tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ushigome H et al. | Two cases of tacrolimus-induced alopecia following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10578326 |
| Bush WW | Overview of transplantation immunology and the pharmacotherapy of adult solid organ transplant recipients: focus on immunosuppression. | 1999 | AACN Clin Issues | pmid:10578712 |
| Lowry PW et al. | Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. | 1999 | Inflamm. Bowel Dis. | pmid:10579116 |
| Mathieu P et al. | Conversion of cyclosporine A to tacrolimus following heart transplantation. | 1999 | Can J Cardiol | pmid:10579737 |
| Horigome A et al. | Lymphocyte-sensitivity to glucocorticoid correlates with the sensitivity to cyclosporin A and tacrolimus in chronic renal failure patients. | 1999 | Br J Clin Pharmacol | pmid:10583028 |
| Busque S et al. | [Hypertrichosis and gingival hypertrophy regression in renal transplants following the substitution of cyclosporin by tacrolimus]. | 1999 | Ann Chir | pmid:10584376 |
| Wong TY et al. | Parvovirus B19 infection causing red cell aplasia in renal transplantation on tacrolimus. | 1999 | Am. J. Kidney Dis. | pmid:10585325 |
| Le Bricon T et al. | Changes in plasma cystatin C after renal transplantation and acute rejection in adults. | 1999 | Clin. Chem. | pmid:10585359 |
| Miyamoto S and Safer B | Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation. | 1999 | Biochem. J. | pmid:10585867 |
| Tsuchida M et al. | T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. | 1999 | J. Immunol. | pmid:10586059 |
| Agarwala S et al. | Co-administration of co-trimoxazole does not augment tacrolimus-induced impairment in kidney function in rats. | 1999 | Ren Fail | pmid:10586426 |
| von Baum H et al. | Prevalence of vancomycin-resistant enterococci among children with end-stage renal failure. Mid-European Pediatric Peritoneal Dialysis Study Group. | 1999 | Clin. Infect. Dis. | pmid:10589909 |
| Maes BD et al. | Differences in gastric motor activity in renal transplant recipients treated with FK-506 versus cyclosporine. | 1999 | Transplantation | pmid:10589943 |
| Fernandez LA et al. | The effects of maintenance doses of FK506 versus cyclosporin A on glucose and lipid metabolism after orthotopic liver transplantation. | 1999 | Transplantation | pmid:10589951 |
| Batten P et al. | Human T cell responses to human and porcine endothelial cells are highly sensitive to cyclosporin A and FK506 in vitro. | 1999 | Transplantation | pmid:10589954 |
| Dickenmann MJ et al. | Blood eosinophilia in tacrolimus-treated patients: an indicator of Pneumocystis carinii pneumonia. | 1999 | Transplantation | pmid:10589963 |
| Yamashita N et al. | Nuclear factor kappa B mediates interleukin-8 production in eosinophils. | 1999 | Int. Arch. Allergy Immunol. | pmid:10592469 |
| Shimoyama M et al. | Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. | 1999 | Circulation | pmid:10595959 |
| Camacho R et al. | Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation. | 1999 | Immunopharmacology | pmid:10598882 |
| Briggs CJ et al. | Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1. | 1999 | Arch. Virol. | pmid:10603169 |
| Xu L et al. | Potential for pharmacology of ryanodine receptor/calcium release channels. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603942 |
| Bers DM et al. | Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603944 |
| MacFarlane GD et al. | Analysis of whole blood tacrolimus concentrations in liver transplant patients exhibiting impaired liver function. | 1999 | Ther Drug Monit | pmid:10604816 |
| Wright DC et al. | A comparison of the sensitivity of pig and human peripheral blood mononuclear cells to the antiproliferative effects of traditional and newer immunosuppressive agents. | 1999 | Transpl. Immunol. | pmid:10608297 |
| Qi Z et al. | Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts. | 1999 | Transpl. Immunol. | pmid:10608300 |
| Olyaei AJ et al. | Immunosuppressant-induced nephropathy: pathophysiology, incidence and management. | 1999 | Drug Saf | pmid:10612271 |
| Freudenberger R et al. | Antithrombotic effect of FK506 vs cyclosporine in cardiac transplant recipients: potential implications in transplant arteriopathy. | 1999 | J. Heart Lung Transplant. | pmid:10612383 |
| Yen MT et al. | Oscillopsia and pseudonystagmus in kidney transplant patients. | 1999 | Am. J. Ophthalmol. | pmid:10612521 |
| Bitker MO et al. | [Combined renal and pancreas transplantation as treatment for chronic renal insufficiency of diabetic origin: a series of 50 consecutive transplantations]. | 1999 | Chirurgie | pmid:10615774 |
| Crétolle-Vastel C et al. | [Role of calcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice]. | 1999 | Chirurgie | pmid:10615777 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Charco R et al. | CD28 regulation in liver transplant recipients treated with two different immunosuppressive regimens. | 1999 | Transplant. Proc. | pmid:10616508 |
| Kindt MV et al. | Tacrolimus toxicity in rhesus monkey: model for clinical side effects. | 1999 | Transplant. Proc. | pmid:10616519 |
| Gaston RS | Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens. | 1999 | Transplant. Proc. | pmid:10616556 |
| Land W | Mycophenolate mofetil-based immunosuppressive therapy: induction, maintenance, and conversion protocols in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616558 |
| Hida H et al. | Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats. | 1999 | Neurosci. Res. | pmid:10616914 |
| Hashii M et al. | cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells. | 2000 | Biochem. J. | pmid:10620496 |
| Uchino T et al. | Effect of FK 506 and lipo prostaglandin E1 on heart allograft survival in rats. | 1999 | Scand. Cardiovasc. J. | pmid:10622549 |
| Patella V et al. | HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. | 2000 | J. Immunol. | pmid:10623799 |
| Mehta P et al. | Increased clearance of tacrolimus in children: need for higher doses and earlier initiation prior to bone marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10627642 |
| Shapiro R et al. | Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. | 1999 | Transplantation | pmid:10628763 |
| Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
| Paul LC | Dialysis and transplantation. | 1999 | Curr. Opin. Nephrol. Hypertens. | pmid:10630810 |
| Vanrenterghem YF | Which calcineurin inhibitor is preferred in renal transplantation: tacrolimus or cyclosporine? | 1999 | Curr. Opin. Nephrol. Hypertens. | pmid:10630811 |
| Wang-Fan W et al. | Application of centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues. I. Selection of solvent systems based on solubility and partition coefficient investigations. | 1999 | J Chromatogr A | pmid:10630872 |
| Furutani M et al. | FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro. | 2000 | Biochemistry | pmid:10631007 |
| Thiers BH | Topical tacrolimus: treatment failure in a patient with alopecia areata. | 2000 | Arch Dermatol | pmid:10632221 |
| Lipper GM et al. | Recent therapeutic advances in dermatology. | 2000 | JAMA | pmid:10634322 |
| Richter-Hintz D et al. | Topical tacrolimus (FK 506) is effective in the treatment of pyoderma gangrenosum. | 2000 | J. Am. Acad. Dermatol. | pmid:10642695 |
| Bekersky I et al. | Dose linearity after oral administration of tacrolimus 1-mg capsules at doses of 3, 7, and 10 mg. | 1999 | Clin Ther | pmid:10645753 |