tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hossain MA et al. | Immunosuppression in auxiliary partial liver transplantation with FK506 in rats. | 1997 | Transplant. Proc. | pmid:9414861 |
| Miyata Y et al. | Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9405642 |
| Zucker K et al. | Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings. | 1997 | Transpl. Immunol. | pmid:9402690 |
| Suzuki J et al. | Inhibition of accelerated coronary atherosclerosis with short-term blockade of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in a heterotopic murine model of heart transplantation. | 1997 | J. Heart Lung Transplant. | pmid:9402514 |
| Misao T et al. | Efficacy of combining donor-specific presensitization with a simultaneous single injection of tacrolimus on pulmonary allografts. | 1997 | J. Heart Lung Transplant. | pmid:9402508 |
| Wijnen RM and Ericzon BG | Update of tacrolimus in pancreas transplantation. | 1997 | Diabet. Med. | pmid:9400914 |
| Mollison KW et al. | Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9400028 |
| Cox TH et al. | Bradycardia associated with intravenous administration of tacrolimus in a liver transplant recipient. | 1997 Nov-Dec | Pharmacotherapy | pmid:9399620 |
| Yamaguchi Y et al. | Enhanced expression of cytokine-induced neutrophil chemoattractant in rat hepatic allografts during acute rejection. | 1997 | Hepatology | pmid:9397996 |
| Su Y et al. | Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. | 1997 | J. Cell Biol. | pmid:9396758 |
| Sabatini DM et al. | Neural roles of immunophilins and their ligands. | 1997 | Mol. Neurobiol. | pmid:9396011 |
| Schweda F et al. | Tacrolimus treatment for steroid- and cyclosporin-resistant minimal-change nephrotic syndrome. | 1997 | Nephrol. Dial. Transplant. | pmid:9394341 |
| Jiang H et al. | Distinct tissue and cellular distribution of two major isoforms of calcineurin. | 1997 | Mol. Immunol. | pmid:9393969 |
| Sokal EM et al. | Early signs and risk factors for the increased incidence of Epstein-Barr virus-related posttransplant lymphoproliferative diseases in pediatric liver transplant recipients treated with tacrolimus. | 1997 | Transplantation | pmid:9392308 |
| Kageyama S et al. | Augmentation of natural killer cell activity induced by cytomegalovirus infection in mice treated with FK506. | 1997 | Acta Virol. | pmid:9391652 |
| Nyanguile O et al. | A nonnatural transcriptional coactivator. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391036 |
| Huang J and Schreiber SL | A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391035 |
| McElwee KJ et al. | Topical FK506: a potent immunotherapy for alopecia areata? Studies using the Dundee experimental bald rat model. | 1997 | Br. J. Dermatol. | pmid:9390322 |
| Thyagarajan GK et al. | FK506-induced fulminant leukoencephalopathy after single-lung transplantation. | 1997 | Ann. Thorac. Surg. | pmid:9386723 |
| Okudaira H et al. | Control of allergic diseases by regulation of cytokine gene transcription. | 1997 | Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M | pmid:9383912 |
| Chakraborty TK et al. | Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. | 1995 | Chem. Biol. | pmid:9383417 |
| Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
| Newell KA et al. | Treatment with either anti-CD4 or anti-CD8 monoclonal antibodies blocks alphabeta T cell-mediated rejection of intestinal allografts in mice. | 1997 | Transplantation | pmid:9381541 |
| De Gasperi A and Rohrer RJ | Scenario number two: sepsis and multiorgan failure after liver transplantation. | 1997 | Liver Transpl Surg | pmid:9377761 |
| Canzanello VJ et al. | Evolution of cardiovascular risk after liver transplantation: a comparison of cyclosporine A and tacrolimus (FK506). | 1997 | Liver Transpl Surg | pmid:9377752 |
| Kuromitsu S et al. | 3-(13-Hydroxytridecyl)-1-[13-(3-pyridyl)tridecyl]pyridinium chloride (YM-53792), a novel inhibitor of NF-AT activation. | 1997 | Biochem. Pharmacol. | pmid:9374420 |
| Cetinkale O et al. | Involvement of neutrophils in ischemic injury. I. Biochemical and histopathological investigation of the effect of FK506 on dorsal skin flaps in rats. | 1997 | Ann Plast Surg | pmid:9374148 |
| Rudant E et al. | Study of the correlation between MEIA and ELISA methods for FK 506 determination in liver transplant recipients. | 1997 | J Clin Pharm Ther | pmid:9373812 |
| Eberlein-König B et al. | Modulation of histamine release in vitro by FK506 and interleukin-3 is determined by sequence of incubation. | 1997 | Arch. Dermatol. Res. | pmid:9373722 |
| Kloke O et al. | Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells. | 1997 | Immunol. Lett. | pmid:9373220 |
| Migita K et al. | FK506 potentiates steroid-induced T-cell apoptosis. | 1997 | Transplantation | pmid:9371682 |
| Lee CM et al. | Outcomes in diabetic patients after simultaneous pancreas-kidney versus kidney alone transplantation. | 1997 | Transplantation | pmid:9371670 |
| Ross DJ et al. | FK 506 'rescue' immunosuppression for obliterative bronchiolitis after lung transplantation. | 1997 | Chest | pmid:9367453 |
| Aoyama S et al. | [The effect of FK 506, an immunosuppressant, on cerebral infarction volume in focal cerebral ischemia in rats]. | 1997 | Nippon Ika Daigaku Zasshi | pmid:9366145 |
| Takao T et al. | [A case of recurrent IgA nephropathy following renal transplantation under tacrolimus (FK506)]. | 1997 | Hinyokika Kiyo | pmid:9365847 |
| Niederstadt C et al. | Effect of FK506 on magnesium homeostasis after renal transplantation. | 1997 | Transplant. Proc. | pmid:9365709 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Kliem V et al. | Long-term results after primary successful FK 506 treatment of steroid- and OKT3-resistant rejection in renal transplant recipients. | 1997 | Transplant. Proc. | pmid:9365627 |
| Demirbas A et al. | FK 506 in simultaneous pancreas/kidney transplantation: the University of Miami experience. | 1997 | Transplant. Proc. | pmid:9365608 |
| Platz KP et al. | Indications for mycofenolate mofetil therapy after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365601 |
| Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
| Mueller AR et al. | Association between hepatitis and rejection: upregulation of cytokines and extracellular matrix parameters. | 1997 | Transplant. Proc. | pmid:9365585 |
| Taylor PJ et al. | Improved therapeutic drug monitoring of tacrolimus (FK506) by tandem mass spectrometry. | 1997 | Clin. Chem. | pmid:9365410 |
| Dumont FJ | FK506 enhances IL-13 production by T cells activated through CD3/CD28. | 1997 | Int. Arch. Allergy Immunol. | pmid:9363914 |
| Xenos EX et al. | The use of tacrolimus as induction and maintenance immunosuppression in renal cadaveric transplant recipients over the age of 60. | 1997 | Clin Transplant | pmid:9361949 |
| Neu AM et al. | Evaluation of neurotoxicity in pediatric renal transplant recipients treated with tacrolimus (FK506). | 1997 | Clin Transplant | pmid:9361932 |
| Reyes J et al. | Graft-versus-host disease after liver and small bowel transplantation in a child. | 1997 | Clin Transplant | pmid:9361921 |
| Nakai A et al. | The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat. | 1997 | Neurobiol. Dis. | pmid:9361306 |
| Rinaldi M et al. | FK506 effectiveness in reducing acute rejection after heart transplantation: a prospective randomized study. | 1997 | J. Heart Lung Transplant. | pmid:9361242 |