tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ohye H et al. | Effects of immunosuppressant agents on growth hormone release and gene expression. | 1998 | Endocr. J. | pmid:9790238 |
| Bajaj-Elliott M et al. | Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. | 1998 | J. Clin. Invest. | pmid:9788959 |
| Masugi T and Otsuka K | [Immunosuppressive drugs and calcineurin]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9788176 |
| Heering P et al. | Distal tubular acidosis induced by FK506. | 1998 | Clin Transplant | pmid:9787958 |
| Wu A et al. | Outcome of 22 successful pregnancies after liver transplantation. | 1998 | Clin Transplant | pmid:9787957 |
| Peddi VR et al. | Use of tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Clin Transplant | pmid:9787948 |
| Rayes N et al. | Pregnancies following liver transplantation--how safe are they? A report of 19 cases under cyclosporine A and tacrolimus. | 1998 | Clin Transplant | pmid:9787947 |
| Nishida T et al. | [FK506 for the prophylaxis of graft-versus-host-disease after bone marrow transplantation from HLA-genotypically mismatched unrelated donor]. | 1998 | Rinsho Ketsueki | pmid:9785975 |
| Maestri M et al. | [Treatment of the nephrotoxicity of immunosuppressive drugs with insulin-like growth factor-I]. | 1998 | Minerva Chir | pmid:9780630 |
| Motamedi H and Shafiee A | The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506. | 1998 | Eur. J. Biochem. | pmid:9780228 |
| Weichert G and Sauder DN | Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum. | 1998 | J. Am. Acad. Dermatol. | pmid:9777778 |
| Chelmicka-Schorr E et al. | Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. | 1998 | J. Autoimmun. | pmid:9776710 |
| Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
| Gómez J et al. | The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. | 1998 | Oncogene | pmid:9771966 |
| Luo Z et al. | Calcineurin inhibitors and cardiac hypertrophy. | 1998 | Nat. Med. | pmid:9771723 |
| Bennett WM | The nephrotoxicity of new and old immunosuppressive drugs. | 1998 | Ren Fail | pmid:9768435 |
| Lamb ML and Jorgensen WL | Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations. | 1998 | J. Med. Chem. | pmid:9767630 |
| Hauser IA et al. | Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells. | 1998 | Kidney Int. | pmid:9767529 |
| Wang JD et al. | Lymphotactin: a key regulator of lymphocyte trafficking during acute graft rejection. | 1998 | Immunology | pmid:9767457 |
| Billaud EM et al. | Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. | 1998 | Br J Clin Pharmacol | pmid:9764970 |
| Karanam BV et al. | Disposition of L-732,531, a potent immunosuppressant, in rats and baboons. | 1998 | Drug Metab. Dispos. | pmid:9763399 |
| Zonneveld IM et al. | Topical tacrolimus is not effective in chronic plaque psoriasis. A pilot study. | 1998 | Arch Dermatol | pmid:9762021 |
| Ohye H et al. | Cellular signaling mechanisms for stimulation of growth hormone secretion and growth hormone primary transcripts by immunosuppressant agents, FK506 and cyclosporin A, in cultured rat pituitary cells. | 1998 Nov-Dec | Neuroimmunomodulation | pmid:9762012 |
| Kliem V and Brunkhorst R | Tacrolimus in kidney transplantation. | 1998 | Contrib Nephrol | pmid:9761977 |
| Schambeck CM et al. | Limit of quantification (functional sensitivity) of the new IMx Tacrolimus II microparticle enzyme immunoassay. | 1998 | Clin. Chem. | pmid:9761266 |
| Ishizuka T et al. | Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells. | 1998 | J. Immunol. | pmid:9759885 |
| Teshima R et al. | Ca2+-ATPase inhibitors and PKC activation synergistically stimulate TNF-alpha production in RBL-2H3 cells. | 1998 | Inflamm. Res. | pmid:9754866 |
| Xu Q et al. | Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin. | 1998 | Plant J. | pmid:9753776 |
| Radkowski M et al. | Detection of hepatitis C virus replication in peripheral blood mononuclear cells after orthotopic liver transplantation. | 1998 | Transplantation | pmid:9753352 |
| Woodle ES et al. | Liver transplantation in the first three months of life. | 1998 | Transplantation | pmid:9753340 |
| Paterson DL et al. | Infectious complications occurring in liver transplant recipients receiving mycophenolate mofetil. | 1998 | Transplantation | pmid:9753337 |
| Sakaguchi M et al. | Cytokine production by T cells infiltrating in the eye of uveitis patients. | 1998 Jul-Aug | Jpn. J. Ophthalmol. | pmid:9749865 |
| Armenti VT et al. | Drug safety issues in pregnancy following transplantation and immunosuppression: effects and outcomes. | 1998 | Drug Saf | pmid:9747668 |
| Weinbrenner C et al. | Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia. | 1998 | Cardiovasc. Res. | pmid:9747435 |
| Ratanatharathorn V et al. | Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. | 1998 | Blood | pmid:9746768 |
| Fornairon S et al. | Can we improve the results of simultaneous pancreas-kidney transplantation? | 1998 | Transplant. Proc. | pmid:9745580 |
| Antoine C et al. | Vascular microthrombosis in renal transplant recipients treated with tacrolimus. | 1998 | Transplant. Proc. | pmid:9745577 |
| Maroun T et al. | Rejection therapy with tacrolimus in renal transplantation: preliminary results of a collaborative multicenter study in 45 patients. Groupe Cooperatif de Transplantation D'ile de France (GCIF). | 1998 | Transplant. Proc. | pmid:9745576 |
| Greenstein SM et al. | Nifedipine prevents tacrolimus-induced intestinal hemodynamic and functional impairments. | 1998 | Transplant. Proc. | pmid:9745540 |
| Timmermann W et al. | Noninvasive videomicroscopic monitoring of rat small bowel rejection. | 1998 | Transplant. Proc. | pmid:9745537 |
| Dutta S et al. | Liposomal tacrolimus and intestinal drug concentration. | 1998 | Transplant. Proc. | pmid:9745533 |
| Gasser M et al. | Effect of selective immunosuppression with FK 506, anti-IL-2R, and anti-ICAM-1 MAb in rat small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745510 |
| Gatti S et al. | Graft-versus-host reaction and graft rejection after liver, small bowel or small bowel allotransplantation in the pig. | 1998 | Transplant. Proc. | pmid:9745509 |
| Walgenbach KJ et al. | Upregulation of basic fibroblast growth factor during chronic rejection of rat intestinal allografts and its downregulation by FK 506. | 1998 | Transplant. Proc. | pmid:9745501 |
| Chen H et al. | Combined effect of rapamycin and FK 506 in prolongation of small bowel graft survival in the mouse. | 1998 | Transplant. Proc. | pmid:9745497 |
| Alessiani M et al. | Effect of perioperative donor bone marrow infusion after small bowel transplantation in swine: preliminary results. | 1998 | Transplant. Proc. | pmid:9745496 |
| Quijano Y et al. | Tolerance: a study in long-term surviving animals after small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745494 |
| Brooksbank RL et al. | Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. | 1998 | Anesthesiology | pmid:9743407 |
| Walensky LD et al. | The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. | 1998 | Mol. Med. | pmid:9742506 |
| Reitamo S et al. | Tacrolimus ointment does not affect collagen synthesis: results of a single-center randomized trial. | 1998 | J. Invest. Dermatol. | pmid:9740230 |