Kuo CJ et al. |
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. |
1992 |
Nature |
pmid:1614535
|
Moutabarrik A et al. |
In vitro FK506 kidney tubular cell toxicity. |
1992 |
Transpl. Int. |
pmid:14621743
|
Okamura N et al. |
Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2. |
1992 |
Transplant. Proc. |
pmid:1371624
|
Moutabarrik A et al. |
FK506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells. |
1992 |
Transpl. Int. |
pmid:14621744
|
Sakr M et al. |
Effect of renal ischemia on plasma levels of FK 506 in rats. |
1992 |
Transplant. Proc. |
pmid:1371625
|
Stangl MJ et al. |
The use of FK506 and RS61443 for reversal of small-bowel rejection. |
1992 |
Transpl. Int. |
pmid:14621800
|
Kusne S et al. |
Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation. |
1992 |
Transplant. Proc. |
pmid:1371626
|
Wijnen RM et al. |
Toxicology of FK506 in the cynomolgus monkey: a clinical, biochemical, and histopathological study. |
1992 |
Transpl. Int. |
pmid:14621844
|
Lee C et al. |
FK-506 binding protein from Tolypocladium inflatum: resistance of FKBP/FK-506 complex against proteolysis. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1371677
|
Jiang H et al. |
Control of humoral and cellular immunity-mediated accelerated heart allograft rejection in sensitized rats by low dose FK 506 and splenectomy. |
1992 |
Transpl. Int. |
pmid:14621859
|
Edkins RD et al. |
Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney. |
1992 |
Biochem. Pharmacol. |
pmid:1371687
|
Kobayashi N et al. |
Abdominal organ cluster transplantation in pigs and FK506. |
1992 |
Transpl. Int. |
pmid:14621861
|
Galat A et al. |
A rapamycin-selective 25-kDa immunophilin. |
1992 |
Biochemistry |
pmid:1371698
|
Metcalfe S et al. |
FK506 and rapamycin: differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes. |
1992 |
Transpl. Int. |
pmid:14621863
|
Hanawa H et al. |
An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats. |
1992 |
Clin. Immunol. Immunopathol. |
pmid:1371730
|
|
Japanese study of kidney transplantation: 1. Results of early phase II study. |
1992 |
Transpl. Int. |
pmid:14621866
|
Hiraoka Y et al. |
The effects of FK-506, a novel and potent immunosuppressant, upon murine Coxsackievirus B3 myocarditis. |
1992 |
J. Pharmacol. Exp. Ther. |
pmid:1372051
|
|
Japanese study of FK 506 on kidney transplantation: 2. Follow-up study of FK 506-treated patients. |
1992 |
Transpl. Int. |
pmid:14621874
|
Chen TS et al. |
Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771. |
1992 |
J. Antibiot. |
pmid:1372307
|
Walpoth B et al. |
Prevention of cardiac allograft rejection by FK506 and rapamycin: assessment by histology and nuclear magnetic resonance. |
1992 |
Transpl. Int. |
pmid:14621877
|
Morisaki M and Arai T |
Identity of immunosuppressant FR-900520 with ascomycin. |
1992 |
J. Antibiot. |
pmid:1372308
|
Asako H et al. |
Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. |
1992 |
Transplantation |
pmid:1384191
|
Doi R et al. |
Effects of FK506 on exocrine pancreas in rats. |
1992 |
Pancreas |
pmid:1372739
|
Furukawa H et al. |
The effect of bile duct ligation and bile diversion on FK506 pharmacokinetics in dogs. |
1992 |
Transplantation |
pmid:1373531
|
Sakr M et al. |
Cytomegalovirus infection of the upper gastrointestinal tract following liver transplantation--incidence, location, and severity in cyclosporine- and FK506-treated patients. |
1992 |
Transplantation |
pmid:1373535
|
Yamada K et al. |
New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney. |
1992 |
Transpl. Int. |
pmid:14621878
|
Demetris AJ et al. |
Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients. |
1992 |
Transplantation |
pmid:1374944
|
Bundick RV et al. |
FK506 as an agonist to induce inhibition of interleukin 2 production. |
1992 |
Transplantation |
pmid:1374947
|
Sakr M et al. |
The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats. |
1992 |
Transplantation |
pmid:1374948
|
Lepre CA et al. |
Solution structure of FK506 bound to FKBP-12. |
1992 |
FEBS Lett. |
pmid:1375171
|
Ruff VA et al. |
FKBP-12 is not an inhibitor of protein kinase C. |
1992 |
Immunol. Invest. |
pmid:1375189
|
Kawaguchi S |
[Effects of FK506 on aminonucleoside-induced nephrotic rats]. |
1992 |
Nihon Jinzo Gakkai Shi |
pmid:1375300
|
Sigal NH and Dumont FJ |
Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. |
1992 |
Annu. Rev. Immunol. |
pmid:1375473
|
Chen TS et al. |
Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]. |
1992 |
J. Antibiot. |
pmid:1375593
|
Meingassner JG and Stütz A |
Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? |
1992 |
J. Invest. Dermatol. |
pmid:1375617
|
Schneck FX et al. |
Pediatric renal transplantation under FK-506 immunosuppression. |
1992 |
J. Urol. |
pmid:1375663
|
Connelly PR and Thomson JA |
Heat capacity changes and hydrophobic interactions in the binding of FK506 and rapamycin to the FK506 binding protein. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1375751
|
Lancaster JR et al. |
EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. |
1992 |
J. Biol. Chem. |
pmid:1375934
|
Santiago SF et al. |
Effect of short-term immunosuppressive therapy with FK 506 or CyA on the donor in small intestine allotransplantation in rats. |
1992 |
Transplant. Proc. |
pmid:1376520
|
Utsunomiya H et al. |
Effect of FK 506 on orthotopic small bowel transplantation in rats. |
1992 |
Transplant. Proc. |
pmid:1376521
|
Yagihashi A et al. |
Changes in cell surface markers in human small bowel transplantation with FK 506. |
1992 |
Transplant. Proc. |
pmid:1376522
|
Abu-Elmagd K et al. |
Management of intestinal transplantation in humans. |
1992 |
Transplant. Proc. |
pmid:1376523
|
Takaori K et al. |
Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. |
1992 |
Transplant. Proc. |
pmid:1376531
|
Ohtsuka S et al. |
The effect of short-term FK 506 therapy on pancreas transplantation using the cuff technique in rats. |
1992 |
Transplant. Proc. |
pmid:1376532
|
Demetris AJ et al. |
Donor dendritic cells after liver and heart allotransplantation under short-term immunosuppression. |
1992 |
Lancet |
pmid:1376851
|
Ichihashi T et al. |
Haemolytic uraemic syndrome during FK506 therapy. |
1992 |
Lancet |
pmid:1376852
|
O'Keefe SJ et al. |
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. |
1992 |
Nature |
pmid:1377361
|
Clipstone NA and Crabtree GR |
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. |
1992 |
Nature |
pmid:1377362
|
Hasegawa S et al. |
Combination use of suboptimal dose of FK 506 and cyclosporine in canine lung transplantation. |
1992 |
J. Thorac. Cardiovasc. Surg. |
pmid:1279319
|
Peattie DA et al. |
Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1279700
|
Lhoëst G et al. |
Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media. |
1992 |
Pharm Acta Helv |
pmid:1279730
|
Kamei T et al. |
Established intraportal islet allograft is rejected despite the acceptance of donor-specific second cardiac allograft. |
1992 |
Transplant. Proc. |
pmid:1281579
|
Woo J et al. |
FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. |
1992 |
Transplant. Proc. |
pmid:1281583
|
Souza ER et al. |
Acute effects of FK 506 on glomerular hemodynamics. |
1992 |
Transplant. Proc. |
pmid:1281585
|
Hanke JH et al. |
FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA. |
1992 |
Lymphokine Cytokine Res. |
pmid:1281674
|
Logan TM et al. |
Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments. |
1992 |
FEBS Lett. |
pmid:1281793
|
Bergstrand H et al. |
Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. |
1992 |
J. Pharmacol. Exp. Ther. |
pmid:1281879
|
DiLella AG et al. |
Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1281998
|
Sawada M et al. |
Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1282000
|
Minoda M et al. |
Effects of gamma-interferon and FK506 on resting B cell proliferation of New Zealand black/white F1 mice. |
1992 |
Microbiol. Immunol. |
pmid:1282197
|
Min DI et al. |
Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. |
1992 |
Am J Hosp Pharm |
pmid:1282779
|
Mochizuki M |
[Immunotherapy in ocular diseases]. |
1992 |
Nippon Ganka Gakkai Zasshi |
pmid:1283052
|
Olejniczak ET et al. |
A 4D HCCH-TOCSY experiment for assigning the side chain 1H and 13C resonances of proteins. |
1992 |
J. Biomol. NMR |
pmid:1283353
|
Aldape RA et al. |
Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex. |
1992 |
J. Biol. Chem. |
pmid:1379588
|
Langrehr JM et al. |
Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat. |
1992 |
J. Clin. Invest. |
pmid:1379617
|
Kumano K et al. |
[Functional and morphological changes in rat kidney induced by FK506 and its reversal by various vasodilators]. |
1992 |
Nippon Hinyokika Gakkai Zasshi |
pmid:1379657
|
Woodle ES et al. |
FK506: inhibition of humoral mechanisms of hepatic allograft rejection. |
1992 |
Transplantation |
pmid:1379749
|
Sato K et al. |
Effectiveness of triple drug immunosuppression for pancreaticoduodenal allotransplantation in dogs. |
1992 |
Transplant. Proc. |
pmid:1379753
|
Kobayashi N et al. |
Abdominal organ cluster transplantation in pigs receiving FK 506. |
1992 |
Transplant. Proc. |
pmid:1379754
|
Yoshimura R et al. |
A comparative study of cyclosporine vs FK 506: role of kidney microsomal cytochrome P-450. |
1992 |
Transplant. Proc. |
pmid:1379755
|
Yamada K et al. |
FK 506-induced juxtaglomerular apparatus hyperplasia and tubular damage in rat kidney--morphologic and biologic analysis. |
1992 |
Transplant. Proc. |
pmid:1379756
|
Fukuse T et al. |
Optimal dose of FK 506 in canine lung allotransplantation. |
1992 |
Transplant. Proc. |
pmid:1379757
|
Wada H et al. |
Combination use of suboptimal doses of FK 506 and cyclosporine in canine lung transplantation. |
1992 |
Transplant. Proc. |
pmid:1379758
|
Cai X et al. |
Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. |
1992 |
Transplant. Proc. |
pmid:1379759
|
Taki J et al. |
DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. |
1992 |
Transplant. Proc. |
pmid:1379760
|
Sato Y et al. |
FK 506 suppresses class II antigen expression in regenerating livers following partial hepatectomy in the rat. |
1992 |
Transplant. Proc. |
pmid:1379761
|
Stütz A |
Immunosuppressive macrolides. |
1992 |
Transplant. Proc. |
pmid:1379762
|
Bolton C |
The efficacy of cyclosporin A, FK-506 and prednisolone to modify the adoptive transfer of experimental allergic encephalomyelitis (EAE). |
1992 |
Agents Actions |
pmid:1380765
|
Terada N et al. |
Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1380801
|
Friccius H et al. |
The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. |
1992 |
Int. J. Immunopharmacol. |
pmid:1380951
|
Dumont FJ et al. |
The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. |
1992 |
J. Exp. Med. |
pmid:1380976
|
Norris AA et al. |
Protective effects of cyclophosphamide, cyclosporin A and FK506 against antigen-induced lung eosinophilia in guinea-pigs. |
1992 |
Clin. Exp. Immunol. |
pmid:1381297
|
Karpas A et al. |
Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1381509
|
Yatscoff RW and Shaw LM |
Therapeutic monitoring of cyclosporine, FK-506, and rapamycin. |
1992 |
Ther Drug Monit |
pmid:1381530
|
Arceci RJ et al. |
Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. |
1992 |
Blood |
pmid:1381629
|
Pahl A and Keller U |
FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type. |
1992 |
J. Bacteriol. |
pmid:1381710
|
Takahashi N |
[Cyclophilin and FK506-binding protein]. |
1992 |
Seikagaku |
pmid:1381737
|
Lee TK et al. |
Mucosal glutamine utilization after small-bowel transplantation: an electrophysiologic study. |
1992 |
J. Surg. Res. |
pmid:1382152
|
Kaye RE et al. |
Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. |
1992 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1382293
|
Edalji R et al. |
High-level expression of recombinant human FK-binding protein from a fusion precursor. |
1992 |
J. Protein Chem. |
pmid:1382438
|
Todo S et al. |
Intestinal transplantation in composite visceral grafts or alone. |
1992 |
Ann. Surg. |
pmid:1384443
|
Massol N et al. |
Rabbit FKBP59-heat shock protein binding immunophillin (HBI) is a calmodulin binding protein. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1384470
|
Siekierka JJ and Sigal NH |
FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond. |
1992 |
Curr. Opin. Immunol. |
pmid:1384551
|
Hultsch T et al. |
The effect of the immunophilin ligands rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines. |
1992 |
Mol. Biol. Cell |
pmid:1384815
|
Petros AM et al. |
Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe. |
1992 |
J. Biomol. NMR |
pmid:1384850
|
Liu J et al. |
The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6. |
1992 |
Int. Arch. Allergy Immunol. |
pmid:1384862
|
Mochizuki M et al. |
Preclinical and clinical study of FK506 in uveitis. |
1992 |
Curr. Eye Res. |
pmid:1385045
|
Chung J et al. |
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. |
1992 |
Cell |
pmid:1377606
|
Xu RX et al. |
Stereospecific assignments and chi 1 rotamers for FKBP when bound to ascomycin from 3JH alpha,H beta and 3HN,H beta coupling constants. |
1992 |
FEBS Lett. |
pmid:1377648
|
Petros AM et al. |
NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein. |
1992 |
J. Med. Chem. |
pmid:1377749
|