tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugimoto K et al. | Assessment of Long-Term Efficacy and Safety of Adalimumab in Patients with Ulcerative Colitis: Results from a 6-Year Real-World Clinical Practice. | 2019 | Dig Dis | pmid:30205400 |
| Shin TH et al. | Formulation and in vivo pharmacokinetic evaluation of ethyl cellulose-coated sustained release multiple-unit system of tacrolimus. | 2018 | Int. J. Biol. Macromol. | pmid:29277422 |
| Moriguchi S et al. | Reduced expression of Na/Ca exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice. | 2018 | Neuropharmacology | pmid:29274751 |
| Gaynor JJ and Ciancio G | The Importance of Using Serially Measured Tacrolimus Clearance Values, Especially During the Early Posttransplantation Period. | 2018 | Transplantation | pmid:29271869 |
| Ohara M et al. | Myasthenia Gravis Complicated with Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS), Following Thymectomy and Longstanding Tacrolimus Therapy. | 2018 | Intern. Med. | pmid:29269644 |
| Hasegawa M et al. | Diagnostic criteria, severity classification and guidelines of lichen sclerosus et atrophicus. | 2018 | J. Dermatol. | pmid:29265410 |
| Gómez-Bravo MA et al. | Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients. | 2018 | Pharmacogenet. Genomics | pmid:29256966 |
| Karagun BS et al. | Eye Movement Disorders Following Allogeneic Bone Marrow Transplantation on FK506 (Tacrolimus) and Ganciclovir. | 2018 | J. Pediatr. Hematol. Oncol. | pmid:28731920 |
| Leiskau C et al. | Side effects and efficacy of renal sparing immunosuppression in pediatric liver transplantation-A single center matched cohort study. | 2018 | Pediatr Transplant | pmid:29729061 |
| Komura Y et al. | Economic assessment of actual prescription of drugs for treatment of atopic dermatitis: Differences between dermatology and pediatrics in large-scale receipt data. | 2018 | J. Dermatol. | pmid:29168213 |
| Cho EJ et al. | Performance of the Dimension TAC assay and comparison of multiple platforms for the measurement of tacrolimus. | 2018 | J. Clin. Lab. Anal. | pmid:29148096 |
| Sir G et al. | Antagonistic Effect of Oxytocin and Tacrolimus Combination on Adipose Tissue - Derived Mesenchymal Stem Cells: Antagonistic effect of oxytocin and tacrolimus. | 2018 | Biomed. Pharmacother. | pmid:29136956 |
| Liu L et al. | New insights of subfertility among transplanted women: Immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization. | 2018 | J. Cell. Biochem. | pmid:29131377 |
| Pham TT et al. | Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model. | 2018 | Biomaterials | pmid:29128846 |
| Kamanamool N et al. | Comparison of disease activity between tacrolimus and mycophenolate mofetil in lupus nephritis: a randomized controlled trial. | 2018 | Lupus | pmid:29105558 |
| Kirchhof J et al. | Learned immunosuppressive placebo responses in renal transplant patients. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29610294 |
| Wu MF et al. | Combination Therapy of Tacrolimus and Chinese Herb Medicated Bath in Children with Inverse Psoriasis. | 2018 | Chin J Integr Med | pmid:28914435 |
| Akamine Y et al. | A comparison of the effects of CYP3A5 polymorphism on tacrolimus blood concentrations measured by 4 immunoassay methods in renal transplant patients. | 2018 | J Clin Pharm Ther | pmid:28891077 |
| Kojima CA et al. | Sirolimus Associated with Tacrolimus at Low Doses in Elderly Kidney Transplant Patients: A Prospective Randomized Controlled Trial. | 2018 | Exp Clin Transplant | pmid:28836934 |
| Lee WS et al. | Tacrolimus regulates endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation: In vitro and collagen-induced arthritis mouse model. | 2018 | Cell Biol. Int. | pmid:28833755 |
| Quintero J et al. | Conversion from twice-daily to once-daily tacrolimus formulation in pediatric liver transplant recipients - a long-term prospective study. | 2018 | Transpl. Int. | pmid:28833714 |
| Zeng K et al. | Dissolution Test of Tacrolimus Capsule: Effects of Filtration and Glass Adsorption. | 2018 | AAPS PharmSciTech | pmid:28828626 |
| Huang F et al. | Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study. | 2018 | Basic Clin. Pharmacol. Toxicol. | pmid:29427400 |
| Fonseca ACRG et al. | Calcineurin is an important factor involved in glucose uptake in human adipocytes. | 2018 | Mol. Cell. Biochem. | pmid:29380240 |
| Mithani Z et al. | De Novo Donor-Specific Antibody Formation in Tacrolimus-Based, Mycophenolate Versus Mammalian Target of Rapamycin Immunosuppressive Regimens. | 2018 | Exp Clin Transplant | pmid:28332959 |
| Felipe C et al. | Adequacy of Initial Everolimus Dose, With and Without Calcineurin Inhibitors, in Kidney Transplant Recipients. | 2018 | Ther Drug Monit | pmid:29271815 |
| Al-Lawati H et al. | Nanomedicine for immunosuppressive therapy: achievements in pre-clinical and clinical research. | 2018 | Expert Opin Drug Deliv | pmid:29261332 |
| Ayala E et al. | Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an older adult patient. | 2018 | Hematol Oncol Stem Cell Ther | pmid:27352259 |
| Velioglu A et al. | Late Pulmonary Toxicity Associated With Everolimus in a Renal Transplant Patient and Review of the Literature. | 2018 | Exp Clin Transplant | pmid:27001620 |
| Kimura Y et al. | Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. | 2018 | Arch. Toxicol. | pmid:29594315 |
| Vandenbussche C et al. | Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation. | 2018 | Arch. Toxicol. | pmid:29362864 |
| Park CS et al. | Tetrahydrocurcumin Ameliorates Tacrolimus-Induced Nephrotoxicity Via Inhibiting Apoptosis. | 2018 | Transplant. Proc. | pmid:30401411 |
| Pflugrad H et al. | Longterm calcineurin inhibitor therapy and brain function in patients after liver transplantation. | 2018 | Liver Transpl. | pmid:29156491 |
| Loeschenberger B et al. | Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells. | 2018 | Eur. J. Immunol. | pmid:29143318 |
| Zaman M et al. | Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges. | 2018 | Int J Nanomedicine | pmid:30127605 |
| Asano T et al. | The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report. | 2018 | Medicine (Baltimore) | pmid:30113451 |
| Liu YJ et al. | Pooled analysis of the comparative efficacy between tacrolimus and infliximab for ulcerative colitis. | 2018 | Medicine (Baltimore) | pmid:30095612 |
| Garaix F et al. | Tacrolimus Granules for Oral Suspension as Post-Transplant Immunosuppression in Routine Medical Practice in France: The OPTIMOD Study. | 2018 | Ann. Transplant. | pmid:30093607 |
| Li P et al. | Risk factors for BK virus infection in living-donor renal transplant recipients: a single-center study from China. | 2018 | Ren Fail | pmid:30052479 |
| Thoms S et al. | Tacrolimus inhibits angiogenesis and induces disaggregation of endothelial cells in spheroids - Toxicity testing in a 3D cell culture approach. | 2018 | Toxicol In Vitro | pmid:30048735 |
| Kaneko T et al. | Comparison of whole-blood tacrolimus concentrations measured by different immunoassay systems. | 2018 | J. Clin. Lab. Anal. | pmid:29974517 |
| Saengram W et al. | Extended release versus immediate release tacrolimus in kidney transplant recipients: a systematic review and meta-analysis. | 2018 | Eur. J. Clin. Pharmacol. | pmid:29961086 |
| Özçakar ZB et al. | Transplantation within the era of anti-IL-1 therapy: case series of five patients with familial Mediterranean fever-related amyloidosis. | 2018 | Transpl. Int. | pmid:29957882 |
| Chao YH et al. | Tolerogenic β2-glycoprotein I DNA vaccine and FK506 as an adjuvant attenuates experimental obstetric antiphospholipid syndrome. | 2018 | PLoS ONE | pmid:29894515 |
| Krogstad V et al. | Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies. | 2018 | Ther Drug Monit | pmid:29578937 |
| Marquet P et al. | Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online. | 2018 | Ther Drug Monit | pmid:29505493 |
| Chen J et al. | Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. | 2018 | J. Biol. Chem. | pmid:29330302 |
| Marquet P et al. | Comparative clinical trial of the variability factors of the exposure indices used for the drug monitoring of two tacrolimus formulations in kidney transplant recipients. | 2018 | Pharmacol. Res. | pmid:29229354 |
| Geng L et al. | Lower tacrolimus trough levels in the late period after living donor liver transplantation contribute to improvements in long-term clinical outcomes. | 2018 | HBPD INT | pmid:29807766 |
| Ding CG et al. | Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation. | 2018 | Chin. Med. J. | pmid:29786042 |
| Malakasioti G et al. | Converting immunosuppression from an oral suspension to a granule formulation of tacrolimus in pediatric renal transplant recipients. | 2018 | Pediatr Transplant | pmid:29767471 |
| Wang DD et al. | Population pharmacokinetics of tacrolimus in paediatric systemic lupus erythematosus based on real-world study. | 2018 | J Clin Pharm Ther | pmid:29766530 |
| Rigo-Bonnin R et al. | Different top-down approaches to estimate measurement uncertainty of whole blood tacrolimus mass concentration values. | 2018 | Clin. Biochem. | pmid:29750938 |
| Strohbehn GW et al. | Large-Scale Variability of Inpatient Tacrolimus Therapeutic Drug Monitoring at an Academic Transplant Center: A Retrospective Study. | 2018 | Ther Drug Monit | pmid:29750738 |
| Sablik KA et al. | Tacrolimus intra-patient variability is not associated with chronic active antibody mediated rejection. | 2018 | PLoS ONE | pmid:29746495 |
| Tang JT et al. | A Low Fixed Tacrolimus Starting Dose Is Effective and Safe in Chinese Renal Transplantation Recipients. | 2018 | Ann. Transplant. | pmid:29735966 |
| Cai W et al. | Limited Sampling Strategy for Estimating Mycophenolic Acid Exposure on Day 7 Post-Transplant for Two Mycophenolate Mofetil Formulations Derived From 20 Chinese Renal Transplant Recipients. | 2018 | Transplant. Proc. | pmid:29735215 |
| Chung YW et al. | Tacrolimus-Induced Apoptosis is Mediated by Endoplasmic Reticulum-derived Calcium-dependent Caspases-3,-12 in Jurkat Cells. | 2018 | Transplant. Proc. | pmid:29731088 |
| Lee KH et al. | Distribution of Anti-ABO Immunoglobulin G Subclass and C1q Antibody in ABO-incompatible Kidney Transplantation. | 2018 | Transplant. Proc. | pmid:29731066 |
| Htun YY et al. | CYP3A5*3 Genetic Polymorphism and Tacrolimus Concentration in Myanmar Renal Transplant Patients. | 2018 | Transplant. Proc. | pmid:29731062 |
| Scherrer M et al. | Tacrolimus-induced symmetric drug-related intertriginous and flexural exanthema (SDRIFE). | 2018 | Contact Derm. | pmid:29722025 |
| Zhang Y and Zhang R | Recent advances in analytical methods for the therapeutic drug monitoring of immunosuppressive drugs. | 2018 | Drug Test Anal | pmid:28851030 |
| Freriksen JJM et al. | Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue. | 2018 | Eur J Pharm Sci | pmid:29655601 |
| Udomkarnjananun S et al. | An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. | 2018 | Am J Case Rep | pmid:29654227 |
| Krzyżowska K et al. | Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction? | 2018 | Biomed Res Int | pmid:29651435 |
| Nakagita K et al. | Effect of fluconazole on the pharmacokinetics of everolimus and tacrolimus in a heart transplant recipient: Case report. | 2018 | Int J Clin Pharmacol Ther | pmid:29648533 |
| Kaya Z et al. | Tacrolimus-Induced Autoimmune Hemolytic Anemia in a Previously Reported Child With History of Thrombocytopenia Following Liver Transplant. | 2018 | Exp Clin Transplant | pmid:29633932 |
| Nanmoku K et al. | Steroid Withdrawal Using Everolimus in ABO-Incompatible Kidney Transplant Recipients With Post-Transplant Diabetes Mellitus. | 2018 | Transplant. Proc. | pmid:29631750 |
| Thishya K et al. | Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation. | 2018 | PLoS ONE | pmid:29621269 |
| Riva N et al. | Survival Time to Biopsy-Proven Acute Rejection and Tacrolimus Adverse Drug Reactions in Pediatric Liver Transplantation. | 2018 | Ther Drug Monit | pmid:29621122 |
| Youssef A et al. | Angiolymphoid hyperplasia with eosinophilia: a case report. | 2018 | J Med Case Rep | pmid:29606120 |
| Hu R et al. | CYP3A5*3 and ABCB1 61A>G Significantly Influence Dose-adjusted Trough Blood Tacrolimus Concentrations in the First Three Months Post-Kidney Transplantation. | 2018 | Basic Clin. Pharmacol. Toxicol. | pmid:29603629 |
| Mücke VT et al. | Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation. | 2018 | Int J Mol Sci | pmid:29587453 |
| Cintra-Cabrera M et al. | Resistant Cytomegalovirus Infection After Renal Transplantation: Literature Review. | 2018 | Transplant. Proc. | pmid:29579856 |
| Takeuchi K et al. | Comparison of Safety and Efficacy of Tacrolimus versus Infliximab for Active Ulcerative Colitis. | 2018 | Dig Dis | pmid:29050007 |
| Goto T et al. | Prospective observational study on the first 51 cases of peripheral blood stem cell transplantation from unrelated donors in Japan. | 2018 | Int. J. Hematol. | pmid:29027623 |
| Schuh MJ and Massoglia G | Pharmacist Impact on Tacrolimus Serum Concentrations in Liver Transplant Patients. | 2018 | Consult Pharm | pmid:29789048 |
| Davidson HE | Shifting Paradigms in Caring for Older Adults. | 2018 | Consult Pharm | pmid:29789044 |
| Jouve T et al. | Tailoring tacrolimus therapy in kidney transplantation. | 2018 | Expert Rev Clin Pharmacol | pmid:29779413 |
| Romano P et al. | UPLC-MS/MS assay validation for tacrolimus quantitative determination in peripheral blood T CD4+ and B CD19+ lymphocytes. | 2018 | J Pharm Biomed Anal | pmid:29471254 |
| Lloberas N et al. | Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype. | 2018 | Pharmacogenomics | pmid:29469606 |
| Brooks EK et al. | Evaluation of Multiple Linear Regression-Based Limited Sampling Strategies for Enteric-Coated Mycophenolate Sodium in Adult Kidney Transplant Recipients. | 2018 | Ther Drug Monit | pmid:29461443 |
| Mashiah J et al. | Topical pimecrolimus for paediatric cutaneous mastocytosis. | 2018 | Clin. Exp. Dermatol. | pmid:29460435 |
| Chen ZH et al. | Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats. | 2018 | Transpl. Immunol. | pmid:29454984 |
| Liu J et al. | Donor and recipient P450 gene polymorphisms influence individual pharmacological effects of tacrolimus in Chinese liver transplantation patients. | 2018 | Int. Immunopharmacol. | pmid:29454235 |
| Choi CB et al. | Outcomes of multitarget therapy using mycophenolate mofetil and tacrolimus for refractory or relapsing lupus nephritis. | 2018 | Lupus | pmid:29448881 |
| Woodworth MH et al. | Tacrolimus concentration to dose ratio in solid organ transplant patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. | 2018 | Transpl Infect Dis | pmid:29446866 |
| Konma J et al. | Efficacy and safety of combination therapy with prednisolone and oral tacrolimus for progressive interstitial pneumonia with systemic sclerosis: A retrospective study. | 2018 | Mod Rheumatol | pmid:29442534 |
| Pircher C et al. | A rare case of Epstein-Barr virus-associated hepatosplenic smooth muscle tumors after kidney transplantation. | 2018 | Transpl Infect Dis | pmid:29427352 |
| Yang Y et al. | Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. | 2018 | Kidney Blood Press. Res. | pmid:29402844 |
| Gadby F et al. | [Pulmonary granuloma in an immunodepressed patient]. | 2018 | Rev Mal Respir | pmid:29395568 |
| Yoshizawa S et al. | Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation. | 2018 | Int J Mol Sci | pmid:30142940 |
| Costa D et al. | Human cryptosporidiosis in immunodeficient patients in France (2015-2017). | 2018 | Exp. Parasitol. | pmid:30107154 |
| Yang MY et al. | High rates of secondary non-adherence causes decreased efficacy of 0.1% topical tacrolimus in adult eczema patients: results from a multicenter clinical trial. | 2018 | J Dermatolog Treat | pmid:28670943 |
| Buchholz BM et al. | Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients. | 2018 | World J. Gastroenterol. | pmid:30065563 |
| Murad A et al. | Primary cutaneous post liver transplant lymphoproliferative disorder (PTLD) successfully treated with radiotherapy. | 2018 | J Dermatolog Treat | pmid:28604230 |
| Wang HD et al. | Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation. | 2018 | Transplantation | pmid:29298238 |
| Kono M et al. | False Elevation of the Blood Tacrolimus Concentration, as Assessed by an Affinity Column-mediated Immunoassay (ACMIA), Led to Acute T Cell-mediated Rejection after Kidney Transplantation. | 2018 | Intern. Med. | pmid:29279473 |
| Heppt MV et al. | Frontal Fibrosing Alopecia: A Retrospective Analysis of 72 Patients from a German Academic Center. | 2018 | Facial Plast Surg | pmid:29278862 |
| Dheer D et al. | Tacrolimus: An updated review on delivering strategies for multifarious diseases. | 2018 | Eur J Pharm Sci | pmid:29277665 |