tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Troppmann C et al. | Perioperative immunosuppression as a critical determinant of early outcome after discordant xenoislet transplantation: a comparative study. | 1996 | Transplant. Proc. | pmid:8623487 |
| McKenna BA et al. | Tacrolimus (FK 506): a whole blood assay as measured on the Abbott IMx analyzer. | 1996 | Transplant. Proc. | pmid:8623491 |
| Stratta RJ et al. | FK 506 induction and rescue therapy in pancreas transplant recipients. | 1996 | Transplant. Proc. | pmid:8623492 |
| Birk PE et al. | Preliminary experience with FK 506 in pediatric renal transplant recipients: a single-center report. | 1996 | Transplant. Proc. | pmid:8623493 |
| Alloway RR et al. | Conversion from cyclosporine to tacrolimus in kidney, kidney/pancreas, and pancreas alone transplant recipients: the Memphis experience. | 1996 | Transplant. Proc. | pmid:8623494 |
| Woodle ES et al. | Role of protocol biopsies in the treatment of refractory renal allograft rejection with FK 506. | 1996 | Transplant. Proc. | pmid:8623495 |
| Appignani BA et al. | Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. | 1996 | AJR Am J Roentgenol | pmid:8623651 |
| Asfar S et al. | Small bowel transplantation. A life-saving option for selected patients with intestinal failure. | 1996 | Dig. Dis. Sci. | pmid:8625758 |
| Fehr T et al. | Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain. | 1996 | J. Antibiot. | pmid:8626235 |
| Zhang BW et al. | T cell responses in calcineurin A alpha-deficient mice. | 1996 | J. Exp. Med. | pmid:8627154 |
| Dragovich PS et al. | Structure-based design of novel, urea-containing FKBP12 inhibitors. | 1996 | J. Med. Chem. | pmid:8627611 |
| Eberhard OK et al. | How best to use tacrolimus (FK506) for treatment of steroid- and OKT3-resistant rejection after renal transplantation. | 1996 | Transplantation | pmid:8629294 |
| Millis JM et al. | Tacrolimus for primary treatment of steroid-resistant hepatic allograft rejection. | 1996 | Transplantation | pmid:8629298 |
| Systemic tacrolimus (FK 506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study. The European FK 506 Multicentre Psoriasis Study Group. | 1996 | Arch Dermatol | pmid:8629845 | |
| DiGiuseppe JA et al. | Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia. | 1996 | Arch. Pathol. Lab. Med. | pmid:8629906 |
| Bierer BE | Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin. | 1995 | Proc. Assoc. Am. Physicians | pmid:8630742 |
| Schuetz EG et al. | Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. | 1996 | Mol. Pharmacol. | pmid:8632764 |
| Sun S et al. | Effect of tacrolimus on hemodynamics and absorption of experimental small intestinal transplants. | 1996 | Transplantation | pmid:8633368 |
| Kashu Y et al. | The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. | 1996 | Transplantation | pmid:8633382 |
| Yoshimura N et al. | A case report of pregnancy in renal transplant recipient treated with FK506 (tacrolimus). | 1996 | Transplantation | pmid:8633388 |
| Ohtomo Y et al. | C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y. | 1996 | Diabetologia | pmid:8635672 |
| Kinoshita I et al. | Myoblast transplantation in monkeys: control of immune response by FK506. | 1996 | J. Neuropathol. Exp. Neurol. | pmid:8642394 |
| Singh N et al. | Recurrent hepatitis C virus hepatitis in liver transplant recipients receiving tacrolimus: association with rejection and increased immunosuppression after transplantation. | 1996 | Surgery | pmid:8644012 |
| Morozumi K et al. | Diagnosis of chronic rejection using peritubular and glomerular capillary lesions. | 1996 | Transplant. Proc. | pmid:8644331 |
| Colombani PM et al. | Liver transplantation in infants younger than 1 year of age. | 1996 | Ann. Surg. | pmid:8645039 |
| Muraoka K et al. | Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. | 1996 | J. Clin. Invest. | pmid:8647935 |
| Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
| Hisatomi A et al. | Effect of Prograf (FK506) on spermatogenesis in rats. | 1996 | Toxicology | pmid:8658548 |
| Harihara Y et al. | Effects of interferon alpha/beta on cardiac allografts. | 1996 | Transplant. Proc. | pmid:8658645 |
| Shinozuka N et al. | Correlation between simplified immunocompetence assay and clinical graft states in kidney or liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8658649 |
| Nishimura Y et al. | Whole organ vascularized thymus allografting effectively modulates cardiac rejection. | 1996 | Transplant. Proc. | pmid:8658660 |
| Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
| Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
| Yuzawa K et al. | Topical immunosuppression in skin grafting with FK 506 ointment. | 1996 | Transplant. Proc. | pmid:8658707 |
| Yagura K et al. | Pharmacokinetic characteristics of two types of liposomal FK 506. | 1996 | Transplant. Proc. | pmid:8658708 |
| Ogawa N et al. | Suppressive effects of combination therapy with mizoribine and FK 506 on the development of accelerated coronary artery disease and myocardial rejection after heart transplantation. | 1996 | Transplant. Proc. | pmid:8658710 |
| Yoshida Y et al. | Effect of lipoprostaglandin E1 in concordant xenografts. | 1996 | Transplant. Proc. | pmid:8658716 |
| Kawauchi M et al. | Which are the target vessels of xeno- and allo-lung rejection?--a primate single lung transplantation study. | 1996 | Transplant. Proc. | pmid:8658719 |
| Sakimoto H et al. | Administration of tacrolimus (FK506) in hamster-to-rat pancreas xenotransplantation. | 1996 | Transplant. Proc. | pmid:8658727 |
| Takeda M et al. | Pretreatment with splenectomy and FK506 in xeno-lung transplantation. | 1996 | Transplant. Proc. | pmid:8658728 |
| Zou XM et al. | Immunosuppressive effect of FK506 on orthotopic liver and small bowel xenotransplantation (xenoOLTx and SBTx). | 1996 | Transplant. Proc. | pmid:8658729 |
| Kokado Y et al. | Hypertension in renal transplant recipients and its effect on long-term renal allograft survival. | 1996 | Transplant. Proc. | pmid:8658802 |
| Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
| Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
| Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
| Hayakawa K et al. | Maintenance of unresponsiveness by short-term pulse therapy with FK 506 in rat transplantation. | 1996 | Transplant. Proc. | pmid:8658904 |
| Ishikawa M et al. | Acetaminophen absorption test as a useful indicator of small intestinal rejection in rats. | 1996 | Transplant. Proc. | pmid:8658911 |
| Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
| Kanzler S et al. | Complete reversal of FK 506 induced diabetes in a liver transplant recipient by change of immunosuppression to cyclosporine A. | 1996 | Z Gastroenterol | pmid:8659188 |
| Schaefer A et al. | Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin. | 1996 | J. Biol. Chem. | pmid:8662717 |
| Owens-Grillo JK et al. | A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. | 1996 | J. Biol. Chem. | pmid:8662874 |
| Kralli A and Yamamoto KR | An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. | 1996 | J. Biol. Chem. | pmid:8663352 |
| Tokunaga Y and Alak AM | FK506 (tacrolimus) and its immunoreactive metabolites in whole blood of liver transplant patients and subjects with mild hepatic dysfunction. | 1996 | Pharm. Res. | pmid:8668663 |
| Vincenti F et al. | One-year follow-up of an open-label trial of FK506 for primary kidney transplantation. A report of the U.S. Multicenter FK506 Kidney Transplant Group. | 1996 | Transplantation | pmid:8669100 |
| Uchikoshi F et al. | Restoration of immune abnormalities in diabetic BB rats after pancreas transplantation. I. Macrochimerism of donor-graft-derived RT6+ T cells responsible for restoration of immune responsiveness and suppression of autoimmune reaction. | 1996 | Transplantation | pmid:8669109 |
| Kay JE | Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases. | 1996 | Biochem. J. | pmid:8670043 |
| Schmaldienst S and Horl WH | Bacterial infections during immunosuppression - immunosuppressive agents interfere not only with immune response, but also with polymorphonuclear cell function. | 1996 | Nephrol. Dial. Transplant. | pmid:8672015 |
| Hall MN | The TOR signalling pathway and growth control in yeast. | 1996 | Biochem. Soc. Trans. | pmid:8674674 |
| Mattila PS | The actions of cyclosporin A and FK506 on T-lymphocyte activation. | 1996 | Biochem. Soc. Trans. | pmid:8674715 |
| Adams DH and Liu Q | FK506 inhibits human lymphocyte migration and the production of lymphocyte chemotactic factors in liver allograft recipients. | 1996 | Hepatology | pmid:8675167 |
| Halloran PF | Molecular mechanisms of new immunosuppressants. | 1996 | Clin Transplant | pmid:8680047 |
| Pullicino P et al. | Posterior leucoencephalopathy syndrome. | 1996 | Lancet | pmid:8684128 |
| Pirenne J et al. | Combined transplantation of small and large bowel. FK506 versus cyclosporine A in a porcine model. | 1996 | Transplantation | pmid:8685944 |
| Tsugita M et al. | Tacrolimus pretreatment attenuates preexisting xenospecific immunity and abrogates hyperacute rejection in a presensitized hamster to rat liver transplant model. | 1996 | Transplantation | pmid:8685952 |
| Huntress JD and Papadakos PJ | The role of calcium-channel antagonists in solid organ transplantation. | 1996 | New Horiz | pmid:8689268 |
| Lampen A et al. | Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. | 1995 | Drug Metab. Dispos. | pmid:8689938 |
| Luan S et al. | Molecular characterization of a FKBP-type immunophilin from higher plants. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8692927 |
| Bashuda H et al. | Induction of persistent allograft tolerance in the rat by combined treatment with anti-leukocyte function-associated antigen-1 and anti-intercellular adhesion molecule-1 monoclonal antibodies, donor-specific transfusion, and FK506. | 1996 | Transplantation | pmid:8693525 |
| Fung JJ et al. | The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation. | 1996 | J. Am. Coll. Surg. | pmid:8696542 |
| Shaw LM et al. | Toxic effects of immunosuppressive drugs: mechanisms and strategies for controlling them. | 1996 | Clin. Chem. | pmid:8697605 |
| Bousvaros A et al. | Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506). | 1996 | Gastroenterology | pmid:8698205 |
| Mach-Pascual S et al. | Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. | 1996 | Am. J. Hematol. | pmid:8701950 |
| Hemenway CS and Heitman J | Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. | 1996 | J. Biol. Chem. | pmid:8702500 |
| Tyedmers J et al. | Efficient folding of firefly luciferase after transport into mammalian microsomes in the absence of luminal chaperones and folding catalysts. | 1996 | J. Biol. Chem. | pmid:8702642 |
| Raufman JP et al. | Calcineurin mediates calcium-induced potentiation of adenylyl cyclase activity in dispersed chief cells from guinea pig stomach. Further evidence for cross-talk between signal transduction pathways that regulate pepsinogen secretion. | 1996 | J. Biol. Chem. | pmid:8702699 |
| Timerman AP et al. | Selective binding of FKBP12.6 by the cardiac ryanodine receptor. | 1996 | J. Biol. Chem. | pmid:8702774 |
| Shih M and Malbon CC | Protein kinase C deficiency blocks recovery from agonist-induced desensitization. | 1996 | J. Biol. Chem. | pmid:8702931 |
| Okadome T et al. | Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo. | 1996 | J. Biol. Chem. | pmid:8702959 |
| Rahfeld JU et al. | Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria. | 1996 | J. Biol. Chem. | pmid:8703024 |
| Hartley AD et al. | cAMP inhibits bud growth in a yeast strain compromised for Ca2+ influx into the Golgi. | 1996 | Mol. Gen. Genet. | pmid:8709962 |
| Tokime T et al. | Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. | 1996 | Neurosci. Lett. | pmid:8710192 |
| Christophers E | Psoriasis: mechanisms and entry points for possible therapeutic interventions. | 1996 | Australas. J. Dermatol. | pmid:8713012 |
| Frezza EE et al. | Small bowel transplantation: current progress and clinical application. | 1996 Mar-Apr | Hepatogastroenterology | pmid:8714229 |
| Shultz SL and Meriney DK | Cyclosporine and tacrolimus: a comparison of immunosuppressants used for liver transplantation. | 1996 Jul-Aug | Dimens Crit Care Nurs | pmid:8717641 |
| Alak AM and Lizak P | Stability of FK506 in blood samples. | 1996 | Ther Drug Monit | pmid:8721287 |
| Yu C et al. | Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8722370 |
| Fealy MJ and Press BH | Pinpointing the moment of allograft rejection. | 1996 | J Hand Surg Am | pmid:8724501 |
| Hashino S et al. | Antitumor effect in cyclosporine A- or FK506-treated mice after syngeneic bone marrow transplantation. | 1996 | Leuk. Lymphoma | pmid:8726416 |
| Soubrane O and Houssin D | [Liver transplantation. Current aspects]. | 1996 | Presse Med | pmid:8728904 |
| Lampen A et al. | Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. | 1996 | Br. J. Pharmacol. | pmid:8732283 |
| Saada V et al. | Comparative evaluation of in vitro and in vivo immunosuppressive potential of cyclosporin G with cyclosporin A and FK-506. | 1996 | Int. J. Immunopharmacol. | pmid:8732436 |
| Asante-Korang A et al. | Experience of FK506 immune suppression in pediatric heart transplantation: a study of long-term adverse effects. | 1996 | J. Heart Lung Transplant. | pmid:8732602 |
| Herzog D et al. | Combined bowel-liver transplantation in an infant with microvillous inclusion disease. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8732907 |
| Okada K et al. | Effect of FK 506 administered topically versus intramuscularly on suppression of the corneal immune reaction in rats. | 1996 | Ophthalmologica | pmid:8738464 |
| Wagner K et al. | Experimental and clinical experience with the use of tacrolimus (FK506) in kidney transplantation. | 1996 | Clin. Nephrol. | pmid:8738666 |
| Hohage H et al. | Influence of cyclosporine A and FK506 on 24 h blood pressure monitoring in kidney transplant recipients. | 1996 | Clin. Nephrol. | pmid:8738668 |
| Herget S et al. | Initial experience with tacrolimus rescue therapy in OKT3 resistant rejection. | 1996 | Clin. Nephrol. | pmid:8738671 |