Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
Loss M et al. | Glucose and lipid metabolism in liver transplant patients under long-term tacrolimus (FK 506) monotherapy. | 1996 | Transplant. Proc. | pmid:8623210 |
Fryer JP et al. | Bacterial translocation in a large-animal model of small-bowel transplantation. Portal vs systemic venous drainage and the effect of tacrolimus immunosuppression. | 1996 | Arch Surg | pmid:8546583 |
Bechstein WO et al. | Tacrolimus (FK 506) therapy is associated with a significant reduction in immunosuppressive treatment failures following primary liver transplantation. | 1996 | Transplant. Proc. | pmid:8623211 |
Sher LS et al. | Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation. | 1996 | Transplant. Proc. | pmid:8623212 |
Millis JM et al. | Treatment of steroid-resistant rejection with tacrolimus prior to OKT3 in liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8623213 |
Washburn WK et al. | Tacrolimus rescue therapy for renal allograft rejection refractory to cyclosporine-based immunosuppression. | 1996 | Transplant. Proc. | pmid:8623214 |
D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
Pirenne J et al. | Bone marrow augmentation of kidney allografts can cause graft-versus-host disease in immunosuppressed recipients. | 1996 | Transplant. Proc. | pmid:8623472 |
Ciancio G et al. | Human donor bone marrow cells can enhance hyporeactivity in renal transplantation using maintenance FK 506 and OKT3 induction therapy. | 1996 | Transplant. Proc. | pmid:8623473 |
D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
Klintmalm GB | Clinical use of FK 506 in liver transplantation. | 1996 | Transplant. Proc. | pmid:8623484 |
Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
Ichikawa Y et al. | Three-times-daily monotherapy with tacrolimus (FK 506) in kidney transplantation. | 1996 | Int. J. Urol. | pmid:8776613 |
Mugiya S et al. | Renal blood flow and serotonin metabolism in tacrolimus treated rats. | 1996 | Int. J. Urol. | pmid:8776615 |
Dmitrewski J et al. | Recurrence of primary biliary cirrhosis in the liver allograft: the effect of immunosuppression. | 1996 | J. Hepatol. | pmid:8778189 |
Schwarz A | [Drug-induced kidney damage]. | 1996 | Z Arztl Fortbild (Jena) | pmid:8779233 |
Newell KA et al. | Posttransplant lymphoproliferative disease in pediatric liver transplantation. Interplay between primary Epstein-Barr virus infection and immunosuppression. | 1996 | Transplantation | pmid:8779685 |
Lufft V et al. | Incidence of Pneumocystis carinii pneumonia after renal transplantation. Impact of immunosuppression. | 1996 | Transplantation | pmid:8779695 |
Wu J et al. | Reversal of multidrug resistance by tacrolimus hydrate. | 1996 | Methods Find Exp Clin Pharmacol | pmid:9121220 |
Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
Cohen DS et al. | Porcine small bowel transplantation with rapamycin-based induction immunosuppression and short-course cyclosporine or FK 506 therapy. | 1996 | Transplant. Proc. | pmid:8907923 |
Toyama Y et al. | Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. | 1996 | Transplant. Proc. | pmid:8907924 |
Yamada T et al. | Synergistic effect of FK 506 and trifluoperazine on the immunosuppression in rat small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907927 |
Rossi G et al. | Results of orthotopic liver-small bowel transplantation in the pig using different immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907932 |
Nishino H et al. | 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression. | 1996 | J. Chem. Neuroanat. | pmid:8811425 |
Sonatore LM et al. | The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. | 1996 | Anal. Biochem. | pmid:8811923 |
Jonas S et al. | Conversion to tacrolimus after liver transplantation. | 1996 | Transpl. Int. | pmid:8748407 |
Cooley HM et al. | Resolution of pyoderma gangrenosum using tacolimus (FK-506) | 1996 | Aust N Z J Med | pmid:8744629 |
Hashino S et al. | Antitumor effect in cyclosporine A- or FK506-treated mice after syngeneic bone marrow transplantation. | 1996 | Leuk. Lymphoma | pmid:8726416 |
Steiner JP et al. | Immunophilin regulation of neurotransmitter release. | 1996 | Mol. Med. | pmid:8784785 |
Herzog D et al. | Combined bowel-liver transplantation in an infant with microvillous inclusion disease. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8732907 |
Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
Wilczek HE et al. | Renal transplant histopathologic changes during the first year in patients with tacrolimus (FK 506). | 1996 | Transplant. Proc. | pmid:8962232 |
Yussim A et al. | Conversion from cyclosporine to tacrolimus in hepatic and renal transplantation. | 1996 | Transplant. Proc. | pmid:8962233 |
Golling M et al. | Tacrolimus reduction improves glucose metabolism and insulin secretion after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962234 |
Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
Yuzawa K et al. | Topical immunosuppression in skin grafting with FK 506 ointment. | 1996 | Transplant. Proc. | pmid:8658707 |
Yagura K et al. | Pharmacokinetic characteristics of two types of liposomal FK 506. | 1996 | Transplant. Proc. | pmid:8658708 |
Ogawa N et al. | Suppressive effects of combination therapy with mizoribine and FK 506 on the development of accelerated coronary artery disease and myocardial rejection after heart transplantation. | 1996 | Transplant. Proc. | pmid:8658710 |
Andoh TF et al. | Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. | 1996 | Kidney Int. | pmid:8887267 |
Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
Mysliwiec J et al. | The effect of tacrolimus (FK506) and cyclosporin A (CyA) on peripheral serotonergic mechanisms in uremic rats. | 1996 | Thromb. Res. | pmid:8837316 |
Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
Lamb GD and Stephenson DG | Effects of FK506 and rapamycin on excitation-contraction coupling in skeletal muscle fibres of the rat. | 1996 | J. Physiol. (Lond.) | pmid:8842013 |
Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
Tanaka K et al. | Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. | 1996 | Pharm. Res. | pmid:8842048 |
Bader A et al. | Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8935714 |
Borvak J et al. | The use of cyclosporine, FK506, and SDZ NIM811 to prevent CD25- quiescent peripheral blood mononuclear cells from producing human immunodeficiency virus. | 1996 | J. Infect. Dis. | pmid:8843228 |
Galat A | A large-scale processing of kinetic data files with derivation of the inhibitory constant Ki: an application to proline isomerases. | 1996 | Comput. Chem. | pmid:8936426 |
Borg AJ et al. | 15-Deoxyspergualin inhibits interleukin 6 production in in vitro stimulated human lymphocytes. | 1996 | Transpl. Immunol. | pmid:8843590 |
Alak AM and Lizak P | Stability of FK506 in blood samples. | 1996 | Ther Drug Monit | pmid:8721287 |
Büttemeyer R et al. | Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. | 1996 | Plast. Reconstr. Surg. | pmid:8532772 |
Yu C et al. | Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8722370 |
Fealy MJ and Press BH | Pinpointing the moment of allograft rejection. | 1996 | J Hand Surg Am | pmid:8724501 |
Hall MN | The TOR signalling pathway and growth control in yeast. | 1996 | Biochem. Soc. Trans. | pmid:8674674 |
Mattila PS | The actions of cyclosporin A and FK506 on T-lymphocyte activation. | 1996 | Biochem. Soc. Trans. | pmid:8674715 |
Adams DH and Liu Q | FK506 inhibits human lymphocyte migration and the production of lymphocyte chemotactic factors in liver allograft recipients. | 1996 | Hepatology | pmid:8675167 |
De Rie MA et al. | Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. | 1996 | Acta Derm. Venereol. | pmid:8891007 |
Timmerman LA et al. | Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. | 1996 | Nature | pmid:8893011 |
Inutsuka K et al. | Reconstruction of trachea and carina with immediate or cryopreserved allografts in dogs. | 1996 | Ann. Thorac. Surg. | pmid:8893587 |
Ezeamuzie CI | Anti-allergic activity of cyclosporin-A metabolites and their interaction with the parent compound and FK 506. | 1996 | Int. J. Immunopharmacol. | pmid:8894806 |
Ockenfels HM et al. | The effect of cyclosporin A and FK 506 on the cAMP content in psoriatic keratinocytes. | 1996 | Skin Pharmacol. | pmid:8896120 |
Nash RA et al. | FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors. | 1996 | Blood | pmid:8896434 |
Rozen TD et al. | Treatment-refractory cyclosporine-associated headache: relief with conversion to FK-506. | 1996 | Neurology | pmid:8909459 |
Hartley AD et al. | cAMP inhibits bud growth in a yeast strain compromised for Ca2+ influx into the Golgi. | 1996 | Mol. Gen. Genet. | pmid:8709962 |
Tokime T et al. | Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. | 1996 | Neurosci. Lett. | pmid:8710192 |
Soubrane O and Houssin D | [Liver transplantation. Current aspects]. | 1996 | Presse Med | pmid:8728904 |
Lampen A et al. | Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. | 1996 | Br. J. Pharmacol. | pmid:8732283 |
Beretta L et al. | Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. | 1996 | EMBO J. | pmid:8599949 |
Saada V et al. | Comparative evaluation of in vitro and in vivo immunosuppressive potential of cyclosporin G with cyclosporin A and FK-506. | 1996 | Int. J. Immunopharmacol. | pmid:8732436 |
Inomata Y et al. | The evolution of immunosuppression with FK506 in pediatric living-related liver transplantation. | 1996 | Transplantation | pmid:8600632 |
Asante-Korang A et al. | Experience of FK506 immune suppression in pediatric heart transplantation: a study of long-term adverse effects. | 1996 | J. Heart Lung Transplant. | pmid:8732602 |
Gruessner RW et al. | A multicenter analysis of the first experience with FK506 for induction and rescue therapy after pancreas transplantation. | 1996 | Transplantation | pmid:8600635 |
Rifai N et al. | The role of lipoproteins in the transport and uptake of cyclosporine and dihydro-tacrolimus into HepG2 and JURKAT cell lines. | 1996 | Clin. Biochem. | pmid:8601324 |
Morris RE | Transplantation. Beware: shifting paradigms ahead. | 1996 Dec 21-28 | Lancet | pmid:8973504 |
Shultz SL and Meriney DK | Cyclosporine and tacrolimus: a comparison of immunosuppressants used for liver transplantation. | 1996 Jul-Aug | Dimens Crit Care Nurs | pmid:8717641 |
Frezza EE et al. | Small bowel transplantation: current progress and clinical application. | 1996 Mar-Apr | Hepatogastroenterology | pmid:8714229 |
Seifeldin R et al. | Effect of nifedipine on renal function in liver transplant recipients receiving tacrolimus. | 1996 May-Jun | Clin Ther | pmid:8829025 |
Cumming DV et al. | Pharmacological preconditioning of primary rat cardiac myocytes by FK506. | 1996 Sep-Oct | Basic Res. Cardiol. | pmid:8922254 |
Soin AS and Jamieson NV | Lessons learnt from the multicentre randomized trials of tacrolimus in liver transplantation. | 1996 Sep-Oct | Natl Med J India | pmid:8937063 |
Kokudo N et al. | Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation for Nagase's analbuminemic rats. | 1996 Sep-Oct | Cell Transplant | pmid:8889223 |
Furukawa M et al. | Analysis of PCR microchimerism induced by intrathymic inoculation of donor alloantigens in rats. | 1996 Sep-Oct | Cell Transplant | pmid:8889237 |
Koneru B et al. | Blood transfusions in liver recipients: a conundrum or a clear benefit in the cyclosporine/tacrolimus era? | 1997 | Transplantation | pmid:9197350 |
Cameron AM et al. | FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. | 1997 | J. Biol. Chem. | pmid:9346894 |
Maurer M et al. | Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. | 1997 | Am. J. Pathol. | pmid:9094998 |
Rinaldi M et al. | FK506 effectiveness in reducing acute rejection after heart transplantation: a prospective randomized study. | 1997 | J. Heart Lung Transplant. | pmid:9361242 |
Holt DW and Johnston A | Tacrolimus quality assessment. | 1997 | Ther Drug Monit | pmid:9108659 |
Nyanguile O et al. | A nonnatural transcriptional coactivator. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391036 |
Scantlebury VP et al. | Outcome of kidney transplantation in African-Americans using tacrolimus. | 1997 | Transplant. Proc. | pmid:9414906 |
Neuhaus P et al. | Tacrolimus-based immunosuppression after liver transplantation: a randomised study comparing dual versus triple low-dose oral regimens. | 1997 | Transpl. Int. | pmid:9249934 |
Shaw LM | Mycophenolate mofetil: pharmacokinetic strategies for optimizing immunosuppression. | 1997 | Drug Metabol Drug Interact | pmid:9713576 |
Scholler G et al. | Comparison of cyclosporine A and FK506 with regard to complaints and psychosocial characteristics before and after liver transplantation. | 1997 | Transplant. Proc. | pmid:9270822 |
Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |