| MeSH term | MeSH ID | Detail |
|---|---|---|
| Amenorrhea | D000568 | 4 associated lipids |
| Amputation, Traumatic | D000673 | 2 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Hemolytic | D000743 | 4 associated lipids |
| Anemia, Hemolytic, Autoimmune | D000744 | 5 associated lipids |
| Anemia, Refractory | D000753 | 3 associated lipids |
| Anemia, Refractory, with Excess of Blasts | D000754 | 2 associated lipids |
| Aneurysm, Dissecting | D000784 | 2 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu MS et al. | Cyclosporine, but not FK 506 and rapamycin, enhances cell proliferation in mouse medullary thick ascending cultured cells. | 1998 | Transplant. Proc. | pmid:9838561 |
| Takayama J et al. | Living related liver transplantation in patients with ABO incompatibility. | 1998 | Transplant. Proc. | pmid:9838537 |
| Sasaki K et al. | Effect of FK 506 and splenectomy on orthotopic small bowel xenotransplantation in the hamster-to-rat animal models. | 1998 | Transplant. Proc. | pmid:9838521 |
| Ko WJ et al. | Clinical trial of FK506 in heart transplant patients in Taiwan: report of 7 cases with immunosuppression switch from cyclosporine to FK506. | 1998 | Transplant. Proc. | pmid:9838474 |
| Ramirez CB et al. | Early steroid withdrawal after liver transplantation. | 1998 | Transplant. Proc. | pmid:9838406 |
| Yoshimura N et al. | Effect of local immunosuppressive therapy with FK 506 on renal allograft survival in the mongrel dog. | 1998 | Transplant. Proc. | pmid:9838372 |
| Takahashi N et al. | Nitric oxide generation in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838306 |
| Carver LA et al. | Characterization of the Ah receptor-associated protein, ARA9. | 1998 | J. Biol. Chem. | pmid:9837941 |
| Armstrong VW et al. | Modified pentamer formation assay for measurement of tacrolimus and its active metabolites: comparison with liquid chromatography-tandem mass spectrometry and microparticle enzyme-linked immunoassay (MEIA-II). | 1998 | Clin. Chem. | pmid:9836720 |
| Fehrman-Ekholm I and Nisell H | A successful pregnancy in a kidney recipient with tacrolimus (Prograf, FK 506) therapy. | 1998 | Nephrol. Dial. Transplant. | pmid:9829528 |
| Basile C et al. | Tacrolimus and gingival hyperplasia. | 1998 | Nephrol. Dial. Transplant. | pmid:9829526 |
| Franz M et al. | Posttransplant hemolytic uremic syndrome in adult retransplanted kidney graft recipients: advantage of FK506 therapy? | 1998 | Transplantation | pmid:9825827 |
| Jain AB et al. | Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data. | 1998 | Transplantation | pmid:9825817 |
| Boillot O et al. | Reversal of early acute rejection with increased doses of tacrolimus in liver transplantation: a pilot study. | 1998 | Transplantation | pmid:9825815 |
| Papatheodoridis GV et al. | Ulcerative colitis has an aggressive course after orthotopic liver transplantation for primary sclerosing cholangitis. | 1998 | Gut | pmid:9824344 |
| Mitsuhashi H et al. | Sulfite is released by human neutrophils in response to stimulation with lipopolysaccharide. | 1998 | J. Leukoc. Biol. | pmid:9823763 |
| Maghrabi K and Bohlega S | Cyclosporine-induced migraine with severe vomiting causing loss of renal graft. | 1998 | Clin Neurol Neurosurg | pmid:9822847 |
| Antoni FA et al. | Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. | 1998 | J. Neurosci. | pmid:9822726 |
| Rossi FM and Blau HM | Recent advances in inducible gene expression systems. | 1998 | Curr. Opin. Biotechnol. | pmid:9821271 |
| Patella V et al. | Endogenous superallergen protein Fv induces IL-4 secretion from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. | 1998 | J. Immunol. | pmid:9820545 |
| Neylan JF et al. | Assessment of the frequency and costs of posttransplantation hospitalizations in patients receiving tacrolimus versus cyclosporine. | 1998 | Am. J. Kidney Dis. | pmid:9820446 |
| Igarashi K et al. | A novel indication of the activities of small molecule inhibitors of protein-protein interactions: application of the yeast two-hybrid system. | 1998 | J. Antibiot. | pmid:9820241 |
| Campo JV et al. | Tacrolimus toxic reaction associated with the use of nefazodone: paroxetine as an alternative agent. | 1998 | Arch. Gen. Psychiatry | pmid:9819077 |
| Perego C et al. | Evidence that SMS 201-995 enhances the immunosuppressive effect of FK506. | 1998 | Int. J. Immunopharmacol. | pmid:9818792 |
| Ader JL and Rostaing L | Cyclosporin nephrotoxicity: pathophysiology and comparison with FK-506. | 1998 | Curr. Opin. Nephrol. Hypertens. | pmid:9818201 |
| Wells WA | Coming full circle. Vertex Pharmaceuticals, Inc. | 1998 | Chem. Biol. | pmid:9818152 |
| Shapiro R et al. | A prospective, randomized trial to compare tacrolimus and prednisone with and without mycophenolate mofetil in patients undergoing renal transplantation: first report. | 1998 | J. Urol. | pmid:9817305 |
| Bachinger A et al. | [Immunosuppression with tacrolimus (FK 506) and cyclosporin A for preventing graft rejection after liver transplantation. Retrospective evaluation of medical costs based on the FG-O157 Study in 224 patients (Germany)]. | 1998 | Chirurg | pmid:9816454 |
| Walder B et al. | Tacrolimus (FK 506)-induced hemolytic uremic syndrome after heart transplantation. | 1998 | J. Heart Lung Transplant. | pmid:9811409 |
| Marton MJ et al. | Drug target validation and identification of secondary drug target effects using DNA microarrays. | 1998 | Nat. Med. | pmid:9809554 |
| Krähenbühl S et al. | Serious interaction between mibefradil and tacrolimus. | 1998 | Transplantation | pmid:9808502 |
| Nakazawa Y et al. | Relationship between in vivo FK506 clearance and in vitro 13-demethylation activity in living-related liver transplantation. | 1998 | Transplantation | pmid:9808496 |
| Cacciarelli TV et al. | Management of posttransplant lymphoproliferative disease in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy. | 1998 | Transplantation | pmid:9808490 |
| Hultsch T et al. | Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. | 1998 | Arch. Dermatol. Res. | pmid:9808344 |
| Cardenas ME et al. | Signal-transduction cascades as targets for therapeutic intervention by natural products. | 1998 | Trends Biotechnol. | pmid:9807840 |
| Faure JD et al. | An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. | 1998 | Plant J. | pmid:9807817 |
| Boguniewicz M et al. | A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. Pediatric Tacrolimus Study Group. | 1998 | J. Allergy Clin. Immunol. | pmid:9802373 |
| Bieber T | Topical tacrolimus (FK 506): a new milestone in the management of atopic dermatitis. | 1998 | J. Allergy Clin. Immunol. | pmid:9802361 |
| Reis A et al. | A comparative investigation of FK506 and cyclosporin A in murine corneal transplantation. | 1998 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:9801895 |
| Conti F et al. | Low level of interleukin 10 synthesis during liver allograft rejection. | 1998 | Lab. Invest. | pmid:9800954 |
| Fisher NC | Renal failure after lung transplantation. | 1998 | Lancet | pmid:9800782 |
| Garcia-Criado FJ et al. | Possible tacrolimus action mechanisms in its protector effects on ischemia-reperfusion injury. | 1998 | Transplantation | pmid:9798713 |
| Sankary HN et al. | FK506 treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation. | 1998 | Transplantation | pmid:9798690 |
| Whitcup SM et al. | Topical liposome-encapsulated FK506 for the treatment of endotoxin-induced uveitis. | 1998 | Ocul. Immunol. Inflamm. | pmid:9798194 |
| Schaefer A et al. | Stimulation of the Ca2+-mediated egr-1 and c-fos expression in murine erythroleukaemia cells by cyclosporin A. | 1998 | Biochem. J. | pmid:9794788 |
| Kobayashi M et al. | Effects of FK506 on experimental membranous glomerulonephritis induced by cationized bovine serum albumin in rats. | 1998 | Nephrol. Dial. Transplant. | pmid:9794552 |
| Hashimoto Y et al. | Effects of intestinal and hepatic metabolism on the bioavailability of tacrolimus in rats. | 1998 | Pharm. Res. | pmid:9794505 |
| Sengoku T et al. | [Effects of tacrolimus ointment on type I (immediate and late) and IV (delayed) cutaneous allergic reactions in mice]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9793077 |
| Toshima K et al. | Effect of FK506 on the activation state of hepatic macrophages in Propionibacterium acnes-treated rats. | 1998 | J. Gastroenterol. Hepatol. | pmid:9792034 |
| Casavilla FA et al. | Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus. | 1998 | Liver Transpl Surg | pmid:9791154 |
| Ohye H et al. | Effects of immunosuppressant agents on growth hormone release and gene expression. | 1998 | Endocr. J. | pmid:9790238 |
| Bajaj-Elliott M et al. | Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. | 1998 | J. Clin. Invest. | pmid:9788959 |
| Masugi T and Otsuka K | [Immunosuppressive drugs and calcineurin]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9788176 |
| Heering P et al. | Distal tubular acidosis induced by FK506. | 1998 | Clin Transplant | pmid:9787958 |
| Wu A et al. | Outcome of 22 successful pregnancies after liver transplantation. | 1998 | Clin Transplant | pmid:9787957 |
| Peddi VR et al. | Use of tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Clin Transplant | pmid:9787948 |
| Rayes N et al. | Pregnancies following liver transplantation--how safe are they? A report of 19 cases under cyclosporine A and tacrolimus. | 1998 | Clin Transplant | pmid:9787947 |
| Nishida T et al. | [FK506 for the prophylaxis of graft-versus-host-disease after bone marrow transplantation from HLA-genotypically mismatched unrelated donor]. | 1998 | Rinsho Ketsueki | pmid:9785975 |
| Maestri M et al. | [Treatment of the nephrotoxicity of immunosuppressive drugs with insulin-like growth factor-I]. | 1998 | Minerva Chir | pmid:9780630 |
| Motamedi H and Shafiee A | The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506. | 1998 | Eur. J. Biochem. | pmid:9780228 |
| Weichert G and Sauder DN | Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum. | 1998 | J. Am. Acad. Dermatol. | pmid:9777778 |
| Chelmicka-Schorr E et al. | Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. | 1998 | J. Autoimmun. | pmid:9776710 |
| Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
| Gómez J et al. | The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. | 1998 | Oncogene | pmid:9771966 |
| Luo Z et al. | Calcineurin inhibitors and cardiac hypertrophy. | 1998 | Nat. Med. | pmid:9771723 |
| Bennett WM | The nephrotoxicity of new and old immunosuppressive drugs. | 1998 | Ren Fail | pmid:9768435 |
| Lamb ML and Jorgensen WL | Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations. | 1998 | J. Med. Chem. | pmid:9767630 |
| Hauser IA et al. | Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells. | 1998 | Kidney Int. | pmid:9767529 |
| Wang JD et al. | Lymphotactin: a key regulator of lymphocyte trafficking during acute graft rejection. | 1998 | Immunology | pmid:9767457 |
| Billaud EM et al. | Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. | 1998 | Br J Clin Pharmacol | pmid:9764970 |
| Karanam BV et al. | Disposition of L-732,531, a potent immunosuppressant, in rats and baboons. | 1998 | Drug Metab. Dispos. | pmid:9763399 |
| Zonneveld IM et al. | Topical tacrolimus is not effective in chronic plaque psoriasis. A pilot study. | 1998 | Arch Dermatol | pmid:9762021 |
| Ohye H et al. | Cellular signaling mechanisms for stimulation of growth hormone secretion and growth hormone primary transcripts by immunosuppressant agents, FK506 and cyclosporin A, in cultured rat pituitary cells. | 1998 Nov-Dec | Neuroimmunomodulation | pmid:9762012 |
| Kliem V and Brunkhorst R | Tacrolimus in kidney transplantation. | 1998 | Contrib Nephrol | pmid:9761977 |
| Schambeck CM et al. | Limit of quantification (functional sensitivity) of the new IMx Tacrolimus II microparticle enzyme immunoassay. | 1998 | Clin. Chem. | pmid:9761266 |
| Ishizuka T et al. | Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells. | 1998 | J. Immunol. | pmid:9759885 |
| Teshima R et al. | Ca2+-ATPase inhibitors and PKC activation synergistically stimulate TNF-alpha production in RBL-2H3 cells. | 1998 | Inflamm. Res. | pmid:9754866 |
| Xu Q et al. | Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin. | 1998 | Plant J. | pmid:9753776 |
| Radkowski M et al. | Detection of hepatitis C virus replication in peripheral blood mononuclear cells after orthotopic liver transplantation. | 1998 | Transplantation | pmid:9753352 |
| Woodle ES et al. | Liver transplantation in the first three months of life. | 1998 | Transplantation | pmid:9753340 |
| Paterson DL et al. | Infectious complications occurring in liver transplant recipients receiving mycophenolate mofetil. | 1998 | Transplantation | pmid:9753337 |
| Sakaguchi M et al. | Cytokine production by T cells infiltrating in the eye of uveitis patients. | 1998 Jul-Aug | Jpn. J. Ophthalmol. | pmid:9749865 |
| Armenti VT et al. | Drug safety issues in pregnancy following transplantation and immunosuppression: effects and outcomes. | 1998 | Drug Saf | pmid:9747668 |
| Weinbrenner C et al. | Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia. | 1998 | Cardiovasc. Res. | pmid:9747435 |
| Ratanatharathorn V et al. | Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. | 1998 | Blood | pmid:9746768 |
| Fornairon S et al. | Can we improve the results of simultaneous pancreas-kidney transplantation? | 1998 | Transplant. Proc. | pmid:9745580 |
| Antoine C et al. | Vascular microthrombosis in renal transplant recipients treated with tacrolimus. | 1998 | Transplant. Proc. | pmid:9745577 |
| Maroun T et al. | Rejection therapy with tacrolimus in renal transplantation: preliminary results of a collaborative multicenter study in 45 patients. Groupe Cooperatif de Transplantation D'ile de France (GCIF). | 1998 | Transplant. Proc. | pmid:9745576 |
| Greenstein SM et al. | Nifedipine prevents tacrolimus-induced intestinal hemodynamic and functional impairments. | 1998 | Transplant. Proc. | pmid:9745540 |
| Timmermann W et al. | Noninvasive videomicroscopic monitoring of rat small bowel rejection. | 1998 | Transplant. Proc. | pmid:9745537 |
| Dutta S et al. | Liposomal tacrolimus and intestinal drug concentration. | 1998 | Transplant. Proc. | pmid:9745533 |
| Gasser M et al. | Effect of selective immunosuppression with FK 506, anti-IL-2R, and anti-ICAM-1 MAb in rat small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745510 |
| Gatti S et al. | Graft-versus-host reaction and graft rejection after liver, small bowel or small bowel allotransplantation in the pig. | 1998 | Transplant. Proc. | pmid:9745509 |
| Walgenbach KJ et al. | Upregulation of basic fibroblast growth factor during chronic rejection of rat intestinal allografts and its downregulation by FK 506. | 1998 | Transplant. Proc. | pmid:9745501 |
| Chen H et al. | Combined effect of rapamycin and FK 506 in prolongation of small bowel graft survival in the mouse. | 1998 | Transplant. Proc. | pmid:9745497 |
| Alessiani M et al. | Effect of perioperative donor bone marrow infusion after small bowel transplantation in swine: preliminary results. | 1998 | Transplant. Proc. | pmid:9745496 |
| Quijano Y et al. | Tolerance: a study in long-term surviving animals after small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745494 |
| Brooksbank RL et al. | Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. | 1998 | Anesthesiology | pmid:9743407 |
| Walensky LD et al. | The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. | 1998 | Mol. Med. | pmid:9742506 |
| Reitamo S et al. | Tacrolimus ointment does not affect collagen synthesis: results of a single-center randomized trial. | 1998 | J. Invest. Dermatol. | pmid:9740230 |