921
Bramham K et al. Breastfeeding and tacrolimus: serial monitoring in breast-fed and bottle-fed infants. 2013 Clin J Am Soc Nephrol pmid:23349333
Khaled SK et al. A phase II study of sirolimus, tacrolimus and rabbit anti-thymocyte globulin as GVHD prophylaxis after unrelated-donor PBSC transplant. 2013 Bone Marrow Transplant. pmid:23000644
Mei Y et al. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. 2013 PLoS ONE pmid:23349825
Gladstone DE et al. Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies. 2013 Biol. Blood Marrow Transplant. pmid:23353119
Nara M et al. Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants. 2013 Eur. J. Clin. Pharmacol. pmid:23354810