| MeSH term | MeSH ID | Detail |
|---|---|---|
| Erectile Dysfunction | D007172 | 19 associated lipids |
| Gingivitis | D005891 | 3 associated lipids |
| Periodontal Pocket | D010514 | 9 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Liver Cirrhosis, Alcoholic | D008104 | 17 associated lipids |
| Nephritis, Interstitial | D009395 | 10 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
| Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
| Lemmens HP et al. | Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis. | 1994 | Transplant. Proc. | pmid:7527983 |
| Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
| Langrehr JM et al. | Mucosal recipient-type mononuclear repopulation and low-grade chronic rejection occur simultaneously in indefinitely surviving recipients of small bowel allografts. | 1994 | Transpl. Int. | pmid:7513999 |
| Leach KL et al. | A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin. | 1994 | J Immunoassay | pmid:7530727 |
| Genestier L et al. | Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. | 1994 | Cell. Immunol. | pmid:7514101 |
| Rao US and Scarborough GA | Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. | 1994 | Mol. Pharmacol. | pmid:7514263 |
| Lieberman DN and Mody I | Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. | 1994 | Nature | pmid:7514273 |
| Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
| Ellis D et al. | Comparison of FK-506 and cyclosporine regimens in pediatric renal transplantation. | 1994 | Pediatr. Nephrol. | pmid:7517171 |
| Petros AM and Fesik SW | Nuclear magnetic resonance methods for studying protein-ligand complexes. | 1994 | Meth. Enzymol. | pmid:7530321 |
| Klintmalm GB | FK 506: an update. | 1994 | Clin Transplant | pmid:7517226 |
| Dawson TM et al. | The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. | 1994 | Neuroscience | pmid:7530348 |
| Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
| Curley RW et al. | Stereospecific assignments of glycine in proteins by stereospecific deuteration and 15N labeling. | 1994 | J. Biomol. NMR | pmid:7517241 |
| Nagase K et al. | Distribution and protein binding of FK506, a potent immunosuppressive macrolide lactone, in human blood and its uptake by erythrocytes. | 1994 | J. Pharm. Pharmacol. | pmid:7517447 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Singh N et al. | Decreased incidence of viral infections in liver transplant recipients. Possible effects of FK506? | 1994 | Dig. Dis. Sci. | pmid:7506641 |
| Kusne S et al. | Infectious complications after small bowel transplantation in adults. | 1994 | Transplant. Proc. | pmid:7518153 |
| Lee TK et al. | Bacterial translocation and the role of postoperative selective bowel decontamination in small intestinal transplantation. | 1994 | Transplant. Proc. | pmid:7518154 |
| Grossi P et al. | Infectious complications in experimental small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518155 |
| Dilling MB et al. | Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. | 1994 | Cancer Res. | pmid:7508822 |
| Yamamoto S et al. | Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent. | 1994 | J. Invest. Dermatol. | pmid:7508960 |
| Logan TM et al. | Structural characterization of the FK506 binding protein unfolded in urea and guanidine hydrochloride. | 1994 | J. Mol. Biol. | pmid:7508991 |
| Ito T et al. | Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. | 1994 | J. Gastroenterol. | pmid:7520321 |
| Cooper MH et al. | Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors. | 1994 | Transplantation | pmid:7509089 |
| Zeniya A et al. | Anti-ulcer effect of FK 506, immunosuppressive agent, in rats. | 1994 | J. Gastroenterol. | pmid:7520322 |
| Yamamoto S et al. | Inhibition of anthralin-caused skin tumor promotion and interleukin-1 alpha production by potent immunosuppressant FK506. | 1994 | Cancer Lett. | pmid:7520353 |
| Dawson TM et al. | Nitric oxide: cellular regulation and neuronal injury. | 1994 | Prog. Brain Res. | pmid:7533914 |
| Enslen H and Soderling TR | Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes. | 1994 | J. Biol. Chem. | pmid:7520433 |
| Gonschior AK et al. | Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). | 1994 | Br J Clin Pharmacol | pmid:7534100 |
| Tacrolimus (FK506) for organ transplants. | 1994 | Med Lett Drugs Ther | pmid:7520968 | |
| Bierer BE | Biology of cyclosporin A and FK506. | 1994 | Prog. Clin. Biol. Res. | pmid:7536944 |
| Malyszko J et al. | FK 506 affects platelet aggregation in vitro. | 1994 | Thromb. Res. | pmid:7521072 |
| Schreier MH | Immunophilins and immunosuppression by cyclosporins and macrolide structures. | 1994 | Acta Derm Venereol Suppl (Stockh) | pmid:7521103 |
| Chen Y et al. | A putative sirolimus (rapamycin) effector protein. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7521160 |
| Tsuchida M et al. | Effects of irradiation, glucocorticoid and FK506 on cell-surface antigen expression by rat thymocytes: a three-colour flow cytofluorometric analysis. | 1994 | Immunology | pmid:7530693 |
| Meadows RP et al. | A computer-based protocol for semiautomated assignments and 3D structure determination of proteins. | 1994 | J. Biomol. NMR | pmid:7510556 |
| Abu-Elmagd K et al. | Three years clinical experience with intestinal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522850 |
| Shapiro R et al. | Improving results of pediatric renal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522851 |
| Moia LJ et al. | Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. | 1994 | Brain Res. | pmid:7522929 |
| Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
| Fung JJ and Starzl TE | FK 506 in solid organ transplantation. | 1994 | Transplant. Proc. | pmid:7524226 |
| Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
| Przepiorka D et al. | Blood tacrolimus concentration unchanged by plasmapheresis. | 1994 | Am J Hosp Pharm | pmid:7524318 |
| Burnett D et al. | Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis. | 1994 | Biochem. Pharmacol. | pmid:7524504 |
| Shaw LM and Brayman KL | FK-506 therapeutic drug monitoring. | 1994 | Clin. Chem. | pmid:7527305 |
| Ishii T et al. | Immunodepressants ameliorate normothermic ischemia injury to the rat liver by down-regulating tumor necrosis factor, not by alleviation of lipid peroxidative injury. | 1994 | Transpl. Int. | pmid:11271294 |
| Winkler M et al. | Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression. | 1994 | Clin. Chem. | pmid:7527306 |
| Platz KP et al. | Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients. | 1994 | Transpl. Int. | pmid:11271297 |
| Lewis HM | Therapeutic progress. II: Treatment of psoriasis. | 1994 | J Clin Pharm Ther | pmid:7527403 |
| Metcalfe S et al. | FK 506 and cyclosporin each block antigen-induced T cell receptor signalling that is dependent on CD4 co-receptor and operates in the absence of detectable cytoplasmic calcium fluxes. | 1994 | Transpl. Int. | pmid:11271304 |
| Chen SR et al. | Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7527548 |
| Moutabarrik A et al. | Effect of immunosuppressive agents FK 506 and cyclosporin and steroids on the expression of IL-6 and its receptor by stimulated lymphocytes and monocytes. | 1994 | Transpl. Int. | pmid:11271305 |
| Mori A et al. | Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512393 |
| Okubo Y et al. | Cytokine production in patients with mite-sensitive bronchial asthma. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512395 |
| Wilson JR et al. | Sensorimotor neuropathy resembling CIDP in patients receiving FK506. | 1994 | Muscle Nerve | pmid:7512691 |
| Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
| Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
| Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
| Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Tabasco-Minguillan J et al. | Long-term insulin requirement after liver transplantation with FK 506 in American veterans. | 1993 | Transplant. Proc. | pmid:7679839 |
| Klintmalm GB et al. | Use of Prograf (FK 506) as rescue therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679840 |
| Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
| Jayaraman T and Marks AR | Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line. | 1993 | J. Biol. Chem. | pmid:7503980 |
| D'Ambrosio R et al. | Validation and quality assurance program for monitoring tacrolimus (FK 506) concentrations in plasma and whole blood. | 1993 | Ther Drug Monit | pmid:7504339 |
| Reese JC et al. | The effect of FK506 on canine bile flow. | 1993 | Transplantation | pmid:7504342 |
| Valdivia LA et al. | Successful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin. | 1993 | Transplantation | pmid:7681230 |
| Fujimura A et al. | Chronopharmacokinetic study of a new immunosuppressive agent, FK 506, in mice. | 1993 | Jpn. J. Pharmacol. | pmid:7681489 |
| Nishinaka Y et al. | Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart. | 1993 | J. Cardiovasc. Pharmacol. | pmid:7681507 |
| Mühl H et al. | Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells. | 1993 | Eur. J. Pharmacol. | pmid:7506668 |
| Simek SL et al. | Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. | 1993 | Genomics | pmid:7507077 |
| Izumi S and Okuhara M | [FK506 and kifunensine, new immunomodulators of microbial origin]. | 1993 | Tanpakushitsu Kakusan Koso | pmid:7692469 |
| Wakugami T et al. | Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. | 1993 | Tohoku J. Exp. Med. | pmid:7692621 |
| Hill CC et al. | Penile prosthesis surgery in the immunosuppressed patient. | 1993 | Transplantation | pmid:7692633 |
| Yatscoff RW et al. | Comparison of the effect of rapamycin and FK506 on release of prostacyclin and endothelin in vitro. | 1993 | Clin. Biochem. | pmid:7507804 |
| Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
| Blaehr H et al. | Acute effects of FK506 and cyclosporine A on cultured human proximal tubular cells. | 1993 | Eur. J. Pharmacol. | pmid:7683267 |
| Textor SC et al. | Systemic and renal hemodynamic differences between FK506 and cyclosporine in liver transplant recipients. | 1993 | Transplantation | pmid:7685934 |
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| Denesyuk AI et al. | Structural similarity of the binding sites of cyclophilin A-cyclosporin A and FKBP-FK506 systems. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7683466 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
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| Yamaoka K et al. | Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells. | 1993 | Immunol. Lett. | pmid:7688712 |
| Smith DF et al. | Two FKBP-related proteins are associated with progesterone receptor complexes. | 1993 | J. Biol. Chem. | pmid:7688746 |
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| Garrity GM et al. | Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin. | 1993 | J. Ind. Microbiol. | pmid:7688970 |
| Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
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| Langrehr JM et al. | Clinical course, morphology, and treatment of chronically rejecting small bowel allografts. | 1993 | Transplantation | pmid:7679526 |