tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oberholzer J et al. | Daclizumab as escape therapy for late acute kidney rejection in the presence of FK506 nephrotoxicity. | 2000 | Transpl. Int. | pmid:10836657 |
| Yoshikawa T et al. | In vivo osteogenic capability of cultured allogeneic bone in porous hydroxyapatite: immunosuppressive and osteogenic potential of FK506 in vivo. | 2000 | J. Bone Miner. Res. | pmid:10841184 |
| Rabinowitz M et al. | Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10843203 |
| Nasr IS | Topical tacrolimus in dermatology. | 2000 | Clin. Exp. Dermatol. | pmid:10844509 |
| Samsonov D et al. | Enhancement of immune tolerance via induction of NK1.1 positive liver-associated-lymphocytes under immunosuppressive conditions. | 2000 | J. Hepatol. | pmid:10845669 |
| Zhang F et al. | Resistance to Friend murine leukemia virus infection conferred by the Fv-4 gene is recessive but appears dominant from the effect of the immune system. | 2000 | J. Virol. | pmid:10846105 |
| Small bowel transplants in adults and multivisceral transplants in adults and children. | 1999 | Tecnologica MAP Suppl | pmid:10848042 | |
| Tyedmers J et al. | Assembly of heterodimeric luciferase after de novo synthesis of subunits in rabbit reticulocyte lysate involves hsc70 and hsp40 at a post-translational stage. | 2000 | Eur. J. Biochem. | pmid:10848974 |
| Gibson SW et al. | Nutritional immunomodulation leads to enhanced allograft survival in combination with cyclosporine A and rapamycin, but not FK506. | 2000 | Transplantation | pmid:10852592 |
| Konrad T et al. | Regulation of glucose tolerance in patients after liver transplantation: impact of cyclosporin versus tacrolimus therapy. | 2000 | Transplantation | pmid:10852599 |
| Schvarcz R et al. | Interaction between nelfinavir and tacrolimus after orthoptic liver transplantation in a patient coinfected with HIV and hepatitis C virus (HCV). | 2000 | Transplantation | pmid:10852623 |
| Rollins CT et al. | A ligand-reversible dimerization system for controlling protein-protein interactions. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10852943 |
| Florio G et al. | The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. | 2000 | AIDS | pmid:10853974 |
| Kochi S et al. | Induction of apoptosis in mouse brain capillary endothelial cells by cyclosporin A and tacrolimus. | 2000 | Life Sci. | pmid:10855946 |
| Bultynck G et al. | Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms. | 2000 | J. Physiol. (Lond.) | pmid:10856121 |
| Granot E et al. | Monitoring of Epstein-Barr virus serology in children after liver transplant: lack of clinical correlation. | 2000 | Transplant. Proc. | pmid:10856551 |
| Ben-Ari Z et al. | Conversion of liver allograft recipients from cyclosporine A to FK 506 immunosuppressive therapy. | 2000 | Transplant. Proc. | pmid:10856553 |
| Barak S et al. | Alveolar bone height in patients after liver transplantation. | 2000 | Transplant. Proc. | pmid:10856558 |
| Gotsman I et al. | Effect of peripheral immune tolerance on liver-associated lymphocytes expressing NK1.1. | 2000 | Transplant. Proc. | pmid:10856569 |
| Malinowski K et al. | Effect of different anti-rejection regimens on the expression of differentiation and activation markers on the surface of host lymphocytes. | 2000 | Transplant. Proc. | pmid:10856579 |
| McLaughlin GE et al. | Effect of aminophylline on urine flow in children with tacrolimus-induced renal insufficiency. | 2000 | Transplant. Proc. | pmid:10856596 |
| Morelli AE et al. | Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus. | 2000 | J. Immunol. | pmid:10861056 |
| Boubenider S et al. | Interaction between theophylline and tacrolimus in a renal transplant patient. | 2000 | Nephrol. Dial. Transplant. | pmid:10862651 |
| Wu K et al. | The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. | 2000 | Gene | pmid:10863099 |
| Oike F et al. | A 12-day course of FK506 allows long-term acceptance of semi-identical liver allograft in inbred miniature swine. | 2000 | Transplantation | pmid:10868630 |
| Yamani MH et al. | The impact of routine mycophenolate mofetil drug monitoring on the treatment of cardiac allograft rejection. | 2000 | Transplantation | pmid:10868634 |
| Blakolmer K et al. | Chronic liver allograft rejection in a population treated primarily with tacrolimus as baseline immunosuppression: long-term follow-up and evaluation of features for histopathological staging. | 2000 | Transplantation | pmid:10868635 |
| Neuhaus P et al. | Quadruple tacrolimus-based induction therapy including azathioprine and ALG does not significantly improve outcome after liver transplantation when compared with standard induction with tacrolimus and steroids: results of a prospective, randomized trial. | 2000 | Transplantation | pmid:10868638 |
| Au WY et al. | Tacrolimus (FK 506) induced thrombotic thrombocytopenic purpura after ABO mismatched second liver transplantation: salvage with plasmapheresis and prostacyclin. | 2000 | Haematologica | pmid:10870125 |
| Queille-Roussel C et al. | SDZ ASM 981 is the first non-steroid that suppresses established nickel contact dermatitis elicited by allergen challenge. | 2000 | Contact Derm. | pmid:10871099 |
| Morales JM et al. | Immunosuppression in older renal transplant patients. | 2000 | Drugs Aging | pmid:10874523 |
| Costantini LC and Isacson O | Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture. | 2000 | Exp. Neurol. | pmid:10877916 |
| Castilho RF et al. | FK506 and cyclosporin A enhance the survival of cultured and grafted rat embryonic dopamine neurons. | 2000 | Exp. Neurol. | pmid:10877919 |
| Allison AC | Immunosuppressive drugs: the first 50 years and a glance forward. | 2000 | Immunopharmacology | pmid:10878284 |
| Assmann T et al. | Applications of tacrolimus for the treatment of skin disorders. | 2000 | Immunopharmacology | pmid:10878290 |
| Hamazaki T et al. | [Prophylaxis with FK-506 for graft-versus-host disease after transplantation of bone marrow from unrelated donors]. | 2000 | Rinsho Ketsueki | pmid:10879106 |
| Ben Abraham R et al. | [FK506 (tacrolimus) does not increase hepatic damage due to hypoperfusion]. | 2000 | Harefuah | pmid:10883243 |
| Romano G et al. | Systemic and intratubular effects of cyclosporin-A and tacrolimus on the rat kidney. | 2000 | Eur. J. Pharmacol. | pmid:10884522 |
| Parker EM et al. | Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression. | 2000 | Neuropharmacology | pmid:10884572 |
| Terashima A et al. | Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca(2+) signaling mechanism in rat hippocampal CA1 neurons. | 2000 | Neuropharmacology | pmid:10884573 |
| Zaman AK | Effects of tacrolimus hydrate (FK-506) on the expression of tissue factor in THP-1 human monocyte cell line. | 2000 | Hokkaido Igaku Zasshi | pmid:10884973 |
| Arthur JM and Shamim S | Interaction of cyclosporine and FK506 with diuretics in transplant patients. | 2000 | Kidney Int. | pmid:10886578 |
| Hooijberg E et al. | NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells. | 2000 | Blood | pmid:10887106 |
| Mori A et al. | Control of IL-5 production by human helper T cells as a treatment for eosinophilic inflammation: comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors. | 2000 | J. Allergy Clin. Immunol. | pmid:10887335 |
| Yue G et al. | The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898719 |
| Mukerjee N et al. | Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. | 2000 | Arch. Biochem. Biophys. | pmid:10898953 |
| Hishinuma S and Ogura K | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. | 2000 | J. Neurochem. | pmid:10899954 |
| Wang L et al. | Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo. | 2000 | Clin. Exp. Pharmacol. Physiol. | pmid:10901387 |
| Fisher NC et al. | The clinical impact of nephrotoxicity in liver transplantation. | 2000 | Transplantation | pmid:10910259 |
| MacDonald AS | Management strategies for nephrotoxicity. | 2000 | Transplantation | pmid:10910262 |
| Reyes J et al. | Long-term results after conversion from cyclosporine to tacrolimus in pediatric liver transplantation for acute and chronic rejection. | 2000 | Transplantation | pmid:10910279 |
| Shapiro AM et al. | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. | 2000 | N. Engl. J. Med. | pmid:10911004 |
| Robertson RP | Successful islet transplantation for patients with diabetes--fact or fantasy? | 2000 | N. Engl. J. Med. | pmid:10911012 |
| Ellis D | Growth and renal function after steroid-free tacrolimus-based immunosuppression in children with renal transplants. | 2000 | Pediatr. Nephrol. | pmid:10912544 |
| Yang GS et al. | Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. | 2000 | Am J Otol | pmid:10912694 |
| Mancilla UE et al. | Primary immunosuppression with tacrolimus in renal transplantation: a multicenter, open-label study. | 1999 Sep-Oct | Adv Ther | pmid:10915396 |
| Lee TJ and Kennedy LA | Tacrolimus: an alternative for graft-versus-host disease prevention. | 2000 | Ann Pharmacother | pmid:10917386 |
| Nieto Y et al. | Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918414 |
| Yanik G et al. | Tacrolimus (FK506) and methotrexate as prophylaxis for acute graft-versus-host disease in pediatric allogeneic stem cell transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918426 |
| Peduto G et al. | Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. | 2000 | Transplantation | pmid:10919579 |
| Younes BS et al. | The effect of immunosuppression on posttransplant lymphoproliferative disease in pediatric liver transplant patients. | 2000 | Transplantation | pmid:10919581 |
| Higgins RM et al. | Conversion from tacrolimus to cyclosporin in stable renal transplant patients: safety, metabolic changes, and pharmacokinetic comparison. | 2000 | Transplantation | pmid:10919600 |
| Puig I Marà JM et al. | Reflex sympathetic dystrophy syndrome of the lower limbs in a renal transplant patient treated with tacrolimus. | 2000 | Transplantation | pmid:10919604 |
| Reitamo S et al. | Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group. | 2000 | Arch Dermatol | pmid:10926735 |
| Sugiura H et al. | Long-term efficacy of tacrolimus ointment for recalcitrant facial erythema resistant to topical corticosteroids in adult patients with atopic dermatitis. | 2000 | Arch Dermatol | pmid:10926750 |
| Sakuma S et al. | FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. | 2000 | Br. J. Pharmacol. | pmid:10928971 |
| Jimenez J and Young JB | Clinical challenges in thoracic organ transplantation: case studies in immunosuppressive therapy. | 2000 | J. Heart Lung Transplant. | pmid:10930823 |
| Schmutz J et al. | [Gingival hypertrophy and tacrolimus]. | 2000 Jun-Jul | Ann Dermatol Venereol | pmid:10930868 |
| Kung L and Halloran PF | Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations. | 2000 | Transplantation | pmid:10933159 |
| Gruber SA et al. | Initial results of solitary pancreas transplants performed without regard to donor/recipient HLA mismatching. | 2000 | Transplantation | pmid:10933170 |
| Chin C et al. | Lipoprotein abnormalities are highly prevalent in pediatric heart transplant recipients. | 2000 | Pediatr Transplant | pmid:10933319 |
| Furlan V et al. | Conversion from cyclosporin A to tacrolimus in pediatric liver transplantation. | 2000 | Pediatr Transplant | pmid:10933321 |
| Minamino T et al. | Chronic treatment with FK506 increases p70 S6 kinase activity associated with reduced nitric oxide synthase activity in rabbit hearts. | 2000 | Cardiovasc Drugs Ther | pmid:10935155 |
| Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
| Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
| Yin DP et al. | Efficacy of FK506, leflunomide, anti-CD4, and CTLA4IG treatments in rat to mouse pancreas xenograft transplantation. | 2000 | Transplant. Proc. | pmid:10936320 |
| Song Z et al. | Protective effect of FK-506 in pig-to-rat islet xenotransplantation is abrogated by prednisolone. | 2000 | Transplant. Proc. | pmid:10936332 |
| Miki T et al. | Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation. | 2000 | Transplant. Proc. | pmid:10936339 |
| Wada Y et al. | Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling. | 2000 | Transplant. Proc. | pmid:10936371 |
| Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
| Goller AL et al. | Loss of serum bicarbonate after discordant liver xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936383 |
| Endoh M et al. | Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts. | 2000 | Transplant. Proc. | pmid:10936397 |
| Matsuda S and Koyasu S | [A second target of cyclosporin A and FK506]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10936966 |
| Uchida N et al. | Myocardial ischemia following allogeneic bone marrow transplantation: possible implication of tacrolimus overdose. | 2000 | Blood | pmid:10939803 |
| Casson DH et al. | Topical tacrolimus may be effective in the treatment of oral and perineal Crohn's disease. | 2000 | Gut | pmid:10940284 |
| Bertram PG et al. | Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. | 2000 | J. Biol. Chem. | pmid:10940301 |
| Woltman AM et al. | The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. | 2000 | Eur. J. Immunol. | pmid:10940869 |
| Bunn SK et al. | Treatment of microvillus inclusion disease by intestinal transplantation. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10941971 |
| Hübner GI and Sziegoleit W | Response to letter from van Gelder. Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients. | 2000 | Ther Drug Monit | pmid:10942194 |
| Flores F and Kerdel FA | Other novel immunosuppressants. | 2000 | Dermatol Clin | pmid:10943542 |
| Youn HD et al. | Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. | 2000 | EMBO J. | pmid:10944115 |
| Misseghers BS et al. | Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. | 2000 | Can. Vet. J. | pmid:10945128 |
| Masuda S et al. | Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient. | 2000 | Clin. Pharmacol. Ther. | pmid:10945321 |
| Sheiner PA | Hepatitis C after liver transplantation. | 2000 | Semin. Liver Dis. | pmid:10946424 |
| Li WE and Nagy JI | Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. | 2000 | Eur. J. Neurosci. | pmid:10947839 |
| Kohlhaw K et al. | [Clinical studies in liver transplantation]. | 2000 | Chirurg | pmid:10948733 |
| Shoker A et al. | Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. | 2000 | Transplantation | pmid:10949194 |
| Straatman LP and Coles JG | Pediatric utilization of rapamycin for severe cardiac allograft rejection. | 2000 | Transplantation | pmid:10949201 |
| Verleden GM | Bronchiolitis obliterans syndrome after lung transplantation: medical treatment. | 2000 | Monaldi Arch Chest Dis | pmid:10949876 |
| Jones JW et al. | Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. | 2000 | N. Engl. J. Med. | pmid:10950668 |