tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Christe W | Neurological disorders in liver and kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7527953 |
| Meiser BM and Reichart B | New trends in clinical immunosuppression. | 1994 | Transplant. Proc. | pmid:7527954 |
| Hara Y et al. | Unresponsiveness to rat cardiac allografts induced by intrathymic injection of donor bone marrow cells and short course of immunosuppression. | 1994 | Transplant. Proc. | pmid:7527955 |
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Fukuzaki T et al. | Nonvascularized islet xenograft rejection in a mouse-to-rat combination where the vascularized heart is rapidly rejected. | 1994 | Transplant. Proc. | pmid:7513472 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Ohtsuka S et al. | Hamster-to-rat xenotransplantation of whole pancreas by FK 506 combined with splenectomy. | 1994 | Transplant. Proc. | pmid:7513473 |
| Iwata H et al. | Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin. | 1994 | Transplant. Proc. | pmid:7513476 |
| Nomoto S et al. | Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance. | 1994 | Transplant. Proc. | pmid:7513477 |
| Kato H et al. | Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma levels of FK 506 in the early phase after liver transplantation. | 1994 | Transplant. Proc. | pmid:7513481 |
| Douglas CM et al. | The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7528927 |
| Breuder T et al. | Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7515500 |
| Lhoëst G et al. | Isolation and identification of a FK-506 C36-C37 dihydrodiol from erythromycin-induced rabbit liver microsomes. | 1994 | J Pharm Biomed Anal | pmid:7516189 |
| Kraus-Friedmann N and Feng L | Reduction of ryanodine binding and cytosolic Ca2+ levels in liver by the immunosuppressant FK506. | 1994 | Biochem. Pharmacol. | pmid:7529023 |
| Ohtsuka S et al. | Experimental rat pancreas transplant: surgical technique and immunological considerations. | 1994 | Surg. Today | pmid:7516209 |
| Hisatomi K et al. | Limited effectiveness of FK506 administration for ongoing rejection in heterotopic rat heart transplantation. | 1994 | Surg. Today | pmid:7516210 |
| Wolter K et al. | Interaction between FK 506 and clarithromycin in a renal transplant patient. | 1994 | Eur. J. Clin. Pharmacol. | pmid:7532134 |
| Raymond M et al. | Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520. | 1994 | Mol. Cell. Biol. | pmid:7505392 |
| Valdivia LA et al. | Complement and target cells belong to the same species after liver xenografting: protection from hyperacute rejection. | 1994 | Transplant. Proc. | pmid:7518123 |
| Hayashi S et al. | Synergistic effect of donor pretreatment using FK 506 in hamster-to-rat cardiac xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518126 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Reyes J et al. | Lymphoproliferative disease after intestinal transplantation under primary FK 506 immunosuppression. | 1994 | Transplant. Proc. | pmid:7518137 |
| Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
| Gottschalk AR et al. | Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7518929 |
| Prasad TN et al. | FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs. | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7518966 |
| Dumont FJ et al. | Quantitative and temporal analysis of the cellular interaction of FK-506 and rapamycin in T-lymphocytes. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7507994 |
| Mueller AR et al. | Neurotoxicity after orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518974 |
| Platz KP et al. | Nephrotoxicity following orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518975 |
| Cakaloglu Y et al. | Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. | 1994 | Hepatology | pmid:7519161 |
| Bäckman L et al. | FK506 trough levels in whole blood and plasma in liver transplant recipients. Correlation with clinical events and side effects. | 1994 | Transplantation | pmid:7509516 |
| Kitamura Y et al. | Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. | 1994 | J. Neuroimmunol. | pmid:7509816 |
| Tze WJ et al. | Successful islet allotransplantation in diabetic rats immunosuppressed with FK506: a functional and immunological study. | 1994 | Metab. Clin. Exp. | pmid:7510012 |
| Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
| Yamauchi T | [Multiple abdominal organ transplantation in swine using FK-506]. | 1994 | Nihon Geka Gakkai Zasshi | pmid:7510015 |
| Jiang H et al. | FK 506 and deoxyspergualin: additive immunosuppressive effect on rat cardiac allograft rejection in vivo and mitogen-stimulated human lymphocyte responses in vitro. | 1994 | Transplant. Proc. | pmid:7520631 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Jensen C et al. | Interaction between tacrolimus and erythromycin. | 1994 | Lancet | pmid:7521928 |
| Winkler M et al. | Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. | 1994 | Ther Drug Monit | pmid:7521978 |
| D'Ambrosio R et al. | Multicenter comparison of tacrolimus (FK 506) whole blood concentrations as measured by the Abbott IMX analyzer and enzyme immunoassay with methylene chloride extraction. | 1994 | Ther Drug Monit | pmid:7521979 |
| Calne RY | Immunosuppression in liver transplantation. | 1994 | N. Engl. J. Med. | pmid:7523947 |
| Schleuning M et al. | Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7523957 |
| Kinoshita I et al. | Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. | 1994 | Muscle Nerve | pmid:7526208 |
| Cullen BR and Heitman J | Human immunodeficiency virus. Chaperoning a pathogen. | 1994 | Nature | pmid:7526224 |
| Connolly JO et al. | Renal arteriopathy associated with FK 506 therapy following liver transplantation. | 1994 | Nephrol. Dial. Transplant. | pmid:7526278 |
| Pham SM et al. | Cardiac transplantation at the University of Pittsburgh: 1994 update. | 1994 | Clin Transpl | pmid:7547531 |
| Radanyi C et al. | The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7526392 |
| Abu-Elmagd K et al. | Hepatic transplantation at the University of Pittsburgh: new horizons and paradigms after 30 years of experience. | 1994 | Clin Transpl | pmid:7547533 |
| Ayres RC et al. | Peripheral neurotoxicity with tacrolimus. | 1994 | Lancet | pmid:7511197 |
| Bendahan J et al. | The effect of administration of FK506 on delayed regeneration in flushed partially hepatectomized livers. | 1994 | Transplantation | pmid:7511255 |
| Yano K et al. | Effects of intrahepatic arterial and intraportal administration of FK 506 on liver allograft survival in rats. | 1994 | Transpl. Int. | pmid:11271200 |
| Chavin KD et al. | Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or rapamycin to induce tolerance. | 1994 | Transplantation | pmid:7511258 |
| Devlin J et al. | Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. | 1994 | Transpl. Int. | pmid:11271207 |
| Yano S et al. | Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes. | 1994 | Jpn. J. Cancer Res. | pmid:7511575 |
| Two-year follow-up study of the efficacy and safety of FK 506 in kidney transplant patients. Japanese FK 506 Study Group. | 1994 | Transpl. Int. | pmid:11271216 | |
| Neuhaus P et al. | Neurological complications in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271222 |
| Bismuth H et al. | Focus on intractable rejection: 6-month results of the European multicentre liver study of FK 506 and cyclosporin A. | 1994 | Transpl. Int. | pmid:11271231 |
| Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
| Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
| Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
| Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Alessiani M et al. | Adverse effects of FK 506 overdosage after liver transplantation. | 1993 | Transplant. Proc. | pmid:7679825 |
| Klintmalm GB et al. | Use of FK 506 for the prevention of recurrent allograft rejection after successful conversion from cyclosporine for refractory rejection. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679826 |
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Schweizer M et al. | Sensitivity of mitochondrial peptidyl-prolyl cis-trans isomerase, pyridine nucleotide hydrolysis and Ca2+ release to cyclosporine A and related compounds. | 1993 | Biochem. Pharmacol. | pmid:7680201 |
| Hirao A et al. | Effects of immunosuppressants, FK506, deoxyspergualin, and cyclosporine A on immature human hematopoiesis. | 1993 | Blood | pmid:7680241 |
| Tamura K et al. | Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production. | 1993 | Clin. Exp. Immunol. | pmid:7680293 |
| Armitage JM et al. | A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7680396 |
| Fischer S et al. | A mechanism for rotamase catalysis by the FK506 binding protein (FKBP). | 1993 | Biochemistry | pmid:7505615 |
| Thomson AW et al. | ICAM-1 and E-selectin expression in lesional biopsies of psoriasis patients responding to systemic FK 506 therapy. | 1993 | Autoimmunity | pmid:7505632 |
| López-Gil JA and GarcÃa Sáiz M | [FK506: an immunosuppressor for the '90's?]. | 1993 | Med Clin (Barc) | pmid:7505871 |
| Yu Y et al. | Mutagenicity of the new immunosuppressive drugs, FK 506, and spergualin. | 1993 | Transplant. Proc. | pmid:7682364 |
| Rao PN et al. | Prediction of early graft function by effluent levels of hyaluronic acid in clinical liver transplantation. | 1993 | Transplant. Proc. | pmid:7682366 |
| Hutchison KA et al. | FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. | 1993 | Biochemistry | pmid:7682438 |
| Iwasaki K et al. | Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7508138 |
| Schwaninger M et al. | Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization. | 1993 | J. Biol. Chem. | pmid:7693684 |
| Smith DF et al. | FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. | 1993 | J. Biol. Chem. | pmid:7693698 |
| Thomson AW et al. | Comparative effects of rapamycin, FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat. | 1993 | Immunopharmacol Immunotoxicol | pmid:7693791 |
| Soldin SJ et al. | Immunophilin receptors for immunosuppressive drugs. | 1993 | Ther Drug Monit | pmid:7510077 |
| McMichael J et al. | Computer-guided concentration-controlled trials in autoimmune disorders. | 1993 | Ther Drug Monit | pmid:7510078 |
| Lemster B et al. | Blood lymphocytes of autoimmune disease patients receiving FK506 exhibit normal ex vivo cytokine gene expression and proliferative responses. | 1993 | Immunol. Lett. | pmid:7510265 |
| Parent SA et al. | Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. | 1993 | J. Gen. Microbiol. | pmid:7510323 |
| Ocain TD et al. | A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7685167 |
| Asami M et al. | Detection of the FK506-FKBP-calcineurin complex by a simple binding assay. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7685169 |
| Metcalfe S et al. | Prodigiosin 25C: effect in in vitro models for T cell activation and T cell cycling and in vivo for rat heart allografts. | 1993 | Int. Arch. Allergy Immunol. | pmid:7685216 |
| Bumgardner GL and Roberts JP | New immunosuppressive agents. | 1993 | Gastroenterol. Clin. North Am. | pmid:7685324 |
| Antoni FA et al. | Inhibitory role for calcineurin in stimulus-secretion coupling revealed by FK506 and cyclosporin A in pituitary corticotrope tumor cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7687429 |
| Denesyuk AI et al. | Comparison of conformations of cyclosporin A and macrolide FK506 fragments: localization of putative binding sites with phosphatase calcineurin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7687433 |
| Altmeyer A and Dumont FJ | Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma. | 1993 | Cytokine | pmid:7687472 |
| Ueda D et al. | Influence of FK 506 on renal blood flow. | 1993 | Transplant. Proc. | pmid:7689280 |
| Ohzato H et al. | Serum interleukin-6 levels as an indicator of acute rejection after liver transplantation in cynomologous monkeys. | 1993 | Surg. Today | pmid:7689373 |
| Fesik SW | NMR structure-based drug design. | 1993 | J. Biomol. NMR | pmid:7689377 |
| McManus BM et al. | Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. | 1993 | Clin. Immunol. Immunopathol. | pmid:7689428 |
| Foxwell BM et al. | Inhibition of activation-induced changes in the structure of the T cell interleukin-7 receptor by cyclosporin A and FK506. | 1993 | Eur. J. Immunol. | pmid:7678231 |
| Hirai T et al. | Prolonged lung allograft survival with a short course of FK 506. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7678313 |
| Ibarra F et al. | Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7678337 |