| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dendritic Cell Sarcoma, Interdigitating | D054739 | 1 associated lipids |
| Polymyositis | D017285 | 1 associated lipids |
| Vestibular Diseases | D015837 | 2 associated lipids |
| Myxedema | D009230 | 2 associated lipids |
| Coccidioidomycosis | D003047 | 2 associated lipids |
| Ileal Neoplasms | D007078 | 2 associated lipids |
| Lichen Planus, Oral | D017676 | 2 associated lipids |
| Lymphomatoid Granulomatosis | D008230 | 2 associated lipids |
| Paresis | D010291 | 2 associated lipids |
| Angiofibroma | D018322 | 2 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
| Beysens AJ et al. | FK 506: monitoring in plasma or in whole blood? | 1991 | Transplant. Proc. | pmid:1721263 |
| Hashikura Y et al. | Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623218 |
| Samuel D et al. | Tacrolimus (FK506)-based dual versus triple therapy following liver transplantation. | 1998 | Transplant. Proc. | pmid:9636563 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |
| Imventarza O et al. | Renal transplantation in baboons under FK 506. | 1990 | Transplant. Proc. | pmid:1689903 |
| Chang HY et al. | Long-term follow-up of arrhythmia characteristics and clinical outcomes in heart transplant patients. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375324 |
| Matevossian E et al. | Liver transplantation in the rat: single-center experience with technique, long-term survival, and functional and histologic findings. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715990 |
| Müller H et al. | Immunosuppression with generic tacrolimus and mycophenolate mofetil in renal transplant recipients: preliminary report in Chile. | 2008 | Transplant. Proc. | pmid:18454992 |
| Mazali FC et al. | Posttransplant diabetes mellitus: incidence and risk factors. | 2008 | Transplant. Proc. | pmid:18455010 |
| de la Fuente S et al. | Long-term survivors after pediatric liver transplatation are at increased risk for development of cardiovascular disease events: analysis of 30 cases. | 2014 | Transplant. Proc. | pmid:25420837 |
| Sigal NH et al. | Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506? | 1991 | Transplant. Proc. | pmid:1721295 |
| Troppmann C et al. | Perioperative immunosuppression as a critical determinant of early outcome after discordant xenoislet transplantation: a comparative study. | 1996 | Transplant. Proc. | pmid:8623487 |
| Bierer BE et al. | FK 506 and rapamycin: molecular probes of T-lymphocyte activation. | 1991 | Transplant. Proc. | pmid:1721296 |
| Walker S et al. | Clinical use and bioavailability of tacrolimus in heart-lung and double lung transplant recipients with cystic fibrosis. | 1998 | Transplant. Proc. | pmid:9636618 |
| Watanabe K et al. | Donor bone marrow cell infusion is effective in inducing tolerance in dogs treated with fractionated lymphoid irradiation and FK506. | 2000 | Transplant. Proc. | pmid:11120286 |
| Schulz T et al. | Tacrolimus/mycophenolate mofetil/steroid-based immunosuppression after pancreas-kidney transplantation with single shot antithymocyte globulin. | 1998 | Transplant. Proc. | pmid:9636623 |
| Perrella A et al. | Cytomegalovirus infection after liver transplantation: prophylaxis and preemptive treatment--a single-center experience. | 2010 | Transplant. Proc. | pmid:20534267 |
| Akiyama T et al. | Mizoribine in combination therapy with tacrolimus for living donor renal transplantation: analysis of a nationwide study in Japan. | 2005 | Transplant. Proc. | pmid:15848551 |
| Watanabe Y et al. | The expression of nonmuscle myosin heavy chain in rat renal transplantation. | 1999 | Transplant. Proc. | pmid:10578260 |
| Meçule A et al. | Once daily tacrolimus formulation: monitoring of plasma levels, graft function, and cardiovascular risk factors. | 2010 | Transplant. Proc. | pmid:20534290 |
| Alloway R et al. | Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen. | 2005 | Transplant. Proc. | pmid:15848559 |
| Chen JS et al. | Effect of CYP3A5 genotype on renal allograft recipients treated with tacrolimus. | 2009 | Transplant. Proc. | pmid:19545678 |
| Andrés A et al. | Extended-release tacrolimus therapy in de novo kidney transplant recipients: single-center experience. | 2010 | Transplant. Proc. | pmid:20970602 |
| Bakar F et al. | Low-density lipoprotein oxidizability and the alteration of its fatty acid content in renal transplant recipients treated with cyclosporine/tacrolimus. | 2009 | Transplant. Proc. | pmid:19545695 |
| Cabello M et al. | Pharmacokinetics of once- versus twice-daily tacrolimus formulations in kidney transplant patients receiving expanded criteria deceased donor organs: a single-center, randomized study. | 2010 | Transplant. Proc. | pmid:20970603 |
| Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
| Erickson L et al. | Gene expression profiling of acute rejection and mixed lymphocyte reaction with tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176407 |
| Hisanaga M et al. | Successful combination therapy with FK 506 and 15-deoxyspergualin in pancreatic islet xenografting. | 1992 | Transplant. Proc. | pmid:1376513 |
| Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
| Didlake R and Grogan J | Effect of FK 506 on rat leukocyte chemotaxis. | 1991 | Transplant. Proc. | pmid:1721327 |
| Mizuta K et al. | Increase of bile acid production by tacrolimus in the rat liver. | 2003 | Transplant. Proc. | pmid:12591477 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Loucaidou M et al. | Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression. | 2005 | Transplant. Proc. | pmid:15919456 |
| Hoshinaga K et al. | Regimen of tacrolimus-based immunosuppression with basiliximab, mycophenolate mofetil, and low-dose steroid reduces acute rejection in kidney transplants. | 2005 | Transplant. Proc. | pmid:15919457 |
| Ping X et al. | Antigen sampling on the Peyer's patches in a murine small bowel transplantation model. | 2010 | Transplant. Proc. | pmid:21094860 |
| Signorell J et al. | Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient. | 2010 | Transplant. Proc. | pmid:21094874 |
| Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in adult cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721358 |
| Scantlebury VP et al. | Renal transplantation under cyclosporine and FK 506 for hemolytic uremic syndrome. | 1995 | Transplant. Proc. | pmid:7533436 |
| Nalesnik MA et al. | Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population. | 1991 | Transplant. Proc. | pmid:1703335 |
| Armitage JM et al. | The clinical trial of FK 506 as primary and rescue immunosuppression in pediatric cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721359 |
| Armitage JM et al. | A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1703336 |
| Dew MA et al. | Quality-of-life advantages of FK 506 vs conventional immunosuppressive drug therapy in cardiac transplantation. | 1991 | Transplant. Proc. | pmid:1721360 |
| Pascual J et al. | Comparison between a two-drug regimen with tacrolimus and steroids and a triple one with azathioprine in kidney transplantation: results of a European trial with 3-year follow up. | 2003 | Transplant. Proc. | pmid:12962764 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Lyne JC et al. | Cadaveric renal transplantation against a positive historic crossmatch under tacrolimus immunosuppression: long-term follow-up. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123015 |
| Charpentier B | A three arm study comparing immediate tacrolimus therapy with ATG induction therapy followed by either tacrolimus or cyclosporine in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176511 |
| Borda B et al. | Functional and histopathologic changes in renal transplant patients with new-onset diabetes and dyslipidemia. | 2011 | Transplant. Proc. | pmid:21620104 |
| Krzyżowska K et al. | No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients. | Transplant. Proc. | pmid:30056895 | |
| Zmonarski S et al. | Expression of PBMC TLR4 in Renal Graft Recipients Who Experienced Delayed Graft Function Reflects Dynamic Balance Between Blood and Tissue Compartments and Helps Select a Problematic Patient. | Transplant. Proc. | pmid:30056893 | |
| Kim K et al. | Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104132 | |
| Weir M | Impact of immunosuppressive regimes on posttransplant diabetes mellitus. | 2001 | Transplant. Proc. | pmid:11498201 |
| Morimoto T et al. | Blood levels of FK506 after intramuscular and intravenous administration in dogs. | 1989 | Transplant. Proc. | pmid:2468207 |
| Doi R et al. | Mechanisms by which FK 506 affects exocrine pancreas in rats. | 1991 | Transplant. Proc. | pmid:1721392 |
| Kaibori M et al. | Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083347 |
| Tsuchimoto S et al. | Orthotopic liver transplantation in rats receiving FK506. | 1989 | Transplant. Proc. | pmid:2468208 |
| Rilo HL et al. | Effect of FK 506 on function of human islets of Langerhans. | 1991 | Transplant. Proc. | pmid:1721393 |
| Terakura M et al. | Effects of peritransplant administration of hematopoietic growth factors on the development of chronic allograft rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083380 |
| Lee S et al. | Mycophenolic acid trough level measurements and clinical outcomes in kidney transplantation recipients on a fixed dose (1.5 g/d) of mycophenolate mofetil in Korea. | 2010 | Transplant. Proc. | pmid:20430174 |
| Kim JM et al. | Preemptive therapy in adult liver transplant recipients in CMV-endemic area. | 2010 | Transplant. Proc. | pmid:20430182 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| el-Ghoroury M et al. | Efficacy and safety of tacrolimus versus cyclosporine in kidney and pancreas transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123461 |
| Ali IH et al. | Incidence and risk factors for post-renal transplant diabetes mellitus. | 2011 | Transplant. Proc. | pmid:21440763 |
| Yokoyama I et al. | Decreased Fas antigen expression of cultured hepatocytes with FK 506. | 1996 | Transplant. Proc. | pmid:8962237 |
| Hariharan S et al. | Long-term renal and pancreas function with tacrolimus rescue therapy following kidney/pancreas transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123462 |
| McGrath JS and Shehata M | Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitution. | 2001 | Transplant. Proc. | pmid:11377500 |
| Baid S et al. | Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis C infection. | 2002 | Transplant. Proc. | pmid:12176569 |
| Kelly JS and Sharkey J | Immunosuppressants-ligands as neuroprotectants. | 2001 | Transplant. Proc. | pmid:11377506 |
| Tsai SF et al. | Trends in maintenance immunosuppressive drugs used in taiwanese kidney transplant recipients: an analysis of the national health insurance research database. | 2012 | Transplant. Proc. | pmid:22310612 |
| Akioka K et al. | Diabetes in renal transplant recipients treated with tacrolimus. | 2002 | Transplant. Proc. | pmid:12176570 |
| Abouljoud M et al. | Conversion to neoral provides effective rescue therapy for liver and kidney transplant patients intolerant of Prograf. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267175 |
| Yoshimi F et al. | Canine total orthotopic small bowel transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721422 |
| Kawauchi M et al. | Which are the target vessels of xeno- and allo-lung rejection?--a primate single lung transplantation study. | 1996 | Transplant. Proc. | pmid:8658719 |
| Collier DS et al. | FK-506 in experimental renal allografts. | 1987 | Transplant. Proc. | pmid:2445063 |
| Berweck S et al. | Clinical use of the euglycemic hyperinsulinemic clamp for diagnosis of tacrolimus-induced insulin resistance after combined pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9723345 |
| Neff GW et al. | Ten years of sirolimus therapy in orthotopic liver transplant recipients. | 2003 | Transplant. Proc. | pmid:12742498 |
| Petz W et al. | Experience with the use of basiliximab in liver transplantation--use in pediatric and adult recipients in combination with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:12176648 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Llull R et al. | Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. | 1995 | Transplant. Proc. | pmid:7544504 |
| Heitman J et al. | Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. | 1994 | Transplant. Proc. | pmid:7524220 |
| Groetzner J et al. | Tacrolimus or cyclosporine for immunosuppression after cardiac transplantation: which treatment reveals more side effects during long-term follow-up? | 2001 Feb-Mar | Transplant. Proc. | pmid:11267373 |
| van den Berg AP et al. | Recurrent HCV infection reduces the requirement for tacrolimus after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267375 |
| Fujino Y et al. | FK 506 treatment of experimental autoimmune uveoretinitis in primates. | 1991 | Transplant. Proc. | pmid:1721454 |
| Liversidge J et al. | FK 506 modulates accessory cell adhesion molecule expression and inhibits CD4 lymphocyte adhesion to retinal pigment epithelial cells in vitro: implications for therapy of uveoretinitis. | 1991 | Transplant. Proc. | pmid:1721455 |
| Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
| Chávez R et al. | Hepatotrophic effect of cyclosporine and FK 506 is not mimicked by rapamycin. | 1999 | Transplant. Proc. | pmid:10500655 |
| EscartÃn A et al. | Orthotopic small bowel transplantation in pigs without steroids. | 1999 | Transplant. Proc. | pmid:10500720 |
| Ginevri F et al. | Expression of collagen by renal fibroblasts treated with FK 506 in vitro. | 1998 | Transplant. Proc. | pmid:9636387 |
| Hutchinson IV et al. | Differences in the mode of action of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636388 |
| Dall'Agnol DJ et al. | Effects of immunosuppressive drugs on gastrointestinal transit of rats: effects of tacrolimus, cyclosporine, and prednisone. | Transplant. Proc. | pmid:25131057 | |
| Iwata H et al. | Prolongation of xenograft survival by combining donor-specific intravenous presensitization with FK 506. | 2002 | Transplant. Proc. | pmid:12431592 |
| Rong G et al. | Influence of CYP3A5 and MDR1(ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. | 2010 | Transplant. Proc. | pmid:21094796 |
| Carroll PB et al. | Effect of the immunosuppressant FK 506 on insulin release from adult rat islets of Langerhans. | 1991 | Transplant. Proc. | pmid:1703688 |
| van Hooff JP et al. | Preservation of renal function and cardiovascular risk factors. | 2006 | Transplant. Proc. | pmid:16979974 |
| Guleria S et al. | Tacrolimus (Pan Graf) as de novo therapy in renal transplant recipients in India. | 2006 | Transplant. Proc. | pmid:16979989 |
| Carl S et al. | Combining FK 506 and mycophenolate mofetil for the treatment of acute corticosteroid-resistant rejection following kidney transplantation: a new therapeutic concept. | 1998 | Transplant. Proc. | pmid:9636502 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |