tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gold BG | FK506 and the role of the immunophilin FKBP-52 in nerve regeneration. | 1999 | Drug Metab. Rev. | pmid:10461545 |
| Morris-Stiff GJ et al. | Conversion from cyclosporin (Neoral) to tacrolimus (Prograf) in renal allograft recipients with chronic graft nephropathy: results of an observational study. | 1999 | Transpl. Int. | pmid:10460877 |
| Burke GA et al. | The role of early renal biopsy in cyclosporin induced thrombotic microangiopathy. | 1999 | Pediatr. Nephrol. | pmid:10460501 |
| Drachenberg CB et al. | Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. | 1999 | Transplantation | pmid:10459544 |
| Van Gelder RN and Kaplan HJ | Immunosuppression in uveitis therapy. | 1999 | Springer Semin. Immunopathol. | pmid:10457590 |
| Hachida M et al. | Combined use of deoxyspergualin and FK 506 for temporary circulatory assist. | 1999 | Transplant. Proc. | pmid:10455968 |
| Kobashigawa JA | Postoperative management following heart transplantation. | 1999 | Transplant. Proc. | pmid:10455966 |
| Jiang H and Kobayashi M | Differences between cyclosporin A and tacrolimus in organ transplantation. | 1999 | Transplant. Proc. | pmid:10455942 |
| Miura S et al. | The beneficial effects of FK 506 on living-related renal transplantation in presensitized recipients. | 1999 | Transplant. Proc. | pmid:10455940 |
| Jones JW et al. | Long-term survival of an extremity composite tissue allograft with FK506-mycophenolate mofetil therapy. | 1999 | Surgery | pmid:10455910 |
| Penson MG et al. | Tacrolimus-based triple-drug immunosuppression minimizes serum lipid elevations in pediatric cardiac transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10452348 |
| Armstrong HM et al. | Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10450987 |
| Goulet MT et al. | C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10450986 |
| Volbracht C et al. | ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation. | 1999 | Mol. Med. | pmid:10449809 |
| Uchiyama H et al. | Approach to withdrawal from tacrolimus in a fully allogeneic murine skin graft model. | 1999 | Immunology | pmid:10447745 |
| Kur F et al. | Tacrolimus (FK506) as primary immunosuppressant after lung transplantation. | 1999 | Thorac Cardiovasc Surg | pmid:10443520 |
| Magee CC et al. | Nocardial infection in a renal transplant recipient on tacrolimus and mycophenolate mofetil. | 1999 | Clin. Nephrol. | pmid:10442495 |
| Moxey-Mims MM | Increased incidence of insulin-dependent diabetes mellitus in pediatric renal transplant patients receiving tacrolimus (FK506) | 1999 | Transplantation | pmid:10440413 |
| Sheikh AM et al. | Concomitant human immunodeficiency virus protease inhibitor therapy markedly reduces tacrolimus metabolism and increases blood levels. | 1999 | Transplantation | pmid:10440408 |
| Tsuji Y et al. | Effects of cyclosporin A, FK506 and steroid hormones on hair growth. | 1999 | Exp. Dermatol. | pmid:10439282 |
| Harikrishnan P and Harden PN | Tacrolimus can resolve cyclosporin-induced gingival hyperplasia. | 1999 | Nephrol. Dial. Transplant. | pmid:10435907 |
| Briggs WA et al. | Lymphocyte suppression by rolipram with other immunosuppressive drugs. | 1999 | J Clin Pharmacol | pmid:10434230 |
| Shinkura N et al. | Autoantibodies to FK506 binding protein 12 (FKBP12) in autoimmune diseases. | 1999 | Autoimmunity | pmid:10433096 |
| Pollock R and Rivera VM | Regulation of gene expression with synthetic dimerizers. | 1999 | Meth. Enzymol. | pmid:10432459 |
| Levy GA | Neoral/cyclosporine-based immunosuppression. | 1999 | Liver Transpl Surg | pmid:10431016 |
| Soccal PM et al. | Improvement of drug-induced chronic renal failure in lung transplantation. | 1999 | Transplantation | pmid:10428288 |
| Reichenspurner H et al. | Optimization of the immunosuppressive protocol after lung transplantation. | 1999 | Transplantation | pmid:10428269 |
| Kahan BD | An immunosuppressive triumvirate to minimize renal injuries associated with calcineurin antagonist therapy. | 1999 | Transplantation | pmid:10428260 |
| Jamieson NV | Adult small intestinal transplantation in Europe. | 1999 Apr-Jun | Acta Gastroenterol. Belg. | pmid:10427790 |
| Pirenne J | Contribution of large animal models to the development of clinical intestinal transplantation. | 1999 Apr-Jun | Acta Gastroenterol. Belg. | pmid:10427786 |
| Kato K et al. | Modulation of long-term potentiation induction in the hippocampus by N-methyl-D-aspartate-mediated presynaptic inhibition. | 1999 | Neuroscience | pmid:10426482 |
| Becker JW et al. | 32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein. | 1999 | J. Med. Chem. | pmid:10425089 |
| Dunn SE et al. | Calcineurin is required for skeletal muscle hypertrophy. | 1999 | J. Biol. Chem. | pmid:10419511 |
| Dalvit C et al. | Use of organic solvents and small molecules for locating binding sites on proteins in solutions. | 1999 | J. Biomol. NMR | pmid:10419292 |
| Remitz A et al. | Tacrolimus ointment improves psoriasis in a microplaque assay. | 1999 | Br. J. Dermatol. | pmid:10417522 |
| Mrowietz U | Macrolide immunosuppressants. | 1999 Jul-Aug | Eur J Dermatol | pmid:10417434 |
| Min DI et al. | Sudden hearing loss associated with tacrolimus in a kidney-pancreas allograft recipient. | 1999 | Pharmacotherapy | pmid:10417040 |
| Finn WF | FK506 nephrotoxicity. | 1999 May-Jul | Ren Fail | pmid:10416209 |
| Kuroda S et al. | The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats. | 1999 | Brain Res. | pmid:10415369 |
| Bavetta S et al. | The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. | 1999 | Exp. Neurol. | pmid:10415144 |
| Przepiorka D et al. | Tacrolimus for prevention of graft-versus-host disease after mismatched unrelated donor cord blood transplantation. | 1999 | Bone Marrow Transplant. | pmid:10414918 |
| Varghese Z et al. | Calcineurin inhibitors enhance low-density lipoprotein oxidation in transplant patients. | 1999 | Kidney Int. Suppl. | pmid:10412758 |
| Muegge I et al. | Evaluation of PMF scoring in docking weak ligands to the FK506 binding protein. | 1999 | J. Med. Chem. | pmid:10411471 |
| Rhew JH et al. | Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts. | 1999 | Exp. Mol. Med. | pmid:10410305 |
| Hebert MF and Lam AY | Diltiazem increases tacrolimus concentrations. | 1999 | Ann Pharmacother | pmid:10410178 |
| Kaibori M et al. | Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-kappaB activation in rat hepatocytes. | 1999 | J. Hepatol. | pmid:10406194 |
| Banerjee C et al. | Ca2+ and calmodulin-dependent protein phosphatase from Leishmania donovani. | 1999 | Parasitology | pmid:10406035 |
| Timmermann W et al. | Videomicroscopic imaging of graft mucosa for monitoring immunosuppressive therapy after small intestinal transplantation in rats. | 1999 | Transplantation | pmid:10401762 |
| Tada H et al. | Role of diltiazem on tacrolimus pharmacokinetics in tacrolimus-induced nephrotoxic rats. | 1999 | Pharmacol. Toxicol. | pmid:10401724 |
| Katayama Y | [Current tendency in treatment for acute ischemic stroke]. | 1999 | Nippon Ika Daigaku Zasshi | pmid:10401232 |
| Haas M et al. | Smooth muscle-specific actin levels in the urine of renal transplant recipients: correlation with cyclosporine or tacrolimus nephrotoxicity. | 1999 | Am. J. Kidney Dis. | pmid:10401019 |
| Gold BG et al. | Efficacy of delayed or discontinuous FK506 administrations on nerve regeneration in the rat sciatic nerve crush model: lack of evidence for a conditioning lesion-like effect. | 1999 | Neurosci. Lett. | pmid:10400242 |
| Magee CC et al. | Immunosuppressive agents in organ transplantation. | 1999 | Hosp Med | pmid:10396414 |
| Kochi S et al. | Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells. | 1999 | Eur. J. Pharmacol. | pmid:10395024 |
| Horowitz MM et al. | Tacrolimus vs. cyclosporine immunosuppression: results in advanced-stage disease compared with historical controls treated exclusively with cyclosporine. | 1999 | Biol. Blood Marrow Transplant. | pmid:10392964 |
| Hasselder AS | The nursing management of a patient receiving Prograf as a primary immunosuppressive agent. | 1998 Apr-Jun | EDTNA ERCA J | pmid:10392057 |
| Liang H et al. | Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. | 1999 | J. Biol. Chem. | pmid:10391929 |
| Gerhardt U et al. | Blood pressure control in kidney transplant recipients: influence of immunosuppression. | 1999 | J Auton Pharmacol | pmid:10385269 |
| Squadrito F et al. | Tacrolimus suppresses tumour necrosis factor-alpha and protects against splanchnic artery occlusion shock. | 1999 | Br. J. Pharmacol. | pmid:10385251 |
| Leung W et al. | Long-term complete remission and immune tolerance after intensive chemotherapy for lymphoproliferative disorders complicating liver transplant. | 1999 | Transplantation | pmid:10385092 |
| Koski GK et al. | Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways. | 1999 | J. Immunol. | pmid:10384103 |
| Henry ML | Cyclosporine and tacrolimus (FK506): a comparison of efficacy and safety profiles. | 1999 | Clin Transplant | pmid:10383101 |
| Higgins RM et al. | Conversion between cyclosporin and tacrolimus--30-fold dose prediction. | 1999 | Nephrol. Dial. Transplant. | pmid:10383044 |
| Cox KL et al. | Paediatric liver transplantation: indications, timing and medical complications. | 1999 | J. Gastroenterol. Hepatol. | pmid:10382641 |
| Lieberman DN and Mody I | Properties of single NMDA receptor channels in human dentate gyrus granule cells. | 1999 | J. Physiol. (Lond.) | pmid:10373689 |
| Kirk AD et al. | Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. | 1999 | Nat. Med. | pmid:10371508 |
| Matzinger P | Graft tolerance: a duel of two signals. | 1999 | Nat. Med. | pmid:10371494 |
| Przepiorka D et al. | Relationship of tacrolimus whole blood levels to efficacy and safety outcomes after unrelated donor marrow transplantation. | 1999 | Biol. Blood Marrow Transplant. | pmid:10371361 |
| Ito F et al. | FK506 and cyclosporin A inhibit stem cell factor-dependent cell proliferation/survival, while inducing upregulation of c-kit expression in cells of the mast cell line MC/9. | 1999 | Arch. Dermatol. Res. | pmid:10367710 |
| Onsager DR et al. | Efficacy of tacrolimus in the treatment of refractory rejection in heart and lung transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10363689 |
| Venz S et al. | Contribution of color and power Doppler sonography to the differential diagnosis of acute and chronic rejection, and tacrolimus nephrotoxicity in renal allografts. | 1999 | Transpl. Int. | pmid:10363595 |
| Jiang H et al. | Tacrolimus versus cyclosporin A: a comparative study on rat renal allograft survival. | 1999 | Transpl. Int. | pmid:10363590 |
| Kanoh S et al. | Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium. | 1999 | Am. J. Physiol. | pmid:10362712 |
| Gummert JF et al. | Newer immunosuppressive drugs: a review. | 1999 | J. Am. Soc. Nephrol. | pmid:10361877 |
| Johnson KL and Lawen A | Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25. | 1999 | Immunol. Cell Biol. | pmid:10361256 |
| Doolabh VB and Mackinnon SE | FK506 accelerates functional recovery following nerve grafting in a rat model. | 1999 | Plast. Reconstr. Surg. | pmid:10359255 |
| Cao S et al. | Long-term outcomes in pediatric liver recipients: comparison between cyclosporin A and tacrolimus. | 1999 | Pediatr Transplant | pmid:10359027 |
| Cheng HH et al. | Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase. | 1999 | J. Biol. Chem. | pmid:10358074 |
| Muramatsu K et al. | Limb allotransplantation in rats: combined immunosuppression by FK-506 and 15-deoxyspergualin. | 1999 | J Hand Surg Am | pmid:10357540 |
| Toung TJ et al. | Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats. | 1999 | Stroke | pmid:10356112 |
| Yang J et al. | Sjögren's syndrome in mice carrying the Ipr(cg) gene and the therapeutic efficacy of an immunosuppressive agent FK506. | 1999 | Pathol. Int. | pmid:10355966 |
| Zarifian A et al. | Cyclosporine-associated thrombotic microangiopathy in renal allografts. | 1999 | Kidney Int. | pmid:10354295 |
| Murata M et al. | A new preconditioning regimen with melphalan, busulphan and total body irradiation followed by low-dose immunosuppressant in allogeneic haemopoietic stem cell transplantation. | 1999 | Br. J. Haematol. | pmid:10354150 |
| Möller A et al. | The disposition of 14C-labeled tacrolimus after intravenous and oral administration in healthy human subjects. | 1999 | Drug Metab. Dispos. | pmid:10348790 |
| Araki T et al. | Increases in [3H]FK-506 and [3H]L-N(G)-nitro-arginine binding in the rat brain after nigrostriatal dopaminergic denervation. | 1999 | Metab Brain Dis | pmid:10348311 |
| Oddis CV et al. | Tacrolimus in refractory polymyositis with interstitial lung disease. | 1999 | Lancet | pmid:10347992 |
| Siemann G et al. | Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context. | 1999 | Mol. Pharmacol. | pmid:10347253 |
| Boehringer M et al. | Kaposi's sarcoma after renal transplantation: treatment with liposomal doxorubicin. | 1999 | Nephrol. Dial. Transplant. | pmid:10344407 |
| Tacrolimus in the prevention of graft rejection: new indication. Helpful alternative to ciclosporin. | 1998 | Prescrire Int | pmid:10342948 | |
| Dresske B et al. | WOFIE augments the immunosuppressive potency of FK-506. Window of opportunity for immunological engagement. | 1998 | Transpl. Immunol. | pmid:10342738 |
| Khanna A et al. | Impact of Flt-3 ligand on donor-derived antigen presenting cells and alloimmune reactivity in heart graft recipients given adjuvant donor bone marrow. | 1998 | Transpl. Immunol. | pmid:10342736 |
| Moffatt SD et al. | Potential for improved therapeutic index of FK506 in liposomal formulation demonstrated in a mouse cardiac allograft model. | 1999 | Transplantation | pmid:10342309 |
| Uchio E et al. | Soluble intercellular adhesion molecule-1 (ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behçet's disease and Vogt-Koyanagi-Harada's disease. | 1999 Mar-Apr | Clin. Exp. Rheumatol. | pmid:10342043 |
| Ruddy SB et al. | Design and characterization of a surfactant-enriched tablet formulation for oral delivery of a poorly water-soluble immunosuppressive agent. | 1999 | Int J Pharm | pmid:10341307 |
| Ma D and Carlow CK | Molecular characterization of FKBP13 from filarial parasites. | 1999 | Mol. Biochem. Parasitol. | pmid:10340490 |
| Conboy IM et al. | Calcineurin and vacuolar-type H+-ATPase modulate macrophage effector functions. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10339586 |
| Ferrand-Drake M et al. | Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia. | 1999 | Neuroscience | pmid:10338300 |
| Steg RE et al. | Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10338054 |
| Gold BG et al. | Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10336507 |
| Shirbacheh MV et al. | Pharmacokinetics of intra-arterial delivery of tacrolimus to vascularly isolated rabbit forelimb. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10336506 |