| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kotowski M et al. | The Importance of New Generation Sequencing (NGS) HLA Typing in Renal Transplantation-Preliminary Report. | Transplant. Proc. | pmid:29937294 | |
| López Lago AM et al. | Evolution of hepatorenal syndrome after orthotopic liver transplantation: comparative analysis with patients who developed acute renal failure in the early postoperative period of liver transplantation. | 2007 | Transplant. Proc. | pmid:17889176 |
| Loinaz C et al. | A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 randomized liver transplant recipients: midterm efficacy and safety. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750472 |
| Jun H et al. | Experiences on conversion to once-daily Advagraf and sirolimus combination in stable kidney recipients. | 2014 | Transplant. Proc. | pmid:24655973 |
| Rostaing L et al. | Early posttransplantation renal hemodynamics in FK 506-treated kidney recipients with or without prior induction therapy. | 1998 | Transplant. Proc. | pmid:9636519 |
| Perrakis A et al. | Impact of the conversion of the immunosuppressive regimen from prograf to advagraf or to sirolimus in long-term stable liver transplant recipients: indications, safety, and outcome. | 2011 | Transplant. Proc. | pmid:22172830 |
| Cherala G et al. | Tacrolimus pharmacokinetics in Hispanic children after kidney transplantation. | 2011 | Transplant. Proc. | pmid:22172831 |
| Gupta S and Brennan DC | Pneumococcal 13-Valent Conjugate Vaccine (Prevnar 13)-Associated Immune Thrombocytopenic Purpura in a Renal Transplant Recipient: A Case Report. | Transplant. Proc. | pmid:26915880 | |
| Crespo M et al. | De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715848 |
| Stringa P et al. | Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study. | Transplant. Proc. | pmid:26915870 | |
| Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
| Wong KM et al. | Tacrolimus versus cyclosporine as primary prophylactic therapy after cadaveric renal transplant: two-year survival study. | 2000 | Transplant. Proc. | pmid:11119907 |
| Porayko MK et al. | Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7679835 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |
| Iwasaki K et al. | Pharmacokinetic study of FK 506 in the rat. | 1991 | Transplant. Proc. | pmid:1721268 |
| Andersson J et al. | FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro. | 1992 | Transplant. Proc. | pmid:1371621 |
| Takada S et al. | HGF prevents tacrolimus (FK 506)-induced nephrotoxicity in SHR rats. | 1996 | Transplant. Proc. | pmid:8623236 |
| Ciancio G et al. | Efficacy and safety of daclizumab induction for primary kidney transplant recipients in combination with tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2003 | Transplant. Proc. | pmid:12644172 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients treated with tacrolimus. | 2002 | Transplant. Proc. | pmid:11959335 |
| Francavilla A et al. | FK 506 as a growth control factor. | 1990 | Transplant. Proc. | pmid:1689912 |
| Mazzaferro V et al. | Studies of the hepatotrophic qualities of FK 506 and CyA. | 1990 | Transplant. Proc. | pmid:1689913 |
| Favi E et al. | Prospective clinical trial comparing two immunosuppressive regimens, tacrolimus and mycophenolate mofetil versus everolimus and low-dose cyclosporine, in de novo renal transplant recipients: results at 6 months follow-up. | 2009 | Transplant. Proc. | pmid:19460503 |
| Steinmueller T et al. | Effect of CsA versus FK 506 on insulin sensitivity and insulin response using a modeling technique. | 1998 | Transplant. Proc. | pmid:9636589 |
| Miura S et al. | The beneficial effects of FK 506 on living-related renal transplantation in presensitized recipients. | 1999 | Transplant. Proc. | pmid:10455940 |
| Liu WT et al. | In vitro generation of tacrolimus metabolites and their detection in whole blood. | 1998 | Transplant. Proc. | pmid:9636590 |
| Jiang H and Kobayashi M | Differences between cyclosporin A and tacrolimus in organ transplantation. | 1999 | Transplant. Proc. | pmid:10455942 |
| Ringe B et al. | Replacement of corticosteroids by mycophenolate mofetil in liver graft recipients on initial tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11120285 |
| Woodle ES et al. | Role of protocol biopsies in the treatment of refractory renal allograft rejection with FK 506. | 1996 | Transplant. Proc. | pmid:8623495 |
| Rao P et al. | Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression. | 1991 | Transplant. Proc. | pmid:1721301 |
| Propper DJ et al. | Low-dose FK 506 inhibits sensitisation after blood transfusions. | 1990 | Transplant. Proc. | pmid:1697114 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Koefoed-Nielsen PB et al. | Comparison of the temporal profile of calcineurin inhibition by cyclosporine and tacrolimus in renal transplant patients. | 2005 | Transplant. Proc. | pmid:15919449 |
| Jain A et al. | Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients. | 1992 | Transplant. Proc. | pmid:1376518 |
| Watanabe K et al. | Factors influencing long-term operational tolerance in dogs treated with fractionated lymphoid irradiation, donor bone marrow cell infusion and FK506. | 1995 | Transplant. Proc. | pmid:7533389 |
| Kitamura T et al. | Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation: a case report. | 2003 | Transplant. Proc. | pmid:12591458 |
| Mizuta K et al. | Increase of bile acid production by tacrolimus in the rat liver. | 2003 | Transplant. Proc. | pmid:12591477 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Borg AJ and Kumagai M | FK 506 and xenogeneic human anti-porcine cellular reactivity. | 1991 | Transplant. Proc. | pmid:1721332 |
| Fung J et al. | A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine. | 1991 | Transplant. Proc. | pmid:1721333 |
| Serrano J et al. | Tacrolimus is effective in both dual and triple regimens after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176469 |
| Lee KK et al. | Comparison of short-term immunosuppressive therapy with cyclosporine and FK 506 in small-bowel transplantation. | 1990 | Transplant. Proc. | pmid:1702239 |
| du Toit DF et al. | Tacrolimus (FK506) monotherapy provides potent and significant suppression of allogeneic foetal rat pancreatic allograft rejection. | 1998 | Transplant. Proc. | pmid:9865300 |
| Niel OR et al. | Long-term glomerular filtration rate in liver allograft recipients according to the type of calcineurin inhibitors. | 2009 | Transplant. Proc. | pmid:19857743 |
| Regazzi MB et al. | Pharmacokinetics of FK506 and mycophenolic acid in experimental and clinical intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142302 |
| Hansen LJ et al. | Early pharmacokinetic profiles of enteral tacrolimus after multivisceral transplantation. | 1997 | Transplant. Proc. | pmid:9142303 |
| Deniz H et al. | Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats. | 2006 | Transplant. Proc. | pmid:16549154 |
| Oltean M et al. | FK506 donor pretreatment improves intestinal graft microcirculation and morphology by concurrent inhibition of early NF-kappaB activation and augmented HSP72 synthesis. | 2005 | Transplant. Proc. | pmid:15919508 |
| Fisniku O et al. | Protective effects of PG490-88 on chronic allograft rejection by changing intragraft gene expression profiles. | 2005 | Transplant. Proc. | pmid:15919518 |
| Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
| Jensen CW et al. | Pediatric renal transplantation under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721364 |
| Solà R et al. | Tacrolimus in induction immunosuppressive treatment in renal transplantation: comparison with cyclosporine. | 2003 | Transplant. Proc. | pmid:12962763 |
| Choong CL et al. | Dose-Response Relationship Between Diltiazem and Tacrolimus and Its Safety in Renal Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30316389 |
| Ciancio G et al. | Effect of daclizumab, tacrolimus and mycophenolate mofetil in racial minority first renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176508 |
| Omar G et al. | FK 506 inhibition of cyclosporine metabolism by human liver microsomes. | 1991 | Transplant. Proc. | pmid:1703356 |
| Eiras G et al. | Effects of FK 506 and cyclosporine on T-cell activation: integrin-mediated adhesion of T cells, proliferation, and maturation of cytotoxic T cells. | 1991 | Transplant. Proc. | pmid:1703357 |
| Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
| Watanabe K et al. | Prolongation effect of FK506 on the survival of 3-day preserved kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9838579 |
| Mueller AR et al. | Is the use of marginal liver grafts justified? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083160 |
| Molmenti E et al. | Noncompliance after pediatric liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083164 |
| Shimizu T et al. | Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts. | 2008 | Transplant. Proc. | pmid:18790237 |
| Zipperle S et al. | Impaired T-cell IL-10 secretion and CD4 helper function in liver transplant patients treated with tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123208 |
| Li W et al. | High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in Mouse cardiac transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123209 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
| Masaki Y et al. | Cellular basis of acquired immunologic tolerance following total bowel transplantation in rats. I. Relation between donor lymphocyte chimerism and host-cell-mediated immunity. | 1995 | Transplant. Proc. | pmid:7536971 |
| Asavakarn S et al. | Systematic Pharmaceutical Educational Approach to Enhance Drug Adherence in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320587 |
| Limsrichamrern S et al. | Correlation of Hematocrit and Tacrolimus Level in Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27320581 |
| Freise CE et al. | Similar clinical presentation of neurotoxicity following FK 506 and cyclosporine in a liver transplant recipient. | 1991 | Transplant. Proc. | pmid:1721397 |
| Eidelman BH et al. | Neurologic complications of FK 506. | 1991 | Transplant. Proc. | pmid:1721398 |
| McGrath JS and Shehata M | The effect of differing immunosuppressive regimes on the functional and morphologic changes in a rat renal allograft model of chronic rejection. | 2001 | Transplant. Proc. | pmid:11377499 |
| Koefoed-Nielsen PB and Jørgensen KA | Alterations in calcineurin phosphatase activity in tacrolimus-treated renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176559 |
| Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
| Arai K et al. | Prolonged limb allograft survival with short-term treatment with FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468256 |
| Gasser M et al. | Putative regulatory function of alloreactive Th2 cells in tolerant recipients after small bowel transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266759 |
| Yessayan L et al. | Race, Calcineurin Inhibitor Exposure, and Renal Function After Solid Organ Transplantation. | 2015 | Transplant. Proc. | pmid:26707323 |
| Jiang H et al. | Inhibition of IL-10 by FK 506 may be responsible for overcoming ongoing allograft rejection in the rat. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083538 |
| Kahan BD | High variability of drug exposure: a biopharmaceutic risk factor for chronic rejection. | 1998 | Transplant. Proc. | pmid:9723224 |
| Sheng H et al. | Ocular complications of heart transplantation in a Chinese population. | 2008 | Transplant. Proc. | pmid:19100445 |
| Zucker MJ et al. | De novo immunosuppression with sirolimus and tacrolimus in heart transplant recipients compared with cyclosporine and mycophenolate mofetil: a one-year follow-up analysis. | 2005 | Transplant. Proc. | pmid:15964386 |
| Fukuzawa M et al. | Effect of donor-specific transfusion and FK 506 on small intestine allotransplantation. | 1991 | Transplant. Proc. | pmid:1721427 |
| Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
| MacDonald AS | Rapamycin in combination with cyclosporine or tacrolimus in liver, pancreas, and kidney transplantation. | 2003 | Transplant. Proc. | pmid:12742497 |
| Neff GW et al. | Ten years of sirolimus therapy in orthotopic liver transplant recipients. | 2003 | Transplant. Proc. | pmid:12742498 |
| Sindhi R et al. | Pharmacodynamics of sirolimus in transplanted children receiving tacrolimus. | 2002 | Transplant. Proc. | pmid:12176644 |
| Petz W et al. | Experience with the use of basiliximab in liver transplantation--use in pediatric and adult recipients in combination with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:12176648 |
| Calne R et al. | Observations about FK-506 in primates. | 1987 | Transplant. Proc. | pmid:2445078 |
| Slatinska J et al. | Long-term follow-up of stable kidney transplant recipients after conversion from tacrolimus twice daily immediate release to tacrolimus once-daily prolonged release: a large single-center experience. | 2013 | Transplant. Proc. | pmid:23726604 |
| Todo S et al. | Orthotopic liver transplantation in dogs receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445079 |
| Chakrabarti P et al. | Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267274 |
| Del Castillo D | Analysis of primary and recurrent rejection following renal transplantation in a large, comparative, multicentre trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267283 |
| Pirsch JD | Mycophenolate mofetil, tacrolimus, Neoral: from clinical trials to the clinic. | 1998 | Transplant. Proc. | pmid:9723448 |
| Antoine C et al. | Vascular microthrombosis in renal transplant recipients treated with tacrolimus. | 1998 | Transplant. Proc. | pmid:9745577 |
| McCauley J et al. | FK 506 in the management of transplant-related nephrotic syndrome and steroid-resistant nephrotic syndrome. | 1991 | Transplant. Proc. | pmid:1721459 |
| Garcia CD et al. | Pediatric renal transplantation under tacrolimus or cyclosporine immunosuppression and basiliximab induction. | 2002 | Transplant. Proc. | pmid:12431513 |
| Owen ER et al. | Peripheral nerve regeneration in human hand transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267484 |
| Fu Q et al. | Risk Factors for Acute Rejection After Deceased Donor Kidney Transplantation in China. | 2018 | Transplant. Proc. | pmid:30316380 |
| Stempfle HU et al. | Rapid trabecular bone loss after cardiac transplantation using FK506 (tacrolimus)-based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636459 |
| Ikeda M et al. | Successful Second Allogeneic Stem Cell Transplantation From a Sibling Donor for Relapse of Myelodysplastic Syndrome in a Recipient of a Renal Transplant From His Mother: Case Report. | 2016 | Transplant. Proc. | pmid:27932152 |
| Filler G | Optimization of immunosuppressive drug monitoring in children. | 2007 | Transplant. Proc. | pmid:17524944 |
| Ericzon BG et al. | Effect of FK 506 on glucose metabolism in the cynomolgus monkey: studies in pancreatic transplant recipients and nontransplanted animals. | 1991 | Transplant. Proc. | pmid:1703695 |
| Kumano K et al. | FK 506-induced nephrotoxicity in rats. | 1991 | Transplant. Proc. | pmid:1703696 |