tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van der Schaft J et al. | First experience with extended release tacrolimus in the treatment of adult patients with severe, difficult to treat atopic dermatitis: Clinical efficacy, safety and dose finding. | 2016 | J. Dermatol. Sci. | pmid:26547110 |
| Gokhale NS | Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. | 2016 | Indian J Ophthalmol | pmid:27050351 |
| Parody R et al. | GvHD prophylaxis with tacrolimus plus sirolimus after reduced intensity conditioning allogeneic transplantation: results of a multicenter study. | 2016 | Bone Marrow Transplant. | pmid:27295268 |
| Muduma G et al. | Indirect treatment comparison of belatacept versus tacrolimus from a systematic review of immunosuppressive therapies for kidney transplant patients. | 2016 | Curr Med Res Opin | pmid:26907083 |
| Sato Y et al. | Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus. | 2016 | Brain Dev. | pmid:26906012 |
| Wen Y et al. | Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats. | 2016 | Ren Fail | pmid:26905810 |
| Rodrigo E et al. | Within-Patient Variability in Tacrolimus Blood Levels Predicts Kidney Graft Loss and Donor-Specific Antibody Development. | 2016 | Transplantation | pmid:26703349 |
| Zhang XS et al. | FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:27757551 |
| Martial LC et al. | A preliminary study searching for the right dose of tacrolimus in very young (≤4 years) renal transplant patients. | 2016 | J. Pharm. Pharmacol. | pmid:27669677 |
| Kim HY et al. | Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26820537 |
| Zeng W et al. | Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability. | 2016 | Colloids Surf B Biointerfaces | pmid:26820107 |
| Joko T et al. | Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. | 2016 | J Nippon Med Sch | pmid:26960587 |
| Snell GI et al. | ABO incompatible renal transplantation following lung transplantation. | 2016 | Transpl. Immunol. | pmid:27663090 |
| Malachowski SJ et al. | Annular Lichenoid Dermatitis of Youth: A Chronic Case Managed Using Pimecrolimus. | 2016 | Pediatr Dermatol | pmid:27653808 |
| Prakash A et al. | Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506. | 2016 | Protein Sci. | pmid:26749369 |
| Hu X et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. | 2016 | Am. J. Transplant. | pmid:26749344 |
| Cameron AM et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. | 2016 | Am. J. Transplant. | pmid:26748958 |
| Karagüzel G et al. | Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. | 2016 | Clin Nutr ESPEN | pmid:28531780 |
| Abdel-Kahaar E et al. | Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:27661400 |
| Kannegieter NM et al. | Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26606072 |
| Wang Z et al. | Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. | 2016 | Int J Pharm | pmid:27568494 |
| El-Asmar J et al. | Clotrimazole troches induce supratherapeutic blood levels of sirolimus and tacrolimus in an allogeneic hematopoietic cell-transplant recipient resulting in acute kidney injury. | 2016 | Hematol Oncol Stem Cell Ther | pmid:26684920 |
| Yang EM et al. | Tacrolimus for children with refractory nephrotic syndrome: a one-year prospective, multicenter, and open-label study of Tacrobell®, a generic formula. | 2016 | World J Pediatr | pmid:26684309 |
| Zegarska J et al. | Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496443 |
| Wilusz M et al. | Effects of Immunosuppressive Drugs on Serum Fatty Acids of Phospholipids Fraction in Renal Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496457 |
| Kociszewska-Najman B et al. | Congenital Infections in Neonates of Women With Liver or Kidney Transplants. | 2016 | Transplant. Proc. | pmid:27496446 |
| O'Donnell JC et al. | Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. | 2016 | J. Neurosci. | pmid:27383588 |
| Saito B et al. | Umbilical cord blood transplantation for adults using tacrolimus with two-day very-short-term methotrexate for graft-versus-host disease prophylaxis. | 2016 | Leuk. Res. | pmid:27376545 |
| Matsui K et al. | Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells. | 2016 | Biol. Pharm. Bull. | pmid:27374298 |
| Zarrinpar A et al. | Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform. | 2016 | Sci Transl Med | pmid:27053773 |
| Deininger KM et al. | CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients. | 2016 | Clin Transplant | pmid:27314545 |
| de Mesquita Coutinho PR et al. | Effects of tacrolimus and erythropoietin in experimental spinal cord lesion in rats: functional and histological evaluation. | 2016 | Spinal Cord | pmid:26481712 |
| Berryhill A et al. | Cysteamine in renal transplantation: A report of two patients with nephropathic cystinosis and the successful re-initiation of cysteamine therapy during the immediate post-transplant period. | 2016 | Pediatr Transplant | pmid:26477696 |
| M Kotowski M et al. | The influence of the tumor necrosis factor-alpa-308G>A polymorphism on the efficacy of immunosuppressive therapy in patients after kidney transplantation. | 2016 | J. Physiol. Pharmacol. | pmid:28195062 |
| Kyaw TH et al. | A 45-Year-Old Woman With 3 Weeks of Cough and Night Sweats. | 2016 | Chest | pmid:26965979 |
| Fields JA et al. | Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. | 2016 | J Neuroinflammation | pmid:27220536 |
| Metzker M et al. | Analytical evaluation of a real-time PCR-based DNA demethylation assay to assess the frequency of naturally occurring regulatory T cells in peripheral blood. | 2016 | Clin. Biochem. | pmid:27220060 |
| Tanzi MG et al. | Pharmacokinetics of prolonged-release tacrolimus and implications for use in solid organ transplant recipients. | 2016 | Clin Transplant | pmid:27220013 |
| Narain S and Furie R | Update on clinical trials in systemic lupus erythematosus. | 2016 | Curr Opin Rheumatol | pmid:27314466 |
| Wen Y et al. | Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. | 2016 | J. Recept. Signal Transduct. Res. | pmid:26400065 |
| Emoto C et al. | Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. | 2016 | Ther Drug Monit | pmid:27310200 |
| Badri PS et al. | Pharmacokinetics of Tacrolimus and Cyclosporine in Liver Transplant Recipients Receiving 3 Direct-Acting Antivirals as Treatment for Hepatitis C Infection. | 2016 | Ther Drug Monit | pmid:27310199 |
| Azzi J et al. | Targeted Delivery of Immunomodulators to Lymph Nodes. | 2016 | Cell Rep | pmid:27134176 |
| RodrÃguez-AusÃn P et al. | Topical tacrolimus 0.03% for the treatment of ocular psoriasis. | 2016 | Arch Soc Esp Oftalmol | pmid:27130870 |
| Khaled SK et al. | Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26325438 |
| Chauvet V et al. | [Removal of senescent cells: towards a better future?] | 2016 | Med Sci (Paris) | pmid:28008848 |
| Giussani A et al. | Posterior reversible encephalopathy syndrome after kidney transplantation in pediatric recipients: Two cases. | 2016 | Pediatr Transplant | pmid:26607205 |
| Wang YY et al. | Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network. | 2016 | Sci Rep | pmid:27052100 |
| Lee DR et al. | Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system. | 2016 | Int J Nanomedicine | pmid:27051286 |
| Lee WS et al. | Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate. | 2016 | Korean J. Intern. Med. | pmid:26961485 |