| MeSH term | MeSH ID | Detail |
|---|---|---|
| Erectile Dysfunction | D007172 | 19 associated lipids |
| Gingivitis | D005891 | 3 associated lipids |
| Periodontal Pocket | D010514 | 9 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Liver Cirrhosis, Alcoholic | D008104 | 17 associated lipids |
| Nephritis, Interstitial | D009395 | 10 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Ferraresso M et al. | Conversion from cyclosporine to tacrolimus for refractory acute rejection in pediatric kidney transplant recipients: a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750525 |
| Garcia CD et al. | Renal transplantation in children less than six years old. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750527 |
| Mendez R | FK 506 and mycophenolate mofetil in renal transplant recipients: six-month results of a multicenter, randomized dose ranging trial. FK 506 MMF Dose-Ranging Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636522 |
| Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
| Nazmul MN et al. | Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. | 2017 | Transplant. Proc. | pmid:29198681 |
| Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
| Suzuki K et al. | Effect of tacrolimus in renal transplant recipients with immunoglobulin-A nephropathy. | 2000 | Transplant. Proc. | pmid:11119910 |
| Bechstein WO et al. | A comparative, randomized trial of concentration-controlled sirolimus combined with reduced-dose tacrolimus or standard-dose tacrolimus in renal allograft recipients. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953523 |
| Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Pedroso JA et al. | Elderly kidney transplant recipient with intermittent fever: a case report of leishmaniasis with acute kidney injury during liposomal amphotericin B therapy. | 2014 | Transplant. Proc. | pmid:25242789 |
| Abu-Elmagd KM et al. | Four-hour versus 24-hour intravenous infusion of FK 506 in liver transplantation. | 1991 | Transplant. Proc. | pmid:1721271 |
| Sakr M et al. | Effect of renal ischemia on plasma levels of FK 506 in rats. | 1992 | Transplant. Proc. | pmid:1371625 |
| Smit JA et al. | Induction of primate TH2 lymphokines to suppress TH1 cells. | 1996 | Transplant. Proc. | pmid:8623334 |
| Hoffman AL et al. | The effect of FK 506 on small intestine allotransplantation in the rat. | 1990 | Transplant. Proc. | pmid:1689907 |
| Lopes CT et al. | Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice. | 2008 | Transplant. Proc. | pmid:18455036 |
| Cantarovich M et al. | Optimal time points for the prediction of the area-under-the-curve in liver transplant patients receiving tacrolimus. | 1998 | Transplant. Proc. | pmid:9636592 |
| Hachida M et al. | Combined use of deoxyspergualin and FK 506 for temporary circulatory assist. | 1999 | Transplant. Proc. | pmid:10455968 |
| Yoshimura N et al. | Combination therapy of tacrolimus (FK506) with azathioprine and steroids in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9474949 |
| Takeuchi H et al. | Lymphocyte sensitivity to cyclosporine and tacrolimus in chronic renal failure patients and clinical significance in renal transplantation. | 1998 | Transplant. Proc. | pmid:9474950 |
| Fukushima N et al. | Role of endothelial apoptosis in delayed xenograft rejection in pig-to-baboon cardiac transplantation. | 1999 | Transplant. Proc. | pmid:10578268 |
| Comuzzi C et al. | Safety of conversion from twice-daily tacrolimus (Prograf) to once-daily prolonged-release tacrolimus (Advagraf) in stable liver transplant recipients. | 2010 | Transplant. Proc. | pmid:20534291 |
| Kar S and Carr B | Gene expression of FK 506-binding protein. | 1991 | Transplant. Proc. | pmid:1721303 |
| Basu A et al. | Reversal of acute cellular rejection after renal transplantation with Campath-1H. | 2005 | Transplant. Proc. | pmid:15848576 |
| Connelly PR | Thermodynamics of interaction of FK 506-binding protein and its ligands. | 1991 | Transplant. Proc. | pmid:1721304 |
| Töz H et al. | Comparison of tacrolimus and cyclosporin in renal transplantation by the protocol biopsies. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013324 |
| Metcalfe S et al. | FK 506 and cyclosporine A: early effects on activation and gene induction in mouse spleen cells. | 1990 | Transplant. Proc. | pmid:1697107 |
| Marchewka Z et al. | Kidney graft function in long-term cyclosporine and tacrolimus treatment: comparative study with nephrotoxicity markers. | 2009 | Transplant. Proc. | pmid:19545703 |
| Herrero MJ et al. | Clinical interest of pharmacogenetic polymorphisms in the immunosuppressive treatment after heart transplantation. | 2010 | Transplant. Proc. | pmid:20970643 |
| Bachetoni A et al. | Preliminary evaluation of the new TACR flex method versus MEIA method in the therapeutic monitoring of tacrolimus in organ transplantation. | 2007 Jul-Aug | Transplant. Proc. | pmid:17692678 |
| Pereira M et al. | Hyperacute Rejection in a Kidney Transplant With Negative Crossmatch: A Case Report. | 2016 | Transplant. Proc. | pmid:27742303 |
| Grossi P et al. | Infectious complications in experimental small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518155 |
| Utsunomiya H et al. | Effect of FK 506 on orthotopic small bowel transplantation in rats. | 1992 | Transplant. Proc. | pmid:1376521 |
| Tsugita M et al. | Prevention of sensitization and hyperacute rejection in liver and heart xenografts by FK 506 plus donor antigens. | 1995 | Transplant. Proc. | pmid:7533393 |
| Izuishi K et al. | Effect of an immunosuppressive agent, tacroliums (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems of rat liver microsomes. | 2003 | Transplant. Proc. | pmid:12591538 |
| Kindt MV et al. | Tacrolimus toxicity in rhesus monkey: model for clinical side effects. | 1999 | Transplant. Proc. | pmid:10616519 |
| Gaston RS | Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens. | 1999 | Transplant. Proc. | pmid:10616556 |
| Hoshinaga K et al. | Regimen of tacrolimus-based immunosuppression with basiliximab, mycophenolate mofetil, and low-dose steroid reduces acute rejection in kidney transplants. | 2005 | Transplant. Proc. | pmid:15919457 |
| D'Alessandro AM et al. | FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1721335 |
| Yoshimura N et al. | Safety analysis after tacrolimus immunosuppression in renal transplant recipients in Japan: 5-year results in >1500 patients. | 2005 | Transplant. Proc. | pmid:15919458 |
| Sugitani A et al. | Long-term results of tacrolimus therapy for renal transplantation in patients with diabetic nephropathy in Japan. | 2005 | Transplant. Proc. | pmid:15919459 |
| Varo E et al. | Alternative immunosuppression for acute renal failure in liver transplantation: role of ultra-low dose tacrolimus and basiliximab. | 2002 | Transplant. Proc. | pmid:12176471 |
| Braun F et al. | Therapeutic drug monitoring of tacrolimus early after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176473 |
| Signorell J et al. | Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient. | 2010 | Transplant. Proc. | pmid:21094874 |
| Hayes D et al. | Aerosolized tacrolimus: a case report in a lung transplant recipient. | 2010 | Transplant. Proc. | pmid:21094875 |
| Braun F et al. | How to handle mycophenolate mofetil in combination with tacrolimus? | 1998 | Transplant. Proc. | pmid:9865309 |
| Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
| Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
| Chamienia A et al. | One-year observation of kidney allograft recipients converted from cyclosporine microemulsion to tacrolimus. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504670 |
| Gregory CR | Immunosuppressive approaches to the prevention of graft vascular disease. | 1998 | Transplant. Proc. | pmid:9595134 |
| Woo J et al. | FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. | 1992 | Transplant. Proc. | pmid:1281583 |
| Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group. | 1991 | Transplant. Proc. | pmid:1721367 | |
| Starzl TE et al. | Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics. | 1991 | Transplant. Proc. | pmid:1703351 |
| Gentil MA et al. | Safety and efficacy of delayed introduction of low-dose tacrolimus in elderly recipients of cadaveric renal transplants from donors over 55 years of age. | 2003 | Transplant. Proc. | pmid:12962766 |
| Garcia I | Efficacy and safety of dual versus triple tacrolimus-based therapy in kidney transplantation: two-year follow-up. | 2002 | Transplant. Proc. | pmid:12176516 |
| Hattori R et al. | FK 506 in cadaveric kidney transplantation from non-heart-beating donors. | 1998 | Transplant. Proc. | pmid:9838666 |
| Fischer L et al. | Hepatitis G virus infection in liver transplant recipients. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083208 |
| Zmonarski S et al. | Expression of PBMC TLR4 in Renal Graft Recipients Who Experienced Delayed Graft Function Reflects Dynamic Balance Between Blood and Tissue Compartments and Helps Select a Problematic Patient. | Transplant. Proc. | pmid:30056893 | |
| Youbin Z et al. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Gene Overexpression Prolongs the Survival of Rat Allogeneic Heart Allografts. | 2015 | Transplant. Proc. | pmid:26518962 |
| Scott-Douglas N et al. | Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy. | 1996 | Transplant. Proc. | pmid:8962226 |
| Suzuki H et al. | Spleen grafting might induce transplantation tolerance in rats. | 1995 | Transplant. Proc. | pmid:7536973 |
| Hsu KH et al. | Combined sirolimus-calcineurin inhibitor immunosuppressive therapy in simultaneous heart and kidney transplantation: a retrospective analysis of a single hospital's experience. | 2010 | Transplant. Proc. | pmid:20430208 |
| DiMartini A et al. | Psychiatric morbidity in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721399 |
| Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
| Nakajima K et al. | Effects of 15-deoxyspergualin and FK506 on the histology and survival of hamster-to-rat cardiac xenotransplantation. | 1989 | Transplant. Proc. | pmid:2468223 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Ochiai T et al. | Comparative studies on the immunosuppressive activity of FK506, 15-deoxyspergualin, and cyclosporine. | 1989 | Transplant. Proc. | pmid:2468228 |
| Mohacsi P et al. | Immunosuppression in ABO-incompatible transplantation. | 2001 | Transplant. Proc. | pmid:11377508 |
| Artz MA et al. | Randomized conversion from cyclosporine to tacrolimus in renal transplant patients: improved lipid profile and unchanged plasma homocysteine levels. | 2002 | Transplant. Proc. | pmid:12176579 |
| Saber LT et al. | Posttransplantation conversion to sirolimus-based immunosuppression: a single center experience. | 2007 | Transplant. Proc. | pmid:18089330 |
| Opelz G | New immunosuppressants and HLA matching. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266911 |
| Fu F et al. | Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083555 |
| Chung YW et al. | Tacrolimus-Induced Apoptosis is Mediated by Endoplasmic Reticulum-derived Calcium-dependent Caspases-3,-12 in Jurkat Cells. | 2018 | Transplant. Proc. | pmid:29731088 |
| Budde K et al. | Long-term outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 1998 | Transplant. Proc. | pmid:9723280 |
| Langrehr JM et al. | FK 506 inhibits nitric oxide production by cells infiltrating sponge matrix allografts. | 1991 | Transplant. Proc. | pmid:1721430 |
| Hayakawa K et al. | Maintenance of unresponsiveness by short-term pulse therapy with FK 506 in rat transplantation. | 1996 | Transplant. Proc. | pmid:8658904 |
| Eun SC et al. | Prolongation of the rat composite tissue allograft survival by the combination of tolerogenic immature dendritic cells and short-term treatment with FK506. | 2013 | Transplant. Proc. | pmid:23769045 |
| Li Y et al. | Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus. | 2013 | Transplant. Proc. | pmid:23769050 |
| Zeevi A et al. | Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A. | 1987 | Transplant. Proc. | pmid:2445073 |
| Liu W et al. | Transfusion of endothelial cells with lentivirus-mediated expression of fas ligand prolonged survival of rat liver allograft. | 2012 | Transplant. Proc. | pmid:22664023 |
| Ishida S et al. | Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104127 | |
| Asensio M et al. | Induction with basiliximab reduces acute rejection in pediatric liver transplant patients treated with tacrolimus and steroids. | 2002 | Transplant. Proc. | pmid:12176650 |
| Kandaswamy R et al. | Can we maintain immunosuppression avoiding nephrotoxic agents in pancreas transplantation? | 2008 | Transplant. Proc. | pmid:18374118 |
| Matevossian E et al. | Nitric oxide inhibition and consecutive Aspisol application show a prolonged survival of orthotopic transplanted livers in a rat model. | 2008 | Transplant. Proc. | pmid:18555092 |
| Sperschneider H | A large, multicentre trial to compare the efficacy and safety of tacrolimus with cyclosporine microemulsion following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267291 |
| Mühlbacher F | Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of a 3-month study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267317 |
| Shapiro R | Tacrolimus in solid organ transplantation: an update. | 1999 | Transplant. Proc. | pmid:10500545 |
| Morales E et al. | Conversion from cyclosporine to FK 506 as rescue therapy in renal transplantation with poorly steroid-responsive acute rejection. | 1999 | Transplant. Proc. | pmid:10500562 |
| Martins L et al. | Conversion to tacrolimus in case-problem kidney transplant recipients under cyclosporine-based immunosuppression. | 2000 | Transplant. Proc. | pmid:11134735 |
| Nardo B et al. | Evidence of microchimerism after pretransplant blood transfusion and FK 506 in liver xenograft. | 2000 | Transplant. Proc. | pmid:11134771 |
| Hanack U et al. | Is there a different impact of cyclosporine versus tacrolimus on delayed graft function after kidney transplantation? | 1998 | Transplant. Proc. | pmid:9723477 |
| Miyata Y et al. | Development of xenogeneic microchimerism correlated with graft outcome in hamster-to-rat heart xenotransplantation. | 1998 | Transplant. Proc. | pmid:9723548 |
| Bolton C | The ability of myelin basic protein-sensitised leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisolone. | 1991 | Transplant. Proc. | pmid:1721462 |
| Nichelle L et al. | Arterial hypertension in renal transplant recipients treated with tacrolimus or cyclosporine-Neoral. | 2002 | Transplant. Proc. | pmid:12431623 |
| Ciancio G et al. | Randomized trial of thymoglobulin versus alemtuzumab (with lower dose maintenance immunosuppression) versus daclizumab in living donor renal transplantation. | 2010 | Transplant. Proc. | pmid:21094804 |
| Lo A et al. | Ganciclovir prophylaxis for cytomegalovirus infection in simultaneous kidney-pancreas transplant recipients receiving tacrolimus, mycophenolate mofetil, and prednisone. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267516 |
| Teng D et al. | Comparison of rapamycin versus FK506 on expression of cytoprotective genes in the rat kidney allografts undergoing chronic allograft nephropathy. | 2006 | Transplant. Proc. | pmid:16980034 |
| Morris RE et al. | Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions. | 1991 | Transplant. Proc. | pmid:1703698 |
| Nakamura A et al. | Effects of elevated tacrolimus trough levels in association with infectious enteritis on graft function in renal transplant recipients. | 2014 | Transplant. Proc. | pmid:24656020 |