| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Glomerulosclerosis, Focal Segmental | D005923 | 4 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Dermatitis | D003872 | 30 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Vomiting | D014839 | 21 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Pharyngitis | D010612 | 2 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
| Reduced incidence of acute, refractory acute, and chronic rejection after liver transplantation with FK506-based immunosuppression. European FK506 Multicentre Liver Study Group. | 1994 | Transplant. Proc. | pmid:7527960 | |
| Nomoto S et al. | Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance. | 1994 | Transplant. Proc. | pmid:7513477 |
| Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
| Kato H et al. | Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma levels of FK 506 in the early phase after liver transplantation. | 1994 | Transplant. Proc. | pmid:7513481 |
| Sewing KF | Pharmacokinetics, dosing principles, and blood level monitoring of FK506. | 1994 | Transplant. Proc. | pmid:7527962 |
| Nishikawa K et al. | Experimental studies of vascularized joint allografts in rats. | 1994 | Transplant. Proc. | pmid:7513482 |
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Fukuzawa M and Okada A | Analysis of mouse xenogeneic T-cell responses and the effect of FK 506 on these responses and on xeno-skin graft rejection. | 1994 | Transplant. Proc. | pmid:7513483 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Petuch BR et al. | Microbial transformation of immunosuppressive compounds. III. Glucosylation of immunomycin (FR 900520) and FK 506 by Bacillus subtilis ATCC 55060. | 1994 | J. Ind. Microbiol. | pmid:7513528 |
| Shaeffer MS et al. | Interaction between FK506 and erythromycin. | 1994 | Ann Pharmacother | pmid:7513563 |
| Lhöest GJ et al. | 15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity. | 1994 | Clin. Chem. | pmid:7513627 |
| Ueda H et al. | FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. | 1994 | J. Antibiot. | pmid:7513682 |
| Kraus-Friedmann N and Feng L | Reduction of ryanodine binding and cytosolic Ca2+ levels in liver by the immunosuppressant FK506. | 1994 | Biochem. Pharmacol. | pmid:7529023 |
| Cardenas ME et al. | Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. | 1994 | EMBO J. | pmid:7529175 |
| Hisatomi K et al. | Limited effectiveness of FK506 administration for ongoing rejection in heterotopic rat heart transplantation. | 1994 | Surg. Today | pmid:7516210 |
| Burkhalter EL et al. | Severe neurological complications following orthotopic liver transplantation in patients receiving FK 506 and prednisone. | 1994 | J. Hepatol. | pmid:7529272 |
| Kawano K et al. | Evidence that FK506 alleviates ischemia/reperfusion injury to the rat liver: in vivo demonstration for suppression of TNF-a production in response to endotoxemia. | 1994 | Eur Surg Res | pmid:7516291 |
| Morozumi K and Takeda A | [Kidney disorders induced by immunosuppressive agents]. | 1994 | Nippon Naika Gakkai Zasshi | pmid:7529294 |
| Wolter K et al. | Interaction between FK 506 and clarithromycin in a renal transplant patient. | 1994 | Eur. J. Clin. Pharmacol. | pmid:7532134 |
| Hashimoto T et al. | Treatment with FK506 prevents rejection of rat colon allografts. | 1994 | Transplantation | pmid:7516586 |
| Alamartine E et al. | In-vitro effects of cyclosporin A, FK506, 6-mercaptopurine, and prednisolone on lymphokine-activated killer cells. | 1994 | Nephrol. Dial. Transplant. | pmid:7529381 |
| Konishi M et al. | Effects of FK506 on surface antigen expression by regenerating thymocytes after sublethal irradiation in the rat. | 1994 | Thymus | pmid:7532330 |
| Krentz AJ et al. | Postoperative glucose metabolism in liver transplant recipients. A two-year prospective randomized study of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7516590 |
| Shapiro R et al. | A prospective, randomized trial of FK-506 in renal transplantation--a comparison between double- and triple-drug therapy. | 1994 | Clin Transplant | pmid:7532475 |
| Ludwig B et al. | Characterization of Mip proteins of Legionella pneumophila. | 1994 | FEMS Microbiol. Lett. | pmid:7516906 |
| Atcherson MM and Trifillis AL | Cytotoxic effects of FK506 on human renal proximal tubule cells in culture. | 1994 | In Vitro Cell. Dev. Biol. Anim. | pmid:7529625 |
| Murthy JN et al. | Identification of a 14 kDa FK-506/rapamycin binding immunophilin from calf thymus. | 1994 | Clin. Biochem. | pmid:7532556 |
| Maruyama K et al. | FK 506 for vascular permeability factor production in minimal change nephrotic syndrome. | 1994 | Nephron | pmid:7517020 |
| Donnelly JG and Soldin SJ | Partial characterization of a 52 kDa CsA/FK506/rapamycin binding protein. | 1994 | Clin. Biochem. | pmid:7532557 |
| High KP | The antimicrobial activities of cyclosporine, FK506, and rapamycin. | 1994 | Transplantation | pmid:7517076 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Reyes J et al. | Lymphoproliferative disease after intestinal transplantation under primary FK 506 immunosuppression. | 1994 | Transplant. Proc. | pmid:7518137 |
| Murase N et al. | Small bowel transplantation in sensitized recipients: comparison with heart, kidney, and liver grafts. | 1994 | Transplant. Proc. | pmid:7518139 |
| Fujisaki S et al. | Effects of preformed antibodies induced by whole blood transfusion on small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518140 |
| Spada M et al. | Monitoring of intestinal myoelectrical activity after isolated small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518141 |
| Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
| Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
| Cakaloglu Y et al. | Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. | 1994 | Hepatology | pmid:7519161 |
| Luan S et al. | Light-regulated, tissue-specific immunophilins in a higher plant. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7508125 |
| Blazar BR et al. | FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation. | 1994 | J. Immunol. | pmid:7519216 |
| Laifer SA et al. | Pregnancy after cardiac transplantation. | 1994 | Am J Perinatol | pmid:7519426 |
| Yoshikawa N et al. | Effect of FK-506 on xenografted human Graves' thyroid tissue is severe combined immunodeficient mice. | 1994 | Clin. Endocrinol. (Oxf) | pmid:7519528 |
| Porayko MK et al. | Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. | 1994 | Mayo Clin. Proc. | pmid:7508536 |
| Kao PN et al. | Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. | 1994 | J. Biol. Chem. | pmid:7519613 |
| Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
| Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
| Yamauchi T | [Multiple abdominal organ transplantation in swine using FK-506]. | 1994 | Nihon Geka Gakkai Zasshi | pmid:7510015 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Masaoka T | Problems of bone marrow transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520634 |
| Okano K et al. | Ameliorative effect of FK 506 on cold ischemia reperfusion injury of the rat liver. | 1994 | Transplant. Proc. | pmid:7520635 |
| Connelly PR et al. | Enthalpy of hydrogen bond formation in a protein-ligand binding reaction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7510408 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Shiraga T et al. | Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. | 1994 | Biochem. Pharmacol. | pmid:7510480 |
| Hirai T et al. | A short course of FK506 can induce limited donor-specific graft acceptance. | 1994 | Ann. Thorac. Surg. | pmid:7520685 |
| Kuwano K and Arai S | The inhibitory effect of FK506 on cytotoxic T-lymphocyte killing. | 1994 | Immunol. Lett. | pmid:7536706 |
| Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
| Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
| Meadows RP et al. | A computer-based protocol for semiautomated assignments and 3D structure determination of proteins. | 1994 | J. Biomol. NMR | pmid:7510556 |
| Okamoto S et al. | The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. | 1994 | J. Biol. Chem. | pmid:7510691 |
| Metcalfe S et al. | FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal. | 1994 | Cell. Immunol. | pmid:7522130 |
| Nichols RA et al. | Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. | 1994 | J. Biol. Chem. | pmid:7522234 |
| Nakagawa H et al. | Tacrolimus ointment for atopic dermatitis. | 1994 | Lancet | pmid:7522297 |
| Sharkey J and Butcher SP | Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. | 1994 | Nature | pmid:7522303 |
| Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
| Schleuning M et al. | Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7523957 |
| Perotti BY et al. | HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. | 1994 | Pharm. Res. | pmid:7524055 |
| FDA approved new drug bulletin: aprotinin injection (trasylol), tacrolimus (prograf). | 1994 | RN | pmid:7524131 | |
| Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
| Steinmüller TM et al. | The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial. | 1994 | Transplantation | pmid:7524203 |
| Singh N et al. | Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants. | 1994 | Transplantation | pmid:7524204 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Connolly JO et al. | Renal arteriopathy associated with FK 506 therapy following liver transplantation. | 1994 | Nephrol. Dial. Transplant. | pmid:7526278 |
| Pham SM et al. | Cardiac transplantation at the University of Pittsburgh: 1994 update. | 1994 | Clin Transpl | pmid:7547531 |
| Radanyi C et al. | The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7526392 |
| Abu-Elmagd K et al. | Hepatic transplantation at the University of Pittsburgh: new horizons and paradigms after 30 years of experience. | 1994 | Clin Transpl | pmid:7547533 |
| Ko S et al. | The pharmacokinetic benefits of newly developed liposome-incorporated FK506. | 1994 | Transplantation | pmid:7526494 |
| Shapiro R et al. | Renal transplantation at the University of Pittsburgh: the impact of FK506. | 1994 | Clin Transpl | pmid:7547544 |
| Holländer GA et al. | Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. | 1994 | Transplantation | pmid:7526495 |
| Ishioka M et al. | FK506 treatment of noninfectious uveitis. | 1994 | Am. J. Ophthalmol. | pmid:7526689 |
| Yano S et al. | Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes. | 1994 | Jpn. J. Cancer Res. | pmid:7511575 |
| Carroll PB et al. | Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results. | 1994 | Arch Dermatol | pmid:7526802 |
| Iwata H et al. | Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin. | 1994 | Int. Immunol. | pmid:7511931 |
| Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
| Mayrleitner M et al. | The calcium release channel of sarcoplasmic reticulum is modulated by FK-506 binding protein: effect of FKBP-12 on single channel activity of the skeletal muscle ryanodine receptor. | 1994 | Cell Calcium | pmid:7511990 |
| Bush KT et al. | Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. | 1994 | Biochem. J. | pmid:7526846 |
| Kahan BD | New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. | 1994 | Ther Immunol | pmid:7584478 |
| Hamajima E et al. | Effects of FK506, an immunosuppressive agent, on genesis of water-immersion stress-induced gastric lesions in rats. | 1994 | Dig. Dis. Sci. | pmid:7512015 |
| Matsumoto T et al. | Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. | 1994 | Dig. Dis. Sci. | pmid:7512017 |
| Todo S et al. | Small intestinal transplantation in humans with or without the colon. | 1994 | Transplantation | pmid:7512291 |
| Moutabarrik A et al. | Effect of immunosuppressive agents FK 506 and cyclosporin and steroids on the expression of IL-6 and its receptor by stimulated lymphocytes and monocytes. | 1994 | Transpl. Int. | pmid:11271305 |
| Winkler M et al. | Optimal FK 506 dosage in patients under primary immunosuppression following liver transplantation. | 1994 | Transpl. Int. | pmid:11271312 |
| Devlin J et al. | FK 506 primary immunosuppression following emergency liver transplantation for fulminant hepatic failure. European FK 506 Study Liver Group. | 1994 | Transpl. Int. | pmid:11271328 |
| Otto G et al. | Corticosteroids and concomitant medication in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271338 |
| Wong P et al. | FK 506 rescue therapy for intractable liver allograft rejection. | 1994 | Transpl. Int. | pmid:11271339 |
| Mor E et al. | Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. | 1994 | Transpl. Int. | pmid:11271340 |
| Uemoto S et al. | Long-term use of FK 506 in living related liver transplantation. | 1994 | Transpl. Int. | pmid:11271341 |